LOCUS       NM_001360669            4952 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus fatty acyl CoA reductase 1 (Far1), transcript variant
            4, mRNA.
ACCESSION   NM_001360669 XM_006508127
VERSION     NM_001360669.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4952)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4952)
  AUTHORS   Pan,B., Yuan,S., Mayernik,L., Yap,Y.T., Moin,K., Chung,C.S.,
            Maddipati,K., Krawetz,S.A., Zhang,Z., Hess,R.A. and Chen,X.
  TITLE     Disrupted intercellular bridges and spermatogenesis in fatty
            acyl-CoA reductase 1 knockout mice: A new model of ether lipid
            deficiency
  JOURNAL   FASEB J 37 (5), e22908 (2023)
   PUBMED   37039784
REFERENCE   3  (bases 1 to 4952)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 4952)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. II. Expression cloning of wax synthase
            cDNAs encoding a member of the acyltransferase enzyme family
  JOURNAL   J Biol Chem 279 (36), 37798-37807 (2004)
   PUBMED   15220349
  REMARK    GeneRIF: wax monoester synthesis in mammals involves a two step
            biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax
            synthase enzymes
REFERENCE   5  (bases 1 to 4952)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. I. Identification of two fatty
            acyl-Coenzyme A reductases with different substrate specificities
            and tissue distributions
  JOURNAL   J Biol Chem 279 (36), 37789-37797 (2004)
   PUBMED   15220348
  REMARK    GeneRIF: fatty alcohol synthesis in mammals is accomplished by two
            fatty acyl-CoA reductase isozymes that are expressed at high levels
            in tissues known to synthesize wax monoesters and ether lipids
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156987.7 and AC102841.7.
            
            On Feb 9, 2018 this sequence version replaced XM_006508127.3.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.170626.1,
                                           SRR1660815.155044.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC156987.7         49441-49544         c
            105-155             AC156987.7         37340-37390         c
            156-345             AC156987.7         23912-24101         c
            346-521             AC156987.7         22667-22842         c
            522-701             AC156987.7         15797-15976         c
            702-879             AC156987.7         13235-13412         c
            880-924             AC156987.7         12261-12305         c
            925-1043            AC156987.7         12025-12143         c
            1044-1111           AC156987.7         11376-11443         c
            1112-1283           AC156987.7         9565-9736           c
            1284-1413           AC156987.7         1873-2002           c
            1414-1541           AC102841.7         89850-89977
            1542-4952           AC102841.7         91560-94970
FEATURES             Location/Qualifiers
     source          1..4952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.21 cM"
     gene            1..4952
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /note="fatty acyl CoA reductase 1"
                     /db_xref="GeneID:67420"
                     /db_xref="MGI:MGI:1914670"
     exon            1..104
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            105..155
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..345
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1704
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /EC_number="1.2.1.84"
                     /note="isoform 1 is encoded by transcript variant 4; male
                     sterility domain containing 2"
                     /codon_start=1
                     /product="fatty acyl-CoA reductase 1 isoform 1"
                     /protein_id="NP_001347598.1"
                     /db_xref="CCDS:CCDS40093.1"
                     /db_xref="GeneID:67420"
                     /db_xref="MGI:MGI:1914670"
                     /translation="MVSIPEYYEGKNILLTGATGFLGKVLLEKLLRSCPRVNSVYVLV
                     RQKAGQTPQERVEEILSSKLFDRLRDENPDFREKIIAINSELTQPKLALSEEDKEIII
                     DSTNVIFHCAATVRFNENLRDAVQLNVIATRQLILLAQQMKNLEVFMHVSTAYAYCNR
                     KHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRPNTYIYTKALAEYVVQQE
                     GAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTMRASNNALADLV
                     PVDVVVNTSLAAAWYSGVNRPRNIMVYNCTTGSTNPFHWGEVEYHVISTFKRNPLEQA
                     FRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRMMKTITRLHKAMVFLE
                     YFTSNSWVWNTDNVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCMGTKKYVLNEEM
                     SGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVVSLCYKFLSYFR
                     ASSTMRY"
     exon            346..521
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..701
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..879
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..924
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1043
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1111
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1283
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1413
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1541
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..4952
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1800..1805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /note="hexamer: ATTAAA"
     polyA_site      1820
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /note="major polyA site"
     regulatory      4304..4309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /note="hexamer: AATAAA"
     polyA_site      4332
                     /gene="Far1"
                     /gene_synonym="2600011M19Rik; 2900034E22Rik;
                     3732409C05Rik; Mlstd2"
                     /note="major polyA site"
ORIGIN      
        1 gctcttcagc agccggtcgg gggcggtgaa aagcgagtga ggagagcgcg accacggcgt
       61 agccatcgct gaagggagag cgaggcccga gcttccgcgt cgagatttgg tgactgagga
      121 aaggacccag agactccttg aacaactaag acaaggatgg tttcaatccc agaatactac
      181 gaggggaaga atatccttct cacaggagcc actggtttct taggcaaggt gcttctggaa
      241 aagttgctga gatcttgtcc cagggtgaat tctgtctatg ttttggtgag gcaaaaagct
      301 ggtcagacac cccaagagcg agtggaggaa atcctcagta gcaagctttt cgacaggttg
      361 agagatgaaa atccagattt tagagagaaa attatagcga tcaacagtga acttacccaa
      421 cctaaactgg ctctcagtga agaagataag gagatcatta tagattctac aaatgtcata
      481 ttccactgtg cggctactgt aagatttaat gaaaatttaa gagatgctgt ccagttaaat
      541 gtgatagcta cacgacagct tattctcctt gcacagcaaa tgaagaatct ggaagtgttc
      601 atgcatgtct caacagcgta tgcctactgc aatcgaaagc atattgatga agtagtttat
      661 ccaccccctg tagatcccaa gaagctgatt gattctttag aatggatgga tgatggccta
      721 gtaaatgata tcacaccaaa attgataggc gacaggccta acacgtacat atacaccaag
      781 gcattggcag agtatgttgt gcagcaggaa ggagcaaagc taaatgttgc cattgtaagg
      841 ccgtcgatcg tcggcgccag ttggaaagaa ccttttccag gatggattga taactttaat
      901 ggaccaagtg gtctcttcat tgcggcaggg aaaggaattc ttcgaacaat gcgtgcctcc
      961 aacaatgccc ttgcagatct cgttcctgta gatgtagtgg tcaacacgag ccttgctgca
     1021 gcctggtatt ctggagttaa tagaccaaga aacatcatgg tgtataattg cacaacaggc
     1081 agcactaatc ctttccactg gggggaagtt gaataccatg taatttccac tttcaagagg
     1141 aatcctctcg aacaggcctt cagacggccc aatgtaaatc taacctccaa tcacctttta
     1201 tatcattact ggattgctgt aagccataag gccccagcat tcctgtatga tatctacctc
     1261 aggatgactg gaagaagccc aaggatgatg aaaacaatca ctcgtcttca caaagccatg
     1321 gtattccttg agtattttac aagtaactct tgggtttgga atactgataa tgtcaatatg
     1381 ttaatgaacc aactaaaccc tgaagataaa aagaccttta atattgatgt acggcagtta
     1441 cattgggcag aatatataga aaactactgc atggggacta agaagtacgt gttgaatgaa
     1501 gagatgtctg gcctccctgc tgctcggaag catctcaaca agttgcggaa tatccgttat
     1561 ggtttcaata caatccttgt gatacttatc tggcgcattt ttattgcaag atcacaaatg
     1621 gcaagaaaca tctggtattt tgtggttagt ctgtgttaca aatttctgtc atacttccga
     1681 gcatccagca ctatgagata ctgaagacca agaatttagc attagaacat ctatgcatat
     1741 ggtgatctaa atgcacaaaa tgtaaaatgt acttaagaca tctcaccttt tgttaagaca
     1801 ttaaaccatc ttaaattgga gcgtggagta aattatggtc cattttatgt agcattttaa
     1861 tgtttatgct caaaacctag tgaacacact gtggtatgcc agctcagaac tgcagtagtc
     1921 actcaaatta tgattcaaca ttttaatcct tggaatgcaa agggtaggaa gggggcagaa
     1981 gtggggctat gggagcattg accagtataa ctgtgcagtt ctggaacata ttaattaaaa
     2041 catgccttaa catgaagtcc taatattcag tgcaatggaa aatgtgcaga cagaaggcct
     2101 agataaatta gttaaggatt tgatttgatt tgattcttca atgttgattt cttttttctt
     2161 tttaatcctt tgagaggtgg ggtttaattt tgctaagacc acagccatgt gttttttctt
     2221 cctgtaagtt acaggtggtg tcaaacgcaa agactcgttc tgattttctt tctgaataaa
     2281 tgtgtgttgc atatcatttt ttataagtaa ttagttgctc ttatgatcag aaggccaaat
     2341 attattctaa agacactaat agatctggat gaatttaaga ttctgtatca atgtatactc
     2401 tgcatttgaa gcaaagtgaa aacatgcacg gtaaaggaaa ccacttttct agtctgcatt
     2461 ttgttcaaat ggaactctgg tgagatgtgt tttcattttg aagaggattt cttgagacgt
     2521 gatgagaggt gggattgggg aaggattcat tatatttatc ctctcctcct tataaatttt
     2581 cccacaggac ttgccccata tgaacatgca ttattatgaa ggaatgtagt tgcagctttt
     2641 aacattaaga aaatgtcctc atgtgtttgc caacacacac taatttgatc ttgaaagctg
     2701 aattccttta aaaatgaata atgcataagt atgtgtataa aattaaataa aggattttac
     2761 catgtaaagt agcaaactgt tgaatgagtt tcaagtcatc atttctttgc atgttgtttt
     2821 agctttagaa agacatgcgt tatagaaaca agtaatagca aaaaattgat gtatatttat
     2881 tgattcaatt ccctttaaat cttactagtt tgttactatt ttatccatat ttttaatggc
     2941 ttgttcagca taacacagtt ataattaagc tgatcaagtt gtactacatt taaatcatca
     3001 gcagtgtatc ttgaaagtgc ttaaagggtt agttcatagt acaagaaatt aaatgcaact
     3061 ttacatttta attttttgtc aattaaaata caatgtagaa gtttatttta ctattgtgga
     3121 cacaaaatgt aaaggaaacc aactttttcc atactgatgt ataatcttga aaaggaaaaa
     3181 aaaaaaaagc ttctctgttg aagccagact ttgtgtagta aaacttttaa acattatttt
     3241 aaaagaaata tgtatataag tatctgtgta ttctttggaa tgattctgaa gtctctggtc
     3301 taggaccatg cctgtataag gtgtgagaga ccatgatggt gtgtgagaat ggaataaatg
     3361 atgcctttga tttaaggtgg cccatataat atacattgag tactccatgt ctccaaatgg
     3421 atttccatga tgtaatgaaa acacactaac ctttttatga tttttataca tctgccaaaa
     3481 tatactgaga atctgataaa ttgtctttgg gtctctgaaa agaatcaggt gcaatgtggg
     3541 caggcctgta aactgaacca gatatgtgtc ttctatttta ttgctcttgt aatctaatgt
     3601 aaagaattgc taactaaggc tgtgctgagg aggtcaaatt aatttttatt tgtttagaat
     3661 tctgttgtca aaagaaaggt aatgaataaa tgatgctcat cctagaatgt ataattttga
     3721 aattagtatg gagtaaaatg tgagagcgtt gagctttatc agctacactt gcattcaagt
     3781 catattgtaa gagtttggag atgtatgctc tttgtaattt gctacagtgt ttttagttct
     3841 gattatattt ttcatataga ttattcaata ggacaactct gttaaataaa ttaatttcat
     3901 tcacctcatt tggcaaaact gtattctgaa ccatttaggg tttttccctt atctttcctt
     3961 ctctgaactc tggcatacat atttgtacac tgtaatgtca ttgtaactgt ttaattgcct
     4021 tggcaatgct aatgtatcgt aacacttagt tgagaaaagc atgaccgggt catatgttgt
     4081 ttgacttaag ggtaacatag aataagtgtt tctccagtct gccagacaaa gcttggtagt
     4141 gggaggggac tctgacctct cccttttgtg tttgtctata ggaattgatt gggaaacttt
     4201 tgttttgtgt tttttgtttg tttgtttgaa gtgtaaactg atactctttt ataagaagta
     4261 aatacaaaca ttattgggtg cctttgtttg taaaccaaaa agtaataaat gaatccctat
     4321 atttctatta tagcatctat tgtattttta cattgtggaa accatccatg agttaaaatg
     4381 gctacgatgg caaaagtagt ccttggatct tttttctttc ttaggtgtcc tcatctattc
     4441 tcatcatctt tttatttatg tcttgagttg ttcacacagc actttagggg aagcatatag
     4501 gcagaatgaa catttattta aaagtatttt tatatagtga ttaataatga gacagatttt
     4561 tttttaatgt aaataaaacc gggagaccac cagcgtgttc caaggatgaa tgacattatg
     4621 ttagtttata ggttcttcac cagtagtaga tctgacttca tttaaaggat tattcatttt
     4681 catagagatt gagtgaagta cttggcgggg gtgctgagag tgtgtcagga tggggttaga
     4741 gtgtaaatgg ctttgtaagc attcctttct aggctgactt ccagctctga cttgaaaccg
     4801 tttgcaccga cttgctctgc tttaagaaaa acattctaac tgcatgagaa gcttagagaa
     4861 aagggtatgt gctgcgtaac ttactacaaa aaatgagttt atcagtctgt ttatatatga
     4921 aatattttct taataaagaa aatttgagca ac
//
