LOCUS       NP_058621               1439 aa            linear   ROD 25-FEB-2025
DEFINITION  Fanconi anemia group A protein homolog [Mus musculus].
ACCESSION   NP_058621
VERSION     NP_058621.2
DBSOURCE    REFSEQ: accession NM_016925.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1439)
  AUTHORS   Bona,N. and Crossan,G.P.
  TITLE     Fanconi anemia DNA crosslink repair factors protect against LINE-1
            retrotransposition during mouse development
  JOURNAL   Nat Struct Mol Biol 30 (10), 1434-1445 (2023)
   PUBMED   37580626
REFERENCE   2  (residues 1 to 1439)
  AUTHORS   Pawlikowska,P., Delestre,L., Gregoricchio,S., Oppezzo,A.,
            Esposito,M., Diop,M.B., Rosselli,F. and Guillouf,C.
  TITLE     FANCA deficiency promotes leukaemic progression by allowing the
            emergence of cells carrying oncogenic driver mutations
  JOURNAL   Oncogene 42 (37), 2764-2775 (2023)
   PUBMED   37573408
REFERENCE   3  (residues 1 to 1439)
  AUTHORS   Gong,Y., Liang,Y., Liu,J., Wei,J., Zhang,S., Chen,F., Zhang,Q.,
            Wang,L., Lan,H., Wu,L., Ge,W., Li,S., Wang,L., Shan,H. and He,H.
  TITLE     DDX24 Is Essential for Cell Cycle Regulation in Vascular Smooth
            Muscle Cells During Vascular Development via Binding to FANCA mRNA
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (9), 1653-1667 (2023)
   PUBMED   37470182
REFERENCE   4  (residues 1 to 1439)
  AUTHORS   Errazquin,R., Page,A., Sunol,A., Segrelles,C., Carrasco,E.,
            Peral,J., Garrido-Aranda,A., Del Marro,S., Ortiz,J., Lorz,C.,
            Minguillon,J., Surralles,J., Belendez,C., Alvarez,M., Balmana,J.,
            Bravo,A., Ramirez,A. and Garcia-Escudero,R.
  TITLE     Development of a mouse model for spontaneous oral squamous cell
            carcinoma in Fanconi anemia
  JOURNAL   Oral Oncol 134, 106184 (2022)
   PUBMED   36191479
REFERENCE   5  (residues 1 to 1439)
  AUTHORS   Lin,Q., Wu,L., Chatla,S., Chowdhury,F.A., Atale,N., Joseph,J. and
            Du,W.
  TITLE     Hematopoietic stem cell regeneration through paracrine regulation
            of the Wnt5a/Prox1 signaling axis
  JOURNAL   J Clin Invest 132 (12) (2022)
   PUBMED   35703178
REFERENCE   6  (residues 1 to 1439)
  AUTHORS   Wong,J.C., Alon,N., Norga,K., Kruyt,F.A., Youssoufian,H. and
            Buchwald,M.
  TITLE     Cloning and analysis of the mouse Fanconi anemia group A cDNA and
            an overlapping penta zinc finger cDNA
  JOURNAL   Genomics 67 (3), 273-283 (2000)
   PUBMED   10936049
REFERENCE   7  (residues 1 to 1439)
  AUTHORS   Cheng,N.C., van de Vrugt,H.J., van der Valk,M.A., Oostra,A.B.,
            Krimpenfort,P., de Vries,Y., Joenje,H., Berns,A. and Arwert,F.
  TITLE     Mice with a targeted disruption of the Fanconi anemia homolog Fanca
  JOURNAL   Hum Mol Genet 9 (12), 1805-1811 (2000)
   PUBMED   10915769
REFERENCE   8  (residues 1 to 1439)
  AUTHORS   Nadler,J.J. and Braun,R.E.
  TITLE     Fanconi anemia complementation group C is required for
            proliferation of murine primordial germ cells
  JOURNAL   Genesis 27 (3), 117-123 (2000)
   PUBMED   10951504
REFERENCE   9  (residues 1 to 1439)
  AUTHORS   van de Vrugt,H.J., Cheng,N.C., de Vries,Y., Rooimans,M.A., de
            Groot,J., Scheper,R.J., Zhi,Y., Hoatlin,M.E., Joenje,H. and
            Arwert,F.
  TITLE     Cloning and characterization of murine fanconi anemia group A gene:
            Fanca protein is expressed in lymphoid tissues, testis, and ovary
  JOURNAL   Mamm Genome 11 (4), 326-331 (2000)
   PUBMED   10754110
REFERENCE   10 (residues 1 to 1439)
  AUTHORS   Abu-Issa,R., Eichele,G. and Youssoufian,H.
  TITLE     Expression of the Fanconi anemia group A gene (Fanca) during mouse
            embryogenesis
  JOURNAL   Blood 94 (2), 818-824 (1999)
   PUBMED   10397750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155810.5.
            
            On Jul 1, 2009 this sequence version replaced NP_058621.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF208116.1, AF178934.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1439
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.1 cM"
     Protein         1..1439
                     /product="Fanconi anemia group A protein homolog"
                     /calculated_mol_wt=161083
     Region          1..20
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JL70.2)"
     Region          19..35
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JL70.2)"
     Region          167..520
                     /region_name="Fanconi_A_N"
                     /note="Fanconi anaemia group A protein N terminus;
                     pfam15865"
                     /db_xref="CDD:464911"
     Region          1246..1308
                     /region_name="Fanconi_A"
                     /note="Fanconi anaemia group A protein; pfam03511"
                     /db_xref="CDD:460952"
     CDS             1..1439
                     /gene="Fanca"
                     /gene_synonym="FACA"
                     /coded_by="NM_016925.4:8..4327"
                     /db_xref="CCDS:CCDS22753.1"
                     /db_xref="GeneID:14087"
                     /db_xref="MGI:MGI:1341823"
ORIGIN      
        1 mpgspargaa mgggprglrk twtellagrv kkqkydpere qklkdsalkl lryhqnmhdl
       61 lleveepqck rlrlselidr dsadassdrs asfirsafrd qasrlgvpvg vlsakvfars
      121 vqqvcvepsh pvllspeqsk klssllmiar hllaqnmfsr ltfcqelwka qnsllleamw
      181 rlhthsvvsl qellqshpds eamamwlfrn lrslceqiga scpspdttea mlsglvqlli
      241 srgfqgssdp rrlveperlp qvatdvlqrm lafsldtlea dpqttldcqa vsgwipiysg
      301 htccgvvten slksffshtl tqilthkpvl kvsdaiqmqk ewsfakthhl ltdlhcrvla
      361 tlgpeesvgr lqevlemqev nwqhvlscvs tlvvcfpeaq qlvkgwvasl marafesyhl
      421 dsmvtafliv rqatlegpyv fpsyadwfke sfgsshgyhs cskktlvflf kflsdlvpwe
      481 aprymqvhif hpplvpskyh slltdyisla ktrladlkvs lenvglyedl sspgdiaere
      541 sqavqdvkka imvfeqtgki pmpvleasif rrpyyvshfl ptllaprvlp evpdprvali
      601 etlkradkip ssiydayrka casaekqqpe natsaqrtea dcakeplgll taaleelral
      661 mtdptqysvi saqvavvsek lnavlghrnd ggslqrakiq lsvlpstlqk qdqavvdlll
      721 tafcqnlmaa ssfvpperqs pwavlfvrtl cghvllpavl trlrqllrhq gqslstshvl
      781 glaalavhlg ecrsmlpevd pdvlapsags lcvpdflnsl ltcrtrdsll fcmnfctaav
      841 syclckfsal rnclspglik kfqfvvlrlf pearapcape haacvpwrpl ylpsadwqra
      901 alslwrrdsf qellkdkefy ltyrdwvqle leiqpeadvl sdmerhdfhq waiyerylpa
      961 ptalggcggd leeactvlvs eimdfhqssr synhsedsdl vlggrtgnkd ilsrlqeial
     1021 dleldqgsav phgcstpqsh flfrvfrrrl qalarpdsma tslrrqqell tckrlllclp
     1081 psvlvggpqa gqpispncge ffslvnselr nfcchgsvlt sditihffrg llrvclrsqd
     1141 palvanqtlt ecqtkcpvil tsallwwssl epvlcgrwmr cyqsplprel rrlqearefa
     1201 snfasasasp apspawiaaa alhfawrgvr kedvtahlqr ldcqreelli alfffslmgl
     1261 lssyltqrdt aehlkavdic aevltclerr kvswlvlfql tekdaklghl lhlapdqhtr
     1321 llplafysll scfsegaavr eaaflhvavd mylkllqlfv dgetrlqghs esqgspvqli
     1381 tkarvfllql ipqcpkqcfs nmtellagrg dcdpevsnal rqrqqadpsf dlyqepqlf
//
