LOCUS       NM_020622                972 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus FAM3 metabolism regulating signaling molecule B
            (Fam3b), mRNA.
ACCESSION   NM_020622
VERSION     NM_020622.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 972)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 972)
  AUTHORS   Lai,F., Chen,Y., Lin,H., Wang,X., Zhu,X., Li,Y., Xiao,H. and Cao,X.
  TITLE     Pancreatic-derived factor impaired glucagon-like Peptide-1
            production from GLUTag enterendorine L-cell line and intestines
  JOURNAL   Mol Cell Endocrinol 452, 110-119 (2017)
   PUBMED   28549991
  REMARK    GeneRIF: these findings indicate that intestinal L cells are
            responsive to PANDER, and elevated PANDER levels impair GLP-1
            production in vitro and in vivo.
REFERENCE   3  (bases 1 to 972)
  AUTHORS   Athanason,M.G., Ratliff,W.A., Chaput,D., MarElia,C.B., Kuehl,M.N.,
            Stevens,S.M. Jr. and Burkhardt,B.R.
  TITLE     Quantitative proteomic profiling reveals hepatic lipogenesis and
            liver X receptor activation in the PANDER transgenic model
  JOURNAL   Mol Cell Endocrinol 436, 41-49 (2016)
   PUBMED   27394190
  REMARK    GeneRIF: PANDER strongly impacts hepatic lipid metabolism across
            metabolic states and may induce a selective hepatic insulin
            resistant phenotype via the LXR pathway.
REFERENCE   4  (bases 1 to 972)
  AUTHORS   Ratliff,W.A., Athanason,M.G., Chechele,A.C., Kuehl,M.N.,
            Fernandez,A.M., MarElia,C.B. and Burkhardt,B.R.
  TITLE     Hepatic nutrient and hormonal regulation of the PANcreatic-DERived
            factor (PANDER) promoter
  JOURNAL   Mol Cell Endocrinol 413, 101-112 (2015)
   PUBMED   26123584
  REMARK    GeneRIF: in-vitro and in-vivo glucose is a potent stimulator of the
            PANDER promoter within the liver and this response may be
            facilitated by ChREBP.
REFERENCE   5  (bases 1 to 972)
  AUTHORS   Mo,X., Yang,C., Wang,X., Burkhardt,B.R., Li,Y., Xia,H. and Cao,X.
  TITLE     F3MB(PANDER) decreases mice hepatic triglyceride and is associated
            with decreased DGAT1 expression
  JOURNAL   PLoS One 10 (2), e0117156 (2015)
   PUBMED   25679806
  REMARK    GeneRIF: F3MB(PANDER) decreases mice hepatic triglyceride and is
            associated with decreased DGAT1 expression
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 972)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   7  (bases 1 to 972)
  AUTHORS   Zhu,Y., Xu,G., Patel,A., McLaughlin,M.M., Silverman,C., Knecht,K.,
            Sweitzer,S., Li,X., McDonnell,P., Mirabile,R., Zimmerman,D.,
            Boyce,R., Tierney,L.A., Hu,E., Livi,G.P., Wolf,B.,
            Abdel-Meguid,S.S., Rose,G.D., Aurora,R., Hensley,P., Briggs,M. and
            Young,P.R.
  TITLE     Cloning, expression, and initial characterization of a novel
            cytokine-like gene family
  JOURNAL   Genomics 80 (2), 144-150 (2002)
   PUBMED   12160727
REFERENCE   8  (bases 1 to 972)
  AUTHORS   Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S.,
            Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E.
  TITLE     From PREDs and open reading frames to cDNA isolation: revisiting
            the human chromosome 21 transcription map
  JOURNAL   Genomics 78 (1-2), 46-54 (2001)
   PUBMED   11707072
REFERENCE   9  (bases 1 to 972)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
REFERENCE   10 (bases 1 to 972)
  AUTHORS   Cabin,D.E., McKee-Johnson,J.W., Matesic,L.E., Wiltshire,T.,
            Rue,E.E., Mjaatvedt,A.E., Huo,Y.K., Korenberg,J.R. and Reeves,R.H.
  TITLE     Physical and comparative mapping of distal mouse chromosome 16. 5
            p5
  JOURNAL   Genome Res 8 (9), 940-950 (1998)
   PUBMED   9750193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF360358.1 and AF494380.1.
            
            On Jan 24, 2017 this sequence version replaced NM_020622.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF494380.1, AF360358.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-851               AF360358.1         2-852
            852-972             AF494380.1         757-877
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 57.47 cM"
     gene            1..972
                     /gene="Fam3b"
                     /gene_synonym="2-21; 9030624C24Rik; D16Jhu19e; ORF9;
                     Pander"
                     /note="FAM3 metabolism regulating signaling molecule B"
                     /db_xref="GeneID:52793"
                     /db_xref="MGI:MGI:1270150"
     exon            1..114
                     /gene="Fam3b"
                     /gene_synonym="2-21; 9030624C24Rik; D16Jhu19e; ORF9;
                     Pander"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..803
                     /gene="Fam3b"
                     /gene_synonym="2-21; 9030624C24Rik; D16Jhu19e; ORF9;
                     Pander"
                     /note="pancreatic-derived factor; cytokine-like protein
                     2-21; protein FAM3B; family with sequence similarity 3,
                     member B"
                     /codon_start=1
                     /product="protein FAM3B precursor"
                     /protein_id="NP_065647.1"
                     /db_xref="CCDS:CCDS37416.1"
                     /db_xref="GeneID:52793"
                     /db_xref="MGI:MGI:1270150"
                     /translation="MRPVATGIFKALVFIFSSLCAWYSGYLLAELIPDVPLSSTLYNI
                     RSIGERPVLKAPAPKRQKCDHWSPCPPDTYAYRLLSGGGRDKYAKICFEDEVLIGEKT
                     GNVARGINIAVVNYETGKVIATKYFDMYEGDNSGPMAKFIQSTPSKSLLFMVTHDDGS
                     SKLKAQAKDAIEALGSKEIKNMKFRSSWVFVAAKGFELPSEIEREKINHSDQSRNRYA
                     GWPAEIQIEGCIPKGLR"
     exon            115..258
                     /gene="Fam3b"
                     /gene_synonym="2-21; 9030624C24Rik; D16Jhu19e; ORF9;
                     Pander"
                     /inference="alignment:Splign:2.1.0"
     exon            259..382
                     /gene="Fam3b"
                     /gene_synonym="2-21; 9030624C24Rik; D16Jhu19e; ORF9;
                     Pander"
                     /inference="alignment:Splign:2.1.0"
     exon            383..441
                     /gene="Fam3b"
                     /gene_synonym="2-21; 9030624C24Rik; D16Jhu19e; ORF9;
                     Pander"
                     /inference="alignment:Splign:2.1.0"
     exon            442..492
                     /gene="Fam3b"
                     /gene_synonym="2-21; 9030624C24Rik; D16Jhu19e; ORF9;
                     Pander"
                     /inference="alignment:Splign:2.1.0"
     exon            493..580
                     /gene="Fam3b"
                     /gene_synonym="2-21; 9030624C24Rik; D16Jhu19e; ORF9;
                     Pander"
                     /inference="alignment:Splign:2.1.0"
     exon            581..713
                     /gene="Fam3b"
                     /gene_synonym="2-21; 9030624C24Rik; D16Jhu19e; ORF9;
                     Pander"
                     /inference="alignment:Splign:2.1.0"
     exon            714..972
                     /gene="Fam3b"
                     /gene_synonym="2-21; 9030624C24Rik; D16Jhu19e; ORF9;
                     Pander"
                     /inference="alignment:Splign:2.1.0"
     regulatory      819..824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam3b"
                     /gene_synonym="2-21; 9030624C24Rik; D16Jhu19e; ORF9;
                     Pander"
                     /note="hexamer: AATAAA"
     polyA_site      847
                     /gene="Fam3b"
                     /gene_synonym="2-21; 9030624C24Rik; D16Jhu19e; ORF9;
                     Pander"
                     /note="major polyA site"
ORIGIN      
        1 ataatctatg tgcagctcaa gcaggtaggc cagctttcat aggtccctgg ggattgcagc
       61 caagagctga gtagaaagag agcagtttct ggaagatgcg tccagttgct acaggcatct
      121 tcaaggcact agtgtttatt ttctcctccc tgtgcgcctg gtattctggg tacctgctcg
      181 cggagctcat tcctgacgtg cccctgtcca gcactctcta caacatccga agcattggag
      241 agagacctgt tctcaaagcc ccagccccca aaagacaaaa atgtgaccat tggtccccat
      301 gtcctcctga cacctatgcc taccggctgc tcagtggtgg tggccgcgac aagtatgcca
      361 agatctgctt tgaggatgaa gtgctaatag gagagaagac ggggaatgtg gcaagaggga
      421 taaacattgc tgtcgtcaac tatgagacag gaaaagtgat agcgacaaag tactttgata
      481 tgtatgaagg tgataactcc gggccaatgg ccaagttcat tcagagcact ccttcaaaat
      541 ccctgctgtt catggtgact catgatgatg gaagttccaa actgaaggct caagcaaagg
      601 atgccataga agcccttgga agcaaagaaa tcaagaacat gaagttcaga tcaagctggg
      661 tgtttgttgc agcaaagggc tttgagctcc cttcagaaat cgagagagaa aaaatcaacc
      721 actcagatca atccaggaac agatatgcag gctggccagc ggagatccag atcgaaggat
      781 gcatacccaa agggctgaga taacggtgct tggacctcaa taaacacgtt ttgtacagat
      841 atactcagct gaatgtcaca ggagtctgat cctttgaagt ccagctgtga aggaaagtgt
      901 tgacggggat ttggcagttt gttgtaaacc actaagacac tgttaatcac acggatccta
      961 agcagctgat gg
//
