LOCUS       NM_138587               2739 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus FAM3 metabolism regulating signaling molecule C
            (Fam3c), mRNA.
ACCESSION   NM_138587
VERSION     NM_138587.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2739)
  AUTHORS   Schmidt,U., Uluca,B., Vokic,I., Malik,B., Kolbe,T., Lassnig,C.,
            Holcmann,M., Moreno-Viedma,V., Robl,B., Muhlberger,C.,
            Gotthardt,D., Sibilia,M., Rulicke,T., Muller,M. and Csiszar,A.
  TITLE     Inducible overexpression of a FAM3C/ILEI transgene has pleiotropic
            effects with shortened life span, liver fibrosis and anemia in mice
  JOURNAL   PLoS One 18 (9), e0286256 (2023)
   PUBMED   37713409
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2739)
  AUTHORS   Malik,B., Vokic,I., Mohr,T., Poppelaars,M., Holcmann,M.,
            Novoszel,P., Timelthaler,G., Lendl,T., Krauss,D., Elling,U.,
            Mildner,M., Penninger,J.M., Petzelbauer,P., Sibilia,M. and
            Csiszar,A.
  TITLE     FAM3C/ILEI protein is elevated in psoriatic lesions and triggers
            psoriasiform hyperproliferation in mice
  JOURNAL   EMBO Mol Med 15 (7), e16758 (2023)
   PUBMED   37226685
  REMARK    GeneRIF: FAM3C/ILEI protein is elevated in psoriatic lesions and
            triggers psoriasiform hyperproliferation in mice.
REFERENCE   3  (bases 1 to 2739)
  AUTHORS   Thuya,W.L., Kong,L.R., Syn,N.L., Ding,L.W., Cheow,E.S.H.,
            Wong,R.T.X., Wang,T., Goh,R.M.W., Song,H., Jayasinghe,M.K.,
            Le,M.T., Hu,J.C., Yong,W.P., Lee,S.C., Wong,A.L., Sethi,G.,
            Hung,H.T., Ho,P.C., Thiery,J.P., Sze,S.K., Guo,T., Soo,R.A.,
            Yang,H., Lim,Y.C., Wang,L. and Goh,B.C.
  TITLE     FAM3C in circulating tumor-derived extracellular vesicles promotes
            non-small cell lung cancer growth in secondary sites
  JOURNAL   Theranostics 13 (2), 621-638 (2023)
   PUBMED   36632230
  REMARK    GeneRIF: FAM3C in circulating tumor-derived extracellular vesicles
            promotes non-small cell lung cancer growth in secondary sites.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2739)
  AUTHORS   Noguchi,K., Dincman,T.A., Dalton,A.C., Howley,B.V., McCall,B.J.,
            Mohanty,B.K. and Howe,P.H.
  TITLE     Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness
            and is transcriptionally up-regulated by upstream stimulatory
            factor-1 (USF-1)
  JOURNAL   J Biol Chem 293 (29), 11401-11414 (2018)
   PUBMED   29871931
  REMARK    GeneRIF: ILEI contributes to melanoma cell invasiveness in vivo
            without affecting primary tumor growth and is transcriptionally
            up-regulated by USF-1.
REFERENCE   5  (bases 1 to 2739)
  AUTHORS   Jansson,A.M., Csiszar,A., Maier,J., Nystrom,A.C., Ax,E.,
            Johansson,P. and Schiavone,L.H.
  TITLE     The interleukin-like epithelial-mesenchymal transition inducer ILEI
            exhibits a non-interleukin-like fold and is active as a
            domain-swapped dimer
  JOURNAL   J Biol Chem 292 (37), 15501-15511 (2017)
   PUBMED   28751379
  REMARK    GeneRIF: Data suggest that Ilei does not form interleukin-like four
            helix-bundle structures; Ilei exists as monomers and as covalent
            dimers; Ilei dimer exhibits a trans-linked domain swap converting
            an intramolecular disulfide to an intermolecular disulfide; dimeric
            Ilei appears to be involved in neoplastic invasiveness.
REFERENCE   6  (bases 1 to 2739)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
REFERENCE   7  (bases 1 to 2739)
  AUTHORS   Pilipenko,V.V., Reece,A., Choo,D.I. and Greinwald,J.H. Jr.
  TITLE     Genomic organization and expression analysis of the murine Fam3c
            gene
  JOURNAL   Gene 335, 159-168 (2004)
   PUBMED   15194199
  REMARK    GeneRIF: FAM3C orthologous protein, may be involved in cell
            differentiation and proliferation during inner ear embryogenesis
REFERENCE   8  (bases 1 to 2739)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2739)
  AUTHORS   Zhu,Y., Xu,G., Patel,A., McLaughlin,M.M., Silverman,C., Knecht,K.,
            Sweitzer,S., Li,X., McDonnell,P., Mirabile,R., Zimmerman,D.,
            Boyce,R., Tierney,L.A., Hu,E., Livi,G.P., Wolf,B.,
            Abdel-Meguid,S.S., Rose,G.D., Aurora,R., Hensley,P., Briggs,M. and
            Young,P.R.
  TITLE     Cloning, expression, and initial characterization of a novel
            cytokine-like gene family
  JOURNAL   Genomics 80 (2), 144-150 (2002)
   PUBMED   12160727
REFERENCE   10 (bases 1 to 2739)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC115039.7.
            
            On Nov 17, 2006 this sequence version replaced NM_138587.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY424275.1, BC009086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC115039.7         24889-24975
            88-141              AC115039.7         37651-37704
            142-246             AC115039.7         41593-41697
            247-276             AC115039.7         51362-51391
            277-400             AC115039.7         52292-52415
            401-459             AC115039.7         58622-58680
            460-510             AC115039.7         59591-59641
            511-595             AC115039.7         61952-62036
            596-722             AC115039.7         71517-71643
            723-2739            AC115039.7         72432-74448
FEATURES             Location/Qualifiers
     source          1..2739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 9.24 cM"
     gene            1..2739
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /note="FAM3 metabolism regulating signaling molecule C"
                     /db_xref="GeneID:27999"
                     /db_xref="MGI:MGI:107892"
     exon            1..87
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /inference="alignment:Splign:2.1.0"
     exon            88..141
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..812
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /note="interleukin-like EMT inducer; family with sequence
                     similarity 3, member C; protein FAM3C"
                     /codon_start=1
                     /product="protein FAM3C precursor"
                     /protein_id="NP_613053.3"
                     /db_xref="CCDS:CCDS39436.1"
                     /db_xref="GeneID:27999"
                     /db_xref="MGI:MGI:107892"
                     /translation="MRVAGAAKLVVAVAVFLLTFYVISQVFEIKMDASLGNLFARSAL
                     DSAIRSTKPPRYKCGISKACPEKHFAFKMASGAANVVGPKICLEDNVLMSGVKNNVGR
                     GINIALVNGKTGEVIDTKFFDMWGGDVAPFIEFLKTIQDGTVVLMATYDDGATKLTDE
                     ARRLIAELGSTSITSLGFRDNWVFCGGKGIKTKSPFEQHIKNNKETNKYEGWPEVVEM
                     EGCIPQKQD"
     exon            142..246
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /inference="alignment:Splign:2.1.0"
     exon            247..276
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /inference="alignment:Splign:2.1.0"
     exon            277..400
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /inference="alignment:Splign:2.1.0"
     exon            401..459
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /inference="alignment:Splign:2.1.0"
     exon            460..510
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /inference="alignment:Splign:2.1.0"
     exon            511..595
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /inference="alignment:Splign:2.1.0"
     exon            596..722
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /inference="alignment:Splign:2.1.0"
     exon            723..2739
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1354..1359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /note="hexamer: AATAAA"
     polyA_site      1379
                     /gene="Fam3c"
                     /gene_synonym="D6Wsu176e; Ilei"
                     /note="major polyA site"
ORIGIN      
        1 cgcgatcggc gcgctcggga ggaggcggcg gcggtggcac ctcccgtcgg cctccgacag
       61 gactgacggc ggcgcgaccg cagacgggac cttcttttgg agacgtgcta gagagtgaga
      121 aggcaaaaat gagggtagca ggagctgcaa agttggtagt ggccgtggca gtattcttac
      181 tgaccttcta tgttatttct caagtatttg aaattaaaat ggatgcaagt ttaggaaatc
      241 tatttgctcg atccgcgctg gactcagcca ttcgttctac gaaacctccg aggtacaagt
      301 gtgggatctc aaaggcgtgc ccagagaagc attttgcttt taagatggct agtggagcag
      361 ccaatgtcgt gggacccaag atctgcctgg aggacaatgt tttgatgagt ggtgtgaaga
      421 ataatgtcgg aagaggaatc aatattgcct tggtaaatgg gaaaacaggg gaagtaatag
      481 acaccaaatt ttttgacatg tggggaggag atgtggcacc attcattgag tttttgaaga
      541 ccatacaaga cggaacagta gtgctaatgg ctacatacga tgatggagca accaaactca
      601 cggatgaggc acggcggctc attgctgaac tgggcagcac ttcgatcacc agtcttggtt
      661 tccgagataa ctgggtcttc tgtggtggga agggcattaa gacaaagagt ccctttgaac
      721 agcacataaa gaacaataag gaaacgaaca agtacgaggg atggcctgag gtggtggaga
      781 tggaaggatg tatcccccag aagcaagact gacgggaagg agcgagaggc gaggaggaac
      841 gcactttgac tctgcaggag agtggtcagg cagccgctct gtgtacatat ttcagtagca
      901 tgtggccgtc cagggtgtgc atgagcaaga ccgtctctgt cgattccagg attatttatt
      961 gctaacagaa atggctacct ttttgtaaat agtcttcatt gagccaatca ctgaactatt
     1021 tgtaagcaca tttccctgaa agtacaacgt gtagacgaca atggcaataa tgtattttaa
     1081 ttctaaaagc atattcaggg ggtaaccacg caggttgtac aggacgccga tatttatcct
     1141 ggttgctggg aaaccctatc atggaataat gtggctttta gggaggagat tttgttcgta
     1201 tacgtgtctc tgtataaaaa tctggcatgt tatggcagta cccttcaaat gaaagagatt
     1261 tttggctagt tgtctgtgta ctgtcacctt acagtccaac tcctgttgta tcttttcaca
     1321 gtctttattt ttgaccttcc aaagaaatcc agaaataaaa tgtttcacac aaaaatttac
     1381 atcagatttg tgaaaagcac aacagttttt ttgttgttgt tatttttttt aataacagtg
     1441 aagaggaata ttaatgtagg tgtcattcag agctcatttt ctcaattctg tgttagcggt
     1501 gtgaattctg tgatgctgtg taagctgtgt agagtgagcc taggggtagg attccacaga
     1561 actgggggcc caggccgagt cccttcctcg acctaatcag gtcattcaag acaactgggt
     1621 cagtacattt agggtaatac aggcattttt ctgctttcat cgaccacatg attttaggac
     1681 aggaatactt gactctcata gccttgattt gtaaaccaag aaattctgtt atttatttct
     1741 aactttgtga tagcagctgt tgcctaaacg tgtagcagaa gccttgaaaa gtcccgatta
     1801 ttgttttttt tagggcattt gatgtctatt atataggtga catacatcca cttcaaatgc
     1861 aacataaaca agtgaaatgt tcatgctgcc ctttgtggga tgaggccaca cgtaaaatct
     1921 gaacctaaaa tttaggtggt ttgtataaaa atctaagagc agtatttgct attttgttaa
     1981 aagctagaag cagcccaggt gtccccttct tgactgttac tgacctgcgc tactgtttct
     2041 ctcctcaaat tgaatgtagt tcatgaggag ataaataatc gtctgtgctc agagaggttt
     2101 tgtagacttt aaatgtagag ttctgctgct cctgtactaa tacatccagc atggatggtt
     2161 tagcttttct ttgtttgttt gttttttgtt tgattttttt tttttttttt tacagttcta
     2221 gggatgggaa aataaacatt gcagggttat tttgtttttt aatactgaat ataagtactc
     2281 ttggtttgac attgtgaatt ttttattttt catttttgta tttgacaaag cactatacct
     2341 gcagaacatc ccctgaaatc cttccttttt tttttttttt tttttttttg gatacatctt
     2401 aacatataaa aattaagttt ttgccattca acatagtagt atcatatggc ctggatatat
     2461 ttgaatgtgt atgaagtaaa gttgcttgag aacaggctaa ccctttgaga gatgggcttt
     2521 ccatttgcat aagctgctgg gagggagaag actggttctg taactgctgt ggcccagtgg
     2581 ggtcttttgg cctggattct gtcttgtact ggttacaccg gctcaactcg ggaagcaata
     2641 atcgactgtt ttatgttcac atcagcctta gaagtggaac agtgctcact tactgttgac
     2701 aacaagtttt ctttattaaa atcaaaaatc tttaacact
//
