LOCUS       NM_001163819            2016 bp    mRNA    linear   ROD 21-AUG-2023
DEFINITION  Mus musculus Fanconi anemia, complementation group E (Fance),
            transcript variant 1, mRNA.
ACCESSION   NM_001163819 XM_001472126 XM_915490 XM_986338
VERSION     NM_001163819.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Zhou Z, Yin H, Suye S, Ren Z, Yan L, Shi L and Fu C.
  TITLE     Fance deficiency inhibits primordial germ cell proliferation
            associated with transcription-replication conflicts accumulate and
            DNA repair defects
  JOURNAL   J Ovarian Res 16 (1), 160 (2023)
   PUBMED   37563658
  REMARK    GeneRIF: Fance deficiency inhibits primordial germ cell
            proliferation associated with transcription-replication conflicts
            accumulate and DNA repair defects.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   Zhou Z, Yin H, Suye S, He J and Fu C.
  TITLE     Pan-cancer analysis of the prognostic and immunological role of
            Fanconi anemia complementation group E
  JOURNAL   Front Genet 13, 1024989 (2023)
   PUBMED   36685883
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Yin H, Suye S, Zhou Z, Cai H and Fu C.
  TITLE     The reduction of oocytes and disruption of the meiotic prophase I
            in Fanconi anemia E-deficient mice
  JOURNAL   Reproduction 164 (3), 71-82 (2022)
   PUBMED   35671285
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Fu C, Begum K, Jordan PW, He Y and Overbeek PA.
  TITLE     Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi
            Anemia E Mutant Male Mice
  JOURNAL   PLoS One 11 (8), e0159800 (2016)
   PUBMED   27486799
  REMARK    GeneRIF: Results provide evidence that fance protein plays an
            important, but not absolutely essential, role in the initial
            developmental expansion of the male germ line.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2016)
  AUTHORS   Fu C, Begum K and Overbeek PA.
  TITLE     Primary Ovarian Insufficiency Induced by Fanconi Anemia E Mutation
            in a Mouse Model
  JOURNAL   PLoS One 11 (3), e0144285 (2016)
   PUBMED   26939056
  REMARK    GeneRIF: Primary ovarian insufficiency is induced by Fance mutation
            in a mouse model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2016)
  AUTHORS   Pace P, Johnson M, Tan WM, Mosedale G, Sng C, Hoatlin M, de Winter
            J, Joenje H, Gergely F and Patel KJ.
  TITLE     FANCE: the link between Fanconi anaemia complex assembly and
            activity
  JOURNAL   EMBO J 21 (13), 3414-3423 (2002)
   PUBMED   12093742
  REMARK    GeneRIF: The fact that defects in the human ortholog result in
            Fanconi anemia disease suggests that this protein has a critical
            function and is likely evolutionarily conserved.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT025652.7.
            
            On or before Aug 8, 2009 this sequence version replaced
            XM_915490.3, XM_986338.2, XM_001472126.1.
            
            Summary: This gene encodes the complementation group E subunit of
            the multimeric Fanconi anemia (FA) nuclear complex composed of
            proteins encoded by over ten Fanconi anemia complementation (FANC)
            group genes: FANCA, FANCB, FANCC, FANCD1 (also called BRCA2),
            FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1),
            FANCL, FANCM and FANCN (also called PALB2). The FA complex is
            necessary for protection against DNA damage. This gene product is
            required for the nuclear accumulation of FANCC and provides a
            critical bridge between the FA complex and FANCD2. Defects in the
            related human gene are a cause of Fanconi anemia, a genetically
            heterogeneous recessive disorder characterized by cytogenetic
            instability, hypersensitivity to DNA crosslinking agents, increased
            chromosomal breakage, and defective DNA repair. Translation of this
            protein is initiated at a non-AUG (CUG) start codon, which is
            inferred from the related human gene and the notion that this
            protein is functionally indispensable. Multiple transcript variants
            encoding different isoforms have been identified. [provided by
            RefSeq, Aug 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. The combination of alternatively
            spliced exons within the coding region and the non-AUG start codon
            (CUG at nt 115) are inferred based on available transcript data,
            and further supported by similar exon-intron structure of the
            orthologous human gene (GeneID:2178) that encodes a functionally
            important protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2019519.1,
                                           SRR7652917.525843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 9147877, 12093742
            RefSeq Select criteria   :: based on conservation, expression,
                                        longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-353               CT025652.7         49160-49512         c
            354-942             CT025652.7         46855-47443         c
            943-987             CT025652.7         46139-46183         c
            988-1053            CT025652.7         45819-45884         c
            1054-1197           CT025652.7         45431-45574         c
            1198-1321           CT025652.7         44886-45009         c
            1322-1400           CT025652.7         44635-44713         c
            1401-1467           CT025652.7         42186-42252         c
            1468-1593           CT025652.7         40271-40396         c
            1594-2016           CT025652.7         36468-36890         c
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.65 cM"
     gene            1..2016
                     /gene="Fance"
                     /gene_synonym="2810451D06Rik"
                     /note="Fanconi anemia, complementation group E"
                     /db_xref="GeneID:72775"
                     /db_xref="MGI:MGI:1920025"
     exon            1..353
                     /gene="Fance"
                     /gene_synonym="2810451D06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1695
                     /gene="Fance"
                     /gene_synonym="2810451D06Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     non-AUG (CUG) translation initiation codon"
                     /codon_start=1
                     /product="Fanconi anemia group E protein isoform 1"
                     /protein_id="NP_001157291.1"
                     /db_xref="CCDS:CCDS89042.1"
                     /db_xref="GeneID:72775"
                     /db_xref="MGI:MGI:1920025"
                     /translation="MATPGSDSVASAGAAPWASLEAPARLLLQALQAGPEGARRGLGV
                     LRALGRRAEHFPWDGFLEALGHLEPEVRGPDGRLELVPLLLRLPGVCQKNLLSLLLAL
                     LPSLPESGLRSVLQLHHQDVSSTTDAWLHALGELLRRDVGVGVAEGSSPLTRSCQLQL
                     RDLCGRLGQGGRGLKLALAPDPEQEDRLSQLCGKRTKEPEEAASPESERSPKRFRGCE
                     EAVEGKEPEERPTLESLGSPPDAGGVLPDTDAQAPETGPGVEGPKGPAESVELPKVVQ
                     DQVPRLQLLLKAFQEGLEGQEKPLVDLQFLHECSPSEMELLCSELQLPQLPDGGLLQL
                     CSHLMGLTPALSLSNASVLARSLFLDRIRSLPSSASRLLRVALVSFCVKYTYAICRAV
                     LCPLLQDPRVGPAQTELLCSLIKDESLESDMQVQILGQVLELAWREETFLVLQTLLER
                     QVEMTPEVFSVLVQRLCKEGPAATTSMAYAKLMLTVMTKYQTSITEQQSLDLAVALEP
                     NATFLKKALQAALRHVTH"
     exon            354..942
                     /gene="Fance"
                     /gene_synonym="2810451D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            943..987
                     /gene="Fance"
                     /gene_synonym="2810451D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1053
                     /gene="Fance"
                     /gene_synonym="2810451D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1197
                     /gene="Fance"
                     /gene_synonym="2810451D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1321
                     /gene="Fance"
                     /gene_synonym="2810451D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1400
                     /gene="Fance"
                     /gene_synonym="2810451D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1467
                     /gene="Fance"
                     /gene_synonym="2810451D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1593
                     /gene="Fance"
                     /gene_synonym="2810451D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..2016
                     /gene="Fance"
                     /gene_synonym="2810451D06Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccttcag gctctacagg gtgctccggc tttccttggc ttcgggagct ttgcgcggct
       61 ggagtggcgc tccgatcccg cgtgtcctag ccgccgcccc gcgtccgctc tgcgctggcg
      121 acgccggggt cggactccgt agcctcggcc ggagcggcgc cctgggcgag cctggaggcc
      181 cctgcccgcc tcctgcttca ggcgctacag gcagggcctg agggtgcgcg gcgcgggcta
      241 ggggttctgc gcgccctcgg ccgccgcgcg gagcacttcc cttgggatgg cttcctggag
      301 gcgctgggcc acttagagcc cgaggtgcgg ggccccgacg gccgcctaga gctggtccca
      361 ctgttgctcc ggctgcctgg ggtctgccag aagaacctgc tgtccctgct gctggctctc
      421 ctaccatcct tacctgaaag cggactccgc tctgtgctgc agctccacca tcaggatgtg
      481 tcctctacca ctgatgcctg gctccatgcc ctgggggagc tgctgcgaag ggatgtgggg
      541 gttggagtcg ctgagggatc ttctccattg accagaagct gtcagttaca gctccgggac
      601 ctgtgtgggc ggctgggcca aggggggagg gggctgaaac tggccctggc tccagatcct
      661 gaacaagagg acagactctc acagctttgc gggaaacgga cgaaagagcc agaagaggct
      721 gccagccctg agtcagagag atcccctaaa aggttccggg gctgtgagga ggcggtggaa
      781 ggaaaggaac cggaggagag acccacgctg gagtcgctgg gatccccacc agatgcagga
      841 ggcgtgttgc ctgacactga cgcccaggct ccggagactg gccctggcgt ggagggtccc
      901 aagggtcccg ctgagagtgt ggagttgccc aaagttgtcc aggaccaggt gcccaggctg
      961 cagctgctgc tgaaggcctt ccaggagggg ctggagggtc aggagaagcc cctagtggac
     1021 ctgcagtttc ttcatgaatg tagtcccagc gagatggagt tgctatgcag cgaactacag
     1081 ctaccccagc tccctgacgg aggtctcctg cagctctgca gccacctgat gggtctcaca
     1141 ccagccctca gcctcagcaa tgcctctgtg ctggccagga gcctctttct tgaccggatc
     1201 cgctccctgc cgtcttctgc ctccaggctt ctcagagtgg ccctcgtctc cttctgtgta
     1261 aagtacacct acgccatctg cagggctgtc ctctgtccct tgctccagga ccctcgtgta
     1321 ggtcctgcgc agaccgagtt actgtgttcc ctcataaagg atgagtccct ggagtcagac
     1381 atgcaggtcc agattttggg gcaggtcctg gagctggcct ggcgagaaga gacgttcctg
     1441 gtgttgcaga cgctcctgga acggcaggta gagatgaccc ctgaggtgtt cagtgtctta
     1501 gtgcagaggc tctgcaaaga gggaccagca gccactacct ccatggccta tgccaagctg
     1561 atgctgacgg tgatgaccaa gtaccagacc agtatcacag agcagcagag cctggacctg
     1621 gctgtggccc tagagcccaa cgccaccttc ctgaagaagg ccctgcaagc agcgctgaga
     1681 catgtgaccc actgaccata cacaaggaca caccgccctg actgcttgtc tcagaacaca
     1741 cagccatctc aggagtcagc tgcctctgcc caacacccca ggctctgcag gggccatatt
     1801 gactccacaa ggagcagaga ggaggccttg ggtaccactc ctgacaacat caggatacag
     1861 gggctgtgga ggatgagtgg gaggtgggca gaaaagctgg cctttcagtg tgagcctttt
     1921 gtgctcaggt atatgttgtg acctcctctg ttttgtttgt ttctgaactg agtaattttg
     1981 taacagtttt aataaaaaga agacagtcca tccagg
//
