LOCUS       NM_146050               1251 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus FAM3 metabolism regulating signaling molecule D
            (Fam3d), mRNA.
ACCESSION   NM_146050
VERSION     NM_146050.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1251)
  AUTHORS   Hu,Y., Li,J., Li,X., Wang,D., Xiang,R., Liu,W., Hou,S., Zhao,Q.,
            Yu,X., Xu,M., Zhao,D., Li,T., Chi,Y. and Yang,J.
  TITLE     Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by
            activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation
  JOURNAL   Metabolism 146, 155661 (2023)
   PUBMED   37454871
  REMARK    GeneRIF: Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by
            activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation.
REFERENCE   2  (bases 1 to 1251)
  AUTHORS   Moser,C., Gossele,K.A., Balaz,M., Balazova,L., Horvath,C.,
            Kunzle,P., Okreglicka,K.M., Li,F., Bluher,M., Stierstorfer,B.,
            Hess,E., Lamla,T., Hamilton,B., Klein,H., Neubauer,H., Wolfrum,C.
            and Wolfrum,S.
  TITLE     FAM3D: A gut secreted protein and its potential in the regulation
            of glucose metabolism
  JOURNAL   Peptides 167, 171047 (2023)
   PUBMED   37328068
  REMARK    GeneRIF: FAM3D: A gut secreted protein and its potential in the
            regulation of glucose metabolism.
REFERENCE   3  (bases 1 to 1251)
  AUTHORS   Shen,Y., Dong,Z., Fan,F., Li,K., Zhu,S., Dai,R., Huang,J., Xie,N.,
            He,L., Gong,Z., Yang,X., Tan,J., Liu,L., Yu,F., Tang,Y., You,Z.,
            Xi,J., Wang,Y., Kong,W., Zhang,Y. and Fu,Y.
  TITLE     Targeting cytokine-like protein FAM3D lowers blood pressure in
            hypertension
  JOURNAL   Cell Rep Med 4 (6), 101072 (2023)
   PUBMED   37301198
  REMARK    GeneRIF: Targeting cytokine-like protein FAM3D lowers blood
            pressure in hypertension.
REFERENCE   4  (bases 1 to 1251)
  AUTHORS   Liang,W., Peng,X., Li,Q., Wang,P., Lv,P., Song,Q., She,S.,
            Huang,S., Chen,K., Gong,W., Yuan,W., Thovarai,V., Yoshimura,T.,
            O'huigin,C., Trinchieri,G., Huang,J., Lin,S., Yao,X., Bian,X.,
            Kong,W., Xi,J., Wang,J.M. and Wang,Y.
  TITLE     FAM3D is essential for colon homeostasis and host defense against
            inflammation associated carcinogenesis
  JOURNAL   Nat Commun 11 (1), 5912 (2020)
   PUBMED   33219235
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1251)
  AUTHORS   He,L., Fu,Y., Deng,J., Shen,Y., Wang,Y., Yu,F., Xie,N., Chen,Z.,
            Hong,T., Peng,X., Li,Q., Zhou,J., Han,J., Wang,Y., Xi,J. and
            Kong,W.
  TITLE     Deficiency of FAM3D (Family With Sequence Similarity 3, Member D),
            A Novel Chemokine, Attenuates Neutrophil Recruitment and
            Ameliorates Abdominal Aortic Aneurysm Development
  JOURNAL   Arterioscler Thromb Vasc Biol 38 (7), 1616-1631 (2018)
   PUBMED   29853563
  REMARK    GeneRIF: FAM3D, as a dual agonist of FPR1 and FPR2, induced
            Mac-1-mediated neutrophil recruitment and aggravated abdominal
            aortic aneurysm development through FPR-related Gi protein and
            beta-arrestin signaling.
REFERENCE   6  (bases 1 to 1251)
  AUTHORS   de Wit,N.J., IJssennagger,N., Oosterink,E., Keshtkar,S.,
            Hooiveld,G.J., Mensink,R.P., Hammer,S., Smit,J.W., Muller,M. and
            van der Meer,R.
  TITLE     Oit1/Fam3D, a gut-secreted protein displaying nutritional
            status-dependent regulation
  JOURNAL   J Nutr Biochem 23 (11), 1425-1433 (2012)
   PUBMED   22226334
  REMARK    GeneRIF: Fam3D is a gut-derived protein that is expressed and
            secreted in a nutritional status-dependent manner
REFERENCE   7  (bases 1 to 1251)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 1251)
  AUTHORS   Zhu,Y., Xu,G., Patel,A., McLaughlin,M.M., Silverman,C., Knecht,K.,
            Sweitzer,S., Li,X., McDonnell,P., Mirabile,R., Zimmerman,D.,
            Boyce,R., Tierney,L.A., Hu,E., Livi,G.P., Wolf,B.,
            Abdel-Meguid,S.S., Rose,G.D., Aurora,R., Hensley,P., Briggs,M. and
            Young,P.R.
  TITLE     Cloning, expression, and initial characterization of a novel
            cytokine-like gene family
  JOURNAL   Genomics 80 (2), 144-150 (2002)
   PUBMED   12160727
REFERENCE   9  (bases 1 to 1251)
  AUTHORS   Fu,X. and Kamps,M.P.
  TITLE     E2a-Pbx1 induces aberrant expression of tissue-specific and
            developmentally regulated genes when expressed in NIH 3T3
            fibroblasts
  JOURNAL   Mol Cell Biol 17 (3), 1503-1512 (1997)
   PUBMED   9032278
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CT025547.17.
            
            On Nov 17, 2006 this sequence version replaced NM_146050.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034193.1, AK010206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               CT025547.17        165056-165262       c
            208-263             CT025547.17        153533-153588       c
            264-371             CT025547.17        151288-151395       c
            372-392             CT025547.17        147975-147995       c
            393-510             CT025547.17        144837-144954       c
            511-569             CT025547.17        143609-143667       c
            570-620             CT025547.17        141963-142013       c
            621-705             CT025547.17        140348-140432       c
            706-832             CT025547.17        138581-138707       c
            833-1251            CT025547.17        135447-135865       c
FEATURES             Location/Qualifiers
     source          1..1251
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 4.83 cM"
     gene            1..1251
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /note="FAM3 metabolism regulating signaling molecule D"
                     /db_xref="GeneID:18300"
                     /db_xref="MGI:MGI:1201784"
     exon            1..207
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..263
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..922
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /note="protein EF-7; oncoprotein-induced protein 1;
                     protein FAM3D; oncoprotein induced transcript 1"
                     /codon_start=1
                     /product="protein FAM3D precursor"
                     /protein_id="NP_666162.1"
                     /db_xref="CCDS:CCDS36802.1"
                     /db_xref="GeneID:18300"
                     /db_xref="MGI:MGI:1201784"
                     /translation="MRVAGLIRVVVFIFTIVTMWVFLRSYTSFSRKTIRLPRWLGITP
                     KDIQTPKSKCGLSKICPNNFFAFKISSGAANVVGPSMCFEDEIIMSPVRNNVGRGLNV
                     ALVNGSTGQVMKKDSFDMYSGDPQLLLNFLTEIPDSTLVLVASYDDPGTKMNDKIKTL
                     FSNLGSSYAKQLGFRDSWVFVGAKDLKSKSPYEQFLKNNPETNKYDGWPELLELEGCV
                     PRKVM"
     exon            264..371
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..392
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..510
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..569
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..620
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..705
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..832
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1251
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1231..1236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /note="hexamer: ATTAAA"
     polyA_site      1251
                     /gene="Fam3d"
                     /gene_synonym="2310076N21Rik; EF-7; Oit1"
                     /note="major polyA site"
ORIGIN      
        1 ctaagagcag ccggctagag agggccagca ccagcaccag caccagcacc agcaccagca
       61 ccactcccat cctgccaaga accagaaggc tgctcttcaa cagccaggcc agaaaagcag
      121 ttggctgggt taaagactca agctatcaac agctgatcca tcacctcttc aacgcgaagg
      181 cagtgaagag tgagccctga gcctcaggtt aacgctgacc tgaccgcaac ccattcttca
      241 cttcaacagg atgagagtgg caggtctgat ccgtgttgtg gtcttcatct ttaccatagt
      301 caccatgtgg gtcttcctcc gcagctacac aagcttcagc aggaaaacaa ttcgtctgcc
      361 acgctggctg ggcataaccc ccaaggacat ccagaccccg aagtccaagt gtgggctcag
      421 caagatctgc ccaaacaact tttttgcatt taaaatcagc agtggagctg ccaatgtggt
      481 gggcccctcc atgtgctttg aagacgaaat tatcatgagt ccagtgcgaa acaacgtggg
      541 cagaggcctg aacgttgctc tggtgaacgg atcaactggc caggtgatga aaaaggacag
      601 ctttgacatg tactctggag acccccaact cctgctgaac ttccttacgg aaattccaga
      661 tagcaccctg gtgctggtag cctcctatga tgacccaggg accaaaatga acgacaaaat
      721 caagacgctt ttctccaacc tgggaagttc ctacgccaag cagctgggct tccgggacag
      781 ctgggtcttt gtaggtgcta aagacctcaa gagtaaaagc ccatatgagc agttcttaaa
      841 gaacaaccca gaaacaaaca aatatgacgg atggccggag ttgctagagc tcgagggctg
      901 tgtgccacgg aaagtaatgt agggtggcct agggagccaa agaaatgccc aacggacttg
      961 agagcagaac ccaggagtgc tgggtctatg ctggcaggag ctgactggga ggaagaaaga
     1021 agccatatgg tacgctctga tcatcccctg cacacagtga ctcacttccc gtctaaggaa
     1081 gcaacagcct cccactgccc catagtggcc atcttgagga tgggcggcca tggggcctgt
     1141 ggaaccggct gttggtagag agaacaagac cttccaagac tgccatggtt gtctccagaa
     1201 ggactggctg cctacactta cttgagcaga attaaattct atttttgctg a
//
