LOCUS       NM_001357456            4524 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus family with sequence similarity 53, member C (Fam53c),
            transcript variant 2, mRNA.
ACCESSION   NM_001357456 XM_006526151
VERSION     NM_001357456.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4524)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ153142.1, AK044469.1 and BC057111.1.
            
            On Oct 27, 2017 this sequence version replaced XM_006526151.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154214.1, AK044469.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               CJ153142.1         1-258
            259-4485            AK044469.1         31-4257
            4486-4524           BC057111.1         4454-4492
FEATURES             Location/Qualifiers
     source          1..4524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18"
     gene            1..4524
                     /gene="Fam53c"
                     /gene_synonym="2810012G03Rik; Gm21179"
                     /note="family with sequence similarity 53, member C"
                     /db_xref="GeneID:66306"
                     /db_xref="MGI:MGI:1913556"
     exon            1..271
                     /gene="Fam53c"
                     /gene_synonym="2810012G03Rik; Gm21179"
                     /inference="alignment:Splign:2.1.0"
     exon            272..501
                     /gene="Fam53c"
                     /gene_synonym="2810012G03Rik; Gm21179"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..1605
                     /gene="Fam53c"
                     /gene_synonym="2810012G03Rik; Gm21179"
                     /note="isoform 1 is encoded by transcript variant 2;
                     protein FAM53C"
                     /codon_start=1
                     /product="protein FAM53C isoform 1"
                     /protein_id="NP_001344385.1"
                     /db_xref="CCDS:CCDS29134.1"
                     /db_xref="GeneID:66306"
                     /db_xref="MGI:MGI:1913556"
                     /translation="MITLITEQLQKQTLDELKCTRFSVSLPLPDHADIPNCGDPFQLV
                     SEGASWRGLPHCSCAEFQDSLNFSYHPSGLSLHLRPPSRGNSPKEPPLSQVLSPEPPD
                     PEKLPVPPAPPSKRHCRSLSVPVDLSRWQPVWRPAPSKLWTPIKHRGNAGGGGPQVPQ
                     QSPPKRVSSLRFLQAPSASSQCAPAHRPYSPPFFSLALAQDSAQPCATSPQSGSWESD
                     AESLSPCPPQRRFSLSPSLGPQASRFLPSARSSPASSPELPWRPRGLRNLPRSRSQPC
                     DLDARKTGVKRRHEEDCRRLRPSLDFDKMNQKPYSGGLCLQETAREEGSNVSPPWFMA
                     CSPPPLSASCSPVEGSSQVLSESEEEEEGSVRWERQALSKRTLCQQDFGDLDLNLIEE
                     N"
     exon            502..559
                     /gene="Fam53c"
                     /gene_synonym="2810012G03Rik; Gm21179"
                     /inference="alignment:Splign:2.1.0"
     exon            560..1344
                     /gene="Fam53c"
                     /gene_synonym="2810012G03Rik; Gm21179"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..4507
                     /gene="Fam53c"
                     /gene_synonym="2810012G03Rik; Gm21179"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4486..4491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam53c"
                     /gene_synonym="2810012G03Rik; Gm21179"
                     /note="hexamer: AATAAT"
     polyA_site      4507
                     /gene="Fam53c"
                     /gene_synonym="2810012G03Rik; Gm21179"
                     /note="major polyA site"
ORIGIN      
        1 ggggtgatta gttagtgagg agacactccg gtccccaaac cacagctcta ggctcctttc
       61 cgacggcgct attctgaaaa agattaaggg agacaccacg tagggcttgg gcctcttcgg
      121 caggttccgg gggattctgt gaatagacgc gatcccccat actctcctca aagaccggtt
      181 ggttcttgcc agcgcctttt aagggcaccg tggggcgaac ggagcgctca gagctgctcc
      241 ggccgcggcc catggagctg taggagccgc ggcacagcag gcatgactgg agagggaggt
      301 cccaatggtg ctagaacggt gctgcagtgg cagaaggagg ctcatgagtg agatccagga
      361 gaacgacaag gaagacatcc accaatcgct ccaaagtgtg caagccaagt cctgggcaga
      421 aacatgatca ccctgatcac ggagcagctc cagaagcaga ccctggatga gctgaaatgc
      481 acgcgcttca gcgtcagtct gcctttgcct gatcatgcag acatacccaa ctgtggggac
      541 cctttccagc ttgtgtctga aggtgcttcc tggaggggcc tgccccactg ttcctgtgct
      601 gagttccagg acagcctcaa cttcagctac catccctcag gcctaagcct gcacctcaga
      661 ccacccagtc ggggaaactc ccccaaggag ccgcccctct cccaagtact gagccccgaa
      721 cccccagacc cagagaagct tcctgtgccc cctgcccctc catccaagag gcactgccgc
      781 tcactctcgg tgcctgtgga cctgtctcgc tggcagccgg tgtggcggcc tgccccctcc
      841 aagctgtgga ctcccatcaa gcaccggggc aatgctggag ggggtgggcc gcaggtgcct
      901 cagcagagcc ctccgaagcg ggtctccagc ctcaggttcc tccaagctcc cagtgcctcg
      961 tctcagtgtg ccccagccca cagaccctac agccctcctt tcttcagcct ggccctggcc
     1021 caagattccg ctcagccctg cgccacctcc cctcagagtg gctcctggga gagtgatgca
     1081 gagtccctgt cgccctgccc accccagcgc cgcttctccc tgtcacccag cctgggccca
     1141 caggcgagcc gcttcctgcc ctctgcccgg agctctcccg cgtcttcccc agagctgccc
     1201 tggagacccc gaggtctccg aaaccttccc cgaagccgct cacagccttg tgatctggat
     1261 gcccgcaaaa ctggtgtcaa gcggcgtcat gaggaagact gcaggcgcct tcggccttcc
     1321 ttggactttg acaagatgaa tcagaaacca tactcaggag gtctctgtct ccaagaaaca
     1381 gcccgagaag aaggcagcaa cgtctctcca ccatggttca tggcctgtag tcccccacct
     1441 ctctctgctt cctgcagtcc cgtcgagggt tcatcccagg tgctgagtga aagcgaagag
     1501 gaggaagagg ggtctgtgcg gtgggaacgg caggcactga gcaagcggac attgtgccag
     1561 caggactttg gggacctgga cctgaatctg attgaagaaa actaaaagtg agaggctgct
     1621 tcctgggccc atgcagactg tgtaatggtt actaacacgt gtgagggccc caaggctgag
     1681 ggcccagcct gggaaagggg gtgaatggag ggctcctact cagggcagcc caagtcttcc
     1741 tgctccagca aactcgacca tgccaagaga ctggcgggga caagataaat ggagctggtg
     1801 acgggaggga cagccccaga gcagaccctc cccatggcgg ccctgagtgt gagtatccct
     1861 gccactaaga gcaatgggca gggaaggaag gggtctgcga ccccagctcg gggaatttca
     1921 ctagcccctt tgcttcaaag ggcacttgtg tcttagaatt tggccagggt gggggggttc
     1981 agtcagcctc ctcggagaaa ttgtgtgagt gtgcgtgcgt gcacgggtgt gtacttgtgt
     2041 gagtgtgtgt gcgtgcatgg gtgtgtactt gtgtgagtgt gtgtgcgtgc gcgcatgggt
     2101 gtgtacttgt gtgagtgtgt gtgtgtgtgt gcatgggtgt gtacttgtgt gagtgtgcgt
     2161 gtgtgcacgg gtgtgtactt gaggaaaggt gcgtgcgttt gtatagcctt agggaaggaa
     2221 ggcagttgct cctttaacag cagagcgtca ggataccccc aggatcttgt gggttttttt
     2281 gtttgtttgt ttccttaata taacattggg cttgttcaag gtgtcaagag gagagagttt
     2341 ttgtttttgt ttttgttttt tttttcggtc ttaatagctc tggagccagg cttttaagtt
     2401 catcgcatca ctgctctgta aatggttctg ttttggggtc tagcagaatc ttttgagtac
     2461 tatgatttca gctaatgggc ttttctgaag tcccgccctc tcccactaga tgaatctagt
     2521 attgaggctt gaggcagtcc ccacacttgt tgttttcatt gtctaagctg tctgcagccc
     2581 gcttctctcg cttgctgaga agctgcaagc agatggacaa ctgaggcaga gctaaggagc
     2641 ttgggcgctc tcctcttccc caaggggacc tttccttttc tgatcttaca agtcagagac
     2701 agggttgctc tccaagaatg tgttgaggca gaccaggagc agtgacatta ttccctggaa
     2761 gtccttgagg ccaccctcag cactgccttt tggaagctgg ctgtagggaa acttactctt
     2821 gcaatatcta ggcccggtct ctctctgatc tgcttgaaaa agaggtaggg tgttcagcat
     2881 ttaatagttt gcttgtcttc cacacttgcc aggaaatgtt tatttgcttc taattggccc
     2941 tgagagacca cagagaggct ggggctcacc gagggattga cttggggtgt gtaaagcaaa
     3001 ggctatgaga agcagctggg agtttgttgt tgttggattg aatttctttt tttgtttctc
     3061 acccacaact tcagccagtg cagcagatcc agtggttgga gggatggact tgaagattgc
     3121 agttaccttg gtagggttgg cacctgtggg catgcatata gaagctgtca ctatgcatcc
     3181 tgtgaggctt tgtttagaac accctgtata gcgaaattgg acctgccctt cccagttgtt
     3241 atagtaaggg cacttttctg ttcaatttcc atggtgtctt aaggcccagt tcctagtgtt
     3301 acagaagaca actaaggtca tgtactttct tccttgtgga attgagcctg atgtttaatg
     3361 tctcccacat gctaatagga atactataga ggcgtcagac tctttgcctc cacttcaggg
     3421 gaggtggcca tgtcttctta aacctgtggc cctcagaggt tctaccttct caaggctcct
     3481 ccctgtctcc tggctagtta ccacatctta ccactgggct accggtctct aagggcctac
     3541 gagagactct cctgagaatt cagggaaact gagcccagga gttatcgtag gtttcatctt
     3601 tccctggttc tccctctttg gtccataatt tccctggtgc cagcttcttt tccacctggg
     3661 gcaacctcat ccctgggctc tctgctgcag atggcagtgt cagcctccag taggtcactg
     3721 gcagtgccaa tggggtctct gcgggcccca agtttaagtg aaggcagtga ttctgcctcc
     3781 aacctggctt tcccaaagcc cttaggtcac cgcccttagg gaaggaggcc tacaattgtc
     3841 atattttaat tccattactt taagtctgga atgttaaact aggcagaact atcatcttgc
     3901 ttcccagttt aaatgcctct ggccctggaa caagcctttt caagacgtga atcgttggtt
     3961 ttacacagta gctctgctcc aacggttctg tgtaaaccaa acgctgtttt ttaatgcatt
     4021 tggactgctg accatgtaaa ggcagcctat gtttgcttct tttgtaaagc aagcaacttc
     4081 cctctacttt agccagtttc atcatttggg ttctcacaca gtgggcttac ccagagtgga
     4141 gcacacctcc ggggcttgtg gctgctgctg tgtagacgcc tgcatctgtg ctgcgtgtgt
     4201 ggtgcgtgtg gctggccagc aggtgagtct tactgcgtgc gtgagtgaag ccactcccag
     4261 gctgatgctc tcctcctgtg cccggtgact gcccagtggc agctctagct gcccttcatt
     4321 cccacctgct gccaaagtcc ctgtgctaat gggattacag aaacaaaaag tggaaaaaaa
     4381 tttttcgtaa actttgtttt atattaaaaa atccataagt ctgtgtgtgt taaaacatga
     4441 ggttctgcct ctgtggctgt gtttgaaaaa ataaagtttt attagaataa tccattttcc
     4501 caagcaaaaa aaaaaaaaaa aaaa
//
