LOCUS       NP_081655                515 aa            linear   ROD 02-MAY-2024
DEFINITION  fatty acyl-CoA reductase 1 isoform 1 [Mus musculus].
ACCESSION   NP_081655
VERSION     NP_081655.2
DBSOURCE    REFSEQ: accession NM_027379.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 515)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 515)
  AUTHORS   Pan,B., Yuan,S., Mayernik,L., Yap,Y.T., Moin,K., Chung,C.S.,
            Maddipati,K., Krawetz,S.A., Zhang,Z., Hess,R.A. and Chen,X.
  TITLE     Disrupted intercellular bridges and spermatogenesis in fatty
            acyl-CoA reductase 1 knockout mice: A new model of ether lipid
            deficiency
  JOURNAL   FASEB J 37 (5), e22908 (2023)
   PUBMED   37039784
REFERENCE   3  (residues 1 to 515)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (residues 1 to 515)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. II. Expression cloning of wax synthase
            cDNAs encoding a member of the acyltransferase enzyme family
  JOURNAL   J Biol Chem 279 (36), 37798-37807 (2004)
   PUBMED   15220349
  REMARK    GeneRIF: wax monoester synthesis in mammals involves a two step
            biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax
            synthase enzymes
REFERENCE   5  (residues 1 to 515)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. I. Identification of two fatty
            acyl-Coenzyme A reductases with different substrate specificities
            and tissue distributions
  JOURNAL   J Biol Chem 279 (36), 37789-37797 (2004)
   PUBMED   15220348
  REMARK    GeneRIF: fatty alcohol synthesis in mammals is accomplished by two
            fatty acyl-CoA reductase isozymes that are expressed at high levels
            in tissues known to synthesize wax monoesters and ether lipids
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156987.7, AK014486.1 and AC102841.7.
            
            On Jul 1, 2005 this sequence version replaced NP_081655.1.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1, 3, and 4 all encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030067.1, AK014405.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.21 cM"
     Protein         1..515
                     /product="fatty acyl-CoA reductase 1 isoform 1"
                     /EC_number="1.2.1.84"
                     /note="male sterility domain containing 2"
                     /calculated_mol_wt=59304
     Region          11..330
                     /region_name="FAR-N_SDR_e"
                     /note="fatty acyl CoA reductases (FARs), extended (e)
                     SDRs; cd05236"
                     /db_xref="CDD:187547"
     Site            order(17,19..22,44..46,111..113,130,151..153,204,208,
                     229..232)
                     /site_type="other"
                     /note="putative NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187547"
     Site            order(131,153,204,208)
                     /site_type="active"
                     /db_xref="CDD:187547"
     Site            order(153,204,231,243,259,265)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:187547"
     Region          357..447
                     /region_name="Sterile"
                     /note="Male sterility protein; pfam03015"
                     /db_xref="CDD:460779"
     Region          451..507
                     /region_name="Necessary and sufficient for PEX19-mediated
                     localization into peroxisome membrane.
                     /evidence=ECO:0000250|UniProtKB:Q8WVX9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q922J9.1)"
     Site            466..483
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q922J9.1)"
     CDS             1..515
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /coded_by="NM_027379.4:161..1708"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS40093.1"
                     /db_xref="GeneID:67420"
                     /db_xref="MGI:MGI:1914670"
ORIGIN      
        1 mvsipeyyeg knilltgatg flgkvllekl lrscprvnsv yvlvrqkagq tpqerveeil
       61 ssklfdrlrd enpdfrekii ainseltqpk lalseedkei iidstnvifh caatvrfnen
      121 lrdavqlnvi atrqlillaq qmknlevfmh vstayaycnr khidevvypp pvdpkklids
      181 lewmddglvn ditpkligdr pntyiytkal aeyvvqqega klnvaivrps ivgaswkepf
      241 pgwidnfngp sglfiaagkg ilrtmrasnn aladlvpvdv vvntslaaaw ysgvnrprni
      301 mvyncttgst npfhwgevey hvistfkrnp leqafrrpnv nltsnhllyh ywiavshkap
      361 aflydiylrm tgrsprmmkt itrlhkamvf leyftsnswv wntdnvnmlm nqlnpedkkt
      421 fnidvrqlhw aeyienycmg tkkyvlneem sglpaarkhl nklrnirygf ntilviliwr
      481 ifiarsqmar niwyfvvslc ykflsyfras stmry
//
