LOCUS       NP_613073                339 aa            linear   ROD 18-MAR-2025
DEFINITION  protein FAM50A [Mus musculus].
ACCESSION   NP_613073
VERSION     NP_613073.2
DBSOURCE    REFSEQ: accession NM_138607.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 339)
  AUTHORS   Wang,W., Xing,J., Zhang,X., Liu,H., Liu,X., Jiang,H., Xu,C.,
            Zhao,X. and Hu,Z.
  TITLE     Control of ciliary transcriptional programs during spermatogenesis
            by antagonistic transcription factors
  JOURNAL   Elife 13, 94754 (2025)
   PUBMED   40009443
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 339)
  AUTHORS   Kim,Y., Hur,S.W., Jeong,B.C., Oh,S.H., Hwang,Y.C., Kim,S.H. and
            Koh,J.T.
  TITLE     The Fam50a positively regulates ameloblast differentiation via
            interacting with Runx2
  JOURNAL   J Cell Physiol 233 (2), 1512-1522 (2018)
   PUBMED   28574578
  REMARK    GeneRIF: Fam50a might be a new positive regulator of ameloblast
            differentiation, increasing binding affinity of Runx2 to Ambn
            promoter by physically interacting with Runx2.
REFERENCE   3  (residues 1 to 339)
  AUTHORS   Sedlacek,Z., Munstermann,E., Dhorne-Pollet,S., Otto,C., Bock,D.,
            Schutz,G. and Poustka,A.
  TITLE     Human and mouse XAP-5 and XAP-5-like (X5L) genes: identification of
            an ancient functional retroposon differentially expressed in testis
  JOURNAL   Genomics 61 (2), 125-132 (1999)
   PUBMED   10534398
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008402.1 and Y18505.1.
            
            On Oct 27, 2009 this sequence version replaced NP_613073.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y18505.1, AK008402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.98 cM"
     Protein         1..339
                     /product="protein FAM50A"
                     /note="protein XAP-5"
                     /calculated_mol_wt=40121
     Region          1..31
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV03.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q14320; propagated from
                     UniProtKB/Swiss-Prot (Q9WV03.1)"
     Region          150..177
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV03.1)"
     Region          <152..338
                     /region_name="XAP5"
                     /note="circadian clock regulator; pfam04921"
                     /db_xref="CDD:461480"
     Region          152..155
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV03.1)"
     CDS             1..339
                     /gene="Fam50a"
                     /gene_synonym="D0HXS9928E; XAP-5"
                     /coded_by="NM_138607.3:183..1202"
                     /db_xref="CCDS:CCDS41021.1"
                     /db_xref="GeneID:108160"
                     /db_xref="MGI:MGI:1351626"
ORIGIN      
        1 maqykgaase agramhlmkk rekqreqmeq mkqriaeeni mksnidkkfs ahydaveael
       61 ksstvglvtl ndmkakqeal vkerekqlak keqskelqlk leklrekerk keakrkissl
      121 sftleeeeeg veeeeemamy eeelereeit tkkkklgknp dvdtsflpdr dreeeenrlr
      181 eelrqeweak qekikseeie itfsywdgsg hrrtvkmkkg ntmqqflqka leilrkdfse
      241 lrsagveqlm yikedliiph hhsfydfivt kargksgplf nfdvhddvrl lsdatvekde
      301 shagkvvlrs wyeknkhifp asrwepydpe kkwdkytir
//
