LOCUS       NP_083258                624 aa            linear   ROD 01-MAY-2024
DEFINITION  protein FAM234B isoform 2 [Mus musculus].
ACCESSION   NP_083258
VERSION     NP_083258.2
DBSOURCE    REFSEQ: accession NM_028982.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 624)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 624)
  AUTHORS   Yu,X., Bauer,K., Koczan,D., Thiesen,H.J. and Ibrahim,S.M.
  TITLE     Combining global genome and transcriptome approaches to identify
            the candidate genes of small-effect quantitative trait loci in
            collagen-induced arthritis
  JOURNAL   Arthritis Res Ther 9 (1), R3 (2007)
   PUBMED   17244351
REFERENCE   3  (residues 1 to 624)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131718.5, AK039401.1 and BC079676.1.
            
            On Jun 10, 2003 this sequence version replaced NP_083258.1.
            
            Transcript Variant: This variant (2) uses an alternate splice
            junction in the 3' end compared to variant 1, that causes a
            frameshift. The resulting isoform (2) has a shorter and distinct
            C-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079676.1, AK039401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 66.02 cM"
     Protein         1..624
                     /product="protein FAM234B isoform 2"
                     /note="protein FAM234B"
                     /calculated_mol_wt=66900
     Region          1..91
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BYI8.1)"
     Site            16
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A2RU67; propagated from
                     UniProtKB/Swiss-Prot (Q8BYI8.1)"
     Site            26
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:A2RU67; propagated from
                     UniProtKB/Swiss-Prot (Q8BYI8.1)"
     Site            30
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BYI8.1)"
     Site            33
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BYI8.1)"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BYI8.1)"
     Site            107..127
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BYI8.1)"
     Region          132..>265
                     /region_name="PQQ"
                     /note="Outer membrane protein assembly factor BamB,
                     contains PQQ-like beta-propeller repeat [Cell
                     wall/membrane/envelope biogenesis]; COG1520"
                     /db_xref="CDD:441129"
     CDS             1..624
                     /gene="Fam234b"
                     /gene_synonym="8430419L09Rik; mKIAA1467"
                     /coded_by="NM_028982.4:79..1953"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS39681.1"
                     /db_xref="GeneID:74525"
                     /db_xref="MGI:MGI:1921775"
ORIGIN      
        1 matvlsralk lpgkkspdlg eydpltqads deseddlvln lqqknggvkn gksalgdlpe
       61 pdsdadvaga akphlsevtp egfpseplgg leqkatsplv syvrtsvfll tlvismvlvl
      121 lcaflipcpp rdlhsawsrr lgsqgggdls pleladvnrd glrdvlltfv ttrngteggv
      181 gsqptadlvc lsgmngstlw ssplpeeaqd vtcldlipgs vakticlvtg trkmlsafna
      241 tsgkvlwtln pnhlsngtla apvvvlpdld edgvrdlvvl aigelqpdlc fllvsgrtgs
      301 pvgrpvkyni vgvgnligpq vyitasgavy ilfgfgniqa valrdifvqa qnrdssppsl
      361 qieepewekh rsvnlselid vysdgvellq lvkapdsnss sllittrqgl vllrgqdltp
      421 hwklnlqglr sqptpgyftd dqtldfllqt qdgdgmkkmt vvdggsgsiv wsysipchmk
      481 etpttsaits dqksvflfwa ealtaaslss ddssgaeppg lyhlyllhpa fpsilldlsn
      541 ttgivtasev gindiwkdaf yvtrttgmsp eghptslvvs klslrwalme gqmvqlkett
      601 pkigrgelrr flsrikfvds pyqi
//
