LOCUS       NM_178912               7562 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus Fanconi anemia, complementation group M (Fancm),
            transcript variant 1, mRNA.
ACCESSION   NM_178912
VERSION     NM_178912.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7562)
  AUTHORS   Panday,A., Willis,N.A., Elango,R., Menghi,F., Duffey,E.E., Liu,E.T.
            and Scully,R.
  TITLE     FANCM regulates repair pathway choice at stalled replication forks
  JOURNAL   Mol Cell 81 (11), 2428-2444 (2021)
   PUBMED   33882298
  REMARK    GeneRIF: FANCM regulates repair pathway choice at stalled
            replication forks.
REFERENCE   2  (bases 1 to 7562)
  AUTHORS   Bloom,J.C. and Schimenti,J.C.
  TITLE     Sexually dimorphic DNA damage responses and mutation avoidance in
            the mouse germline
  JOURNAL   Genes Dev 34 (23-24), 1637-1649 (2020)
   PUBMED   33184219
REFERENCE   3  (bases 1 to 7562)
  AUTHORS   McNairn,A.J., Chuang,C.H., Bloom,J.C., Wallace,M.D. and
            Schimenti,J.C.
  TITLE     Female-biased embryonic death from inflammation induced by genomic
            instability
  JOURNAL   Nature 567 (7746), 105-108 (2019)
   PUBMED   30787433
REFERENCE   4  (bases 1 to 7562)
  AUTHORS   Yin,H., Ma,H., Hussain,S., Zhang,H., Xie,X., Jiang,L., Jiang,X.,
            Iqbal,F., Bukhari,I., Jiang,H., Ali,A., Zhong,L., Li,T., Fan,S.,
            Zhang,B., Gao,J., Li,Y., Nazish,J., Khan,T., Khan,M., Zubair,M.,
            Hao,Q., Fang,H., Huang,J., Huleihel,M., Sha,J., Pandita,T.K.,
            Zhang,Y. and Shi,Q.
  TITLE     A homozygous FANCM frameshift pathogenic variant causes male
            infertility
  JOURNAL   Genet Med 21 (1), 62-70 (2019)
   PUBMED   29895858
  REMARK    GeneRIF: The loss-of-function FANCM pathogenic variants (PV)
            increased ICL sensitivity in lymphocytes of patients and
            Fancm(DeltaC/DeltaC) spermatogonia.neither bone marrow failure nor
            cancer/tumor was detected in all the patients or adult
            Fancm(DeltaC/DeltaC) mice.  These findings revealed male
            infertility to be a novel phenotype of human patients with a
            biallelic FANCM PV.
            Erratum:[Genet Med. 2019 Jan;21(1):266. doi:
            10.1038/s41436-018-0127-0.. PMID: 30158692]
REFERENCE   5  (bases 1 to 7562)
  AUTHORS   Wang,H., Li,S., Oaks,J., Ren,J., Li,L. and Wu,X.
  TITLE     The concerted roles of FANCM and Rad52 in the protection of common
            fragile sites
  JOURNAL   Nat Commun 9 (1), 2791 (2018)
   PUBMED   30022024
  REMARK    GeneRIF: Suppression of Rad52 expression in combination with FANCM
            knockout drastically reduces cell and tumor growth, suggesting a
            synthetic lethality interaction between these two genes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7562)
  AUTHORS   Luo,Y. and Schimenti,J.C.
  TITLE     MCM9 deficiency delays primordial germ cell proliferation
            independent of the ATM pathway
  JOURNAL   Genesis 53 (11), 678-684 (2015)
   PUBMED   26388201
REFERENCE   7  (bases 1 to 7562)
  AUTHORS   Luo,Y., Hartford,S.A., Zeng,R., Southard,T.L., Shima,N. and
            Schimenti,J.C.
  TITLE     Hypersensitivity of primordial germ cells to compromised
            replication-associated DNA repair involves ATM-p53-p21 signaling
  JOURNAL   PLoS Genet 10 (7), e1004471 (2014)
   PUBMED   25010009
  REMARK    Erratum:[PLoS Genet. 2014 Sep;10(9):e1004730]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7562)
  AUTHORS   Bakker,S.T., van de Vrugt,H.J., Rooimans,M.A., Oostra,A.B.,
            Steltenpool,J., Delzenne-Goette,E., van der Wal,A., van der
            Valk,M., Joenje,H., te Riele,H. and de Winter,J.P.
  TITLE     Fancm-deficient mice reveal unique features of Fanconi anemia
            complementation group M
  JOURNAL   Hum Mol Genet 18 (18), 3484-3495 (2009)
   PUBMED   19561169
  REMARK    GeneRIF: Fancm(Delta2/Delta2) mice also showed unique features
            atypical for Fanconi anemia mice, including underrepresentation of
            female Fancm(Delta2/Delta2) mice and decreased overall and
            tumor-free survival.
REFERENCE   9  (bases 1 to 7562)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 7562)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159621.2, AK050306.1, AK173211.1, AK050832.1 and AK085388.1.
            
            On Jun 16, 2018 this sequence version replaced NM_178912.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC159621.2         87600-87602         c
            4-4281              AK050306.1         2-4279
            4282-6367           AK173211.1         4299-6384
            6368-7409           AK050832.1         481-1522
            7410-7562           AK085388.1         550-702
FEATURES             Location/Qualifiers
     source          1..7562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 27.21 cM"
     gene            1..7562
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /note="Fanconi anemia, complementation group M"
                     /db_xref="GeneID:104806"
                     /db_xref="MGI:MGI:2442306"
     exon            1..575
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..6169
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fanconi anemia group M protein homolog; ATP-dependent RNA
                     helicase FANCM"
                     /codon_start=1
                     /product="Fanconi anemia group M protein homolog isoform
                     1"
                     /protein_id="NP_849243.2"
                     /db_xref="CCDS:CCDS25941.1"
                     /db_xref="GeneID:104806"
                     /db_xref="MGI:MGI:2442306"
                     /translation="MSGRQRTLFQTWGPSLVRGSGDSGCGQPRSPAMAEALPEEDDEV
                     LLVAAYEAERQLDPGDGGFCAAAGALWIYPTNCPVRDYQLDISRSALFCNTLVCLPTG
                     LGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQMEACFHVMGIPQSHMAEMTGST
                     QAVNRKEIWSSRRVLFLTPQVMVNDLTRGAVPATHVKCLVVDEAHKALGNYAYCQVVR
                     ELVKYTTHFRILALSATPGSDIKAVQQVITNLLIGKIELRSEESPDILPYSHERRVEK
                     LVVPLGEELGAIQKTYIQILETFASSLIHRNVLMKRDIPNLTKYQIILARDQFRKNPS
                     PNIVGIQQGIIEGEFALCISLYHGYELLQQMGMRSLYFFLSGIMDGTKGMTRARNELS
                     RNEDFMKLYTHLQSAFAPASTSDASAFQRGNKEKKFVYSHPKLKKLEEVILEHFKSWN
                     AKATTEKKCHESRVMIFSSFRDSVEEIAEMLLQHRPVIRVMTFVGHASGKNTKGFTQK
                     EQLQVVRQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKR
                     QGRIVVILAEGREERTYNQSQSNKKNIYKAISGNRQVLRLYQGSPRMVPDKINPELHK
                     MYITHGVYEPEKARSVQRRPFSSRGGIKASKSNKDGLLSEEEFNLWSRLYRLGDSDQV
                     KGVALPQSHFPSLQEDRVIQDPTTRIHQLSLSEWSLWQDRPLPTHQVDHSDRCHHFIS
                     IMKMIEGMRHEEGECSYELKIRPFLQMEDVCSKYHAPRNGYNNVASVASSAHQKSSFR
                     PSVDAGGSLTVIESEEEHADTVKQRDSKWTKITSLREKPCRAGRKGQTCEHSEGEGED
                     GDAGSSDADGQSPAEADSQVDPPSGERMADVGGISILGAVTEEDNHPGTLQMECQVTN
                     KSCARYSLDSGYSSFSDEKSVSSNLFLPLEEELFTDRAAEQFYNCRPMTEDVLANVER
                     FLSRSPPSLSGLSDLVYDVTQGCEFDNASCSPYPEHEHSPRPVSPASHSAGNSQQNLE
                     SNSAKRISHPTEKYCLPGTTHNKVSDRPSFCESDSEGHNIKYQNSGSNSCAQIQADLE
                     NNFVDKNSHDDSEPPVLFTDEDESLLLFEDDFKNIEDGPEELNGASLPPFNSISQPLR
                     VSGKTLTSEMPPVSHFLISDELLLDDDSEPEDQIVCGAKSWKCQEGVEDGQEELRTDG
                     QTFDCSVDLFSVTFDLGFRCSSGSDDEMLAGASDRTRTLGAADVSGRHSDKEIKDAGG
                     ASGPLGRAISPIPTETAQWSPWAQNKEYASFHVASSSPVKQRVRSTPLSKSHASSKTG
                     AHMLKTLDSTKEKAGGQGFKMALNPRLGHLGFSVEETKSSDQVFVHQSPRRTEVEHLT
                     SESEDDVFLRKTKKPKRNVLKSPEDQKNNEVDSPIHAVKKPRVLRSELASSDDESENF
                     GRTCPRLEHFKGRNRNIRKGSAAQKNRSQVKTMARRFLDDEAEVSGEDVDCVSADEED
                     ESENEQDSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYRMVREKRPNMNI
                     FSQIPEQDENYLEDSFCVDEEESCKSQSSEEEISVDFNLTKDSFTDEDIRYKTRYAVK
                     IKQMNKKQNYTRPRKKLSRIILPDDDSSEEENIPKDREHSVAGGHAAAEHTQQGQLWA
                     SGPSGSSVPPQVLSDPSWNQSSRQRLQVQPSITDAVPRTLNVKAQSHNKIKSASPPCT
                     GVESRKEYGNHPVQLKADSQEHSDTSAAPCSTSLLHVAEGHTAPRHLQEGNRACILVD
                     SREITTGLEVISSLRTVHGLQVEICPLNGCDYIVSSRMVVVRRSQSEMLSNTSKNKFI
                     EQMQRLQSMFQRICVIVEKDREKAGDTSKKFRRTKCYDSLLTALVGAGIRILFSSGQE
                     ETADLLKELSLVEQRKNAGIHIPAVLNTSKLEALPFYLSIPGISYITALNMCHQFSSV
                     KKMANSSPEEISTCAQVNHQKAEEIYKYIHYIFDMQMLPNDLNQERQKPDTCLTLGVA
                     MKELS"
     exon            576..748
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            749..826
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            827..985
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1117
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1250
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1367
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1454
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1639
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1846
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2051
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2203
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2359
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..4223
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4309
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            4310..4372
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            4373..4504
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            4505..4661
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            4662..4768
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            4769..5329
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            5330..5702
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            5703..5994
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     exon            5995..7562
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6349..6354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /note="hexamer: AATAAA"
     polyA_site      6369
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /note="major polyA site"
     regulatory      7425..7430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /note="hexamer: AATAAA"
     polyA_site      7447
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /note="major polyA site"
     regulatory      7524..7529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /note="hexamer: AATAAA"
     polyA_site      7562
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
ORIGIN      
        1 acccactgtg tcgctggcgg gagactaatg ggcgtccgag tcgcggcggt tgcgctgcca
       61 tccaggcggg ttcctcagcg gagctccgct gctgctgggc accatgagcg gacggcagag
      121 aacgctcttc cagacgtggg gcccgagcct cgtgcggggc tccggagact cgggatgcgg
      181 ccagccgcgc tcgcccgcga tggcggaggc gctgccggag gaggacgacg aggtgctgct
      241 ggtggcggcg tacgaggctg agcggcagct ggatcccggg gatggcggct tctgcgcggc
      301 tgcgggagcc ctgtggatct accccaccaa ttgccccgtg cgcgactacc agctggacat
      361 ctcccggagc gcgctgttct gcaacaccct ggtgtgcctg cccaccgggc tggggaagac
      421 cttcattgcc gccgtggtca tgtataattt ctaccgctgg ttcccttctg gcaaggtggt
      481 tttcatggca cccacgaagc ccctggtaac acagcagatg gaagcctgct tccacgtgat
      541 gggtattcca cagtctcaca tggctgaaat gacaggttca actcaagctg ttaacaggaa
      601 ggagatatgg tccagcagga gggttctttt cctgacaccg caggtcatgg taaatgacct
      661 tactagaggg gctgttcctg ccacccacgt aaagtgtctt gtggtggatg aagctcataa
      721 ggcacttggg aactatgctt actgccaggt ggtaagagaa ttggtcaaat acaccactca
      781 ctttcgtatc ttggctctta gtgccacgcc aggtagtgat atcaaggctg tgcaacaggt
      841 gatcactaac ctactaattg ggaagataga gcttcgttcg gaagagtctc ccgatatttt
      901 gccttactct catgaaagaa gagttgagaa gctcgttgtc ccccttgggg aagaactagg
      961 agccattcaa aagacgtata tccagatttt ggaaacattt gccagttctt tgattcatag
     1021 aaatgttttg atgaaaagag acattcccaa tctaacaaaa taccagataa ttctggcaag
     1081 agatcaattt aggaaaaacc catccccaaa tattgtggga attcagcaag gcataattga
     1141 aggggagttt gccctctgca ttagtttata tcatggttat gagttactgc agcaaatggg
     1201 aatgcggtca ttgtatttct ttctttctgg aatcatggat ggaactaaag gaatgacacg
     1261 ggcaagaaat gagctcagcc gaaatgagga cttcatgaag ctgtacactc acctgcagag
     1321 cgcgtttgca ccagccagca ccagcgatgc ttcggctttc cagagaggaa ataaagagaa
     1381 aaaatttgtc tatagtcatc caaagttaaa gaaactggaa gaagttatac tggaacactt
     1441 caagtcatgg aatgctaaag ccaccactga gaagaagtgc cacgagagca gagtcatgat
     1501 cttctcgtca ttccgagata gcgttgagga gattgcagaa atgcttttac agcaccggcc
     1561 agttattaga gtgatgacct ttgttggcca tgcttcaggg aaaaacacaa aaggttttac
     1621 ccagaaggaa caactgcagg tggtgagaca gttccgagac ggtggctata acacactggt
     1681 ttccacctgt gttggagaag aaggtttgga tataggggaa gtggatctta taatatgctt
     1741 tgatgcccag aagagcccaa tccgcctcat ccagcgcatg ggtagaactg gccgcaaacg
     1801 gcaaggcagg attgtcgtta tcctcgctga aggacgggaa gagcgtacat ataatcagag
     1861 tcagtccaac aaaaaaaata tttataaagc catttcaggt aacagacaag tgctgcgttt
     1921 ataccaagga agtccacgaa tggttcctga taaaatcaat cctgaattac acaaaatgta
     1981 tatcacacat ggtgtctatg aaccagagaa ggctcggagt gtacagcgaa ggccgttttc
     2041 ctcaaggggt ggaataaaag ctagtaaatc gaataaagat gggctgttat cagaagagga
     2101 atttaaccta tggagcagac tctataggtt aggagacagt gaccaggtta aaggagtggc
     2161 attgcctcag tctcacttcc catctttaca ggaggacaga gtgattcaag acccaactac
     2221 tagaattcac caactctctc tctctgaatg gagtctctgg caagatcgtc cgcttcctac
     2281 acatcaagtt gaccattcag atcgttgcca ccattttata agcattatga aaatgataga
     2341 aggaatgaga cacgaagagg gtgaatgcag ctatgagttg aaaattagac cttttctaca
     2401 aatggaagat gtctgctcaa aatatcacgc tcctaggaat ggatataata atgtagccag
     2461 tgtcgccagt agtgctcacc agaagtcttc atttagaccg agtgtagatg caggaggctc
     2521 cttgacggtg atagagtctg aggaagagca tgctgacact gttaaacaaa gggattctaa
     2581 atggaccaag attacttctc taagggaaaa accctgtaga gcaggaagaa aaggccagac
     2641 ctgtgagcac agtgagggtg agggtgagga tggggatgca ggttcttccg atgctgatgg
     2701 acagtctcct gccgaagctg attcccaggt agacccaccc agtggtgaaa ggatggcaga
     2761 tgtaggtggg atctccatct tgggtgctgt cactgaagag gataaccatc caggaacatt
     2821 acaaatggag tgtcaggtca caaataaatc atgtgccagg tactcattag attctggtta
     2881 tagtagtttc agtgatgaga aatctgtatc atcaaatttg tttcttccat tggaagaaga
     2941 gctgttcacc gatcgagctg ctgagcagtt ttataattgt cggcccatga cagaagacgt
     3001 actagctaat gtggagagat ttttatcccg ttctcccccg tctctcagtg gactctcaga
     3061 cttggtatat gatgttactc agggttgtga atttgataat gcatcctgtt caccctaccc
     3121 agagcatgaa cacagtccta gacctgtttc tccagcgtca cactctgctg ggaattctca
     3181 acaaaactta gaatcgaatt cagctaaacg tattagtcat cctactgaaa aatactgtct
     3241 ccctggcacc actcataata aggtttctga tcggccctcc ttctgtgagt ctgatagcga
     3301 aggccataat attaaatatc aaaattcagg atctaacagt tgtgctcaaa tacaagcaga
     3361 ccttgaaaat aacttcgttg acaagaacag ccatgatgat agtgaacccc cagtattgtt
     3421 cactgatgaa gatgaaagct tactattatt tgaagatgat tttaagaata ttgaagatgg
     3481 tcctgaagag ttaaatgggg cgagccttcc tcccttcaac agtatcagtc agcccctccg
     3541 tgtgtcaggt aaaactctca caagtgaaat gcctccagtc tctcacttct taatttctga
     3601 tgaactgttg ttagatgatg attctgaacc tgaagaccaa atcgtctgtg gtgccaagag
     3661 ttggaaatgt caggaagggg tggaggatgg acaagaagag ctgaggactg acggacagac
     3721 ttttgattgc tctgtagact tattttctgt tacctttgac ttaggatttc gttgtagttc
     3781 gggttcagat gatgaaatgc tagcaggtgc atctgatagg actcgcaccc tgggagcggc
     3841 cgatgtgtct ggaaggcatt ctgataagga gataaaggat gccggtggcg cttcaggtcc
     3901 actgggtaga gccatatcac caatcccaac tgagacagcg cagtggtcgc cttgggcaca
     3961 gaacaaggaa tatgcttctt tccacgttgc ctcatcctcg ccagtgaagc agagagtcag
     4021 gagcacaccg ctgtctaagt cacacgcgag ctccaagaca ggagcacaca tgctcaagac
     4081 actagactct accaaggaga aagcaggtgg acagggcttc aaaatggcat tgaacccaag
     4141 actgggccat ctaggatttt ctgtagaaga gaccaagagc agcgatcagg tctttgtgca
     4201 tcagtcccct cggcgcactg aagttgaaca cttaactagt gaaagcgaag atgatgtttt
     4261 cctgagaaaa actaaaaaac caaaaagaaa tgtcctaaag tccccggagg atcagaaaaa
     4321 caacgaagtt gactcaccca ttcatgctgt aaaaaaaccc agagttctca ggtcagaatt
     4381 agcatctagc gatgatgaga gtgagaattt tggcagaacg tgtccaagat tggaacactt
     4441 caagggtcgt aacaggaaca tcagaaaagg ctccgcagcc caaaagaacc ggagtcaagt
     4501 aaagactatg gctcggaggt ttttagacga cgaggcagag gtttctggag aggatgtgga
     4561 ctgtgtctca gcagatgagg aggatgagtc tgagaacgag caggattcct ccctgctcga
     4621 ctttgtaaat gaccggaccc agctttcaca ggctataaat gattctgaaa tgagagctat
     4681 ttacatgaag tctgtacgca gtccattgat gagcactaag tacagaatgg tccgtgagaa
     4741 gcgtcccaac atgaacattt tctcacagat tcctgagcaa gatgaaaact atttagagga
     4801 cagtttttgt gttgatgaag aagagtcttg caaaagccaa tcaagtgaag aagaaatttc
     4861 tgttgatttt aacttaacta aagattcctt tacagatgag gacatacgat ataaaactcg
     4921 gtatgcagta aagatcaaac aaatgaacaa gaaacaaaac tacacacggc caagaaagaa
     4981 attgtctaga attatcttac ccgacgatga ctctagtgag gaagaaaaca tcccgaagga
     5041 cagagaacac tccgttgctg gtggccacgc tgctgctgag cacacacagc agggccagct
     5101 ctgggcttca gggccatccg ggtcctcagt gcctccccag gtcctttctg atccatcgtg
     5161 gaatcagtca tccaggcaga gactacaggt gcaacccagt ataacagatg ccgtgcctag
     5221 aaccttgaac gtgaaggctc agagccataa taaaatcaaa tctgcttcac caccatgtac
     5281 tggtgttgaa tcaaggaaag aatatgggaa ccatccagtt cagttgaagg ctgacagtca
     5341 ggagcacagt gacacctcag cagcaccctg ttctacttca ctcctgcatg tggctgaggg
     5401 acatacagcc cctagacatc tgcaagaagg aaacagggct tgcattcttg tagacagtcg
     5461 tgaaatcact accggtttgg aagtaatctc ttcgctaaga acagttcatg ggttacaagt
     5521 agagatttgt cctcttaatg gctgtgacta catcgtaagc agccgaatgg tcgtagtaag
     5581 gaggtctcag tctgaaatgt taagtaatac cagcaagaac aagttcatcg agcagatgca
     5641 gcgcctgcag agcatgtttc aaaggatatg tgtgattgtg gaaaaagaca gagaaaaagc
     5701 aggagacaca tcaaaaaaat tcagaagaac gaagtgctat gacagtttgc tgactgcctt
     5761 agttggcgcc ggaatccgaa tccttttcag ctctggacaa gaagaaactg cagatttact
     5821 aaaggagctg tcattggtgg aacaaagaaa gaatgctggt attcatatcc cagcagtgct
     5881 aaacactagt aaacttgaag cacttccatt ctatttaagt attcctggta taagttacat
     5941 cacagcctta aatatgtgtc accagttttc atctgtgaaa aagatggcta acagctcccc
     6001 tgaagaaatc tccacatgtg cgcaagtaaa tcatcaaaag gctgaagaga tctataaata
     6061 tattcactat atatttgaca tgcaaatgtt accaaatgat cttaaccagg aaagacaaaa
     6121 acctgataca tgcttaacac ttggagtcgc tatgaaagaa ctctcataat gctaatgtat
     6181 ttcaataatc attgtagttt gagatgacca gtttaaaata tgtaaatatt catctcttaa
     6241 tgatctttat attatatata ctttttattt atagactata tatttttaaa aggaaatctt
     6301 tgatgttcca taatcatttt gattggaccg tgaaacaaac ttttattgaa taaatcaagg
     6361 ctatttgaag ggtttggtca gagtgattta agcatctaag taaggcaaag ggctggaagc
     6421 tgcccaagcc tgacaacctc aggtcatccc tgtgctggct gctcttaagt caacttaagc
     6481 tatctggaag gagggaaact gctgtaagta gttgttgatg gagtggcccc agcccattgt
     6541 tggtactatc cctgggctgc tgctcctggg gtctaagaaa gcaaggtgag caagtcatgg
     6601 gaagcaggcc aataagcagc atccctccct ccatggcctc tgcatcagct cctgcctcta
     6661 agtgcaagcc ctgcttgagt tcctgtcctc gcttcctcca aagaagagac tatagtctgg
     6721 aaatataagc caagtaagcc ctttcctcca cagcttgact tttggttatg gtgttgcatc
     6781 gcagcaatag aaacctaaga caatacagtg ctggggactt cagaaaatgg aggctatcag
     6841 gagtttgcaa acgctgtatc aggatggcaa agttggtgag ctccatgttc atcggaaaac
     6901 tgtctggcca ccacacaaat aatgcttgcc tgtgtgttca catcttcatt catacacaga
     6961 aaagatgagt catctttgat gacatactcc tggaatacca aaacattgta ggccaaggca
     7021 gtaggcacat gctataaggc tagccttggc cttaacaaga tcctgtctca aaagagcata
     7081 gaagcaagat gtattttaga atttttccaa gaattaagta ctatgattta ttattggcaa
     7141 aaactttata ataatttgtg ctgtatgtga attatgtaac attttaagta tactaagtct
     7201 aggacctgaa gagatggcgc agaggttaaa agcacacact gctcttgtat gtccagcagc
     7261 aaccccatca ggtagcttca gtggatctaa agtctctgcc ttcttaggca gtgcactgac
     7321 attgtacaga cgtgtgtgta ctcaatcatg catagtgagt aaagtagatg tgaaacacat
     7381 gatctaataa agtcaaatgt ttactaagta tatcattacc accaaataaa ccttccatcc
     7441 aactgtagtc caatatttaa catgaacttt tgttttgtct catgccatat gtattttaag
     7501 atatgcctct gtttataatg tgcaataaat aggagacttt ccccgtcttc atactttctc
     7561 ca
//
