LOCUS       NM_001282942            2937 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus Fanconi anemia, complementation group C (Fancc),
            transcript variant 3, mRNA.
ACCESSION   NM_001282942
VERSION     NM_001282942.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2937)
  AUTHORS   Lin,Q., Wu,L., Chatla,S., Chowdhury,F.A., Atale,N., Joseph,J. and
            Du,W.
  TITLE     Hematopoietic stem cell regeneration through paracrine regulation
            of the Wnt5a/Prox1 signaling axis
  JOURNAL   J Clin Invest 132 (12) (2022)
   PUBMED   35703178
REFERENCE   2  (bases 1 to 2937)
  AUTHORS   Broxmeyer,H.E., Capitano,M.L., Cooper,S., Potchanant,E.S. and
            Clapp,D.W.
  TITLE     Numbers of long-term hematopoietic stem cells from bone marrow of
            fanca and fancc knockout mice can be greatly enhanced by their
            collection and processing in physioxia conditions
  JOURNAL   Blood Cells Mol Dis 86, 102492 (2021)
   PUBMED   32896825
  REMARK    GeneRIF: Numbers of long-term hematopoietic stem cells from bone
            marrow of fanca and fancc knockout mice can be greatly enhanced by
            their collection and processing in physioxia conditions.
REFERENCE   3  (bases 1 to 2937)
  AUTHORS   Tiwari,S.K., Dang,J.W., Lin,N., Qin,Y., Wang,S. and Rana,T.M.
  TITLE     Zika virus depletes neural stem cells and evades selective
            autophagy by suppressing the Fanconi anemia protein FANCC
  JOURNAL   EMBO Rep 21 (12), e49183 (2020)
   PUBMED   33073500
  REMARK    GeneRIF: Zika virus depletes neural stem cells and evades selective
            autophagy by suppressing the Fanconi anemia protein FANCC.
REFERENCE   4  (bases 1 to 2937)
  AUTHORS   Li,X., Wu,L., Zopp,M., Kopelov,S. and Du,W.
  TITLE     p53-TP53-Induced Glycolysis Regulator Mediated Glycolytic
            Suppression Attenuates DNA Damage and Genomic Instability in
            Fanconi Anemia Hematopoietic Stem Cells
  JOURNAL   Stem Cells 37 (7), 937-947 (2019)
   PUBMED   30977208
REFERENCE   5  (bases 1 to 2937)
  AUTHORS   Huang,F., Ben Aissa,M., Levesque,G. and Carreau,M.
  TITLE     FANCC localizes with UNC5A at neurite outgrowth and promotes
            neuritogenesis
  JOURNAL   BMC Res Notes 11 (1), 662 (2018)
   PUBMED   30213274
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2937)
  AUTHORS   Whitney,M.A., Royle,G., Low,M.J., Kelly,M.A., Axthelm,M.K.,
            Reifsteck,C., Olson,S., Braun,R.E., Heinrich,M.C., Rathbun,R.K.,
            Bagby,G.C. and Grompe,M.
  TITLE     Germ cell defects and hematopoietic hypersensitivity to
            gamma-interferon in mice with a targeted disruption of the Fanconi
            anemia C gene
  JOURNAL   Blood 88 (1), 49-58 (1996)
   PUBMED   8704201
REFERENCE   7  (bases 1 to 2937)
  AUTHORS   Chen,M., Tomkins,D.J., Auerbach,W., McKerlie,C., Youssoufian,H.,
            Liu,L., Gan,O., Carreau,M., Auerbach,A., Groves,T., Guidos,C.J.,
            Freedman,M.H., Cross,J., Percy,D.H., Dick,J.E., Joyner,A.L. and
            Buchwald,M.
  TITLE     Inactivation of Fac in mice produces inducible chromosomal
            instability and reduced fertility reminiscent of Fanconi anaemia
  JOURNAL   Nat Genet 12 (4), 448-451 (1996)
   PUBMED   8630504
REFERENCE   8  (bases 1 to 2937)
  AUTHORS   Wevrick,R., Clarke,C.A. and Buchwald,M.
  TITLE     Cloning and analysis of the murine Fanconi anemia group C cDNA
  JOURNAL   Hum Mol Genet 2 (6), 655-662 (1993)
   PUBMED   7689006
REFERENCE   9  (bases 1 to 2937)
  AUTHORS   Wevrick,R., Barker,J.E., Nadeau,J.H., Szpirer,C. and Buchwald,M.
  TITLE     Mapping of the murine and rat Facc genes and assessment of
            flexed-tail as a candidate mouse homolog of Fanconi anemia group C
  JOURNAL   Mamm Genome 4 (8), 440-444 (1993)
   PUBMED   7690622
REFERENCE   10 (bases 1 to 2937)
  AUTHORS   Strathdee,C.A., Duncan,A.M. and Buchwald,M.
  TITLE     Evidence for at least four Fanconi anaemia genes including FACC on
            chromosome 9
  JOURNAL   Nat Genet 1 (3), 196-198 (1992)
   PUBMED   1303234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163161.1, AK147025.1 and BY431920.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, initiates translation at a
            downstream in-frame start codon, and lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 4. The encoded
            isoform (2) has a shorter N-terminus, compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660813.258927.1, SRR1660817.66523.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AK163161.1         2-22
            22-296              AK147025.1         2-276
            297-2935            AK147025.1         474-3112
            2936-2937           BY431920.1         427-428
FEATURES             Location/Qualifiers
     source          1..2937
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.8 cM"
     gene            1..2937
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /note="Fanconi anemia, complementation group C"
                     /db_xref="GeneID:14088"
                     /db_xref="MGI:MGI:95480"
     exon            1..296
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            297..381
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            382..476
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..1808
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /note="isoform 2 is encoded by transcript variant 3;
                     fanconi anemia group C protein homolog"
                     /codon_start=1
                     /product="Fanconi anemia group C protein homolog isoform
                     2"
                     /protein_id="NP_001269871.1"
                     /db_xref="CCDS:CCDS70472.1"
                     /db_xref="GeneID:14088"
                     /db_xref="MGI:MGI:95480"
                     /translation="MNKEPRTSAESGLNSWIRGLLSHVLSAFRFDMKEVCLFTKSLGY
                     ESIDYYPSLLKNMVLSLVSELRESHLNGLSTQSRMAPERMMSLSEVCVPLVTLPDMEP
                     LVEALLTYHGHEPQEVLAPEFFEAVNEAFLSEKIVLPTSSVVSLWFRHLPSLEKATLH
                     LFEKLFSSKIICLRRMECCIRESFLPQAACQPAIFRIVDEMFRFVLLETDGAPEVLAA
                     LQVFTSCLVEALKKENKQLTFALRTYFPYGAPCLAAALSQHPEAIPQGHRLQPLLHIS
                     QLLREAVEDCTRGSPRNPFESWFLFVHFGGWVDLAVAELLLREEAEPPAGLLWLLVFY
                     YSPQDGSQQREQSMVELKVLINRLLMLLRSGPLSATDLQEAAESPSGDPRPPVCGQLV
                     RRLLLSLLLWTPEGHAIVWEAVTHMAHTDAVIHEIIGFLDQTLYRSQHLCVEASRKLA
                     RDLLKELQAQV"
     exon            477..590
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            591..655
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            656..820
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            821..977
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1030
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1130
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1206
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1288
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1466
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1670
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..2937
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2317..2322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /note="hexamer: AGTAAA"
     polyA_site      2339
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /note="major polyA site"
     regulatory      2698..2703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /note="hexamer: AATAAA"
     polyA_site      2721
                     /gene="Fancc"
                     /gene_synonym="Facc"
ORIGIN      
        1 gcactgcgcg tgcgtgcgag cgcgcgcgca gccccactcc cttgcggccg cgggaaaatt
       61 ccaaacacgt caaaacaaaa aaagttccgt gaggctgtgc caagttttca agccgcagaa
      121 gccgggcggt ggcttctttt ccgccgcggc ccagtctgct gaggcagctc tgggtgagga
      181 ccacccggga agaccgccgt ttcctgctag ggcagagaag actcgcgaga acgtgcgccc
      241 gagtctcaac gtgggcgagc cgcgctcccg cggcgcggtg gagctgaggc aggacggatt
      301 ctgatgcaat cctggaaagg ttccccacaa ttggtcaact gttggcaaaa gcttgttgga
      361 atcctctcat cttagcatat gatgaaagcc aaaaaattgt aatatggtgc ttatgttgtc
      421 tgatgaacaa agaacctcgg acttctgcag agtcaggact taactcgtgg atccggggtt
      481 tgttatctca tgtactttct gcattcagat tcgacatgaa agaagtttgt ctttttacca
      541 aaagtcttgg atatgagtct attgattact atcctagttt gcttaaaaat atggttttgt
      601 cattagtgtc tgagctcaga gagagtcatc ttaatggact gagcactcaa agtcggatgg
      661 ctcctgagcg catgatgtcc ctgtcagaag tttgtgtccc tcttgtcact ctgcctgata
      721 tggaacccct ggtagaggct ctactcacct accatggaca tgagccccag gaagtcctgg
      781 ctcctgagtt cttcgaagct gtaaatgagg ccttcttgtc ggaaaaaatt gttctaccca
      841 cgtcctctgt ggtcagcctc tggtttcggc atctccccag tcttgaaaaa gcaacgctgc
      901 atctttttga aaagcttttc tccagcaaga taatttgcct gagaaggatg gagtgctgta
      961 taagagagtc attcctgcct caagcagcct gccaacctgc catcttcaga attgttgatg
     1021 aaatgttcag gtttgtgctg ctggaaactg acggagcccc agaagtacta gctgctcttc
     1081 aggttttcac atcgtgcttg gtagaagctc tgaaaaaaga aaacaagcag ctgacgtttg
     1141 ccctcaggac ctactttcct tacggtgctc catgtcttgc tgcagcgctg tcccagcacc
     1201 ctgaagcaat cccacaggga caccggctcc agcctctgct gcacatttcc caactcctca
     1261 gagaagcagt tgaagactgt actcgtgggt ctccgcgaaa tccctttgag agctggtttt
     1321 tgtttgttca ctttggagga tgggttgacc tggctgtggc agagttactg ctgagggagg
     1381 aagctgagcc tcctgctggc ctgctgtggc tcttggtgtt ctattacagc ccacaggatg
     1441 ggagtcagca gagagagcag agcatggtgg agctgaaggt attaatcaac cgtctcctga
     1501 tgctgctcag aagcggcccc ctctcagcta ctgatctgca ggaagcagct gagagtccca
     1561 gtggagaccc cagaccacct gtatgtggac agctggtcag acgccttctt cttagtctct
     1621 tgctctggac cccagaaggc catgcaattg tctgggaagc tgtcacccat atggcccaca
     1681 cggatgctgt aatccatgag attattggtt ttcttgacca gaccttgtac agatcacaac
     1741 atctttgtgt tgaagcctcg agaaaactgg ccagagacct cctaaaggag ctgcaagccc
     1801 aggtctagca ggtagtacag aatgtgggca cctgcggtga agctccctca gtggatgaga
     1861 tgctgtttct gaggcaagaa caagtgagag tggttgaaca tattcgtgcc ttggcctgat
     1921 ggagtgatgt gtaccacctc ccacgctgta ctgcctggcc ccggcggtcc atgagtatta
     1981 tgaagggaag ggcccagact gcctgttagg ttccagccat tcataagagc tagcactggc
     2041 tggtgtgctg actctcttta tccttccctc tctagtgaag gtgtggggga tgcccagtag
     2101 caggagacat gagccctgta gtggatgagg ctgtaccgta cagatgagca cctgcctcac
     2161 cggtgactgt cgctcagtga ggcctttgtt cctcagtgca gaaatgctgc aaggcaccca
     2221 ctatagtgga aggaatgaga ggtggccaga gaagggtcat tccttcctcc tcctctaaac
     2281 ccccaaaagg caaaacacat ctgcttccct atgtctagta aacaggattt ggaaactgag
     2341 agtgagtcct tgtcctcctg cacttgctgt gggtggggat gacgggcatg gctgttgttt
     2401 tctagtgaga atatatacaa gtgagcagtg tgtgggctgt gaccctcctg cacatctgct
     2461 atgagaaccc ttgccccatg tgaaatcagc ttcaattctc acagtaggac atttgatgac
     2521 tgcactcagg ctgtctaggg gggttgtggc ataaagtcat gaaggcctgg gttttctctt
     2581 gcatctgcac atccaggctt tgccgggcaa acactgactg gcagtggatt cgtcttttac
     2641 ccacctgctg atgggctcac agtggagtgg agctggactt tctacttttt cattctgaat
     2701 aaaaagttgt acttaatttt atattcagac cttcctactc ctacctatgg aagcttcagg
     2761 tcacacaaac cttaggcctg gcttggaaaa gatcaattat gacttacctc tggataaact
     2821 gggatcctgt caccaaacaa gggagaatgt ccagagggca gatagttgtg tgtacgtact
     2881 cagagttgtt tcccatttcc tgtaagccaa atttgattat aactacactt aactcag
//
