LOCUS       NM_001381858            5268 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus family with sequence similarity 53, member B (Fam53b),
            transcript variant 4, mRNA.
ACCESSION   NM_001381858 XM_030243107
VERSION     NM_001381858.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5268)
  AUTHORS   Ohkawara,B., Kurokawa,M., Kanai,A., Imamura,K., Chen,G., Zhang,R.,
            Masuda,A., Higashi,K., Mori,H., Suzuki,Y., Kurokawa,K. and Ohno,K.
  TITLE     Transcriptome profile of subsynaptic myonuclei at the neuromuscular
            junction in embryogenesis
  JOURNAL   J Neurochem 168 (4), 342-354 (2024)
   PUBMED   37994470
REFERENCE   2  (bases 1 to 5268)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5268)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5268)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 5268)
  AUTHORS   Kizil,C., Kuchler,B., Yan,J.J., Ozhan,G., Moro,E., Argenton,F.,
            Brand,M., Weidinger,G. and Antos,C.L.
  TITLE     Simplet/Fam53b is required for Wnt signal transduction by
            regulating beta-catenin nuclear localization
  JOURNAL   Development 141 (18), 3529-3539 (2014)
   PUBMED   25183871
  REMARK    GeneRIF: Simplet/Fam53b is required for Wnt signal transduction by
            regulating beta-catenin nuclear localization.
REFERENCE   6  (bases 1 to 5268)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 5268)
  AUTHORS   Somma,G., Alger,H.M., McGuire,R.M., Kretlow,J.D., Ruiz,F.R.,
            Yatsenko,S.A., Stankiewicz,P., Harrison,W., Funk,E.,
            Bergamaschi,A., Oghalai,J.S., Mikos,A.G., Overbeek,P.A. and
            Pereira,F.A.
  TITLE     Head bobber: an insertional mutation causes inner ear defects,
            hyperactive circling, and deafness
  JOURNAL   J Assoc Res Otolaryngol 13 (3), 335-349 (2012)
   PUBMED   22383091
REFERENCE   8  (bases 1 to 5268)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 5268)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099627.10.
            
            On Apr 16, 2020 this sequence version replaced XM_030243107.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927934.4953292.1,
                                           SRR10223971.8228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               AC099627.10        167683-167950       c
            269-518             AC099627.10        133238-133487       c
            519-570             AC099627.10        125680-125731       c
            571-1349            AC099627.10        113491-114269       c
            1350-5268           AC099627.10        66186-70104         c
FEATURES             Location/Qualifiers
     source          1..5268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 76.31 cM"
     gene            1..5268
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /note="family with sequence similarity 53, member B"
                     /db_xref="GeneID:77938"
                     /db_xref="MGI:MGI:1925188"
     exon            1..268
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /inference="alignment:Splign:2.1.0"
     exon            269..518
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..1709
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /note="isoform a is encoded by transcript variant 4;
                     protein FAM53B"
                     /codon_start=1
                     /product="protein FAM53B isoform a"
                     /protein_id="NP_001368787.1"
                     /db_xref="GeneID:77938"
                     /db_xref="MGI:MGI:1925188"
                     /translation="MVMILRRSLINQGADSGAHRTFIPELHTPKMSQGPTLLSCGIME
                     NDRWRDLDRKCPLQIDQPSASIWECLPEKCQDGSLWHQEAVTACAVTSLIKDLNINDH
                     NGNPSAPPSKRQCRSLSFSDEMSSCRTSWRPLGSKVWTPVEKRRCYSGGSVQRYSNGV
                     SPMQRSSSFSLPARANGLSSPCHQSSLHHRFGGQPCQGAPGSAPCGQAGDSWSPDPHP
                     VGGGRLDLQRSLSCSHEQFSFPEYCPPSANSTPASTPELARRSSGLARSRSQPCVLND
                     KKIGVKRRRPDEVQEQRPSLDLAKMAQNCQTFSSLSCLNMGVDDHSSQSPFALVSSTR
                     SWTALLSASSPGGRTPAGTPVPEPVPHSFDDQFTCQEDLSCDESDGCSLDEDCCRKGD
                     PATSWRDRGACTNSLCSLDGELDIEQIENN"
     exon            519..570
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /inference="alignment:Splign:2.1.0"
     exon            571..1349
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..5268
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5247..5252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /note="hexamer: AATAAA"
     polyA_site      5268
                     /gene="Fam53b"
                     /gene_synonym="A930008G19Rik; mKIAA0140"
                     /note="major polyA site"
ORIGIN      
        1 gacgccgccc gcacagcgcc accgagttca cgcagccgcg gtcgagctgc ccggcggcag
       61 cagtgggcat tggcggcctg gccgaggtcg gttaaaggga cgagttgcaa acagttcagg
      121 aagtgacaag tcgatttcct cctccccggg agtcgctcgg tacaaagcgc tcggcgccgg
      181 ccggagagcg tgcgcacggc ggacgcgggc gtgcagcccg gacgacttgg cgagcgcttg
      241 cagtgacggc ccgcgtccgg cgcgcacagc cgttgactac ttttggccat tcccagaggc
      301 cagtctgagc aactgatggg gagctgtttc tagtgacctc actctccgga atgcccaggt
      361 atcactgtta atcaagtctt ccccgctgaa gatggcctgt gcccagcctg ggatgcagcc
      421 cagttcctga ggtccttacc atggtgatga tcctaaggag aagcctcatc aaccagggag
      481 ctgactctgg agcacacagg accttcatcc ctgaactgca cacgccaaag atgagtcaag
      541 gacctaccct cctttcctgt ggaattatgg aaaatgacag atggcgagac ctggatagaa
      601 aatgccctct tcagattgac cagccaagcg ccagcatctg ggaatgtctg cctgaaaagt
      661 gtcaggatgg ctccctgtgg caccaggagg cagtgactgc ctgtgcggtg accagcctaa
      721 tcaaagacct caacataaat gaccacaatg ggaacccctc agctcctccc agcaaacgcc
      781 agtgccggtc actatccttc tctgatgaga tgtccagttg ccggacgtca tggcggccct
      841 tggggtccaa agtctggact cccgtggaga agagacgatg ctacagcgga ggcagcgtcc
      901 agcgctactc caatggcgtc agccccatgc agcggagctc tagcttcagc ctccctgcca
      961 gggccaatgg gctctcttca ccttgccacc agtcgagcct gcaccaccgc tttggggggc
     1021 aaccctgcca aggagcacca ggctcagccc cctgtggaca ggcgggtgat agctggagcc
     1081 cagacccaca cccagtggga gggggccggc tggacctgca gcggtccctc tcttgctcgc
     1141 atgagcagtt ttccttccca gaatactgtc ccccctcagc caacagcaca cctgcctcaa
     1201 cgccagagct ggcaagacgc tccagtgggc ttgcccgcag ccgctctcag ccctgtgtcc
     1261 ttaatgacaa gaagatcggt gtgaaacggc ggcgtccgga tgaagtgcag gagcaaagac
     1321 cttctctaga ccttgccaag atggcacaga actgtcagac cttcagcagc ctcagttgcc
     1381 tgaacatggg ggtggacgac cacagctccc agagcccctt tgccctcgtc agcagtaccc
     1441 gatcctggac cgcattgctc tcagcctcca gcccaggggg caggactcct gctgggaccc
     1501 cagttcctga gcctgttccc cactcctttg atgaccagtt cacctgccag gaggacctat
     1561 cctgtgacga gtcagatggc tgcagtctag atgaggattg ctgcaggaag ggggatccgg
     1621 ccacatcctg gcgggaccgg ggagcctgca cgaacagcct ctgctctttg gatggcgagc
     1681 tggacattga gcagatagag aacaactgag ggccctgacc tggggaggag gcactcctct
     1741 aggccttagg tcactctaag ggggacctgg ctcctgggtc tgacagaggc tcctccaaaa
     1801 aatggagccc acccattttc aaaggaacca gccatcaccc tgtagtgccc aaatttgtga
     1861 aggcaacttg gccacacctc acaggcgaca gctggcctcc caccagttcc atggaactac
     1921 tgtagcccaa aacaggtttt cggtttggta tcctcctctt tgttccttac ggagtgctgg
     1981 gtagccacca ttttccagta gggctgggcc agctgcaccc ttcaggtagg atgccggggg
     2041 cctgagcccc cttatagcct tgctcaggtt ccttctgggg agttacccaa agcctccttt
     2101 acttagttta ctccgtgcct tctctcccag gtctccctgg cccaggcttg ggaaggttcg
     2161 ggagacacct cttgtagtga cagcagaccg tgtggcctta atccatttgg ggcactggca
     2221 gggattctgg gataatccat gtcccatttt tcgggatcag gggatagtta ggaatgacca
     2281 gaagccatcc atattgggta ggcatttggt ggttgtgttg actgaaaggt gggcccacca
     2341 gctctcccat gtcaccaaga atcacccaca cctctgccac ctcaggggct gccttggcaa
     2401 ggctgacatt ggtagccttc cttctgtccc cagtccctga gagctgagct cagtgaattc
     2461 agctgtgtat agagatgtca gtggcaagat gacctcttca tagtgtcctc aggatctaca
     2521 aacaggtgca gaagtctcgg ccctgtgtac attcctgggt agagggatgt ctgctggctg
     2581 ctttgcaggc tagccactct gcaggctcct ctctgtagca gtctatgttg ggggcctgca
     2641 agcctccacc acattcctag cacattgttg cttgttcaca gacactgctg gctttaatga
     2701 aagcatacca ccgttggctt caagacaccc cccaccccca gtccactgat gtgagcctag
     2761 ccccaggctc tcctctgcag gcccagccac agcatggctt gaatcacact cccccttgca
     2821 gctcctcact cccagcataa ttcccagagg gcatccgttc cggcagctcc cctcagtcct
     2881 ccctgcagac atgctacagg gctctgcacg ctgggactct ggcttttagc aaacttggca
     2941 tcttctgcag acaatagcaa gtgggctggc ttacacaagt ggcttgtttt cccataaggc
     3001 taaaaataac tggtgcattc tcttgggttt gcggacatgt gatctaggca catttgtagt
     3061 tgctctgctg tgcctaccct ctgagatttc actgtctgct ggctgagccc aaatggctgt
     3121 tacctttctc ctaaagaaag accttgatgg gaaccttttg tttcaacttt aatttgtcca
     3181 tacaccagaa gaaccgaggc tcaagttctg atgtataagg caatgtttct ctaaaaccag
     3241 acccaaagta caggaagccc cgctcctata accccaggtt gggtagcctg gtgggtccct
     3301 gtggtggtgg tcggggccca gctggccttg ggggcactga gaaagcaaag tagaaagctg
     3361 gtggaggcat gacctacaag ccctgcctgg tggatcacag aggaaggtag ttgagagggc
     3421 gtgggatgca caccccagtg ccctggttcc cagaaagccc acagtgaggg attctgttat
     3481 ctgaaagaac tttatggtcc ctaaagctat tcccactccc ccacccccca ggaaaggaga
     3541 ggctgggctc tgtcccctgg tctgcttcac acaggctgtt aaggccaaag cacagaacag
     3601 ttgccagctg cctctcctga ggactgggac ctgagctcct ggtggcaggt gtgtgtctta
     3661 aggctgatgt gtggccggct tgtccgtaga ctagctctct tgagcctgct ggcggaagga
     3721 caaacaggaa cttgctgagt gacagcttca tctttgcttc ctgcctctag gagactgttc
     3781 cctgggcggc agtactccaa acccggggtg ggggttggcc ctttgcagtt tcctcaggct
     3841 tttcttgatg tccctgtccc actaaggcct cagtccaagc acccagcaaa agcagccaga
     3901 aaagatggtg gtagcttttc tgcctagtgt gttcatttgc tttctgatgt tcttttcatc
     3961 aagtaaagca ggttttgtct agaaggtttc cagtcagctt tcagcagttg tgtgacccag
     4021 acagacccat tcatccaccc cattcactgg cccccagacc tctggtcttg gatctcctgg
     4081 aagaaggttc acctgggagg tccactctgt ctcctgtgtg cgtggcagca caggcagcag
     4141 gcagactggc tcacccgagt gccacacccc agagaagctg agggtgggct tcaccactca
     4201 cctgcctagg cagcctccac caaagccgac tgggcctctt agcacgtgac atcccgttca
     4261 ctccagaagc cactgaaccg acagagttgc cctaagccgg gtacctgacc tgagttcagg
     4321 gtagcagcct agacagttta catgactgcc cactcctgcc ttactcctgg gtggtgaagg
     4381 tagaagctgg ccagcaccac gggctccctt catgtaggtc catggaactt gttctgccca
     4441 cacatgcaga tgtgtattct cagaaagcct tactttaaaa aaaaaatttt tttttgtagc
     4501 aggaaagttt tctaaatttg tatgcagaaa gttaaataaa atgaaggccc acattaaaca
     4561 ggacatgctc actcccccag tttctagatg ggtctcctat gcagaccaat ggccatattt
     4621 tattatgggt tcatttagtg ttcacagcag ttagaactca cccctggatc ctgcaaccca
     4681 tttccactga tgtggttaaa attacttgaa tgatggccac ttaaaacgta agccaggggc
     4741 cagggctcag ggacgctccg cccatacaac ccatgatgct gccccttgcc atgcccatgc
     4801 tgctggtccc acccctgccc ctggtgccag gcctctgaag gaggcagaga aagatactct
     4861 agaattgcag actgatggag ctcctttagg ctagatagga tagcctgacg tagcatagtc
     4921 tcattggcaa atgaactgca tcgtcagtgt ttgggggcac ccaggggtca gggacagatg
     4981 agcccacagg ccgtgctagg gccacgtgtg ccgtcccagc caggcagcag cagcagcagc
     5041 agcagcagca gcggtactgt ttgaggcagt gtggtgaatg gcgtggtgag ccagaaccca
     5101 tcagggctgc agcctgtagg ctgcccatgc tgggtctgct cgttagcacc acgcaccatc
     5161 gcctgcctcc ccccctgaca ggccgtgact gtcttgcact acagccactc tagtctcagg
     5221 aatttgcttg ttccttttac tgtgtaaata aagcttcctg gtccaaca
//
