LOCUS       NM_176836               3663 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus family with sequence similarity 76, member B (Fam76b),
            transcript variant 1, mRNA.
ACCESSION   NM_176836 XM_973133 XM_973166 XM_973207
VERSION     NM_176836.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3663)
  AUTHORS   Wang,J., Zhao,X., Wang,Q., Zheng,X., Simayi,D., Zhao,J., Yang,P.,
            Mao,Q. and Xia,H.
  TITLE     FAM76B regulates PI3K/Akt/NF-kappaB-mediated M1 macrophage
            polarization by influencing the stability of PIK3CD mRNA
  JOURNAL   Cell Mol Life Sci 81 (1), 107 (2024)
   PUBMED   38421448
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3663)
  AUTHORS   Wang,D., Zheng,X., Chai,L., Zhao,J., Zhu,J., Li,Y., Yang,P., Mao,Q.
            and Xia,H.
  TITLE     FAM76B regulates NF-kappaB-mediated inflammatory pathway by
            influencing the translocation of hnRNPA2B1
  JOURNAL   Elife 12, e85659 (2023)
   PUBMED   37643469
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010488.9.
            
            On Feb 4, 2022 this sequence version replaced NM_176836.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043120.1, AK052430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               CT010488.9         109803-110120       c
            319-383             CT010488.9         109040-109104       c
            384-438             CT010488.9         108085-108139       c
            439-594             CT010488.9         106727-106882       c
            595-794             CT010488.9         104693-104892       c
            795-842             CT010488.9         101932-101979       c
            843-923             CT010488.9         101681-101761       c
            924-1059            CT010488.9         100892-101027       c
            1060-1161           CT010488.9         98123-98224         c
            1162-3663           CT010488.9         91334-93835         c
FEATURES             Location/Qualifiers
     source          1..3663
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 3.51 cM"
     gene            1..3663
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /note="family with sequence similarity 76, member B"
                     /db_xref="GeneID:72826"
                     /db_xref="MGI:MGI:1920076"
     exon            1..318
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1251
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM76B"
                     /codon_start=1
                     /product="protein FAM76B isoform 1"
                     /protein_id="NP_789806.1"
                     /db_xref="CCDS:CCDS22819.1"
                     /db_xref="GeneID:72826"
                     /db_xref="MGI:MGI:1920076"
                     /translation="MAASALYACTKCTQRYPFEELSQGQQLCKECRIAHPIVKCTYCR
                     SEFQQESKTNTICKKCAQNVKQFGTPKPCQYCNIIAAFIGTKCQRCTNSEKKYGAPQT
                     CEQCKQQCAFDRKEEGRRKVDGKLLCWLCTLSYKRVLQKTKEQRKSLGSSHSNSSSSS
                     LTEKDQHHSKHHHHHHHHHHRHSSGHHKVSSLSPEQEQGLWKQSHKSSAAIQNETPKK
                     KPKLESKPSNGDSSSINQSADSGGTDNFVLISQLKEEVMSLKRLLQQRDQTILEKDKK
                     LTELKADFQYQESNLRTKMNSMEKAHKETVEQLQAKNRELLKQVAALSKGKKFDKSGS
                     VLTSP"
     exon            319..383
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            384..438
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            439..594
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            595..794
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            795..842
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            843..923
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1059
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1161
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..3663
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2402..2407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2424
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /note="major polyA site"
     regulatory      3635..3640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3663
                     /gene="Fam76b"
                     /gene_synonym="2810485I05Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggaatccacc gcctagctcc cgcttcgtct ccctccgccg cggtccgggc ctaaacggga
       61 gcggcggggc gggcggcagt aggtgtcccg ggacggcggc ggaggcggag ggagacgcag
      121 gggacccggc agttaccggg actgggccac agcagcagaa gagcccgcgg gcggggcagc
      181 cgagttcccg gaggccccgc ctgagcgcgc gcggaggagc cggaaagcag gatggcggcg
      241 tcggccttgt acgcctgcac caagtgcacg cagcgctacc ccttcgagga gctctcgcag
      301 ggccaacagc tctgcaagga atgtcggatt gcacatccta ttgtaaaatg tacttactgc
      361 agatcagaat ttcagcagga gagtaaaact aacacaattt gtaagaagtg tgctcaaaat
      421 gtcaagcaat ttggaacacc taagccttgt cagtactgta acataattgc agcatttatt
      481 ggtaccaagt gtcagcgttg tacaaattca gaaaagaaat atggagcacc tcagacctgt
      541 gagcagtgca aacagcagtg tgcttttgat cgcaaggagg aaggaagaag gaaagttgat
      601 gggaagttgc tgtgctggct ctgcaccttg tcatacaaga gagttttaca gaagacaaaa
      661 gaacagagga agagtttggg gtcttcacat tctaactcct catcttcatc tcttactgag
      721 aaagaccagc accattctaa acaccaccac caccaccacc atcaccatca ccgccacagc
      781 agtggccacc acaaagtcag cagtctaagt cctgagcagg agcagggact gtggaaacag
      841 agccataaat cctctgcagc aattcagaat gaaactccaa agaaaaagcc caagttggaa
      901 tctaagccat ctaatggaga tagtagctct ataaatcagt cagcagatag tgggggaaca
      961 gacaattttg tccttatcag tcaactgaaa gaagaagtga tgtcacttaa acgtctctta
     1021 cagcaaagag accagactat tttggaaaaa gataaaaagt taactgaact gaaggcagac
     1081 tttcaatacc aagagtcaaa tttgaggact aagatgaaca gtatggaaaa agcgcacaaa
     1141 gaaactgtgg aacaactcca ggccaaaaac agagaactac tcaaacaggt tgcagccttg
     1201 tctaagggta aaaagtttga caagagtgga agcgtgctaa catctccctg aaaaagtcac
     1261 ttgtttagca tttctgccca acagtgtgta cttgaggtgt cctgtgacac ccttagattc
     1321 tgtgcagtgg aaagatattt ttacatgcca aattaattgg tatgtctcct attcactttt
     1381 gtaacttaca cacagcattt tttaagttgt aaacatgcag ataaaacttc agctggcttg
     1441 gagtgacttc ttaattcttt gataccggaa cttttttcta gcaatagtat tgatggtgtg
     1501 gagtgcacag gtgcactgtg taaaatgcaa catgcaataa tggagtggct ggcagagcag
     1561 cagcaggggt ggggctttgc gtttgtttaa cactatgctg ttttcaaata aatagttttc
     1621 catttagaaa tgcaaaactt ttaaacaagg aaaatgatgg tgaacactgt ttttttggga
     1681 attgtatttt tacttcacat caacatgaat ttagagaatc atggtgcttt tattaaaaga
     1741 gcttcagagt atatgtaaat acgtttttaa aagtcacgtc gctgatatca gttaggtaac
     1801 ctaacatttc actactgctc taggattgat gtgcactgta cagcatccga ggtaaaacgt
     1861 ggttttgttt tgtaaaaact gtagattttt acttacaagt gcctttttgc cacctaatgt
     1921 ttttatttat aggaatgctg atcttttgta catatggttt gttttaaaat catgttaata
     1981 agtttgtata taagtgcata tgtatataac cggatttcaa aaagaaatca aagttattag
     2041 taacatgcaa gattgcatat taagaattaa ctgataaatg catatagact ttaggtgatt
     2101 ttgtggtttg ctgctgtatc ataagggaag ctgttggtca ttgagttcat ttaattatgt
     2161 tggaatactt tcctaaagat ttaattttaa ctccattttg atagagtgat tttattttta
     2221 tgttgtgtgg cttcgtgttt atattttgtg agttacatgt tttgctttat ttttatataa
     2281 aatttcttta aaatttataa cgtttctata acagcccata tatctgcttt tttataatgt
     2341 gttctaagtt aatatttatg tacaccatac ttactttgta aatttaatac aaatctggaa
     2401 aattaaataa cttttataat caaatccgtg cttatgtctg aataattgaa atctgtaaga
     2461 ttcagacact atttataagt aatttgcctc aaaagaataa aattgtctat aaaaggttaa
     2521 catagtgtgg gatagattct gagaaattac agatcagctt ctgatgttag ttctggcttc
     2581 aaggtgaatt ctaaaccttc aggcactgct ggccacacca tatgacttct ttctcttagg
     2641 aatgtgcagt tacacttgtt ttcatcagtc ctgaaaggtt tatttttaga gaattgttta
     2701 tatggtcttc atatcaaaga ttagtgttaa gaatacatat aacaattcat tttaaattac
     2761 tcaggtttta gtaaacttcc cacagtagtt tgctacaagt gaaaggaaat ctacaagttc
     2821 agaaagacct cattttcaag tgacagtaag attgaattag tcagctttgg taagagtcag
     2881 ctgtgtgctg tcctggggcc tcagaagcac actcgctcgc tcactgtttt ccactttggt
     2941 agacaatgcc ttactgtggg gattcctgtc tgcaggatct gctgcattca taaagtcctt
     3001 attacattgc tttacgtttt gtttgattac agtttcttgg ccagttttca atccacagta
     3061 gtcataattc taaatgaact acagtagttc tgataccttg ctggagaaga tagaaacaga
     3121 atccctcctc ccctttttag ctaacatgga aattggaaat cagtttaaaa tagtgaagct
     3181 ttgtaaagtg caaggctaaa actaaaattt aggactttac agtattcagc cctaatcaga
     3241 catactcttt attccataac tttattttat aacttaaatt ttttttgcaa ttgtataaat
     3301 tagtgattga gtctcagtcc cagatctgta gtgtattgat ctaatgaatt gatactcttt
     3361 aaacgtggac ctgtccagag gtactatggt gtgctgtatt gtgcttttag cctgtttgct
     3421 gcagttagca tatcccagtg agggtcatat agactccagt ttatcatgta ttaatagcct
     3481 gtgaatatta cagtcatttt tagagtatat tggtctaaat atgcattttc cgatgagcct
     3541 gttaagctgg tcacatgtat agattaacaa aatactgtac ctgtatacat ctgactgttg
     3601 gcattttgta cttttttcta agccaatatt tcacaataaa atatgccgaa agctttgtgt
     3661 tga
//
