LOCUS       NM_001115087            1691 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Fanconi anemia, complementation group F (Fancf), mRNA.
ACCESSION   NM_001115087 XM_001474977
VERSION     NM_001115087.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1691)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1691)
  AUTHORS   Bakker,S.T., van de Vrugt,H.J., Visser,J.A., Delzenne-Goette,E.,
            van der Wal,A., Berns,M.A., van de Ven,M., Oostra,A.B., de
            Vries,S., Kramer,P., Arwert,F., van der Valk,M., de Winter,J.P. and
            te Riele,H.
  TITLE     Fancf-deficient mice are prone to develop ovarian tumours
  JOURNAL   J Pathol 226 (1), 28-39 (2012)
   PUBMED   21915857
  REMARK    GeneRIF: Our results suggest that FANCF suppresses ovarian
            tumourigenesis through its role in normal gonadal development, but
            also by maintaining genome stability
REFERENCE   3  (bases 1 to 1691)
  AUTHORS   Saberwal,G., Horvath,E., Hu,L., Zhu,C., Hjort,E. and Eklund,E.A.
  TITLE     The interferon consensus sequence binding protein (ICSBP/IRF8)
            activates transcription of the FANCF gene during myeloid
            differentiation
  JOURNAL   J Biol Chem 284 (48), 33242-33254 (2009)
   PUBMED   19801548
  REMARK    GeneRIF: Data identify the gene encoding Fanconi F (FANCF) as an
            ICSBP target gene.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158345.8.
            
            On Mar 5, 2008 this sequence version replaced XM_001474977.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1691              AC158345.8         152347-154037       c
FEATURES             Location/Qualifiers
     source          1..1691
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 32.87 cM"
     gene            1..1691
                     /gene="Fancf"
                     /gene_synonym="A730016A17"
                     /note="Fanconi anemia, complementation group F"
                     /db_xref="GeneID:100040608"
                     /db_xref="MGI:MGI:3689889"
     exon            1..1691
                     /gene="Fancf"
                     /gene_synonym="A730016A17"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1045
                     /gene="Fancf"
                     /gene_synonym="A730016A17"
                     /codon_start=1
                     /product="Fanconi anemia group F protein"
                     /protein_id="NP_001108559.1"
                     /db_xref="CCDS:CCDS52261.1"
                     /db_xref="GeneID:100040608"
                     /db_xref="MGI:MGI:3689889"
                     /translation="MEPLVQQTERFSELLAVSCGSLVSTWDAEKVRRALQWARYLLHV
                     YRRFAGRGRVREALERRLPARGGPLGLRSFAALESGDARLALRLLRNRALAPAAARAL
                     PSLLFPGPAADHRDDVPQSRLVLLARRGSALRLLCRLGGDAPRSALLRTHAELLDARL
                     HELGGADSAAARKLLDTLWTRGPREHVLDVTAEALLLREEDPEPAQATDPAGADETQK
                     LLRWLLESPEVLAAFCRHLPAKRLASVAGCHHALSRAYLDLLTTWATRLHYDLQKGAW
                     VPTQMEDMPWEELCLRLQSLCHAQPFLQEEVLVTLRSRKALDGDFEVPGMSIWTDLLV
                     VLECGIVLE"
     regulatory      1668..1673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fancf"
                     /gene_synonym="A730016A17"
                     /note="hexamer: ATTAAA"
     polyA_site      1691
                     /gene="Fancf"
                     /gene_synonym="A730016A17"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcggcc gccatggagc cgcttgtgca gcaaaccgag cgattctccg agctgttggc
       61 cgtgtcgtgt gggtcgctgg tgagcacgtg ggacgccgaa aaggtgcgca gggcgctgca
      121 gtgggcgcgt tatctgctcc acgtgtaccg acgcttcgcg ggccgcggcc gcgtgcggga
      181 ggcgctcgag aggcggctcc ccgcgcgggg agggccgctc gggctgcgca gcttcgcggc
      241 gctggagtcc ggggacgcgc ggctcgccct ccgcctgctg cggaaccgcg cgctcgcgcc
      301 cgccgccgcc cgcgcgctgc cgagcttgct gttcccgggc cccgccgcgg accaccgaga
      361 cgacgtgccg cagtcgcgcc tggtcctcct ggcgcgccgc ggaagcgcgc tgcgcctgct
      421 gtgccgcctc ggcggggacg cgcccaggag cgcgctgctg cgcacgcacg cggagctgct
      481 ggacgcgcgc ctgcacgagc tgggcggggc cgactccgcg gccgcgcgca aactcctgga
      541 cacgttgtgg acgcgcgggc cgcgggagca cgtgctcgac gtgactgccg aagcgctgct
      601 gctacgcgag gaagacccgg agccagccca ggccacggac cctgcgggtg cggatgagac
      661 acagaaacta ctgcgctggc ttctcgaaag tcccgaggta ttggccgctt tttgccgcca
      721 tctgccagcc aagcgcctgg cctccgtggc gggctgccac cacgcactgt ctcgcgccta
      781 cctggacctg ctcacaacgt gggccacgcg gctgcactat gatctgcaaa agggtgcctg
      841 ggtccctaca cagatggagg acatgccctg ggaagagctg tgcctaaggc tgcagagctt
      901 gtgccatgcc cagccatttc tgcaggaaga ggtgctggtg accctaaggt cccgcaaagc
      961 cttggatgga gatttcgagg ttcctgggat gagcatctgg acagacctcc tggtggtgct
     1021 tgagtgtggg atcgtgctag agtagattct cagttcccag gctgggcatc tggacagacc
     1081 ctgtcccata gagggaataa caagcatact tctcaccaaa gcctctatgc acagcatcct
     1141 gctacttctt gactatgcag tttacaaatt gtcagtgttc tccccaattc cctatataca
     1201 tgctcccaaa acctaattat tcaggggcca attttaaatg gttcataata taaatatata
     1261 taatatgcac aatatctata aatttatata ttatataata tgtattatat agagattgtt
     1321 tttgttctgg taatggaccc aggaccctgc ctatgttagt gttcaccact gagctacatc
     1381 attaatcgtg aaagaattct taaagccatc gaattttcag cttgtttcgt ataaagctaa
     1441 tttgtaagaa tactaaaact agattcaccc taaaaagaaa aggcagcttt acgttttcca
     1501 agaagggtac ttttgtatga tttacttggt tcctaacact cttcagtagt acaaagtttt
     1561 attcaaccag caacatgtgg tagcatcatg ttaacttcaa agctgactgg gctagagtta
     1621 gagccctaaa cttgctttct tttacctgtt taccaaccta tgtgtgcatt aaaattgcat
     1681 tgctcagaaa a
//
