LOCUS       NM_001170571            1322 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus family with sequence similarity 47, member E (Fam47e),
            transcript variant 2, mRNA.
ACCESSION   NM_001170571
VERSION     NM_001170571.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1322)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1322)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1322)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144479.1, AA244788.1, AK050399.1 and AC123850.3.
            
            Transcript Variant: This variant (2) lacks two alternate exons,
            resulting in the loss of an in-frame segment in the central coding
            region, compared to variant 1. The encoded isoform (2) is shorter
            than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.105121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AK144479.1         1-146
            147-485             AA244788.1         128-466
            486-1316            AK050399.1         187-1017
            1317-1322           AC123850.3         161292-161297
FEATURES             Location/Qualifiers
     source          1..1322
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.09 cM"
     gene            1..1322
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /note="family with sequence similarity 47, member E"
                     /db_xref="GeneID:384198"
                     /db_xref="MGI:MGI:2686227"
     exon            1..174
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..652
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="protein FAM47E isoform 2"
                     /protein_id="NP_001164042.1"
                     /db_xref="CCDS:CCDS51548.1"
                     /db_xref="GeneID:384198"
                     /db_xref="MGI:MGI:2686227"
                     /translation="MLSCIQPLPTLHFLCIIREHLACDCLPRCLSPSCIAEATQRPKK
                     TLISRSGQWLCEEKSSKVDSLYKDRLLHDDVHRGVTDFCHWAEDLNPQKPKRVKMRYG
                     AWYLNTSLWKRQRADEPLVDPMVSHKAQDSTFKEQLQEQGELLAGLRGTAAFKDFILS
                     RGYRMPRFLEKIYAEEKNKSENIKAPKKLTQTEKNPGSR"
     exon            175..319
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     exon            320..475
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     exon            476..553
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     exon            554..1322
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1296..1301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /note="hexamer: AATAAA"
     polyA_site      1320
                     /gene="Fam47e"
                     /gene_synonym="C730043O17; Gm1381"
                     /note="major polyA site"
ORIGIN      
        1 gggcctgggc tcagtgtcac ttcagcagag agactctctc tgtagaaatt ggatgctgtc
       61 ctgcatccag ccgcttccca ccttacattt tctttgcatc atccgtgagc acctggcatg
      121 tgattgtctg cctcgatgtc tctctccatc ctgcatagcc gaagccacgc aaaggcctaa
      181 gaagacgctg atctcacgtt caggccagtg gctttgtgaa gaaaagtcaa gcaaagtgga
      241 ttcactctat aaagacagac tcctccatga tgacgtacac agaggagtca ccgacttctg
      301 ccactgggcc gaggacctta atcctcagaa gccgaagcgg gtaaagatga ggtacggagc
      361 ctggtacctg aacaccagct tgtggaagag gcaaagagcg gatgaacctc tggtcgaccc
      421 catggtctca cacaaagctc aagattcaac ctttaaagag cagcttcagg agcaggggga
      481 gctgcttgca ggcctgcgag ggacagcagc ctttaaggac ttcattctaa gcaggggcta
      541 caggatgccc aggttccttg agaagatata tgcggaggag aaaaataaat ctgaaaatat
      601 taaggctcct aaaaaactca cgcaaacaga gaagaatccc gggagcagat gagtcggctt
      661 tgattgacag catccttgga tactgcccca ttagtttaat taataagtag aatatagcag
      721 tgccctccgt gaaggcttca acctggcagc atctacaaat ataaaactga acacaaatgt
      781 ctttctaaac agctttttaa aggctttagg gtttttttgt agtattttta gttatgtaca
      841 gctgtgtatg tctgcatgtg ggtaggtgca cacaagtcta ggagccttca gaagcctgaa
      901 gcgttgaatg ccctggagcc gcagttacag agggttgtga gccaccatgt gggtgctggg
      961 aactgaacct tggtcctctc gacgaacagt gagctgtccc gatggctgat ccatctctcc
     1021 agcctccact gatcaatgtt ttgtttgctt gtttgtttgg tttgggggtt tggccttctt
     1081 tagggagagt cttgctatgt ggcctaggct gacctctaat tagtcatccc cctgtgttag
     1141 cctctcaggg tctagagttg cagctctgca ccaacacacc tggtgcacaa aataatacat
     1201 tttgtatatt taccaactat gggctcaata ttcgtgtgta gtcctctcac gctttcgtgt
     1261 tatgaagatg ccataaatga ttgatttctt gtaaaaataa aatcataggc aaagtcacaa
     1321 tt
//
