LOCUS       NM_001374714            1900 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus family with sequence similarity 47, member E (Fam47e),
            transcript variant 3, mRNA.
ACCESSION   NM_001374714 XM_011249496
VERSION     NM_001374714.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123850.3.
            
            On Oct 9, 2019 this sequence version replaced XM_011249496.3.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.364551.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC123850.3         125061-125160
            101-437             AC123850.3         132234-132570
            438-571             AC123850.3         135941-136074
            572-716             AC123850.3         144582-144726
            717-818             AC123850.3         148485-148586
            819-899             AC123850.3         149617-149697
            900-1055            AC123850.3         155269-155424
            1056-1133           AC123850.3         157529-157606
            1134-1900           AC123850.3         160529-161295
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.09 cM"
     gene            1..1900
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /note="family with sequence similarity 47, member E"
                     /db_xref="GeneID:384198"
                     /db_xref="MGI:MGI:2686227"
     exon            1..100
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1232
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="protein FAM47E isoform 3"
                     /protein_id="NP_001361643.1"
                     /db_xref="CCDS:CCDS89938.1"
                     /db_xref="GeneID:384198"
                     /db_xref="MGI:MGI:2686227"
                     /translation="MAECGQRLQPTTLAPRLLRERQNCGWYLGNLPPKRFIRRNRLTC
                     QGFLNSRHWVFVKEDNFRKDCPPHQSPKDAFLPLIHRGAPSATPEKRQSTLLKGATLL
                     SKLSKAGKAFLEDVEAEAAQHPLTLYPQLTEALPAELLLQVLEVLDPERKLEDVWAYC
                     QDTRKPMKEPTELVGKRSSQERPPKKTLISRSGQWLCEEKSSKVDSLYKDRLLHDDVH
                     RGVTDFCHWAEDLGSSAIEEEFVLQQFDIGYQTRRSCDALLRLRLNQDKLFINRPPSL
                     REHCGHWSEPRSSGRANPQKPKRVKMRYGAWYLNTSLWKRQRADEPLVDPMVSHKAQD
                     STFKEQLQEQGELLAGLRGTAAFKDFILSRGYRMPRFLEKIYAEEKNKSENIKAPKKL
                     TQTEKNPGSR"
     exon            101..437
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     exon            438..571
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     exon            572..716
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     exon            717..818
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     exon            819..899
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1055
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1133
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1900
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1876..1881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /note="hexamer: AATAAA"
     polyA_site      1900
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /note="major polyA site"
ORIGIN      
        1 gccacacaag actgggcagt gccatggcgg agtgtgggca gcggctccag cccacgaccc
       61 tggctcctag actgctgagg gagcgccaga actgcgggtg gtacctcggg aacctgcctc
      121 ccaagcgttt cataaggcgg aaccggctga catgccaggg cttcttgaac agccggcact
      181 gggtgtttgt gaaagaggat aacttcagga aagactgccc cccgcaccag agccccaagg
      241 atgcctttct acctcttatt catcgcggag cccccagtgc taccccagag aagaggcaga
      301 gcacactgct caagggggca acgctgttgt ctaagctttc gaaagctggg aaggcattcc
      361 tggaggatgt ggaagctgag gcggctcagc acccgctgac tctctaccca caacttacag
      421 aagctctgcc tgctgagctc ttattgcagg tgctggaggt actggaccct gagaggaagc
      481 tggaggatgt gtgggcttat tgccaggata ccaggaagcc aatgaaggaa cccacagagc
      541 ttgtaggaaa acgctcttcc caagaacgcc cgcctaagaa gacgctgatc tcacgttcag
      601 gccagtggct ttgtgaagaa aagtcaagca aagtggattc actctataaa gacagactcc
      661 tccatgatga cgtacacaga ggagtcaccg acttctgcca ctgggccgag gaccttggaa
      721 gctctgccat tgaggaagag ttcgtcctgc agcagtttga catcggctat cagactagac
      781 gcagctgtga tgcgcttctc aggctgaggc tgaaccagga caaactcttc atcaatagac
      841 caccttccct gcgagaacac tgtgggcact ggagtgaacc tcggtcctct ggaagagcaa
      901 atcctcagaa gccgaagcgg gtaaagatga ggtacggagc ctggtacctg aacaccagct
      961 tgtggaagag gcaaagagcg gatgaacctc tggtcgaccc catggtctca cacaaagctc
     1021 aagattcaac ctttaaagag cagcttcagg agcaggggga gctgcttgca ggcctgcgag
     1081 ggacagcagc ctttaaggac ttcattctaa gcaggggcta caggatgccc aggttccttg
     1141 agaagatata tgcggaggag aaaaataaat ctgaaaatat taaggctcct aaaaaactca
     1201 cgcaaacaga gaagaatccc gggagcagat gagtcggctt tgattgacag catccttgga
     1261 tactgcccca ttagtttaat taataagtag aatatagcag tgccctccgt gaaggcttca
     1321 acctggcagc atctacaaat ataaaactga acacaaatgt ctttctaaac agctttttaa
     1381 aggctttagg gtttttttgt agtattttta gttatgtaca gctgtgtatg tctgcatgtg
     1441 ggtaggtgca cacaagtcta ggagccttca gaagcctgaa gcgttgaatg ccctggagcc
     1501 gcagttacag agggttgtga gccaccatgt gggtgctggg aactgaacct tggtcctctc
     1561 gacgaacagt gagctgtccc gatggctgat ccatctctcc agcctccact gatcaatgtt
     1621 ttgtttgctt gtttgtttgg tttgggggtt tggccttctt tagggagagt cttgctatgt
     1681 ggcctaggct gacctctaat tagtcatccc cctgtgttag cctctcaggg tctagagttg
     1741 cagctctgca ccaacacacc tggtgcacaa aataatacat tttgtatatt taccaactat
     1801 gggctcaata ttcgtgtgta gtcctctcac gctttcgtgt tatgaagatg ccataaatga
     1861 ttgatttctt gtaaaaataa aatcataggc aaagtcacaa
//
