LOCUS       NM_001379182            1593 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus FAM3 metabolism regulating signaling molecule A
            (Fam3a), transcript variant 4, mRNA.
ACCESSION   NM_001379182 XM_030251475
VERSION     NM_001379182.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1593)
  AUTHORS   Chen,X., Tao,X., Wang,M., Cannon,R.D., Chen,B., Yu,X., Qi,H.,
            Saffery,R., Baker,P.N., Zhou,X., Han,T.L. and Zhang,H.
  TITLE     Circulating extracellular vesicle-derived miR-1299 disrupts hepatic
            glucose homeostasis by targeting the STAT3/FAM3A axis in
            gestational diabetes mellitus
  JOURNAL   J Nanobiotechnology 22 (1), 509 (2024)
   PUBMED   39182087
  REMARK    GeneRIF: Circulating extracellular vesicle-derived miR-1299
            disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A
            axis in gestational diabetes mellitus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1593)
  AUTHORS   Li,X., Yuan,F., Xiong,Y., Tang,Y., Li,Z., Ai,J., Miao,J., Ye,W.,
            Zhou,S., Wu,Q., Wang,X., Xu,D., Li,J., Huang,J., Chen,Q., Shen,W.,
            Liu,Y., Hou,F.F. and Zhou,L.
  TITLE     FAM3A plays a key role in protecting against tubular cell
            pyroptosis and acute kidney injury
  JOURNAL   Redox Biol 74, 103225 (2024)
   PUBMED   38875957
  REMARK    GeneRIF: FAM3A plays a key role in protecting against tubular cell
            pyroptosis and acute kidney injury.
REFERENCE   3  (bases 1 to 1593)
  AUTHORS   Hu,C.Q., Hou,T., Xiang,R., Li,X., Li,J., Wang,T.T., Liu,W.J.,
            Hou,S., Wang,D., Zhao,Q.H., Yu,X.X., Xu,M., Liu,X.K., Chi,Y.J. and
            Yang,J.C.
  TITLE     PANX1-mediated ATP release confers FAM3A's suppression effects on
            hepatic gluconeogenesis and lipogenesis
  JOURNAL   Mil Med Res 11 (1), 41 (2024)
   PUBMED   38937853
  REMARK    GeneRIF: PANX1-mediated ATP release confers FAM3A's suppression
            effects on hepatic gluconeogenesis and lipogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1593)
  AUTHORS   Xu,T., Wang,J., Liu,X., Xiang,R., Li,H., Wang,S., Yang,J. and Xu,M.
  TITLE     FAM3A Deficiency - Induced Mitochondrial Dysfunction Underlies
            Post-Infarct Mortality and Heart Failure
  JOURNAL   J Cardiovasc Transl Res 17 (1), 104-120 (2024)
   PUBMED   37014466
  REMARK    GeneRIF: FAM3A Deficiency - Induced Mitochondrial Dysfunction
            Underlies Post-Infarct Mortality and Heart Failure.
REFERENCE   5  (bases 1 to 1593)
  AUTHORS   Lei,C., Kan,H., Xian,X., Chen,W., Xiang,W., Song,X., Wu,J., Yang,D.
            and Zheng,Y.
  TITLE     FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm
            by regulating KLF4 ubiquitination
  JOURNAL   Nat Commun 14 (1), 5360 (2023)
   PUBMED   37660071
  REMARK    GeneRIF: FAM3A reshapes VSMC fate specification in abdominal aortic
            aneurysm by regulating KLF4 ubiquitination.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1593)
  AUTHORS   Sala,D., Cunningham,T.J., Stec,M.J., Etxaniz,U., Nicoletti,C.,
            Dall'Agnese,A., Puri,P.L., Duester,G., Latella,L. and Sacco,A.
  TITLE     The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage
            progression by inducing mitochondrial respiration
  JOURNAL   Nat Commun 10 (1), 1796 (2019)
   PUBMED   30996264
  REMARK    GeneRIF: Study identified Fam3a, a cytokine-like protein, as a
            major Stat3 downstream effector in muscle stem cells and
            demonstrated that Fam3a is required for muscle stem cell commitment
            and skeletal muscle development. These findings indicate that Fam3a
            is a Stat3-regulated secreted factor that promotes muscle stem cell
            oxidative metabolism and differentiation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1593)
  AUTHORS   Chen,Z., Wang,J., Yang,W., Chen,J., Meng,Y., Geng,B., Cui,Q. and
            Yang,J.
  TITLE     FAM3A mediates PPARgamma's protection in liver ischemia-reperfusion
            injury by activating Akt survival pathway and repressing
            inflammation and oxidative stress
  JOURNAL   Oncotarget 8 (30), 49882-49896 (2017)
   PUBMED   28562339
  REMARK    GeneRIF: FAM3A protects against liver IRI by activating Akt
            survival pathways, repressing inflammation and attenuating
            oxidative stress. Moreover, the protective effects of PPARgamma
            agonist(s) on liver IRI are dependent on FAM3A-ATP-Akt pathway.
REFERENCE   8  (bases 1 to 1593)
  AUTHORS   Chi,Y., Li,J., Li,N., Chen,Z., Ma,L., Peng,W., Pan,X., Li,M.,
            Yu,W., He,X., Geng,B., Cui,Q., Liu,Y. and Yang,J.
  TITLE     FAM3A enhances adipogenesis of 3T3-L1 preadipocytes via activation
            of ATP-P2 receptor-Akt signaling pathway
  JOURNAL   Oncotarget 8 (28), 45862-45873 (2017)
   PUBMED   28515350
  REMARK    GeneRIF: FAM3A enhances the adipogenesis of preadipocytes by
            activating ATP-P2 receptor-Akt pathway. Under obese condition, a
            decrease in FAM3A expression in adipose tissues plays important
            roles in the development of adipose dysfunction and type 2
            diabetes.
REFERENCE   9  (bases 1 to 1593)
  AUTHORS   Song,Q., Gou,W.L. and Zhang,R.
  TITLE     FAM3A attenuates ER stress-induced mitochondrial dysfunction and
            apoptosis via CHOP-Wnt pathway
  JOURNAL   Neurochem Int 94, 82-89 (2016)
   PUBMED   26939760
  REMARK    GeneRIF: FAM3A has a protective role against cytotoxicity via
            regulating the CHOP-Wnt pathway in mitochondria.
REFERENCE   10 (bases 1 to 1593)
  AUTHORS   Wang,C., Chi,Y., Li,J., Miao,Y., Li,S., Su,W., Jia,S., Chen,Z.,
            Du,S., Zhang,X., Zhou,Y., Wu,W., Zhu,M., Wang,Z., Yang,H., Xu,G.,
            Wang,S., Yang,J. and Guan,Y.
  TITLE     FAM3A activates PI3K p110alpha/Akt signaling to ameliorate hepatic
            gluconeogenesis and lipogenesis
  JOURNAL   Hepatology 59 (5), 1779-1790 (2014)
   PUBMED   24806753
  REMARK    GeneRIF: FAM3A plays crucial roles in the regulation of glucose and
            lipid metabolism in the liver, where it activates the PI3K-Akt
            signaling pathway by way of a Ca(2+) /CaM-dependent mechanism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807376.4.
            
            On Mar 31, 2022 this sequence version replaced NM_001379182.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.629490.1,
                                           SRR17784644.384231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AL807376.4         175485-175636       c
            153-225             AL807376.4         175061-175133       c
            226-339             AL807376.4         173377-173490       c
            340-363             AL807376.4         172860-172883       c
            364-542             AL807376.4         170014-170192       c
            543-601             AL807376.4         169824-169882       c
            602-652             AL807376.4         169420-169470       c
            653-737             AL807376.4         169018-169102       c
            738-864             AL807376.4         168808-168934       c
            865-1593            AL807376.4         167093-167821       c
FEATURES             Location/Qualifiers
     source          1..1593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.0 cM"
     gene            1..1593
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /note="FAM3 metabolism regulating signaling molecule A"
                     /db_xref="GeneID:66294"
                     /db_xref="MGI:MGI:1913544"
     exon            1..152
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            153..225
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            226..339
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            340..363
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            364..542
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..960
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /note="isoform 3 is encoded by transcript variant 4;
                     protein FAM3A; family with sequence similarity 3, member
                     A"
                     /codon_start=1
                     /product="protein FAM3A isoform 3"
                     /protein_id="NP_001366111.1"
                     /db_xref="GeneID:66294"
                     /db_xref="MGI:MGI:1913544"
                     /translation="MGHICYHYSEPRARKYKCGLPQPCPEEHLSFRIVSGAANVIGPK
                     ICLEDKMLMSSVKDNVGRGLNIALVNGVSGELLEARAFDMWAGDVNDLLKFIRPLHEG
                     TLVFVASYDDPATKMNEETRKLFSELGSRNAKDLAFRDSWVFVGAKGVQNKSPFEQHM
                     KNSKHTNKYEGWPEALEMEGCIPRRSIAG"
     exon            543..601
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            602..652
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            653..737
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            738..864
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1593
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1534..1539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /note="hexamer: AATAAA"
     regulatory      1557..1562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1558
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
                     /note="major polyA site"
     polyA_site      1593
                     /gene="Fam3a"
                     /gene_synonym="1810037C20Rik"
ORIGIN      
        1 gtgaggacct gcggacctac agcacagcct atgggcctat ggcggagcga cgcctgtggg
       61 ctgtggcctt ctgcgggcgg ccattgtcgt gcctgataag cttttctacg tgactcactt
      121 gcttcaccta gccggcagag cgagacaact ggaacccaca gttcccaaac agtgcacctg
      181 cgggagatct caacccagct ggagaagtgg acatgaggtt ggcaggcccc ctgcgcatcg
      241 tggccctaat catcattatg ggtctcacct ggatcctagt caccatcctc ctaggtggtc
      301 ctggtgttgg ccttcctcga attcagcagt tcttcaccag cccagagaac tcagtgactg
      361 cagatctcag gtgacaccag ggccaggcat atgggtcaca tctgctatca ttactcagaa
      421 ccaagggcca ggaagtacaa atgcggcctg ccccagcctt gtcctgaaga gcacctgagc
      481 tttcgaatag tcagcggggc tgccaatgtc atcgggccca agatctgcct cgaggacaag
      541 atgctcatga gcagcgtcaa agacaatgtg ggccgtggcc tgaacatcgc cctggtgaat
      601 ggggtcagtg gtgagctcct agaagccaga gcctttgaca tgtgggctgg agatgtcaat
      661 gatctcttga agttcatccg gccactgcat gaaggtaccc tggtgtttgt ggcttcctat
      721 gatgatccag ctaccaagat gaatgaagag accaggaagc ttttttctga gctgggcagc
      781 aggaatgcca aggatctagc cttccgtgac agctgggtgt ttgtgggagc caaaggtgtg
      841 cagaacaaga gcccctttga gcagcatatg aagaacagta agcacaccaa caagtatgag
      901 ggctggccag aggccctgga gatggaaggc tgtatccctc gaaggagcat agcgggctag
      961 cacagcagag ctctgggacc agactgaagg aggcagcatg gcaccagtgt caggtggaga
     1021 ctgtgcccca tgcccaggca tgaggctccc cctccctaac acattagggc ttgaaagtgg
     1081 cctcaaggtg atgggggctg cagggctggc ccatttcatt ttgtcaggga gcttaggtac
     1141 ctgtgtcctt gttttcctaa agctgatccc acagtcagtt cccacccagc cccttcctct
     1201 gcccctcatg tgtcatcttc tatttctctt tttttttcat cttctatttc ttgagtgccc
     1261 cccagaggca agggtcttca atgcttgccc ctgtcactgg agcaggtatt gggtaggttg
     1321 ggacatcttc aagaaactct ccctcccaga ggcactgcac tggtatccaa ccctgttttc
     1381 agtgatcctt taagccaaat cagaactgat tggatgactt ctgcaagcct gaatggagca
     1441 atctggcctt aagtgcccaa gtagctggag tccaatcaga gttcctcaca aggtgtctgt
     1501 cagagggctc accttctaaa tgacctgttt gttaataaac taatttcttg cagtggaata
     1561 aagtgtattc agatgtcctc agtggagagt caa
//
