LOCUS       NM_053081               2723 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus Fanconi anemia, complementation group G (Fancg),
            transcript variant 1, mRNA.
ACCESSION   NM_053081
VERSION     NM_053081.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2723)
  AUTHORS   Shah R, van den Berk PCM, Pritchard CEJ, Song JY, Kreft M,
            Pilzecker B and Jacobs H.
  TITLE     A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially
            Captures the Human Phenotype
  JOURNAL   Int J Mol Sci 24 (13), 11129 (2023)
   PUBMED   37446306
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2723)
  AUTHORS   Zhou Y, He Y, Xing W, Zhang P, Shi H, Chen S, Shi J, Bai J, Rhodes
            SD, Zhang F, Yuan J, Yang X, Zhu X, Li Y, Hanenberg H, Xu M,
            Robertson KA, Yuan W, Nalepa G, Cheng T, Clapp DW and Yang FC.
  TITLE     An abnormal bone marrow microenvironment contributes to
            hematopoietic dysfunction in Fanconi anemia
  JOURNAL   Haematologica 102 (6), 1017-1027 (2017)
   PUBMED   28341737
REFERENCE   3  (bases 1 to 2723)
  AUTHORS   Nguyen TV, Riou L, Aoufouchi S and Rosselli F.
  TITLE     Fanca deficiency reduces A/T transitions in somatic hypermutation
            and alters class switch recombination junctions in mouse B cells
  JOURNAL   J Exp Med 211 (6), 1011-1018 (2014)
   PUBMED   24799500
REFERENCE   4  (bases 1 to 2723)
  AUTHORS   Park E, Kim H, Kim JM, Primack B, Vidal-Cardenas S, Xu Y, Price BD,
            Mills AA and D'Andrea AD.
  TITLE     FANCD2 activates transcription of TAp63 and suppresses
            tumorigenesis
  JOURNAL   Mol Cell 50 (6), 908-918 (2013)
   PUBMED   23806336
REFERENCE   5  (bases 1 to 2723)
  AUTHORS   van de Vrugt HJ, Koomen M, Bakker S, Berns MA, Cheng NC, van der
            Valk MA, de Vries Y, Rooimans MA, Oostra AB, Hoatlin ME, Te Riele
            H, Joenje H and Arwert F.
  TITLE     Evidence for complete epistasis of null mutations in murine Fanconi
            anemia genes Fanca and Fancg
  JOURNAL   DNA Repair (Amst) 10 (12), 1252-1261 (2011)
   PUBMED   22036606
  REMARK    GeneRIF: null mutations in Fanca or Fancg are fully epistatic
REFERENCE   6  (bases 1 to 2723)
  AUTHORS   van de Vrugt HJ, Koomen M, Berns MA, de Vries Y, Rooimans MA, van
            der Weel L, Blom E, de Groot J, Schepers RJ, Stone S, Hoatlin ME,
            Cheng NC, Joenje H and Arwert F.
  TITLE     Characterization, expression and complex formation of the murine
            Fanconi anaemia gene product Fancg
  JOURNAL   Genes Cells 7 (3), 333-342 (2002)
   PUBMED   11918676
  REMARK    GeneRIF: Characterization and expression of the murine Fanconi
            anaemia gene product
REFERENCE   7  (bases 1 to 2723)
  AUTHORS   Koomen M, Cheng NC, van de Vrugt HJ, Godthelp BC, van der Valk MA,
            Oostra AB, Zdzienicka MZ, Joenje H and Arwert F.
  TITLE     Reduced fertility and hypersensitivity to mitomycin C characterize
            Fancg/Xrcc9 null mice
  JOURNAL   Hum Mol Genet 11 (3), 273-281 (2002)
   PUBMED   11823446
  REMARK    GeneRIF: Mice deficient in Fancg were not anemic, but showed
            hypogonadism, impaired fertility, and hypersensitivity to mitomycin
            C
REFERENCE   8  (bases 1 to 2723)
  AUTHORS   Yang Y, Kuang Y, Montes De Oca R, Hays T, Moreau L, Lu N, Seed B
            and D'Andrea AD.
  TITLE     Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9
  JOURNAL   Blood 98 (12), 3435-3440 (2001)
   PUBMED   11719385
REFERENCE   9  (bases 1 to 2723)
  AUTHORS   Demuth I, Wlodarski M, Tipping AJ, Morgan NV, de Winter JP, Thiel
            M, Grasl S, Schindler D, D'Andrea AD, Altay C, Kayserili H,
            Zatterale A, Kunze J, Ebell W, Mathew CG, Joenje H, Sperling K and
            Digweed M.
  TITLE     Spectrum of mutations in the Fanconi anaemia group G gene,
            FANCG/XRCC9
  JOURNAL   Eur J Hum Genet 8 (11), 861-868 (2000)
   PUBMED   11093276
REFERENCE   10 (bases 1 to 2723)
  AUTHORS   Nadler,J.J. and Braun,R.E.
  TITLE     Fanconi anemia complementation group C is required for
            proliferation of murine primordial germ cells
  JOURNAL   Genesis 27 (3), 117-123 (2000)
   PUBMED   10951504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY350437.1, AY049715.1 and AL672276.9.
            
            [WARNING] On Dec 7, 2023 this sequence was replaced by NM_053081.3.
            
            On Jul 11, 2009 this sequence version replaced NM_053081.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY049715.1, AF112439.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               BY350437.1         1-200
            201-2076            AY049715.1         1-1876
            2077-2723           AL672276.9         138545-139191       c
FEATURES             Location/Qualifiers
     source          1..2723
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 22.97 cM"
     gene            1..2723
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /note="Fanconi anemia, complementation group G"
                     /db_xref="GeneID:60534"
                     /db_xref="MGI:MGI:1926471"
     exon            1..300
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..2076
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fanconi anemia group G protein homolog"
                     /codon_start=1
                     /product="Fanconi anemia group G protein homolog isoform
                     1"
                     /protein_id="NP_444311.1"
                     /db_xref="CCDS:CCDS18087.1"
                     /db_xref="GeneID:60534"
                     /db_xref="MGI:MGI:1926471"
                     /translation="MSSQVIPALPKTFSSSLDLWREKNDQLVRQAKQLTRDSRPSLRR
                     QQSAQDTLEGLRELLLTLQGLPAAVPALPLELTVLCNCIILRASLVQAFTEDLTQDLQ
                     RGLERVLEAQHHLEPKSQQGLKELWHSVLSASSLPPELLPALHCLASLQAVFWMSTDH
                     LEDLTLLLQTLNGSQTQSSEDLLLLLKSWSPPAEESPAPLILQDAESLRDVLLTAFAC
                     RQGFQELITGSLPHAQSNLHEAASGLCPPSVLVQVYTALGACLRKMGNPQRALLYLTE
                     ALKVGTTCALPLLEASRVYRQLGDRAAELESLELLVEALSATHSSETFKSLIEVELLL
                     PQPDPASPLHCGTQSQAKHLLASRCLQTGRAEDAAEHYLDLLAMLLGGSETRFSPPTS
                     SLGPCIPELCLEAAAALIQAGRALDALTVCEELLNRTSSLLPKMSSLWENARKRAKEL
                     PCCPVWVSATHLLQGQAWSQLKAQKEALSEFSQCLELLFRTLPEDKEQGSDCEQKCRS
                     DVALKQLRVAALISRGLEWVASGQDTKALSDFLLSVQICPGNRDGSFYLLQTLKRLDR
                     KNEASAFWREAHSQLPLEDAAGSLPLYLETCLSWIHPPNREAFLEEFGTSVLESCVL"
     exon            301..394
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            395..526
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            527..729
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            730..865
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            866..996
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1143
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1295
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1362
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1652
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1699
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1849
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1967
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2723
                     /gene="Fancg"
                     /gene_synonym="Xrcc9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcttggcca accacaggcg cggtgggtgg tggcggggac tgagaggtgg gtttctggtc
       61 agggagagca agcccggctg cgacccgggg ggagtccggt ggggtgcaga agtggcttct
      121 tgcggttagg gtgaagacac cggtgggacc agcctccacc catgaaaaga ccccttcggg
      181 taacagtgat ctacctcggc gacaatgtcc agccaggtca ttccagccct ccccaaaaca
      241 ttttccagta gcctggacct gtggagggaa aagaacgacc agcttgttag acaggctaag
      301 caactcacca gggattctcg tccctctctg aggcgacagc aatcggccca agacacactg
      361 gaagggctta gggaactcct cctcactcta caaggactcc ctgctgctgt ccccgctctc
      421 cccttggagc tgactgtcct ctgtaattgt ataatcctga gggctagcct agtccaggct
      481 ttcactgaag atcttaccca ggatcttcaa aggggcctcg aaagagtgct ggaggcccag
      541 catcacctgg agcccaagtc acagcaggga ctcaaggagc tgtggcactc tgtcctctct
      601 gcttcctccc ttccaccgga gctgctgcct gccttacact gcctggccag ccttcaagct
      661 gtcttctgga tgagtaccga ccacctggag gacctgacct tgctgttaca aaccctaaat
      721 ggcagccaga ctcagtcctc tgaggatctg ctactactgc taaaatcctg gagtcctcca
      781 gctgaggagt cacccgcccc actgattctg caggatgccg agagtttgag ggatgtcctt
      841 ctgactgcat ttgcctgccg ccaaggcttc caggagctaa tcacagggag cctgccccat
      901 gcacagagca acctgcatga agcagcctca ggtctgtgtc cgccgtccgt gttagtccag
      961 gtgtacacgg ccctgggggc ctgtctccgt aagatgggaa atccacagag agcactgttg
     1021 tacttgactg aagccctgaa agtgggaaca acctgtgccc ttccgcttct ggaggcttcc
     1081 agagtatata ggcaactagg agacagagca gcagaactgg agagtctgga actgctggtt
     1141 gaggccttga gtgccaccca tagttctgaa acattcaaaa gtctcattga agtagaattg
     1201 ctacttccac aacctgaccc agcctctcct cttcattgtg gcacacagag ccaggccaag
     1261 cacctgctag caagtcgatg cctgcagacg gggagggcag aagatgctgc agagcattac
     1321 ctggacctgc tggcaatgtt gctgggtggc tcagagacaa ggttctcccc acccacctcc
     1381 tctctaggtc cctgtatacc agagttatgt ctggaggcag cagcagcact gatccaggca
     1441 ggccgagcct tagacgcttt gactgtgtgt gaggagctgc tcaaccgtac ctcgtctctg
     1501 cttcccaaaa tgtcctcctt gtgggaaaat gccaggaaaa gagccaaaga actgccgtgt
     1561 tgcccagtct gggtctctgc cacccacctg cttcagggcc aggcctggtc acaactaaag
     1621 gctcagaaag aggcacttag tgaatttagc cagtgtcttg agctgctctt tcggaccctg
     1681 cctgaggaca aagaacaagg ctccgactgt gagcagaagt gtaggtctga cgtggcactg
     1741 aaacagctgc gagtggctgc tctgatcagt cgtggactgg agtgggtagc cagtggccag
     1801 gataccaaag ccttaagtga cttcctcctc agtgtgcaga tatgcccagg caatagagat
     1861 ggctcctttt acctgcttca gactctgaaa agattggatc ggaagaatga ggccagtgct
     1921 ttttggcggg aggcccacag ccagctgcca ctggaggacg ctgccgggtc tcttccactg
     1981 tatttagaaa cctgtttgag ctggatccat ccccctaacc gcgaagcctt ccttgaggag
     2041 tttgggactt cggtgttgga gtcttgtgtc ctttagcttc cttgtttcca ggatcttgaa
     2101 ctttggcctc tgtggactct ttccttgggg agggttttag atcttctttt ttttgttttc
     2161 ttctgcctta tcctctttgg agagtggctg gaactgattg tttctaagta actcttttgc
     2221 tcctgaggct ggtcctgtga accttgatct acttgctacc agtctagttc cagagtggtt
     2281 ccatgaacaa atcactgtct gctcatggca cttttcttcc ttccttcctt tctctcttgt
     2341 gtgttgagta aaatcttcta tttatgtctt atctgcttac tacacatagt tgaatgggaa
     2401 ggaaggctca tggcaagcta gttgggtatt ggctgtttaa gatgctctat ttccaacatc
     2461 cgtcttctgt ctgccttccc tgtctcccta actccccctt ccttcccatt gtctttttgg
     2521 taggttggat tctggggact aaactgcagt tcctcataaa aatccccatt cctacccttt
     2581 tcccaccctg ccatctaccg taagagcttg agacacaagc ctttctgagg gaaaggctat
     2641 gttaatcctt ctggaggagc agttttaagt tactaattta tccttcttaa gttactatta
     2701 aaattttgaa ttgcttattt taa
//
