LOCUS       NM_027379               4956 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus fatty acyl CoA reductase 1 (Far1), transcript variant
            1, mRNA.
ACCESSION   NM_027379
VERSION     NM_027379.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4956)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4956)
  AUTHORS   Pan,B., Yuan,S., Mayernik,L., Yap,Y.T., Moin,K., Chung,C.S.,
            Maddipati,K., Krawetz,S.A., Zhang,Z., Hess,R.A. and Chen,X.
  TITLE     Disrupted intercellular bridges and spermatogenesis in fatty
            acyl-CoA reductase 1 knockout mice: A new model of ether lipid
            deficiency
  JOURNAL   FASEB J 37 (5), e22908 (2023)
   PUBMED   37039784
REFERENCE   3  (bases 1 to 4956)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 4956)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. II. Expression cloning of wax synthase
            cDNAs encoding a member of the acyltransferase enzyme family
  JOURNAL   J Biol Chem 279 (36), 37798-37807 (2004)
   PUBMED   15220349
  REMARK    GeneRIF: wax monoester synthesis in mammals involves a two step
            biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax
            synthase enzymes
REFERENCE   5  (bases 1 to 4956)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. I. Identification of two fatty
            acyl-Coenzyme A reductases with different substrate specificities
            and tissue distributions
  JOURNAL   J Biol Chem 279 (36), 37789-37797 (2004)
   PUBMED   15220348
  REMARK    GeneRIF: fatty alcohol synthesis in mammals is accomplished by two
            fatty acyl-CoA reductase isozymes that are expressed at high levels
            in tissues known to synthesize wax monoesters and ether lipids
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156987.7, AK014486.1 and AC102841.7.
            
            On Feb 9, 2018 this sequence version replaced NM_027379.3.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1, 3, and 4 all encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030067.1, AK014405.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC156987.7         49481-49544         c
            65-1705             AK014486.1         38-1678
            1706-4956           AC102841.7         91720-94970
FEATURES             Location/Qualifiers
     source          1..4956
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.21 cM"
     gene            1..4956
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /note="fatty acyl CoA reductase 1"
                     /db_xref="GeneID:67420"
                     /db_xref="MGI:MGI:1914670"
     exon            1..104
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            105..155
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..349
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1708
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /EC_number="1.2.1.84"
                     /note="isoform 1 is encoded by transcript variant 1; male
                     sterility domain containing 2"
                     /codon_start=1
                     /product="fatty acyl-CoA reductase 1 isoform 1"
                     /protein_id="NP_081655.2"
                     /db_xref="CCDS:CCDS40093.1"
                     /db_xref="GeneID:67420"
                     /db_xref="MGI:MGI:1914670"
                     /translation="MVSIPEYYEGKNILLTGATGFLGKVLLEKLLRSCPRVNSVYVLV
                     RQKAGQTPQERVEEILSSKLFDRLRDENPDFREKIIAINSELTQPKLALSEEDKEIII
                     DSTNVIFHCAATVRFNENLRDAVQLNVIATRQLILLAQQMKNLEVFMHVSTAYAYCNR
                     KHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRPNTYIYTKALAEYVVQQE
                     GAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTMRASNNALADLV
                     PVDVVVNTSLAAAWYSGVNRPRNIMVYNCTTGSTNPFHWGEVEYHVISTFKRNPLEQA
                     FRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRMMKTITRLHKAMVFLE
                     YFTSNSWVWNTDNVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCMGTKKYVLNEEM
                     SGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVVSLCYKFLSYFR
                     ASSTMRY"
     exon            350..525
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..705
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..883
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..928
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1047
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1115
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1287
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1417
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1545
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..4956
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1804..1809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /note="hexamer: ATTAAA"
     polyA_site      1824
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /note="major polyA site"
     regulatory      4308..4313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /note="hexamer: AATAAA"
     polyA_site      4336
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /note="major polyA site"
ORIGIN      
        1 gctcttcagc agccggtcgg gggcggtgaa aagcgagtga ggagagcgcg accacggcgt
       61 agccatcgct gaagggagag cgaggcccga gcttccgcgt cgagatttgg tgactgagga
      121 aaggacccag agactccttg aacaactaag acaagtcagg atggtttcaa tcccagaata
      181 ctacgagggg aagaatatcc ttctcacagg agccactggt ttcttaggca aggtgcttct
      241 ggaaaagttg ctgagatctt gtcccagggt gaattctgtc tatgttttgg tgaggcaaaa
      301 agctggtcag acaccccaag agcgagtgga ggaaatcctc agtagcaagc ttttcgacag
      361 gttgagagat gaaaatccag attttagaga gaaaattata gcgatcaaca gtgaacttac
      421 ccaacctaaa ctggctctca gtgaagaaga taaggagatc attatagatt ctacaaatgt
      481 catattccac tgtgcggcta ctgtaagatt taatgaaaat ttaagagatg ctgtccagtt
      541 aaatgtgata gctacacgac agcttattct ccttgcacag caaatgaaga atctggaagt
      601 gttcatgcat gtctcaacag cgtatgccta ctgcaatcga aagcatattg atgaagtagt
      661 ttatccaccc cctgtagatc ccaagaagct gattgattct ttagaatgga tggatgatgg
      721 cctagtaaat gatatcacac caaaattgat aggcgacagg cctaacacgt acatatacac
      781 caaggcattg gcagagtatg ttgtgcagca ggaaggagca aagctaaatg ttgccattgt
      841 aaggccgtcg atcgtcggcg ccagttggaa agaacctttt ccaggatgga ttgataactt
      901 taatggacca agtggtctct tcattgcggc agggaaagga attcttcgaa caatgcgtgc
      961 ctccaacaat gcccttgcag atctcgttcc tgtagatgta gtggtcaaca cgagccttgc
     1021 tgcagcctgg tattctggag ttaatagacc aagaaacatc atggtgtata attgcacaac
     1081 aggcagcact aatcctttcc actgggggga agttgaatac catgtaattt ccactttcaa
     1141 gaggaatcct ctcgaacagg ccttcagacg gcccaatgta aatctaacct ccaatcacct
     1201 tttatatcat tactggattg ctgtaagcca taaggcccca gcattcctgt atgatatcta
     1261 cctcaggatg actggaagaa gcccaaggat gatgaaaaca atcactcgtc ttcacaaagc
     1321 catggtattc cttgagtatt ttacaagtaa ctcttgggtt tggaatactg ataatgtcaa
     1381 tatgttaatg aaccaactaa accctgaaga taaaaagacc tttaatattg atgtacggca
     1441 gttacattgg gcagaatata tagaaaacta ctgcatgggg actaagaagt acgtgttgaa
     1501 tgaagagatg tctggcctcc ctgctgctcg gaagcatctc aacaagttgc ggaatatccg
     1561 ttatggtttc aatacaatcc ttgtgatact tatctggcgc atttttattg caagatcaca
     1621 aatggcaaga aacatctggt attttgtggt tagtctgtgt tacaaatttc tgtcatactt
     1681 ccgagcatcc agcactatga gatactgaag accaagaatt tagcattaga acatctatgc
     1741 atatggtgat ctaaatgcac aaaatgtaaa atgtacttaa gacatctcac cttttgttaa
     1801 gacattaaac catcttaaat tggagcgtgg agtaaattat ggtccatttt atgtagcatt
     1861 ttaatgttta tgctcaaaac ctagtgaaca cactgtggta tgccagctca gaactgcagt
     1921 agtcactcaa attatgattc aacattttaa tccttggaat gcaaagggta ggaagggggc
     1981 agaagtgggg ctatgggagc attgaccagt ataactgtgc agttctggaa catattaatt
     2041 aaaacatgcc ttaacatgaa gtcctaatat tcagtgcaat ggaaaatgtg cagacagaag
     2101 gcctagataa attagttaag gatttgattt gatttgattc ttcaatgttg atttcttttt
     2161 tctttttaat cctttgagag gtggggttta attttgctaa gaccacagcc atgtgttttt
     2221 tcttcctgta agttacaggt ggtgtcaaac gcaaagactc gttctgattt tctttctgaa
     2281 taaatgtgtg ttgcatatca ttttttataa gtaattagtt gctcttatga tcagaaggcc
     2341 aaatattatt ctaaagacac taatagatct ggatgaattt aagattctgt atcaatgtat
     2401 actctgcatt tgaagcaaag tgaaaacatg cacggtaaag gaaaccactt ttctagtctg
     2461 cattttgttc aaatggaact ctggtgagat gtgttttcat tttgaagagg atttcttgag
     2521 acgtgatgag aggtgggatt ggggaaggat tcattatatt tatcctctcc tccttataaa
     2581 ttttcccaca ggacttgccc catatgaaca tgcattatta tgaaggaatg tagttgcagc
     2641 ttttaacatt aagaaaatgt cctcatgtgt ttgccaacac acactaattt gatcttgaaa
     2701 gctgaattcc tttaaaaatg aataatgcat aagtatgtgt ataaaattaa ataaaggatt
     2761 ttaccatgta aagtagcaaa ctgttgaatg agtttcaagt catcatttct ttgcatgttg
     2821 ttttagcttt agaaagacat gcgttataga aacaagtaat agcaaaaaat tgatgtatat
     2881 ttattgattc aattcccttt aaatcttact agtttgttac tattttatcc atatttttaa
     2941 tggcttgttc agcataacac agttataatt aagctgatca agttgtacta catttaaatc
     3001 atcagcagtg tatcttgaaa gtgcttaaag ggttagttca tagtacaaga aattaaatgc
     3061 aactttacat tttaattttt tgtcaattaa aatacaatgt agaagtttat tttactattg
     3121 tggacacaaa atgtaaagga aaccaacttt ttccatactg atgtataatc ttgaaaagga
     3181 aaaaaaaaaa aagcttctct gttgaagcca gactttgtgt agtaaaactt ttaaacatta
     3241 ttttaaaaga aatatgtata taagtatctg tgtattcttt ggaatgattc tgaagtctct
     3301 ggtctaggac catgcctgta taaggtgtga gagaccatga tggtgtgtga gaatggaata
     3361 aatgatgcct ttgatttaag gtggcccata taatatacat tgagtactcc atgtctccaa
     3421 atggatttcc atgatgtaat gaaaacacac taaccttttt atgattttta tacatctgcc
     3481 aaaatatact gagaatctga taaattgtct ttgggtctct gaaaagaatc aggtgcaatg
     3541 tgggcaggcc tgtaaactga accagatatg tgtcttctat tttattgctc ttgtaatcta
     3601 atgtaaagaa ttgctaacta aggctgtgct gaggaggtca aattaatttt tatttgttta
     3661 gaattctgtt gtcaaaagaa aggtaatgaa taaatgatgc tcatcctaga atgtataatt
     3721 ttgaaattag tatggagtaa aatgtgagag cgttgagctt tatcagctac acttgcattc
     3781 aagtcatatt gtaagagttt ggagatgtat gctctttgta atttgctaca gtgtttttag
     3841 ttctgattat atttttcata tagattattc aataggacaa ctctgttaaa taaattaatt
     3901 tcattcacct catttggcaa aactgtattc tgaaccattt agggtttttc ccttatcttt
     3961 ccttctctga actctggcat acatatttgt acactgtaat gtcattgtaa ctgtttaatt
     4021 gccttggcaa tgctaatgta tcgtaacact tagttgagaa aagcatgacc gggtcatatg
     4081 ttgtttgact taagggtaac atagaataag tgtttctcca gtctgccaga caaagcttgg
     4141 tagtgggagg ggactctgac ctctcccttt tgtgtttgtc tataggaatt gattgggaaa
     4201 cttttgtttt gtgttttttg tttgtttgtt tgaagtgtaa actgatactc ttttataaga
     4261 agtaaataca aacattattg ggtgcctttg tttgtaaacc aaaaagtaat aaatgaatcc
     4321 ctatatttct attatagcat ctattgtatt tttacattgt ggaaaccatc catgagttaa
     4381 aatggctacg atggcaaaag tagtccttgg atcttttttc tttcttaggt gtcctcatct
     4441 attctcatca tctttttatt tatgtcttga gttgttcaca cagcacttta ggggaagcat
     4501 ataggcagaa tgaacattta tttaaaagta tttttatata gtgattaata atgagacaga
     4561 ttttttttta atgtaaataa aaccgggaga ccaccagcgt gttccaagga tgaatgacat
     4621 tatgttagtt tataggttct tcaccagtag tagatctgac ttcatttaaa ggattattca
     4681 ttttcataga gattgagtga agtacttggc gggggtgctg agagtgtgtc aggatggggt
     4741 tagagtgtaa atggctttgt aagcattcct ttctaggctg acttccagct ctgacttgaa
     4801 accgtttgca ccgacttgct ctgctttaag aaaaacattc taactgcatg agaagcttag
     4861 agaaaagggt atgtgctgcg taacttacta caaaaaatga gtttatcagt ctgtttatat
     4921 atgaaatatt ttcttaataa agaaaatttg agcaac
//
