LOCUS       NP_001139553             853 aa            linear   ROD 13-JUN-2024
DEFINITION  Fanconi anemia group B protein homolog isoform 1 [Mus musculus].
ACCESSION   NP_001139553
VERSION     NP_001139553.1
DBSOURCE    REFSEQ: accession NM_001146081.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 853)
  AUTHORS   Cen,C., Chen,J., Lin,L., Chen,M., Dong,F., Shen,Z., Cui,X., Hou,X.
            and Gao,F.
  TITLE     Fancb deficiency causes premature ovarian insufficiency in
            micedagger
  JOURNAL   Biol Reprod 107 (3), 790-799 (2022)
   PUBMED   35596251
  REMARK    GeneRIF: Fancb deficiency causes premature ovarian insufficiency in
            micedagger.
REFERENCE   2  (residues 1 to 853)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 853)
  AUTHORS   Alavattam,K.G., Kato,Y., Sin,H.S., Maezawa,S., Kowalski,I.J.,
            Zhang,F., Pang,Q., Andreassen,P.R. and Namekawa,S.H.
  TITLE     Elucidation of the Fanconi Anemia Protein Network in Meiosis and
            Its Function in the Regulation of Histone Modifications
  JOURNAL   Cell Rep 17 (4), 1141-1157 (2016)
   PUBMED   27760317
REFERENCE   4  (residues 1 to 853)
  AUTHORS   Du,W., Amarachintha,S., Erden,O., Wilson,A., Meetei,A.R.,
            Andreassen,P.R., Namekawa,S.H. and Pang,Q.
  TITLE     Fancb deficiency impairs hematopoietic stem cell function
  JOURNAL   Sci Rep 5, 18127 (2015)
   PUBMED   26658157
  REMARK    GeneRIF: Data suggest that Fanconi anemia complementation group B
            protein Fancb(-/y) mouse model for studying the Fanconi anemia (FA)
            pathway not only in germ cell development but also in the
            maintenance of hematopoietic stem cell (HSC) function.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 853)
  AUTHORS   Kato,Y., Alavattam,K.G., Sin,H.S., Meetei,A.R., Pang,Q.,
            Andreassen,P.R. and Namekawa,S.H.
  TITLE     FANCB is essential in the male germline and regulates H3K9
            methylation on the sex chromosomes during meiosis
  JOURNAL   Hum Mol Genet 24 (18), 5234-5249 (2015)
   PUBMED   26123487
  REMARK    GeneRIF: FANCB functions at critical stages of germ cell
            development and reveal a novel function of the FA pathway in the
            regulation of H3K9 methylation in the germline.
REFERENCE   6  (residues 1 to 853)
  AUTHORS   Kim,T.M., Son,M.Y., Dodds,S., Hu,L., Luo,G. and Hasty,P.
  TITLE     RECQL5 and BLM exhibit divergent functions in cells defective for
            the Fanconi anemia pathway
  JOURNAL   Nucleic Acids Res 43 (2), 893-903 (2015)
   PUBMED   25520194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732426.6.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169374.1, AK132251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..853
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 76.75 cM"
     Protein         1..853
                     /product="Fanconi anemia group B protein homolog isoform
                     1"
                     /note="fanconi anemia group B protein homolog"
                     /calculated_mol_wt=96785
     CDS             1..853
                     /gene="Fancb"
                     /coded_by="NM_001146081.2:217..2778"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS53242.1"
                     /db_xref="GeneID:237211"
                     /db_xref="MGI:MGI:2448558"
ORIGIN      
        1 mpfneqakfl cyhgeilvfq lsrgeradle mptdplvlgv krmmfdrets tfllistvfl
       61 ninekdshlk ilccncvsdl rtrinlpcvl iqcrkynsea fkycilllhn lnrverllsf
      121 elnhaldent kifdgpivfw qylnqffyis saigkvttis lmlssiewig eienfglgfl
      181 glaepsedkc tqklsesdye fsnsslcaya lksqemlsng yliplaystm vthvhvwaae
      241 mvdhqlrtsl ialtrknqli lfqngipvra cqlpfpgprs vqildagkrn rffivsfpsk
      301 acavsekkfk vvakweqlsl vlvndfagvg teqvlvvfed sldadqltsf tvtdfvkiwy
      361 stkpldcced plaeeeheny ylvlpalegq ldnsfiflnk iqqhisfkdk fiakswkall
      421 navygkgdsl psdemvkldq dglvpfcdeg edsvptpeen lpdnfpepeh iveqtwchvl
      481 dddlvvgakv tslkesnemt lslimnqgnr ssfhlmkchs qvislsmnsf peaylmskea
      541 gpdsermqlv sssveaessf cgqsskaest riitavtsls pllvfnqlcc tvllnisdrd
      601 npkatvhdyi vcgnldfnlq dlfsknhlla fpkkesveht edlfsllgvl pkypfcvtsp
      661 thapnfmkvw llkhmkceri qecteiylyk klrncgalfs weqrtasegi ltiycrsqgv
      721 lfqcldhlik vlpeicsfky lkvenedflv dhlsstleae lvtfcsvsts afeyvrggyn
      781 crirrtdnra mtflgrraki rqskrkvqre rilkhlnmtv ngssyaemtl alaeiqlksd
      841 livktlanfv ial
//
