LOCUS       NM_177893               4809 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus FANCD2/FANCI-associated nuclease 1 (Fan1), mRNA.
ACCESSION   NM_177893 XM_885802 XM_976717
VERSION     NM_177893.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4809)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4809)
  AUTHORS   Zhao,X., Lu,H. and Usdin,K.
  TITLE     FAN1's protection against CGG repeat expansion requires its
            nuclease activity and is FANCD2-independent
  JOURNAL   Nucleic Acids Res 49 (20), 11643-11652 (2021)
   PUBMED   34718701
  REMARK    GeneRIF: FAN1's protection against CGG repeat expansion requires
            its nuclease activity and is FANCD2-independent.
REFERENCE   3  (bases 1 to 4809)
  AUTHORS   Goold,R., Hamilton,J., Menneteau,T., Flower,M., Bunting,E.L.,
            Aldous,S.G., Porro,A., Vicente,J.R., Allen,N.D., Wilkinson,H.,
            Bates,G.P., Sartori,A.A., Thalassinos,K., Balmus,G. and
            Tabrizi,S.J.
  TITLE     FAN1 controls mismatch repair complex assembly via MLH1 retention
            to stabilize CAG repeat expansion in Huntington's disease
  JOURNAL   Cell Rep 36 (9), 109649 (2021)
   PUBMED   34469738
REFERENCE   4  (bases 1 to 4809)
  AUTHORS   Loupe,J.M., Pinto,R.M., Kim,K.H., Gillis,T., Mysore,J.S.,
            Andrew,M.A., Kovalenko,M., Murtha,R., Seong,I., Gusella,J.F.,
            Kwak,S., Howland,D., Lee,R., Lee,J.M., Wheeler,V.C. and
            MacDonald,M.E.
  TITLE     Promotion of somatic CAG repeat expansion by Fan1 knock-out in
            Huntington's disease knock-in mice is blocked by Mlh1 knock-out
  JOURNAL   Hum Mol Genet 29 (18), 3044-3053 (2020)
   PUBMED   32876667
  REMARK    GeneRIF: Promotion of somatic CAG repeat expansion by Fan1
            knock-out in Huntington's disease knock-in mice is blocked by Mlh1
            knock-out.
REFERENCE   5  (bases 1 to 4809)
  AUTHORS   Hill,R.J. and Crossan,G.P.
  TITLE     DNA cross-link repair safeguards genomic stability during
            premeiotic germ cell development
  JOURNAL   Nat Genet 51 (8), 1283-1294 (2019)
   PUBMED   31367016
REFERENCE   6  (bases 1 to 4809)
  AUTHORS   Kogan,J.H., Gross,A.K., Featherstone,R.E., Shin,R., Chen,Q.,
            Heusner,C.L., Adachi,M., Lin,A., Walton,N.M., Miyoshi,S.,
            Miyake,S., Tajinda,K., Ito,H., Siegel,S.J. and Matsumoto,M.
  TITLE     Mouse Model of Chromosome 15q13.3 Microdeletion Syndrome
            Demonstrates Features Related to Autism Spectrum Disorder
  JOURNAL   J Neurosci 35 (49), 16282-16294 (2015)
   PUBMED   26658876
REFERENCE   7  (bases 1 to 4809)
  AUTHORS   Pennell,S., Declais,A.C., Li,J., Haire,L.F., Berg,W.,
            Saldanha,J.W., Taylor,I.A., Rouse,J., Lilley,D.M. and Smerdon,S.J.
  TITLE     FAN1 activity on asymmetric repair intermediates is mediated by an
            atypical monomeric virus-type replication-repair nuclease domain
  JOURNAL   Cell Rep 8 (1), 84-93 (2014)
   PUBMED   24981866
REFERENCE   8  (bases 1 to 4809)
  AUTHORS   Cheverud,J.M., Lawson,H.A., Bouckaert,K., Kossenkov,A.V.,
            Showe,L.C., Cort,L., Blankenhorn,E.P., Bedelbaeva,K.,
            Gourevitch,D., Zhang,Y. and Heber-Katz,E.
  TITLE     Fine-mapping quantitative trait loci affecting murine external ear
            tissue regeneration in the LG/J by SM/J advanced intercross line
  JOURNAL   Heredity (Edinb) 112 (5), 508-518 (2014)
   PUBMED   24569637
REFERENCE   9  (bases 1 to 4809)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   10 (bases 1 to 4809)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129199.3 and AC139849.5.
            
            On Jun 17, 2019 this sequence version replaced NM_177893.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.60786.1,
                                           SRR11927932.1517700.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AC129199.3         24083-24204         c
            123-1616            AC129199.3         22409-23902         c
            1617-1757           AC129199.3         21667-21807         c
            1758-1959           AC139849.5         187560-187761       c
            1960-2193           AC139849.5         185095-185328       c
            2194-2325           AC139849.5         183070-183201       c
            2326-2434           AC139849.5         181672-181780       c
            2435-2554           AC139849.5         180480-180599       c
            2555-2719           AC139849.5         172911-173075       c
            2720-2870           AC139849.5         172116-172266       c
            2871-2974           AC139849.5         168575-168678       c
            2975-3169           AC139849.5         167857-168051       c
            3170-3298           AC139849.5         167388-167516       c
            3299-4809           AC139849.5         163925-165435       c
FEATURES             Location/Qualifiers
     source          1..4809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 34.64 cM"
     gene            1..4809
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /note="FANCD2/FANCI-associated nuclease 1"
                     /db_xref="GeneID:330554"
                     /db_xref="MGI:MGI:3045266"
     exon            1..122
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     exon            123..1616
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..3436
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /EC_number="3.1.4.1"
                     /note="coiled-coil domain-containing protein MTMR15;
                     myotubularin-related protein 15"
                     /codon_start=1
                     /product="fanconi-associated nuclease 1"
                     /protein_id="NP_808561.2"
                     /db_xref="CCDS:CCDS52265.1"
                     /db_xref="GeneID:330554"
                     /db_xref="MGI:MGI:3045266"
                     /translation="MPSQRKSPDQKRPRRSLSTSKTAKSQCHSITSYFNSAPPAKLAC
                     STCHKMVPRYDLIRHLDESCANNGVGDDVQVEPAQAGLMSPTVPTSDLPSGPLENVTP
                     QKLSPPKRSLISVQCGSKLGIQQQTSPYFKDALVSKDQNELPNQSVEIMPLGSLTSKL
                     SRRYLNAKKSLAKNEGLASQCPQTSPSTPGTSLTDNCPEMEDKDEVLNSSQKENIYSC
                     APLKEENASEQKVKNNKITGDESQKASCGEPALTPASAEHASILLSSDSTLVSNTKSS
                     PGDTLVKQESARRADVGLAEPLEVRSHKEVQMTFDAAAKTLVSGEAESNGPTDVDMSD
                     MTTWSNNQELVREAGSVLHCPLEQGSSCGGPSETAQLALSHPYYLRSFLVVLQALLGN
                     EEDMKLFDEQEKAIITRFYQLSASGQKLYVRLFQRKLTWIKMSKLEYEEIASDLTPVV
                     EELKDSGFLQTESELQELSDVLELLSAPELKALAKTFHLVSPGGQKQQLVDAFHKLAK
                     QRSVCTWGKTQPGIRAVILKRAKDLAGRSLRVCKGPRAVFARILLLFSLTDSMEDEEA
                     ACGGQGQLSTVLLVNLGRMEFPQYTICRKTQIFRDREDLIRYAAAAHMLSDISAAMAS
                     GNWEDAKELARSAKRDWEQLKSHPSLRYHEALPPFLRCFTVGWIYTRISSRAVEVLER
                     LHMYEEAVKELENLLSQKIYCPDSRGRWWDRLALNLHQHLKRLEEAIRCIREGLADPH
                     VRTGHRLSLYQRAVRLRESPSCRKYKHLFSRLPEVAVGDVKHVTITGRLCPQHGMGKS
                     VFVMESGDGANPTTVLCSVEELALGYYRQSGFDQGIHGEGSTFSTLCGLLLWDIIFMD
                     GIPDVFRNAYQASPLDLLTDSFFASREQALEARLQLIHSAPAESLRAWVGEAWQAQQG
                     RVASLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRRLAADFRHCRGGLPDLVVWNSQSH
                     HCKLVEVKGPSDRLSCKQMIWLYELQKLGADVEVCHVVAVGAKSKGLG"
     exon            1617..1757
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1959
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2193
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2325
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2434
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2554
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2719
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2870
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2974
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3169
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3298
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..4809
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3952
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
     regulatory      3988..3993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /note="hexamer: AATACA"
     polyA_site      4011
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /note="major polyA site"
     regulatory      4192..4197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
                     /note="hexamer: ATTAAA"
     polyA_site      4226
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
     polyA_site      4809
                     /gene="Fan1"
                     /gene_synonym="6030441H18Rik; mFAN1; Mtmr15"
ORIGIN      
        1 gactgcccgc cttgtggccc tttgagagcg actcagcctg ttccgctgca gtgagttcag
       61 gggagtctga gcgagtcagc gtcctctttt taagacaaac ggttcttaga aaggccctga
      121 aagaagaagt tgaacgaata acgacatcaa atgctatttc actttgtatt agttcacggc
      181 gagagtaaaa gtaacccttt agggtccttc acctggggtg gccgctgtat taactgatga
      241 ggaggtagca gggacccttt ttttttgttg ttgtttttac taattcaagc caagtgaatg
      301 aaagtaaaac atttcggtcc ttacctgaga tgacctgatt ttcttcttgg gtcgcccact
      361 ttctctaata gtcatgccgt cacaaaggaa atcacctgat caaaaaagac cccgtagaag
      421 cttatctacc agcaaaactg caaaaagcca gtgtcattcg attacttcgt attttaacag
      481 tgcaccacct gctaaacttg catgttcaac ttgtcataaa atggtgccca ggtatgacct
      541 cattcggcac cttgatgagt cttgtgctaa caacggtgtt ggtgatgacg ttcaagtaga
      601 gcctgctcag gctggattaa tgagtccaac tgtgcctaca tcagatttac ccagtggtcc
      661 tttagagaat gtgacacctc agaaattatc accaccaaag agaagtttaa tttctgtcca
      721 atgtggttca aaactgggca tacaacagca gaccagtccc tactttaaag atgccttagt
      781 gtccaaagat caaaatgagc ttccaaatca gagtgtagaa attatgcctt tgggaagtct
      841 gacatcgaaa ttgtccagac gatacttaaa cgctaaaaaa tcactcgcta agaatgaggg
      901 actagccagt cagtgcccac agacttctcc gtccacacct ggcaccagcc tgactgataa
      961 ctgtccagag atggaagaca aagatgaggt tttgaacagt tcccaaaagg aaaacattta
     1021 ttcatgtgca cctctaaaag aagagaatgc ttcagaacag aaggtaaaga acaataaaat
     1081 aacgggagat gaaagccaga aagcttcctg cggggagcca gccctcaccc ctgcatctgc
     1141 agagcatgct tccatattac tgtcctcaga ttcaactctc gtcagtaaca cgaaatcctc
     1201 tccgggagac actcttgtaa agcaagaaag tgccagaagg gcagatgtag ggcttgctga
     1261 gccgctcgag gtgcgcagtc acaaagaagt acaaatgact ttcgatgctg cggccaaaac
     1321 gctggtgtct ggggaggcag aatcaaatgg tcctaccgat gttgacatgt ctgacatgac
     1381 tacgtggagt aacaaccaag agcttgtcag ggaagctggc agtgtcttac actgccctct
     1441 ggagcagggg tccagctgcg gtggccccag tgagacagct caactggcac tgagtcaccc
     1501 gtactacctg cggagcttcc tggtggtgct gcaggccctc cttgggaacg aagaggacat
     1561 gaagctcttc gatgagcagg agaaggcgat tatcaccagg ttttaccagt tgtcagctag
     1621 tggtcaaaag ttgtatgtga ggctctttca acgtaaatta acctggatta aaatgagtaa
     1681 actggagtat gaagagattg cctccgactt aacccctgtg gttgaagaat tgaaggactc
     1741 aggctttcta cagacagaat ctgagttgca agaactctct gatgtacttg aactcctttc
     1801 tgctcctgag ctgaaagccc tggccaaaac cttccacttg gtgagtcccg gtgggcagaa
     1861 gcagcagctg gtagacgcct ttcacaaact ggccaaacag cgctcagtct gcacgtgggg
     1921 caagactcag cctggaatcc gagcagtgat tttaaaaaga gccaaagact tggctggccg
     1981 gtcgcttcga gtctgtaaag gccctagggc tgtgtttgcc cgaatcttgc ttctgttctc
     2041 attgactgat tccatggaag acgaagaagc tgcttgtggg ggtcaaggtc agctgtctac
     2101 tgtgctattg gtcaatctgg gccgaatgga gtttcctcag tacaccatct gccggaagac
     2161 ccagatcttc agggacagag aggacctcat cagatacgca gcagccgcac acatgctgag
     2221 tgacatctca gctgccatgg ccagtgggaa ctgggaggac gctaaggagc ttgctcggag
     2281 tgcaaaaagg gactgggaac aactgaaaag ccacccttcc ctgaggtacc acgaggcctt
     2341 gccgcccttc ctgcgctgct ttaccgtcgg gtggatctac acaaggattt cctctcgggc
     2401 tgttgaagtc ctagagaggc ttcacatgta cgaggaagct gtcaaggaac ttgaaaacct
     2461 cttgtctcag aaaatctatt gtcctgacag cagaggccgc tggtgggatc gcctggctct
     2521 taacctgcac cagcacctga agcgtctgga agaggcaatt aggtgcatca gggaaggcct
     2581 ggcagaccca cacgtgagga caggacaccg actttctctt tatcagcgag ccgtgcgcct
     2641 gcgagagtct ccgagctgca ggaagtacaa gcacctcttc agccggctgc ccgaggttgc
     2701 cgtgggagac gtcaagcatg tgaccatcac gggcaggctg tgcccacagc atggcatggg
     2761 caagtctgtg tttgtcatgg agagtggaga cggcgccaac cccaccacag tcctgtgttc
     2821 tgtggaggag ctggccctgg gttattacag gcagagtggc tttgaccaag ggattcatgg
     2881 agaagggtcc accttcagca ccctgtgtgg cctcctgctg tgggatatca tcttcatgga
     2941 tggaatacca gacgtcttca gaaatgccta ccaggcatcc ccactggatt tgctcacgga
     3001 cagcttcttc gcaagcaggg agcaggccct ggaagccagg ctgcagctga tccacagcgc
     3061 ccctgctgag agcctgcggg cctgggtggg cgaagcatgg caggcccagc aaggcagagt
     3121 ggcctctctg gtcagctggg accgcttcac ctccctacag caagctcagg atcttgtctc
     3181 ctgcctcggg ggtcctgtcc tcagtggtgt gtgcaggcgc ctggctgctg actttcggca
     3241 ctgccgaggg ggcctcccag acttggtggt gtggaattct cagagccacc attgcaagct
     3301 ggtggaggtg aaaggcccca gtgatcgact ttcatgtaag cagatgatct ggctgtacga
     3361 actccaaaag ctgggggctg atgtagaagt gtgccatgtg gttgcagttg gtgctaagag
     3421 caaaggtctt ggctgaaaga tgtcacacta gggacatctg gccatctact gggacaagat
     3481 cttcaagtgg ataaaagttg tcacactggg gacatctggc catccactgg gacaagatct
     3541 tcagatggat aaaagttgtc acactgggga catctggcca tccactggga caagatcttc
     3601 agatggataa aagttgtcac actggggaca tctggccatc cactgggaca agatcttcag
     3661 atggataaaa gttgtcacac tggggacatc tggccatcca ctgggacaag attgtcaaca
     3721 ggataaagct gtttgcatgg gctccacttg gacttgtcct gacacctgag attggaatga
     3781 ctcatccttg tacagtttct gtgtgtcgca aaacttggtc tctgctggag aacactggat
     3841 cccctgtggg tgggtgggtg ggctgttgaa aatatagacg tctgcgtgga tgccgtagga
     3901 gctgaaggct tccatgttgt taagctttta aaaaaaactg ccagagggaa aatgagcgtg
     3961 atgaatttag ttgacacttt aggttttaat acacaatgtc tctctactaa atgcactggc
     4021 aatggtgatc cctgaatttg gggttgtctt atggttatcc aagaagggaa gaacccgtag
     4081 gaattttgat ttccataggg ggaaagtaaa aacaaccaaa acaaattctt tcatttaaag
     4141 ggaggaagga tcacaatacg tatcaagctt caagcttttg gattatgtgt gattaaaaat
     4201 gtgtgccaag atattagaaa acagtacctt cctgaggtat cctaactttg ccagaagttg
     4261 gtctggaacc tcactcagct ctcacagttg actgtgagat ggtttacctc atcaaagaaa
     4321 actgaattag cccattcctg aaagtgaagt cgactctctg ctggccacgc ctcctcctgc
     4381 tcacctcgct gagcccagcc ccagcacgga cagtgagacc tgtgctctgc tgcccatttg
     4441 ccaaggagct gcttaccagg tcgactcatg tgttcatgaa ctgactggct actgtatgcc
     4501 aggtatagga gtttaaaagc caggaaggta atatatgatt tttgtctcct gtggtcacaa
     4561 agaagctttg ggggaggagg aatctatgaa aataaccaag tacaatacaa tacaatacaa
     4621 tacaatacaa tacatggtaa cagttactag aggaaggaaa aggggtgggg gactttattt
     4681 agaggataaa aatgtttgtg ctagtcaaag taaattatgt tgctgggaat ggtggctcac
     4741 acctgtaatc ccagcacttg ggaggctgag acaggaggat taccttgagt ttaaggtcag
     4801 accaggcta
//
