LOCUS       NP_848733                812 aa            linear   ROD 28-APR-2025
DEFINITION  protein FAM83G [Mus musculus].
ACCESSION   NP_848733
VERSION     NP_848733.2
DBSOURCE    REFSEQ: accession NM_178618.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 812)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 812)
  AUTHORS   Liu,C., Huang,X.Y. and Huang,Y.
  TITLE     FAM83G promotes proliferation, invasion, and metastasis by
            regulating PI3K/AKT signaling in hepatocellular carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 567, 63-71 (2021)
   PUBMED   34144502
  REMARK    GeneRIF: FAM83G promotes proliferation, invasion, and metastasis by
            regulating PI3K/AKT signaling in hepatocellular carcinoma cells.
REFERENCE   3  (residues 1 to 812)
  AUTHORS   Balmer,P., Fellay,A.K., Sayar,B.S., Hariton,W.V.J., Wiener,D.J.,
            Galichet,A., Muller,E.J. and Roosje,P.J.
  TITLE     FAM83G/Fam83g genetic variants affect canine and murine hair
            formation
  JOURNAL   Exp Dermatol 28 (4), 350-354 (2019)
   PUBMED   29963719
  REMARK    GeneRIF: In this study, we demonstrate that FAM83G/Fam83g is
            associated with hair morphogenesis, differentiation and cycling and
            provide first insights into functional consequences of
            FAM83G/Fam83g variants.
REFERENCE   4  (residues 1 to 812)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   5  (residues 1 to 812)
  AUTHORS   Radden,L.A. 2nd, Child,K.M., Adkins,E.B., Spacek,D.V.,
            Feliciano,A.M. and King,T.R.
  TITLE     The wooly mutation (wly) on mouse chromosome 11 is associated with
            a genetic defect in Fam83g
  JOURNAL   BMC Res Notes 6, 189 (2013)
   PUBMED   23656696
  REMARK    GeneRIF: suggest that this mutation in Fam83g is the likely basis
            of the mouse wooly phenotype
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY062936.1, BC085279.1, AK009716.1 and BX631674.1.
            
            On Nov 9, 2006 this sequence version replaced NP_848733.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085279.1, AK028566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     Protein         1..812
                     /product="protein FAM83G"
                     /calculated_mol_wt=89699
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:A6ND36; propagated from
                     UniProtKB/Swiss-Prot (Q5SWY7.1)"
     Site            4
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A6ND36; propagated from
                     UniProtKB/Swiss-Prot (Q5SWY7.1)"
     Region          20..307
                     /region_name="PLDc_SF"
                     /note="Catalytic domain of phospholipase D superfamily
                     proteins; cl15239"
                     /db_xref="CDD:472788"
     Region          76..119
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWY7.1)"
     Site            124
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A6ND36; propagated from
                     UniProtKB/Swiss-Prot (Q5SWY7.1)"
     Site            127
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A6ND36; propagated from
                     UniProtKB/Swiss-Prot (Q5SWY7.1)"
     Site            order(255,257,270,272,281)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:197283"
     Site            255
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:197283"
     Site            356
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A6ND36; propagated from
                     UniProtKB/Swiss-Prot (Q5SWY7.1)"
     Region          362..389
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWY7.1)"
     Region          455..509
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWY7.1)"
     Region          521..812
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWY7.1)"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A6ND36; propagated from
                     UniProtKB/Swiss-Prot (Q5SWY7.1)"
     Site            613
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A6ND36; propagated from
                     UniProtKB/Swiss-Prot (Q5SWY7.1)"
     Site            615
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A6ND36; propagated from
                     UniProtKB/Swiss-Prot (Q5SWY7.1)"
     Site            649
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A6ND36; propagated from
                     UniProtKB/Swiss-Prot (Q5SWY7.1)"
     CDS             1..812
                     /gene="Fam83g"
                     /gene_synonym="2310040C09Rik; wly"
                     /coded_by="NM_178618.3:125..2563"
                     /db_xref="CCDS:CCDS36175.1"
                     /db_xref="GeneID:69640"
                     /db_xref="MGI:MGI:1916890"
ORIGIN      
        1 mafsqvqcld dnhvnwrsse skpeffysee qrlalealva rgrdafyevl krenirdfls
       61 elelsrivea ievydpgsed prvsgrrpep qdnggadase etsaaggppa tetlpsleyw
      121 pqksdrsipq ldlgwpdtia yrgvtrasvy mqppidgqph ikevvrkmvs qaqkviavvm
      181 dmftdvdifk dlldagfkrk vavyiivdes nvkyflhmce rarmhlghlk nlrvrssggt
      241 efftrsatkf kgvlaqkfmf vdgdravcgs ysftwsaart drnvisvlsg qvvemfdrqf
      301 qelylmsqsv slkdipmeke pepepivlps vvplvptgtm akklvnpkya lvkaksvdei
      361 aksssdkqev trppglrgpa vaerpgdlse llppvhpgll nleranmfey lptwvepdpe
      421 pgsdilgyin iidpniwnpq pnqmnrikir dtahasaqhq lwkqsqgarp cpapcpppap
      481 rdsqgvvpae ngfpqgnpep qapvpkprtv pvasvlardg sdigwaldtp eketpqngid
      541 prlpstases evpqqqhssm tqddpdgler glpngldede dddddyvtls dqdslsgssg
      601 pgpghrrpsv assmsdeyfe vrersvplqr rhseqmangp ghpprrqlsa phvtrgtfgg
      661 plssplwaqg rsredvdasr iqgqrpmdrq aqgqhfhrhg sttsrtpgpp rfrpaadgtq
      721 ssskkaspaa agphhwqpkg sptprmlpdp gsprptrntr lraelratee haspfgipys
      781 klsqskhlka raggsqwaps dskrrardhk ep
//
