LOCUS       NP_849243               2021 aa            linear   ROD 28-APR-2025
DEFINITION  Fanconi anemia group M protein homolog isoform 1 [Mus musculus].
ACCESSION   NP_849243
VERSION     NP_849243.2
DBSOURCE    REFSEQ: accession NM_178912.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2021)
  AUTHORS   Panday,A., Willis,N.A., Elango,R., Menghi,F., Duffey,E.E., Liu,E.T.
            and Scully,R.
  TITLE     FANCM regulates repair pathway choice at stalled replication forks
  JOURNAL   Mol Cell 81 (11), 2428-2444 (2021)
   PUBMED   33882298
  REMARK    GeneRIF: FANCM regulates repair pathway choice at stalled
            replication forks.
REFERENCE   2  (residues 1 to 2021)
  AUTHORS   Bloom,J.C. and Schimenti,J.C.
  TITLE     Sexually dimorphic DNA damage responses and mutation avoidance in
            the mouse germline
  JOURNAL   Genes Dev 34 (23-24), 1637-1649 (2020)
   PUBMED   33184219
REFERENCE   3  (residues 1 to 2021)
  AUTHORS   McNairn,A.J., Chuang,C.H., Bloom,J.C., Wallace,M.D. and
            Schimenti,J.C.
  TITLE     Female-biased embryonic death from inflammation induced by genomic
            instability
  JOURNAL   Nature 567 (7746), 105-108 (2019)
   PUBMED   30787433
REFERENCE   4  (residues 1 to 2021)
  AUTHORS   Yin,H., Ma,H., Hussain,S., Zhang,H., Xie,X., Jiang,L., Jiang,X.,
            Iqbal,F., Bukhari,I., Jiang,H., Ali,A., Zhong,L., Li,T., Fan,S.,
            Zhang,B., Gao,J., Li,Y., Nazish,J., Khan,T., Khan,M., Zubair,M.,
            Hao,Q., Fang,H., Huang,J., Huleihel,M., Sha,J., Pandita,T.K.,
            Zhang,Y. and Shi,Q.
  TITLE     A homozygous FANCM frameshift pathogenic variant causes male
            infertility
  JOURNAL   Genet Med 21 (1), 62-70 (2019)
   PUBMED   29895858
  REMARK    GeneRIF: The loss-of-function FANCM pathogenic variants (PV)
            increased ICL sensitivity in lymphocytes of patients and
            Fancm(DeltaC/DeltaC) spermatogonia.neither bone marrow failure nor
            cancer/tumor was detected in all the patients or adult
            Fancm(DeltaC/DeltaC) mice.  These findings revealed male
            infertility to be a novel phenotype of human patients with a
            biallelic FANCM PV.
            Erratum:[Genet Med. 2019 Jan;21(1):266. doi:
            10.1038/s41436-018-0127-0. PMID: 30158692]
REFERENCE   5  (residues 1 to 2021)
  AUTHORS   Wang,H., Li,S., Oaks,J., Ren,J., Li,L. and Wu,X.
  TITLE     The concerted roles of FANCM and Rad52 in the protection of common
            fragile sites
  JOURNAL   Nat Commun 9 (1), 2791 (2018)
   PUBMED   30022024
  REMARK    GeneRIF: Suppression of Rad52 expression in combination with FANCM
            knockout drastically reduces cell and tumor growth, suggesting a
            synthetic lethality interaction between these two genes.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2021)
  AUTHORS   Luo,Y. and Schimenti,J.C.
  TITLE     MCM9 deficiency delays primordial germ cell proliferation
            independent of the ATM pathway
  JOURNAL   Genesis 53 (11), 678-684 (2015)
   PUBMED   26388201
REFERENCE   7  (residues 1 to 2021)
  AUTHORS   Luo,Y., Hartford,S.A., Zeng,R., Southard,T.L., Shima,N. and
            Schimenti,J.C.
  TITLE     Hypersensitivity of primordial germ cells to compromised
            replication-associated DNA repair involves ATM-p53-p21 signaling
  JOURNAL   PLoS Genet 10 (7), e1004471 (2014)
   PUBMED   25010009
  REMARK    Erratum:[PLoS Genet. 2014 Sep;10(9):e1004730]
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 2021)
  AUTHORS   Bakker,S.T., van de Vrugt,H.J., Rooimans,M.A., Oostra,A.B.,
            Steltenpool,J., Delzenne-Goette,E., van der Wal,A., van der
            Valk,M., Joenje,H., te Riele,H. and de Winter,J.P.
  TITLE     Fancm-deficient mice reveal unique features of Fanconi anemia
            complementation group M
  JOURNAL   Hum Mol Genet 18 (18), 3484-3495 (2009)
   PUBMED   19561169
  REMARK    GeneRIF: Fancm(Delta2/Delta2) mice also showed unique features
            atypical for Fanconi anemia mice, including underrepresentation of
            female Fancm(Delta2/Delta2) mice and decreased overall and
            tumor-free survival.
REFERENCE   9  (residues 1 to 2021)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (residues 1 to 2021)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159621.2, AK050306.1, AK173211.1, AK050832.1 and AK085388.1.
            
            On Oct 13, 2004 this sequence version replaced NP_849243.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2021
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 27.21 cM"
     Protein         1..2021
                     /product="Fanconi anemia group M protein homolog isoform
                     1"
                     /EC_number="3.6.4.13"
                     /note="fanconi anemia group M protein homolog;
                     ATP-dependent RNA helicase FANCM"
                     /calculated_mol_wt=225888
     Site            30
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IYD8; propagated from
                     UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Region          80..>604
                     /region_name="MPH1"
                     /note="ERCC4-related helicase [Replication, recombination
                     and repair]; COG1111"
                     /db_xref="CDD:440728"
     Region          202..205
                     /region_name="DEAH box.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00541"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Region          638..657
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Region          657..770
                     /region_name="FANCM-MHF_bd"
                     /note="FANCM to MHF binding domain; pfam16783"
                     /db_xref="CDD:465270"
     Region          837..886
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Region          1002..1049
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Region          1244..1273
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Region          1296..1319
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Region          1369..1441
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Region          1447..1466
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Region          1615..1700
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Site            1637
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IYD8; propagated from
                     UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Region          1689..2009
                     /region_name="Interaction with FAAP24.
                     /evidence=ECO:0000250|UniProtKB:Q8IYD8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Region          1712..1732
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGE5.3)"
     Region          1780..1917
                     /region_name="XPF_nuclease_FANCM"
                     /note="XPF-like nuclease domain of Fanconi anemia group M
                     protein (FANCM); cd20077"
                     /db_xref="CDD:410853"
     Site            order(1815,1825)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:410853"
     Site            order(1842,1845..1846,1849,1875,1877,1880..1881,
                     1883..1885,1887..1889,1891,1894..1895,1901,1904..1905,
                     1908..1909,1912)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410853"
     Region          <1926..1988
                     /region_name="uvrC"
                     /note="excinuclease ABC subunit UvrC; PRK00558"
                     /db_xref="CDD:234792"
     CDS             1..2021
                     /gene="Fancm"
                     /gene_synonym="C730036B14Rik; D12Ertd364e"
                     /coded_by="NM_178912.4:104..6169"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS25941.1"
                     /db_xref="GeneID:104806"
                     /db_xref="MGI:MGI:2442306"
ORIGIN      
        1 msgrqrtlfq twgpslvrgs gdsgcgqprs pamaealpee ddevllvaay eaerqldpgd
       61 ggfcaaagal wiyptncpvr dyqldisrsa lfcntlvclp tglgktfiaa vvmynfyrwf
      121 psgkvvfmap tkplvtqqme acfhvmgipq shmaemtgst qavnrkeiws srrvlfltpq
      181 vmvndltrga vpathvkclv vdeahkalgn yaycqvvrel vkytthfril alsatpgsdi
      241 kavqqvitnl ligkielrse espdilpysh errveklvvp lgeelgaiqk tyiqiletfa
      301 sslihrnvlm krdipnltky qiilardqfr knpspnivgi qqgiiegefa lcislyhgye
      361 llqqmgmrsl yfflsgimdg tkgmtrarne lsrnedfmkl ythlqsafap astsdasafq
      421 rgnkekkfvy shpklkklee vilehfkswn akattekkch esrvmifssf rdsveeiaem
      481 llqhrpvirv mtfvghasgk ntkgftqkeq lqvvrqfrdg gyntlvstcv geegldigev
      541 dliicfdaqk spirliqrmg rtgrkrqgri vvilaegree rtynqsqsnk kniykaisgn
      601 rqvlrlyqgs prmvpdkinp elhkmyithg vyepekarsv qrrpfssrgg ikasksnkdg
      661 llseeefnlw srlyrlgdsd qvkgvalpqs hfpslqedrv iqdpttrihq lslsewslwq
      721 drplpthqvd hsdrchhfis imkmiegmrh eegecsyelk irpflqmedv cskyhaprng
      781 ynnvasvass ahqkssfrps vdaggsltvi eseeehadtv kqrdskwtki tslrekpcra
      841 grkgqtcehs egegedgdag ssdadgqspa eadsqvdpps germadvggi silgavteed
      901 nhpgtlqmec qvtnkscary sldsgyssfs deksvssnlf lpleeelftd raaeqfyncr
      961 pmtedvlanv erflsrspps lsglsdlvyd vtqgcefdna scspypeheh sprpvspash
     1021 sagnsqqnle snsakrishp tekyclpgtt hnkvsdrpsf cesdseghni kyqnsgsnsc
     1081 aqiqadlenn fvdknshdds eppvlftded eslllfeddf kniedgpeel ngaslppfns
     1141 isqplrvsgk tltsemppvs hflisdelll dddsepedqi vcgakswkcq egvedgqeel
     1201 rtdgqtfdcs vdlfsvtfdl gfrcssgsdd emlagasdrt rtlgaadvsg rhsdkeikda
     1261 ggasgplgra ispiptetaq wspwaqnkey asfhvasssp vkqrvrstpl skshassktg
     1321 ahmlktldst kekaggqgfk malnprlghl gfsveetkss dqvfvhqspr rtevehltse
     1381 seddvflrkt kkpkrnvlks pedqknnevd spihavkkpr vlrselassd desenfgrtc
     1441 prlehfkgrn rnirkgsaaq knrsqvktma rrflddeaev sgedvdcvsa deedeseneq
     1501 dsslldfvnd rtqlsqaind semraiymks vrsplmstky rmvrekrpnm nifsqipeqd
     1561 enyledsfcv deeescksqs seeeisvdfn ltkdsftded iryktryavk ikqmnkkqny
     1621 trprkklsri ilpdddssee enipkdrehs vagghaaaeh tqqgqlwasg psgssvppqv
     1681 lsdpswnqss rqrlqvqpsi tdavprtlnv kaqshnkiks asppctgves rkeygnhpvq
     1741 lkadsqehsd tsaapcstsl lhvaeghtap rhlqegnrac ilvdsreitt glevisslrt
     1801 vhglqveicp lngcdyivss rmvvvrrsqs emlsntsknk fieqmqrlqs mfqricvive
     1861 kdrekagdts kkfrrtkcyd slltalvgag irilfssgqe etadllkels lveqrknagi
     1921 hipavlntsk lealpfylsi pgisyitaln mchqfssvkk mansspeeis tcaqvnhqka
     1981 eeiykyihyi fdmqmlpndl nqerqkpdtc ltlgvamkel s
//
