LOCUS       NM_212473               5211 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus family with sequence similarity 53, member B (Fam53b),
            transcript variant 1, mRNA.
ACCESSION   NM_212473
VERSION     NM_212473.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5211)
  AUTHORS   Ohkawara,B., Kurokawa,M., Kanai,A., Imamura,K., Chen,G., Zhang,R.,
            Masuda,A., Higashi,K., Mori,H., Suzuki,Y., Kurokawa,K. and Ohno,K.
  TITLE     Transcriptome profile of subsynaptic myonuclei at the neuromuscular
            junction in embryogenesis
  JOURNAL   J Neurochem 168 (4), 342-354 (2024)
   PUBMED   37994470
REFERENCE   2  (bases 1 to 5211)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5211)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5211)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 5211)
  AUTHORS   Kizil,C., Kuchler,B., Yan,J.J., Ozhan,G., Moro,E., Argenton,F.,
            Brand,M., Weidinger,G. and Antos,C.L.
  TITLE     Simplet/Fam53b is required for Wnt signal transduction by
            regulating beta-catenin nuclear localization
  JOURNAL   Development 141 (18), 3529-3539 (2014)
   PUBMED   25183871
  REMARK    GeneRIF: Simplet/Fam53b is required for Wnt signal transduction by
            regulating beta-catenin nuclear localization.
REFERENCE   6  (bases 1 to 5211)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 5211)
  AUTHORS   Somma,G., Alger,H.M., McGuire,R.M., Kretlow,J.D., Ruiz,F.R.,
            Yatsenko,S.A., Stankiewicz,P., Harrison,W., Funk,E.,
            Bergamaschi,A., Oghalai,J.S., Mikos,A.G., Overbeek,P.A. and
            Pereira,F.A.
  TITLE     Head bobber: an insertional mutation causes inner ear defects,
            hyperactive circling, and deafness
  JOURNAL   J Assoc Res Otolaryngol 13 (3), 335-349 (2012)
   PUBMED   22383091
REFERENCE   8  (bases 1 to 5211)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 5211)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051299.1 and BC035523.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147350.1, SRR1660813.240740.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2668              AK051299.1         2-2669
            2669-5211           BC035523.1         2601-5143
FEATURES             Location/Qualifiers
     source          1..5211
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 76.31 cM"
     gene            1..5211
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /note="family with sequence similarity 53, member B"
                     /db_xref="GeneID:77938"
                     /db_xref="MGI:MGI:1925188"
     exon            1..131
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /inference="alignment:Splign:2.1.0"
     exon            132..381
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..1572
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /note="isoform a is encoded by transcript variant 1;
                     protein FAM53B"
                     /codon_start=1
                     /product="protein FAM53B isoform a"
                     /protein_id="NP_997638.1"
                     /db_xref="CCDS:CCDS21926.1"
                     /db_xref="GeneID:77938"
                     /db_xref="MGI:MGI:1925188"
                     /translation="MVMILRRSLINQGADSGAHRTFIPELHTPKMSQGPTLLSCGIME
                     NDRWRDLDRKCPLQIDQPSASIWECLPEKCQDGSLWHQEAVTACAVTSLIKDLNINDH
                     NGNPSAPPSKRQCRSLSFSDEMSSCRTSWRPLGSKVWTPVEKRRCYSGGSVQRYSNGV
                     SPMQRSSSFSLPARANGLSSPCHQSSLHHRFGGQPCQGAPGSAPCGQAGDSWSPDPHP
                     VGGGRLDLQRSLSCSHEQFSFPEYCPPSANSTPASTPELARRSSGLARSRSQPCVLND
                     KKIGVKRRRPDEVQEQRPSLDLAKMAQNCQTFSSLSCLNMGVDDHSSQSPFALVSSTR
                     SWTALLSASSPGGRTPAGTPVPEPVPHSFDDQFTCQEDLSCDESDGCSLDEDCCRKGD
                     PATSWRDRGACTNSLCSLDGELDIEQIENN"
     exon            382..433
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /inference="alignment:Splign:2.1.0"
     exon            434..1212
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..5131
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5110..5115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /note="hexamer: AATAAA"
     polyA_site      5131
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /note="major polyA site"
ORIGIN      
        1 gagccccgaa gttccgcatc gtttgcagac aactcttttg ttcacggaag tttacacccg
       61 ccacccctgg gatgcgggcg cgcagggacg actccaaggc tacacgactg acccgcgcgg
      121 tgtcgatggg ggccgttgac tacttttggc cattcccaga ggccagtctg agcaactgat
      181 ggggagctgt ttctagtgac ctcactctcc ggaatgccca ggtatcactg ttaatcaagt
      241 cttccccgct gaagatggcc tgtgcccagc ctgggatgca gcccagttcc tgaggtcctt
      301 accatggtga tgatcctaag gagaagcctc atcaaccagg gagctgactc tggagcacac
      361 aggaccttca tccctgaact gcacacgcca aagatgagtc aaggacctac cctcctttcc
      421 tgtggaatta tggaaaatga cagatggcga gacctggata gaaaatgccc tcttcagatt
      481 gaccagccaa gcgccagcat ctgggaatgt ctgcctgaaa agtgtcagga tggctccctg
      541 tggcaccagg aggcagtgac tgcctgtgcg gtgaccagcc taatcaaaga cctcaacata
      601 aatgaccaca atgggaaccc ctcagctcct cccagcaaac gccagtgccg gtcactatcc
      661 ttctctgatg agatgtccag ttgccggacg tcatggcggc ccttggggtc caaagtctgg
      721 actcccgtgg agaagagacg atgctacagc ggaggcagcg tccagcgcta ctccaatggc
      781 gtcagcccca tgcagcggag ctctagcttc agcctccctg ccagggccaa tgggctctct
      841 tcaccttgcc accagtcgag cctgcaccac cgctttgggg ggcaaccctg ccaaggagca
      901 ccaggctcag ccccctgtgg acaggcgggt gatagctgga gcccagaccc acacccagtg
      961 ggagggggcc ggctggacct gcagcggtcc ctctcttgct cgcatgagca gttttccttc
     1021 ccagaatact gtcccccctc agccaacagc acacctgcct caacgccaga gctggcaaga
     1081 cgctccagtg ggcttgcccg cagccgctct cagccctgtg tccttaatga caagaagatc
     1141 ggtgtgaaac ggcggcgtcc ggatgaagtg caggagcaaa gaccttctct agaccttgcc
     1201 aagatggcac agaactgtca gaccttcagc agcctcagtt gcctgaacat gggggtggac
     1261 gaccacagct cccagagccc ctttgccctc gtcagcagta cccgatcctg gaccgcattg
     1321 ctctcagcct ccagcccagg gggcaggact cctgctggga ccccagttcc tgagcctgtt
     1381 ccccactcct ttgatgacca gttcacctgc caggaggacc tatcctgtga cgagtcagat
     1441 ggctgcagtc tagatgagga ttgctgcagg aagggggatc cggccacatc ctggcgggac
     1501 cggggagcct gcacgaacag cctctgctct ttggatggcg agctggacat tgagcagata
     1561 gagaacaact gagggccctg acctggggag gaggcactcc tctaggcctt aggtcactct
     1621 aagggggacc tggctcctgg gtctgacaga ggctcctcca aaaaatggag cccacccatt
     1681 ttcaaaggaa ccagccatca ccctgtagtg cccaaatttg tgaaggcaac ttggccacac
     1741 ctcacaggcg acagctggcc tcccaccagt tccatggaac tactgtagcc caaaacaggt
     1801 tttcggtttg gtatcctcct ctttgttcct tacggagtgc tgggtagcca ccattttcca
     1861 gtagggctgg gccagctgca cccttcaggt aggatgccgg gggcctgagc ccccttatag
     1921 ccttgctcag gttccttctg gggagttacc caaagcctcc tttacttagt ttactccgtg
     1981 ccttctctcc caggtctccc tggcccaggc ttgggaaggt tcgggagaca cctcttgtag
     2041 tgacagcaga ccgtgtggcc ttaatccatt tggggcactg gcagggattc tgggataatc
     2101 catgtcccat ttttcgggat caggggatag ttaggaatga ccagaagcca tccatattgg
     2161 gtaggcattt ggtggttgtg ttgactgaaa ggtgggccca ccagctctcc catgtcacca
     2221 agaatcaccc acacctctgc cacctcaggg gctgccttgg caaggctgac attggtagcc
     2281 ttccttctgt ccccagtccc tgagagctga gctcagtgaa ttcagctgtg tatagagatg
     2341 tcagtggcaa gatgacctct tcatagtgtc ctcaggatct acaaacaggt gcagaagtct
     2401 cggccctgtg tacattcctg ggtagaggga tgtctgctgg ctgctttgca ggctagccac
     2461 tctgcaggct cctctctgta gcagtctatg ttgggggcct gcaagcctcc accacattcc
     2521 tagcacattg ttgcttgttc acagacactg ctggctttaa tgaaagcata ccaccgttgg
     2581 cttcaagaca ccccccaccc ccagtccact gatgtgagcc tagccccagg ctctcctctg
     2641 caggcccagc cacagcatgg cttgaatcac actccccctt gcagctcctc actcccagca
     2701 taattcccag agggcatccg ttccggcagc tcccctcagt cctccctgca gacatgctac
     2761 agggctctgc acgctgggac tctggctttt agcaaacttg gcatcttctg cagacaatag
     2821 caagtgggct ggcttacaca agtggcttgt tttcccataa ggctaaaaat aactggtgca
     2881 ttctcttggg tttgcggaca tgtgatctag gcacatttgt agttgctctg ctgtgcctac
     2941 cctctgagat ttcactgtct gctggctgag cccaaatggc tgttaccttt ctcctaaaga
     3001 aagaccttga tgggaacctt ttgtttcaac tttaatttgt ccatacacca gaagaaccga
     3061 ggctcaagtt ctgatgtata aggcaatgtt tctctaaaac cagacccaaa gtacaggaag
     3121 ccccgctcct ataaccccag gttgggtagc ctggtgggtc cctgtggtgg tggtcggggc
     3181 ccagctggcc ttgggggcac tgagaaagca aagtagaaag ctggtggagg catgacctac
     3241 aagccctgcc tggtggatca cagaggaagg tagttgagag ggcgtgggat gcacacccca
     3301 gtgccctggt tcccagaaag cccacagtga gggattctgt tatctgaaag aactttatgg
     3361 tccctaaagc tattcccact cccccacccc ccaggaaagg agaggctggg ctctgtcccc
     3421 tggtctgctt cacacaggct gttaaggcca aagcacagaa cagttgccag ctgcctctcc
     3481 tgaggactgg gacctgagct cctggtggca ggtgtgtgtc ttaaggctga tgtgtggccg
     3541 gcttgtccgt agactagctc tcttgagcct gctggcggaa ggacaaacag gaacttgctg
     3601 agtgacagct tcatctttgc ttcctgcctc taggagactg ttccctgggc ggcagtactc
     3661 caaacccggg gtgggggttg gccctttgca gtttcctcag gcttttcttg atgtccctgt
     3721 cccactaagg cctcagtcca agcacccagc aaaagcagcc agaaaagatg gtggtagctt
     3781 ttctgcctag tgtgttcatt tgctttctga tgttcttttc atcaagtaaa gcaggttttg
     3841 tctagaaggt ttccagtcag ctttcagcag ttgtgtgacc cagacagacc cattcatcca
     3901 ccccattcac tggcccccag acctctggtc ttggatctcc tggaagaagg ttcacctggg
     3961 aggtccactc tgtctcctgt gtgcgtggca gcacaggcag caggcagact ggctcacccg
     4021 agtgccacac cccagagaag ctgagggtgg gcttcaccac tcacctgcct aggcagcctc
     4081 caccaaagcc gactgggcct cttagcacgt gacatcccgt tcactccaga agccactgaa
     4141 ccgacagagt tgccctaagc cgggtacctg acctgagttc agggtagcag cctagacagt
     4201 ttacatgact gcccactcct gccttactcc tgggtggtga aggtagaagc tggccagcac
     4261 cacgggctcc cttcatgtag gtccatggaa cttgttctgc ccacacatgc agatgtgtat
     4321 tctcagaaag ccttacttta aaaaaaaaat ttttttttgt agcaggaaag ttttctaaat
     4381 ttgtatgcag aaagttaaat aaaatgaagg cccacattaa acaggacatg ctcactcccc
     4441 cagtttctag atgggtctcc tatgcagacc aatggccata ttttattatg ggttcattta
     4501 gtgttcacag cagttagaac tcacccctgg atcctgcaac ccatttccac tgatgtggtt
     4561 aaaattactt gaatgatggc cacttaaaac gtaagccagg ggccagggct cagggacgct
     4621 ccgcccatac aacccatgat gctgcccctt gccatgccca tgctgctggt cccacccctg
     4681 cccctggtgc caggcctctg aaggaggcag agaaagatac tctagaattg cagactgatg
     4741 gagctccttt aggctagata ggatagcctg acgtagcata gtctcattgg caaatgaact
     4801 gcatcgtcag tgtttggggg cacccagggg tcagggacag atgagcccac aggccgtgct
     4861 agggccacgt gtgccgtccc agccaggcag cagcagcagc agcagcagca gcagcggtac
     4921 tgtttgaggc agtgtggtga atggcgtggt gagccagaac ccatcagggc tgcagcctgt
     4981 aggctgccca tgctgggtct gctcgttagc accacgcacc atcgcctgcc tccccccctg
     5041 acaggccgtg actgtcttgc actacagcca ctctagtctc aggaatttgc ttgttccttt
     5101 tactgtgtaa ataaagcttc ctggtccaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     5161 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
