LOCUS       NM_001403523            1355 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus FAM3 metabolism regulating signaling molecule A
            (Fam3a), transcript variant 10, mRNA.
ACCESSION   NM_001403523
VERSION     NM_001403523.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1355)
  AUTHORS   Chen,X., Tao,X., Wang,M., Cannon,R.D., Chen,B., Yu,X., Qi,H.,
            Saffery,R., Baker,P.N., Zhou,X., Han,T.L. and Zhang,H.
  TITLE     Circulating extracellular vesicle-derived miR-1299 disrupts hepatic
            glucose homeostasis by targeting the STAT3/FAM3A axis in
            gestational diabetes mellitus
  JOURNAL   J Nanobiotechnology 22 (1), 509 (2024)
   PUBMED   39182087
  REMARK    GeneRIF: Circulating extracellular vesicle-derived miR-1299
            disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A
            axis in gestational diabetes mellitus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1355)
  AUTHORS   Li,X., Yuan,F., Xiong,Y., Tang,Y., Li,Z., Ai,J., Miao,J., Ye,W.,
            Zhou,S., Wu,Q., Wang,X., Xu,D., Li,J., Huang,J., Chen,Q., Shen,W.,
            Liu,Y., Hou,F.F. and Zhou,L.
  TITLE     FAM3A plays a key role in protecting against tubular cell
            pyroptosis and acute kidney injury
  JOURNAL   Redox Biol 74, 103225 (2024)
   PUBMED   38875957
  REMARK    GeneRIF: FAM3A plays a key role in protecting against tubular cell
            pyroptosis and acute kidney injury.
REFERENCE   3  (bases 1 to 1355)
  AUTHORS   Hu,C.Q., Hou,T., Xiang,R., Li,X., Li,J., Wang,T.T., Liu,W.J.,
            Hou,S., Wang,D., Zhao,Q.H., Yu,X.X., Xu,M., Liu,X.K., Chi,Y.J. and
            Yang,J.C.
  TITLE     PANX1-mediated ATP release confers FAM3A's suppression effects on
            hepatic gluconeogenesis and lipogenesis
  JOURNAL   Mil Med Res 11 (1), 41 (2024)
   PUBMED   38937853
  REMARK    GeneRIF: PANX1-mediated ATP release confers FAM3A's suppression
            effects on hepatic gluconeogenesis and lipogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1355)
  AUTHORS   Xu,T., Wang,J., Liu,X., Xiang,R., Li,H., Wang,S., Yang,J. and Xu,M.
  TITLE     FAM3A Deficiency - Induced Mitochondrial Dysfunction Underlies
            Post-Infarct Mortality and Heart Failure
  JOURNAL   J Cardiovasc Transl Res 17 (1), 104-120 (2024)
   PUBMED   37014466
  REMARK    GeneRIF: FAM3A Deficiency - Induced Mitochondrial Dysfunction
            Underlies Post-Infarct Mortality and Heart Failure.
REFERENCE   5  (bases 1 to 1355)
  AUTHORS   Lei,C., Kan,H., Xian,X., Chen,W., Xiang,W., Song,X., Wu,J., Yang,D.
            and Zheng,Y.
  TITLE     FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm
            by regulating KLF4 ubiquitination
  JOURNAL   Nat Commun 14 (1), 5360 (2023)
   PUBMED   37660071
  REMARK    GeneRIF: FAM3A reshapes VSMC fate specification in abdominal aortic
            aneurysm by regulating KLF4 ubiquitination.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1355)
  AUTHORS   Sala,D., Cunningham,T.J., Stec,M.J., Etxaniz,U., Nicoletti,C.,
            Dall'Agnese,A., Puri,P.L., Duester,G., Latella,L. and Sacco,A.
  TITLE     The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage
            progression by inducing mitochondrial respiration
  JOURNAL   Nat Commun 10 (1), 1796 (2019)
   PUBMED   30996264
  REMARK    GeneRIF: Study identified Fam3a, a cytokine-like protein, as a
            major Stat3 downstream effector in muscle stem cells and
            demonstrated that Fam3a is required for muscle stem cell commitment
            and skeletal muscle development. These findings indicate that Fam3a
            is a Stat3-regulated secreted factor that promotes muscle stem cell
            oxidative metabolism and differentiation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1355)
  AUTHORS   Chen,Z., Wang,J., Yang,W., Chen,J., Meng,Y., Geng,B., Cui,Q. and
            Yang,J.
  TITLE     FAM3A mediates PPARgamma's protection in liver ischemia-reperfusion
            injury by activating Akt survival pathway and repressing
            inflammation and oxidative stress
  JOURNAL   Oncotarget 8 (30), 49882-49896 (2017)
   PUBMED   28562339
  REMARK    GeneRIF: FAM3A protects against liver IRI by activating Akt
            survival pathways, repressing inflammation and attenuating
            oxidative stress. Moreover, the protective effects of PPARgamma
            agonist(s) on liver IRI are dependent on FAM3A-ATP-Akt pathway.
REFERENCE   8  (bases 1 to 1355)
  AUTHORS   Chi,Y., Li,J., Li,N., Chen,Z., Ma,L., Peng,W., Pan,X., Li,M.,
            Yu,W., He,X., Geng,B., Cui,Q., Liu,Y. and Yang,J.
  TITLE     FAM3A enhances adipogenesis of 3T3-L1 preadipocytes via activation
            of ATP-P2 receptor-Akt signaling pathway
  JOURNAL   Oncotarget 8 (28), 45862-45873 (2017)
   PUBMED   28515350
  REMARK    GeneRIF: FAM3A enhances the adipogenesis of preadipocytes by
            activating ATP-P2 receptor-Akt pathway. Under obese condition, a
            decrease in FAM3A expression in adipose tissues plays important
            roles in the development of adipose dysfunction and type 2
            diabetes.
REFERENCE   9  (bases 1 to 1355)
  AUTHORS   Song,Q., Gou,W.L. and Zhang,R.
  TITLE     FAM3A attenuates ER stress-induced mitochondrial dysfunction and
            apoptosis via CHOP-Wnt pathway
  JOURNAL   Neurochem Int 94, 82-89 (2016)
   PUBMED   26939760
  REMARK    GeneRIF: FAM3A has a protective role against cytotoxicity via
            regulating the CHOP-Wnt pathway in mitochondria.
REFERENCE   10 (bases 1 to 1355)
  AUTHORS   Wang,C., Chi,Y., Li,J., Miao,Y., Li,S., Su,W., Jia,S., Chen,Z.,
            Du,S., Zhang,X., Zhou,Y., Wu,W., Zhu,M., Wang,Z., Yang,H., Xu,G.,
            Wang,S., Yang,J. and Guan,Y.
  TITLE     FAM3A activates PI3K p110alpha/Akt signaling to ameliorate hepatic
            gluconeogenesis and lipogenesis
  JOURNAL   Hepatology 59 (5), 1779-1790 (2014)
   PUBMED   24806753
  REMARK    GeneRIF: FAM3A plays crucial roles in the regulation of glucose and
            lipid metabolism in the liver, where it activates the PI3K-Akt
            signaling pathway by way of a Ca(2+) /CaM-dependent mechanism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807376.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.1105081.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AL807376.4         175485-175636       c
            153-225             AL807376.4         175061-175133       c
            226-339             AL807376.4         173377-173490       c
            340-363             AL807376.4         172860-172883       c
            364-414             AL807376.4         169420-169470       c
            415-499             AL807376.4         169018-169102       c
            500-626             AL807376.4         168808-168934       c
            627-1355            AL807376.4         167093-167821       c
FEATURES             Location/Qualifiers
     source          1..1355
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.0 cM"
     gene            1..1355
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /note="FAM3 metabolism regulating signaling molecule A"
                     /db_xref="GeneID:66294"
                     /db_xref="MGI:MGI:1913544"
     exon            1..152
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            153..225
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..722
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /note="isoform 6 precursor is encoded by transcript
                     variant 10; protein FAM3A; family with sequence similarity
                     3, member A"
                     /codon_start=1
                     /product="protein FAM3A isoform 6 precursor"
                     /protein_id="NP_001390452.1"
                     /db_xref="GeneID:66294"
                     /db_xref="MGI:MGI:1913544"
                     /translation="MRLAGPLRIVALIIIMGLTWILVTILLGGPGVGLPRIQQFFTSP
                     ENSVTAGVSGELLEARAFDMWAGDVNDLLKFIRPLHEGTLVFVASYDDPATKMNEETR
                     KLFSELGSRNAKDLAFRDSWVFVGAKGVQNKSPFEQHMKNSKHTNKYEGWPEALEMEG
                     CIPRRSIAG"
     exon            226..339
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            340..363
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            364..414
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            415..499
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            500..626
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            627..1355
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1296..1301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /note="hexamer: AATAAA"
     regulatory      1319..1324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1320
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /note="major polyA site"
     polyA_site      1355
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
ORIGIN      
        1 gtgaggacct gcggacctac agcacagcct atgggcctat ggcggagcga cgcctgtggg
       61 ctgtggcctt ctgcgggcgg ccattgtcgt gcctgataag cttttctacg tgactcactt
      121 gcttcaccta gccggcagag cgagacaact ggaacccaca gttcccaaac agtgcacctg
      181 cgggagatct caacccagct ggagaagtgg acatgaggtt ggcaggcccc ctgcgcatcg
      241 tggccctaat catcattatg ggtctcacct ggatcctagt caccatcctc ctaggtggtc
      301 ctggtgttgg ccttcctcga attcagcagt tcttcaccag cccagagaac tcagtgactg
      361 caggggtcag tggtgagctc ctagaagcca gagcctttga catgtgggct ggagatgtca
      421 atgatctctt gaagttcatc cggccactgc atgaaggtac cctggtgttt gtggcttcct
      481 atgatgatcc agctaccaag atgaatgaag agaccaggaa gcttttttct gagctgggca
      541 gcaggaatgc caaggatcta gccttccgtg acagctgggt gtttgtggga gccaaaggtg
      601 tgcagaacaa gagccccttt gagcagcata tgaagaacag taagcacacc aacaagtatg
      661 agggctggcc agaggccctg gagatggaag gctgtatccc tcgaaggagc atagcgggct
      721 agcacagcag agctctggga ccagactgaa ggaggcagca tggcaccagt gtcaggtgga
      781 gactgtgccc catgcccagg catgaggctc cccctcccta acacattagg gcttgaaagt
      841 ggcctcaagg tgatgggggc tgcagggctg gcccatttca ttttgtcagg gagcttaggt
      901 acctgtgtcc ttgttttcct aaagctgatc ccacagtcag ttcccaccca gccccttcct
      961 ctgcccctca tgtgtcatct tctatttctc tttttttttc atcttctatt tcttgagtgc
     1021 cccccagagg caagggtctt caatgcttgc ccctgtcact ggagcaggta ttgggtaggt
     1081 tgggacatct tcaagaaact ctccctccca gaggcactgc actggtatcc aaccctgttt
     1141 tcagtgatcc tttaagccaa atcagaactg attggatgac ttctgcaagc ctgaatggag
     1201 caatctggcc ttaagtgccc aagtagctgg agtccaatca gagttcctca caaggtgtct
     1261 gtcagagggc tcaccttcta aatgacctgt ttgttaataa actaatttct tgcagtggaa
     1321 taaagtgtat tcagatgtcc tcagtggaga gtcaa
//
