LOCUS       NM_175027               2423 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus Fanconi anemia, complementation group B (Fancb),
            transcript variant 2, mRNA.
ACCESSION   NM_175027
VERSION     NM_175027.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2423)
  AUTHORS   Cen,C., Chen,J., Lin,L., Chen,M., Dong,F., Shen,Z., Cui,X., Hou,X.
            and Gao,F.
  TITLE     Fancb deficiency causes premature ovarian insufficiency in
            micedagger
  JOURNAL   Biol Reprod 107 (3), 790-799 (2022)
   PUBMED   35596251
  REMARK    GeneRIF: Fancb deficiency causes premature ovarian insufficiency in
            micedagger.
REFERENCE   2  (bases 1 to 2423)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2423)
  AUTHORS   Alavattam,K.G., Kato,Y., Sin,H.S., Maezawa,S., Kowalski,I.J.,
            Zhang,F., Pang,Q., Andreassen,P.R. and Namekawa,S.H.
  TITLE     Elucidation of the Fanconi Anemia Protein Network in Meiosis and
            Its Function in the Regulation of Histone Modifications
  JOURNAL   Cell Rep 17 (4), 1141-1157 (2016)
   PUBMED   27760317
REFERENCE   4  (bases 1 to 2423)
  AUTHORS   Du,W., Amarachintha,S., Erden,O., Wilson,A., Meetei,A.R.,
            Andreassen,P.R., Namekawa,S.H. and Pang,Q.
  TITLE     Fancb deficiency impairs hematopoietic stem cell function
  JOURNAL   Sci Rep 5, 18127 (2015)
   PUBMED   26658157
  REMARK    GeneRIF: Data suggest that Fanconi anemia complementation group B
            protein Fancb(-/y) mouse model for studying the Fanconi anemia (FA)
            pathway not only in germ cell development but also in the
            maintenance of hematopoietic stem cell (HSC) function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2423)
  AUTHORS   Kato,Y., Alavattam,K.G., Sin,H.S., Meetei,A.R., Pang,Q.,
            Andreassen,P.R. and Namekawa,S.H.
  TITLE     FANCB is essential in the male germline and regulates H3K9
            methylation on the sex chromosomes during meiosis
  JOURNAL   Hum Mol Genet 24 (18), 5234-5249 (2015)
   PUBMED   26123487
  REMARK    GeneRIF: FANCB functions at critical stages of germ cell
            development and reveal a novel function of the FA pathway in the
            regulation of H3K9 methylation in the germline.
REFERENCE   6  (bases 1 to 2423)
  AUTHORS   Kim,T.M., Son,M.Y., Dodds,S., Hu,L., Luo,G. and Hasty,P.
  TITLE     RECQL5 and BLM exhibit divergent functions in cells defective for
            the Fanconi anemia pathway
  JOURNAL   Nucleic Acids Res 43 (2), 893-903 (2015)
   PUBMED   25520194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732426.6.
            
            On Apr 26, 2022 this sequence version replaced NM_175027.4.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            segment in the 3' coding region, compared to variant 1, resulting
            in an isoform (2) that is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083151.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164132 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AL732426.6         41076-41204
            130-1146            AL732426.6         42831-43847
            1147-1299           AL732426.6         46954-47106
            1300-1392           AL732426.6         48099-48191
            1393-1536           AL732426.6         51939-52082
            1537-1700           AL732426.6         53125-53288
            1701-1779           AL732426.6         55738-55816
            1780-1922           AL732426.6         56373-56515
            1923-2423           AL732426.6         57164-57664
FEATURES             Location/Qualifiers
     source          1..2423
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 76.75 cM"
     gene            1..2423
                     /gene="Fancb"
                     /note="Fanconi anemia, complementation group B"
                     /db_xref="GeneID:237211"
                     /db_xref="MGI:MGI:2448558"
     exon            1..129
                     /gene="Fancb"
                     /inference="alignment:Splign:2.1.0"
     exon            130..1146
                     /gene="Fancb"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..2337
                     /gene="Fancb"
                     /note="isoform 2 is encoded by transcript variant 2;
                     fanconi anemia group B protein homolog"
                     /codon_start=1
                     /product="Fanconi anemia group B protein homolog isoform
                     2"
                     /protein_id="NP_778192.3"
                     /db_xref="CCDS:CCDS90772.1"
                     /db_xref="GeneID:237211"
                     /db_xref="MGI:MGI:2448558"
                     /translation="MPFNEQAKFLCYHGEILVFQLSRGERADLEMPTDPLVLGVKRMM
                     FDRETSTFLLISTVFLNINEKDSHLKILCCNCVSDLRTRINLPCVLIQCRKYNSEAFK
                     YCILLLHNLNRVERLLSFELNHALDENTKIFDGPIVFWQYLNQFFYISSAIGKVTTIS
                     LMLSSIEWIGEIENFGLGFLGLAEPSEDKCTQKLSESDYEFSNSSLCAYALKSQEMLS
                     NGYLIPLAYSTMVTHVHVWAAEMVDHQLRTSLIALTRKNQLILFQNGIPVRACQLPFP
                     GPRSVQILDAGKRNRFFIVSFPSKACAVSEKKFKVVAKWEQLSLVLVNDFAGVGTEQV
                     LVVFEDSLDADQLTSFTVTDFVKIWYSTKPLDCCEDPLAEEEHENYYLVLPALEGQLD
                     NSFIFLNKIQQHISFKDKFIAKSWKALLNAVYGKGDSLPSDEMVKLDQDGLVPFCDEG
                     EDSVPTPEENLPDNFPEPEHIVEQTWCHVLDDDLVVGAKVTSLKESNEMTLSLIMNQG
                     NRSSFHLMKCHSQVWLLKHMKCERIQECTEIYLYKKLRNCGALFSWEQRTASEGILTI
                     YCRSQGVLFQCLDHLIKVLPEICSFKYLKVENEDFLVDHLSSTLEAELVTFCSVSTSA
                     FEYVRGGYNCRIRRTDNRAMTFLGRRAKIRQSKRKVQRERILKHLNMTVNGSSYAEMT
                     LALAEIQLKSDLIVKTLANFVIAL"
     exon            1147..1299
                     /gene="Fancb"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1392
                     /gene="Fancb"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1536
                     /gene="Fancb"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1700
                     /gene="Fancb"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1779
                     /gene="Fancb"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1922
                     /gene="Fancb"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2423
                     /gene="Fancb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2401..2406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fancb"
                     /note="hexamer: ATTAAA"
     polyA_site      2423
                     /gene="Fancb"
                     /note="major polyA site"
ORIGIN      
        1 agcgtgcaat gcgcgggcgg gaggtttgga gtcctttggt gcaactggaa cgtggcaatt
       61 tggcagcctt ggagaactgg ttttggtttg gtttggtttt ctcctgaccg ctcgcagata
      121 acttgcattg attaaaggcc tcaactggaa tccatttgca gttggaactg gatcaacaca
      181 gagacttgat gcattagagt ggccggcaaa caagcaatgc catttaatga gcaagcaaag
      241 ttcttgtgct atcatgggga aatccttgtc tttcagttgt ccagaggaga gcgtgcagat
      301 ttagaaatgc ctacagatcc actggtctta ggtgtcaaaa ggatgatgtt tgacagagaa
      361 actagtacat tccttctgat atccactgtt tttttaaaca tcaacgaaaa agattctcat
      421 ttaaaaattc tgtgttgtaa ctgtgtgtcc gatttgagaa ctagaattaa ccttccttgc
      481 gttttgatac aatgtagaaa gtacaatagt gaagctttca aatattgtat cctgcttctt
      541 cacaatctca acagagtgga gagacttttg agttttgaac taaaccatgc attggatgag
      601 aacacaaaga tctttgacgg ccctatagtt ttctggcagt atctcaacca gttcttctat
      661 atctcttctg caattgggaa agttactact atatcactta tgctttcctc tattgagtgg
      721 atcggtgaga ttgaaaactt tggcctaggt ttcttggggc tagcagaacc atctgaggat
      781 aaatgtaccc agaagctttc agaatcagac tatgaatttt ccaattccag cctttgcgca
      841 tatgctctta aaagtcaaga aatgttaagc aatggttacc tgatccctct tgcttacagt
      901 actatggtaa cacacgtgca tgtctgggcg gcggagatgg ttgaccacca gttaagaaca
      961 tctctgattg ccctgactcg aaagaatcag ctcattttgt ttcaaaatgg cattcctgta
     1021 agagcatgtc agcttccatt tccaggtccc cgttcagttc agattctaga tgcagggaaa
     1081 agaaaccgat ttttcatcgt gtcattcccg tccaaggctt gtgctgtttc agaaaagaaa
     1141 tttaaggttg ttgctaagtg ggaacaactt agcttagtac tggtgaatga ctttgctgga
     1201 gttggaactg aacaagtact ggtcgttttt gaggactctc tggatgcaga tcagctgacc
     1261 tcatttacag taacagattt tgtcaaaata tggtattcaa ccaaaccact ggattgctgt
     1321 gaagaccctt tggctgaaga ggagcatgaa aattattatt tggtgcttcc agcactggaa
     1381 ggccaattag acaattcttt tatttttctt aacaaaatcc agcagcatat ctcttttaag
     1441 gataaattta ttgcaaagtc ttggaaggct cttttaaacg cagtttatgg gaaaggtgac
     1501 agtctgccaa gtgatgaaat ggttaagtta gaccaggacg gtcttgttcc tttctgtgat
     1561 gaaggtgaag acagtgtccc tacccctgag gaaaacttac cagacaattt tccagagcca
     1621 gaacatattg tagagcagac atggtgccat gtactagatg atgacttagt tgtgggcgca
     1681 aaagtcacat ctttgaagga atctaatgag atgactttat cactgataat gaatcaaggc
     1741 aacaggtcca gttttcatct tatgaagtgt cacagtcagg tatggctctt gaaacacatg
     1801 aaatgtgaaa gaattcaaga atgtacagaa atataccttt ataaaaagct acgaaattgt
     1861 ggagcactct tctcctggga gcagagaaca gcatctgaag gaattttaac aatatattgc
     1921 aggagccaag gagttttgtt ccagtgtctc gaccatctca tcaaagttct ccctgaaata
     1981 tgttccttca aatatctgaa ggtcgaaaat gaggatttct tagttgatca tttgtcatcc
     2041 actttggagg cagaactggt taccttttgt tcagtttcta cttctgcctt cgagtatgtt
     2101 agaggtggat ataactgtag aataaggaga acagataata gggccatgac atttttaggg
     2161 agaagggcca aaatccgtca gtccaagcgc aaagttcaga gagaaaggat actgaagcac
     2221 cttaatatga cagtaaatgg cagcagctat gcggagatga ctttggcgtt ggctgagatt
     2281 cagttgaaat cagacctcat tgtaaagaca ctggccaatt ttgtaattgc actttaaaac
     2341 tcatgattta aaatattcca taattatttg cctcacttgt taggttttga taatataaag
     2401 attaaagctt attataattc cta
//
