LOCUS       NM_007985               3134 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus Fanconi anemia, complementation group C (Fancc),
            transcript variant 1, mRNA.
ACCESSION   NM_007985
VERSION     NM_007985.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3134)
  AUTHORS   Lin,Q., Wu,L., Chatla,S., Chowdhury,F.A., Atale,N., Joseph,J. and
            Du,W.
  TITLE     Hematopoietic stem cell regeneration through paracrine regulation
            of the Wnt5a/Prox1 signaling axis
  JOURNAL   J Clin Invest 132 (12) (2022)
   PUBMED   35703178
REFERENCE   2  (bases 1 to 3134)
  AUTHORS   Broxmeyer,H.E., Capitano,M.L., Cooper,S., Potchanant,E.S. and
            Clapp,D.W.
  TITLE     Numbers of long-term hematopoietic stem cells from bone marrow of
            fanca and fancc knockout mice can be greatly enhanced by their
            collection and processing in physioxia conditions
  JOURNAL   Blood Cells Mol Dis 86, 102492 (2021)
   PUBMED   32896825
  REMARK    GeneRIF: Numbers of long-term hematopoietic stem cells from bone
            marrow of fanca and fancc knockout mice can be greatly enhanced by
            their collection and processing in physioxia conditions.
REFERENCE   3  (bases 1 to 3134)
  AUTHORS   Tiwari,S.K., Dang,J.W., Lin,N., Qin,Y., Wang,S. and Rana,T.M.
  TITLE     Zika virus depletes neural stem cells and evades selective
            autophagy by suppressing the Fanconi anemia protein FANCC
  JOURNAL   EMBO Rep 21 (12), e49183 (2020)
   PUBMED   33073500
  REMARK    GeneRIF: Zika virus depletes neural stem cells and evades selective
            autophagy by suppressing the Fanconi anemia protein FANCC.
REFERENCE   4  (bases 1 to 3134)
  AUTHORS   Li,X., Wu,L., Zopp,M., Kopelov,S. and Du,W.
  TITLE     p53-TP53-Induced Glycolysis Regulator Mediated Glycolytic
            Suppression Attenuates DNA Damage and Genomic Instability in
            Fanconi Anemia Hematopoietic Stem Cells
  JOURNAL   Stem Cells 37 (7), 937-947 (2019)
   PUBMED   30977208
REFERENCE   5  (bases 1 to 3134)
  AUTHORS   Huang,F., Ben Aissa,M., Levesque,G. and Carreau,M.
  TITLE     FANCC localizes with UNC5A at neurite outgrowth and promotes
            neuritogenesis
  JOURNAL   BMC Res Notes 11 (1), 662 (2018)
   PUBMED   30213274
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3134)
  AUTHORS   Whitney,M.A., Royle,G., Low,M.J., Kelly,M.A., Axthelm,M.K.,
            Reifsteck,C., Olson,S., Braun,R.E., Heinrich,M.C., Rathbun,R.K.,
            Bagby,G.C. and Grompe,M.
  TITLE     Germ cell defects and hematopoietic hypersensitivity to
            gamma-interferon in mice with a targeted disruption of the Fanconi
            anemia C gene
  JOURNAL   Blood 88 (1), 49-58 (1996)
   PUBMED   8704201
REFERENCE   7  (bases 1 to 3134)
  AUTHORS   Chen,M., Tomkins,D.J., Auerbach,W., McKerlie,C., Youssoufian,H.,
            Liu,L., Gan,O., Carreau,M., Auerbach,A., Groves,T., Guidos,C.J.,
            Freedman,M.H., Cross,J., Percy,D.H., Dick,J.E., Joyner,A.L. and
            Buchwald,M.
  TITLE     Inactivation of Fac in mice produces inducible chromosomal
            instability and reduced fertility reminiscent of Fanconi anaemia
  JOURNAL   Nat Genet 12 (4), 448-451 (1996)
   PUBMED   8630504
REFERENCE   8  (bases 1 to 3134)
  AUTHORS   Wevrick,R., Clarke,C.A. and Buchwald,M.
  TITLE     Cloning and analysis of the murine Fanconi anemia group C cDNA
  JOURNAL   Hum Mol Genet 2 (6), 655-662 (1993)
   PUBMED   7689006
REFERENCE   9  (bases 1 to 3134)
  AUTHORS   Wevrick,R., Barker,J.E., Nadeau,J.H., Szpirer,C. and Buchwald,M.
  TITLE     Mapping of the murine and rat Facc genes and assessment of
            flexed-tail as a candidate mouse homolog of Fanconi anemia group C
  JOURNAL   Mamm Genome 4 (8), 440-444 (1993)
   PUBMED   7690622
REFERENCE   10 (bases 1 to 3134)
  AUTHORS   Strathdee,C.A., Duncan,A.M. and Buchwald,M.
  TITLE     Evidence for at least four Fanconi anaemia genes including FACC on
            chromosome 9
  JOURNAL   Nat Genet 1 (3), 196-198 (1992)
   PUBMED   1303234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163161.1, AK147025.1 and BY431920.1.
            
            On Sep 24, 2013 this sequence version replaced NM_007985.2.
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 4, resulting in
            an isoform (1) that is shorter than isoform 3. Both variants 1 and
            2 encode isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147025.1, SRR1660813.258927.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AK163161.1         2-22
            22-3132             AK147025.1         2-3112
            3133-3134           BY431920.1         427-428
FEATURES             Location/Qualifiers
     source          1..3134
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.8 cM"
     gene            1..3134
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /note="Fanconi anemia, complementation group C"
                     /db_xref="GeneID:14088"
                     /db_xref="MGI:MGI:95480"
     exon            1..296
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            297..493
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..2005
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fanconi anemia group C protein homolog"
                     /codon_start=1
                     /product="Fanconi anemia group C protein homolog isoform
                     1"
                     /protein_id="NP_032011.2"
                     /db_xref="CCDS:CCDS36700.1"
                     /db_xref="GeneID:14088"
                     /db_xref="MGI:MGI:95480"
                     /translation="MAQESADLASDCQSWLQKLSAWEQASSEETQKDTCLHLSGFQEF
                     LRQMYEILKEMDSDAILERFPTIGQLLAKACWNPLILAYDESQKIVIWCLCCLMNKEP
                     RTSAESGLNSWIRGLLSHVLSAFRFDMKEVCLFTKSLGYESIDYYPSLLKNMVLSLVS
                     ELRESHLNGLSTQSRMAPERMMSLSEVCVPLVTLPDMEPLVEALLTYHGHEPQEVLAP
                     EFFEAVNEAFLSEKIVLPTSSVVSLWFRHLPSLEKATLHLFEKLFSSKIICLRRMECC
                     IRESFLPQAACQPAIFRIVDEMFRFVLLETDGAPEVLAALQVFTSCLVEALKKENKQL
                     TFALRTYFPYGAPCLAAALSQHPEAIPQGHRLQPLLHISQLLREAVEDCTRGSPRNPF
                     ESWFLFVHFGGWVDLAVAELLLREEAEPPAGLLWLLVFYYSPQDGSQQREQSMVELKV
                     LINRLLMLLRSGPLSATDLQEAAESPSGDPRPPVCGQLVRRLLLSLLLWTPEGHAIVW
                     EAVTHMAHTDAVIHEIIGFLDQTLYRSQHLCVEASRKLARDLLKELQAQV"
     exon            494..578
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            579..673
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            674..787
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            788..852
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1017
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1174
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1227
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1327
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1403
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1485
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1663
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1867
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..3134
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2514..2519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /note="hexamer: AGTAAA"
     polyA_site      2536
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /note="major polyA site"
     regulatory      2895..2900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /note="hexamer: AATAAA"
     polyA_site      2918
                     /gene="Fancc"
                     /gene_synonym="Facc"
ORIGIN      
        1 gcactgcgcg tgcgtgcgag cgcgcgcgca gccccactcc cttgcggccg cgggaaaatt
       61 ccaaacacgt caaaacaaaa aaagttccgt gaggctgtgc caagttttca agccgcagaa
      121 gccgggcggt ggcttctttt ccgccgcggc ccagtctgct gaggcagctc tgggtgagga
      181 ccacccggga agaccgccgt ttcctgctag ggcagagaag actcgcgaga acgtgcgccc
      241 gagtctcaac gtgggcgagc cgcgctcccg cggcgcggtg gagctgaggc aggacggctg
      301 ctgtgaaggg acagtgctgc tctcagagat ggctcaggag tctgcagacc ttgcttctga
      361 ctgtcagtct tggctgcaga agctttctgc atgggaacag gcctcttctg aggaaaccca
      421 gaaggacact tgtcttcact tgtccgggtt ccaggagttc ctgaggcaga tgtatgaaat
      481 cttgaaggag atggattctg atgcaatcct ggaaaggttc cccacaattg gtcaactgtt
      541 ggcaaaagct tgttggaatc ctctcatctt agcatatgat gaaagccaaa aaattgtaat
      601 atggtgctta tgttgtctga tgaacaaaga acctcggact tctgcagagt caggacttaa
      661 ctcgtggatc cggggtttgt tatctcatgt actttctgca ttcagattcg acatgaaaga
      721 agtttgtctt tttaccaaaa gtcttggata tgagtctatt gattactatc ctagtttgct
      781 taaaaatatg gttttgtcat tagtgtctga gctcagagag agtcatctta atggactgag
      841 cactcaaagt cggatggctc ctgagcgcat gatgtccctg tcagaagttt gtgtccctct
      901 tgtcactctg cctgatatgg aacccctggt agaggctcta ctcacctacc atggacatga
      961 gccccaggaa gtcctggctc ctgagttctt cgaagctgta aatgaggcct tcttgtcgga
     1021 aaaaattgtt ctacccacgt cctctgtggt cagcctctgg tttcggcatc tccccagtct
     1081 tgaaaaagca acgctgcatc tttttgaaaa gcttttctcc agcaagataa tttgcctgag
     1141 aaggatggag tgctgtataa gagagtcatt cctgcctcaa gcagcctgcc aacctgccat
     1201 cttcagaatt gttgatgaaa tgttcaggtt tgtgctgctg gaaactgacg gagccccaga
     1261 agtactagct gctcttcagg ttttcacatc gtgcttggta gaagctctga aaaaagaaaa
     1321 caagcagctg acgtttgccc tcaggaccta ctttccttac ggtgctccat gtcttgctgc
     1381 agcgctgtcc cagcaccctg aagcaatccc acagggacac cggctccagc ctctgctgca
     1441 catttcccaa ctcctcagag aagcagttga agactgtact cgtgggtctc cgcgaaatcc
     1501 ctttgagagc tggtttttgt ttgttcactt tggaggatgg gttgacctgg ctgtggcaga
     1561 gttactgctg agggaggaag ctgagcctcc tgctggcctg ctgtggctct tggtgttcta
     1621 ttacagccca caggatggga gtcagcagag agagcagagc atggtggagc tgaaggtatt
     1681 aatcaaccgt ctcctgatgc tgctcagaag cggccccctc tcagctactg atctgcagga
     1741 agcagctgag agtcccagtg gagaccccag accacctgta tgtggacagc tggtcagacg
     1801 ccttcttctt agtctcttgc tctggacccc agaaggccat gcaattgtct gggaagctgt
     1861 cacccatatg gcccacacgg atgctgtaat ccatgagatt attggttttc ttgaccagac
     1921 cttgtacaga tcacaacatc tttgtgttga agcctcgaga aaactggcca gagacctcct
     1981 aaaggagctg caagcccagg tctagcaggt agtacagaat gtgggcacct gcggtgaagc
     2041 tccctcagtg gatgagatgc tgtttctgag gcaagaacaa gtgagagtgg ttgaacatat
     2101 tcgtgccttg gcctgatgga gtgatgtgta ccacctccca cgctgtactg cctggccccg
     2161 gcggtccatg agtattatga agggaagggc ccagactgcc tgttaggttc cagccattca
     2221 taagagctag cactggctgg tgtgctgact ctctttatcc ttccctctct agtgaaggtg
     2281 tgggggatgc ccagtagcag gagacatgag ccctgtagtg gatgaggctg taccgtacag
     2341 atgagcacct gcctcaccgg tgactgtcgc tcagtgaggc ctttgttcct cagtgcagaa
     2401 atgctgcaag gcacccacta tagtggaagg aatgagaggt ggccagagaa gggtcattcc
     2461 ttcctcctcc tctaaacccc caaaaggcaa aacacatctg cttccctatg tctagtaaac
     2521 aggatttgga aactgagagt gagtccttgt cctcctgcac ttgctgtggg tggggatgac
     2581 gggcatggct gttgttttct agtgagaata tatacaagtg agcagtgtgt gggctgtgac
     2641 cctcctgcac atctgctatg agaacccttg ccccatgtga aatcagcttc aattctcaca
     2701 gtaggacatt tgatgactgc actcaggctg tctagggggg ttgtggcata aagtcatgaa
     2761 ggcctgggtt ttctcttgca tctgcacatc caggctttgc cgggcaaaca ctgactggca
     2821 gtggattcgt cttttaccca cctgctgatg ggctcacagt ggagtggagc tggactttct
     2881 actttttcat tctgaataaa aagttgtact taattttata ttcagacctt cctactccta
     2941 cctatggaag cttcaggtca cacaaacctt aggcctggct tggaaaagat caattatgac
     3001 ttacctctgg ataaactggg atcctgtcac caaacaaggg agaatgtcca gagggcagat
     3061 agttgtgtgt acgtactcag agttgtttcc catttcctgt aagccaaatt tgattataac
     3121 tacacttaac tcag
//
