LOCUS       NM_181452               1229 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus family with sequence similarity 89, member B (Fam89b),
            transcript variant 1, mRNA.
ACCESSION   NM_181452
VERSION     NM_181452.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1229)
  AUTHORS   Cordero,A., Santamaria,P.G. and Gonzalez-Suarez,E.
  TITLE     Rank ectopic expression in the presence of Neu and MMTV oncogenes
            alters mammary epithelial cell populations and their tumorigenic
            potential
  JOURNAL   J Mammary Gland Biol Neoplasia 28 (1), 2 (2023)
   PUBMED   36808257
  REMARK    GeneRIF: Rank ectopic expression in the presence of Neu and MMTV
            oncogenes alters mammary epithelial cell populations and their
            tumorigenic potential.
            Erratum:[J Mammary Gland Biol Neoplasia. 2023 Mar 7;28(1):4. doi:
            10.1007/s10911-023-09532-2.. PMID: 36929445]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1229)
  AUTHORS   Lee,I.C.J., Leung,T. and Tan,I.
  TITLE     Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related
            Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in
            lamellipodial F-actin dynamics
  JOURNAL   J Biol Chem 289 (39), 26989-27003 (2014)
   PUBMED   25107909
REFERENCE   3  (bases 1 to 1229)
  AUTHORS   Sone,M., Hayashi,T., Tarui,H., Agata,K., Takeichi,M. and
            Nakagawa,S.
  TITLE     The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear
            domain in a subset of neurons
  JOURNAL   J Cell Sci 120 (Pt 15), 2498-2506 (2007)
   PUBMED   17623775
REFERENCE   4  (bases 1 to 1229)
  AUTHORS   Kokura,K., Kim,H., Shinagawa,T., Khan,M.M., Nomura,T. and Ishii,S.
  TITLE     The Ski-binding protein C184M negatively regulates tumor growth
            factor-beta signaling by sequestering the Smad proteins in the
            cytoplasm
  JOURNAL   J Biol Chem 278 (22), 20133-20139 (2003)
   PUBMED   12646588
REFERENCE   5  (bases 1 to 1229)
  AUTHORS   Fowles,L.F., Bennetts,J.S., Berkman,J.L., Williams,E., Koopman,P.,
            Teasdale,R.D. and Wicking,C.
  TITLE     Genomic screen for genes involved in mammalian craniofacial
            development
  JOURNAL   Genesis 35 (2), 73-87 (2003)
   PUBMED   12533789
REFERENCE   6  (bases 1 to 1229)
  AUTHORS   Stewart,A.F.
  TITLE     Identification of human homologues of the mouse mammary tumor virus
            receptor
  JOURNAL   Arch Virol 147 (3), 577-581 (2002)
   PUBMED   11958456
REFERENCE   7  (bases 1 to 1229)
  AUTHORS   Sakuma-Takagi,M., Tohyama,Y., Kasama-Yoshida,H., Sakagami,H.,
            Kondo,H. and Kurihara,T.
  TITLE     Novel related cDNAs (C184L, C184M, and C184S) from developing mouse
            brain encoding two apparently unrelated proteins
  JOURNAL   Biochem Biophys Res Commun 263 (3), 737-742 (1999)
   PUBMED   10512749
REFERENCE   8  (bases 1 to 1229)
  AUTHORS   Stankewich,M.C., Tse,W.T., Peters,L.L., Ch'ng,Y., John,K.M.,
            Stabach,P.R., Devarajan,P., Morrow,J.S. and Lux,S.E.
  TITLE     A widely expressed betaIII spectrin associated with Golgi and
            cytoplasmic vesicles
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14158-14163 (1998)
   PUBMED   9826670
REFERENCE   9  (bases 1 to 1229)
  AUTHORS   Golovkina,T.V., Dzuris,J., van den Hoogen,B., Jaffe,A.B.,
            Wright,P.C., Cofer,S.M. and Ross,S.R.
  TITLE     A novel membrane protein is a mouse mammary tumor virus receptor
  JOURNAL   J Virol 72 (4), 3066-3071 (1998)
   PUBMED   9525630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ132526.1, BM942073.1 and BC056166.1.
            
            On Aug 14, 2009 this sequence version replaced NM_181452.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF212920.1, SRR1660819.124092.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                CJ132526.1         1-74
            75-725              BM942073.1         1-651
            726-1229            BC056166.1         672-1175
FEATURES             Location/Qualifiers
     source          1..1229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..1229
                     /gene="Fam89b"
                     /gene_synonym="1110021A21Rik; MMTV; Mtvr2"
                     /note="family with sequence similarity 89, member B"
                     /db_xref="GeneID:17826"
                     /db_xref="MGI:MGI:106595"
     exon            1..430
                     /gene="Fam89b"
                     /gene_synonym="1110021A21Rik; MMTV; Mtvr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..709
                     /gene="Fam89b"
                     /gene_synonym="1110021A21Rik; MMTV; Mtvr2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mammary tumor virus receptor 2; C184M protein; MMTV
                     receptor; protein FAM89B; C184L ORF2 protein; leucine
                     repeat adapter protein 25"
                     /codon_start=1
                     /product="leucine repeat adapter protein 25 isoform 1"
                     /protein_id="NP_852117.2"
                     /db_xref="CCDS:CCDS37890.1"
                     /db_xref="GeneID:17826"
                     /db_xref="MGI:MGI:106595"
                     /translation="MNGLPATEAPGGAGCALAGLPPLPRGLSGLLNASGGSWRELERV
                     YSQRSRIHDELSRAARAPDGPRHAAGSANSGSAAGPRRPVNLDSALAALRKEMVGLRQ
                     LDMSLLCQLWGLYESIQDYKHLCQDLSLCQDLSSSLHSDSSYPPDAGLSDDEEPPDAS
                     LPPDPPPLTVPQTHNARDQWLQDAFQISL"
     exon            431..1212
                     /gene="Fam89b"
                     /gene_synonym="1110021A21Rik; MMTV; Mtvr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1191..1196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam89b"
                     /gene_synonym="1110021A21Rik; MMTV; Mtvr2"
                     /note="hexamer: AATAAA"
     polyA_site      1212
                     /gene="Fam89b"
                     /gene_synonym="1110021A21Rik; MMTV; Mtvr2"
                     /note="major polyA site"
ORIGIN      
        1 gacggaacaa agcacggcct gcgggcggtg gctgagatct ctccggagac cgggccacgg
       61 agagctggtt ctctgggcaa cagcccgctg aaaacgtaag aggggtccag gcggcatcgt
      121 ggtccacgcc tgcctggcta tgaacgggct gcccgcgact gaggcgccgg gcggcgcggg
      181 ctgcgctctg gccgggctcc cgccgctacc gcgcggcctc agcggccttc ttaacgctag
      241 tgggggctcg tggagggagc tggagcgtgt ctacagccaa cggagccgca tccacgacga
      301 actgagtcgt gccgcccgcg ccccggatgg tcctcgccat gccgctggat ctgctaactc
      361 aggttctgca gcgggcccgc gccgcccggt taacctcgac tctgcactag ccgcgctgcg
      421 caaggagatg gtggggctgc gacagctgga tatgtccctg ttgtgccagc tgtggggcct
      481 gtacgagtcg atccaggact acaagcatct gtgccaagac ctgagcttgt gccaggacct
      541 gtcatcctct ctgcactcgg acagctccta cccacctgat gccggcctgt ctgatgacga
      601 ggagcctcct gatgccagcc tgcccccaga ccctccaccc ctcaccgtac cccagactca
      661 caatgcccgt gaccagtggt tgcaggatgc tttccaaatc agcctttgaa agctgaggtg
      721 gataggaacg cacccataca aaaggctcaa aacttgccct tcagcaagtc cttagtctac
      781 agtgcctgct cttttaccgg taccacctca cctcacttca ggagggcaag gcattatacc
      841 catcaggcaa agcggtcaag attgcagcct gtgcccagtg tcctgggctt ccacttctcc
      901 cacatgtgtg caccctagct tggccagccc ttagtctgac tgtggggccc aaagcgtctt
      961 gcactcccgt ttgcatctct gggactggga tgagtgccta gctctcatct ctttttcgtc
     1021 ttttgctgcc tcttgcagct gctggctcag cggcatccct accagtggcc ccaggggttc
     1081 attgcctggg acaagggctc cagaacccac ctctgtagcc acccacgacc agaaaggcta
     1141 aggtctttat gctggatatt taagtttagc ggccagttcc tgggcgggaa aataaataat
     1201 ttcagcattg taaaaaaaaa aaaaaaaaa
//
