LOCUS       NM_029455               1858 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus family with sequence similarity 227, member B
            (Fam227b), mRNA.
ACCESSION   NM_029455
VERSION     NM_029455.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929175.6 and AL845292.4.
            
            On Feb 15, 2013 this sequence version replaced NM_029455.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849384 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AL929175.6         21499-21592         c
            95-135              AL929175.6         15819-15859         c
            136-189             AL929175.6         13858-13911         c
            190-421             AL845292.4         181041-181272       c
            422-489             AL845292.4         179199-179266       c
            490-525             AL845292.4         178775-178810       c
            526-627             AL845292.4         178186-178287       c
            628-726             AL845292.4         175178-175276       c
            727-828             AL845292.4         173189-173290       c
            829-955             AL845292.4         170198-170324       c
            956-1090            AL845292.4         155095-155229       c
            1091-1188           AL845292.4         61432-61529         c
            1189-1354           AL845292.4         58023-58188         c
            1355-1430           AL845292.4         43162-43237         c
            1431-1505           AL845292.4         42091-42165         c
            1506-1575           AL845292.4         40451-40520         c
            1576-1858           AL845292.4         37678-37960         c
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..1858
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /note="family with sequence similarity 227, member B"
                     /db_xref="GeneID:75823"
                     /db_xref="MGI:MGI:1923073"
     exon            1..94
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            95..135
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1713
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /codon_start=1
                     /product="protein FAM227B"
                     /protein_id="NP_083731.2"
                     /db_xref="CCDS:CCDS50697.1"
                     /db_xref="GeneID:75823"
                     /db_xref="MGI:MGI:1923073"
                     /translation="MELPVPQKLPDPPRSFDEFLKSQNWDYWPRDVHFRDSDIWEDTL
                     KKLEEAISYTSIYSYLWTNVPRLYDIVDSLESKLKESSHLLQHHASRLFESDKMISKK
                     RSYTNLERYKAFVKEHYRPKKIALSDRMETEKNIEGCTFLFNQNEVTQLPRHLDAKQI
                     YLYVLKTHNFEEKVFKVWKTHVLSDCSIALLHDSFWWWFLHKFKPDKRDEDFLFDRIA
                     ESYVTLFIKIPLRRKDAFFKMYPDCLTQAVYTTFQESFPESCSLFNDKFKEDLGNTIF
                     LWLSGLKPETGFWTHWKLQDLCTTTIHGSRRVPVKLRRSVIPSQEHIPGIRDLKIEDI
                     LKNPRAYAMPKLMKESVASKAATKPSHYRSLGPEFHKVLFDFGGQSPLILYYLKMHEL
                     GGISVTHNPKGTKFTKILREPSPAPTYCDIIRDAKRKFADNKKDFKRVKQRIKDDIKF
                     LREQQELIDKELDRIQAKASKNLQEVKNEFENFLHKQRVEAKLKEEYGGSTSASESPQ
                     SMQSPQSSSSFPTISEDFNNVEEG"
     exon            136..189
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            190..421
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            422..489
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            490..525
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            526..627
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            628..726
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            727..828
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            829..955
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1090
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1188
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1354
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1430
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1505
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1575
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1858
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1788..1793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1806
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
     regulatory      1831..1836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1854
                     /gene="Fam227b"
                     /gene_synonym="4930525F21Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaaggaaccg tcagcttcct gctgtgccgc ccgttgtggg cccccagcgc aactggggac
       61 gtgttccgga acagcctttt cgaaagtagt ttctgtcaag ggaaggttca gtggatggag
      121 ttgcctgtcc ctcagaaatt accggatccc ccaaggagct ttgatgaatt cttaaagtct
      181 caaaactggg attattggcc cagggatgtt cattttagag atagtgatat atgggaagat
      241 actctgaaaa aactagaaga ggctatttca tatacttcta tttattctta tctgtggacc
      301 aacgtgcctc ggctgtatga tatcgtcgac agcttggagt caaaattaaa ggaaagctca
      361 catcttttgc aacaccatgc ctccagatta tttgaaagtg acaaaatgat ttccaagaaa
      421 aggtcatata caaacctgga acgctacaaa gcatttgtaa aagaacacta taggccaaag
      481 aaaatcgcgc tttcagatcg aatggagaca gagaagaata tagagggttg caccttttta
      541 ttcaaccaaa atgaagtgac acaattaccc agacatttgg atgctaaaca aatttatctt
      601 tatgttttaa aaacacataa ctttgaggaa aaggtattta aagtctggaa aacccatgtt
      661 ctctcagatt gctccattgc tcttttgcat gactcctttt ggtggtggtt tctacataaa
      721 ttcaagcctg acaaaagaga tgaagatttc ttgtttgata gaattgcaga aagttatgtc
      781 acacttttca taaaaatacc tctaaggaga aaggatgcat tctttaagat gtatcctgac
      841 tgcttgactc aagctgtcta cacaaccttc caggaatcat ttccagaatc ctgcagcctc
      901 ttcaatgata aattcaaaga agacctagga aacacgattt ttctttggtt gtcaggtcta
      961 aagcctgaaa ctggcttttg gacccactgg aaactgcaag acctctgcac aaccaccatt
     1021 catggcagca ggcgtgtacc tgtgaagttg agaaggagcg tcattcccag ccaggagcac
     1081 ataccaggca ttagagactt gaaaatcgag gatattctaa agaacccaag agcgtacgca
     1141 atgcctaaac tcatgaaaga gtccgtagca tcaaaagcag caaccaagcc ttcccactat
     1201 aggagcttgg gtccagagtt tcacaaagtt ctctttgact ttggaggcca gagcccactg
     1261 attctgtact atcttaagat gcacgagcta ggaggtattt ccgtcactca caatccgaag
     1321 ggaaccaagt tcaccaagat actccgggag ccatcacctg ctccaacata ctgcgacatc
     1381 atcagggatg ccaaaagaaa atttgcagat aacaagaagg attttaagag agtaaagcaa
     1441 agaatcaaag atgatatcaa gttcctgaga gagcaacagg aactaattga caaggagctt
     1501 gaccggatcc aagcaaaggc ttccaaaaat ctccaagaag tcaaaaatga atttgagaat
     1561 tttctacata aacaacgtgt tgaggcaaaa ctcaaggagg aatatggagg atcaacatca
     1621 gcatcagagt cgccacagtc gatgcagtca ccacaatcat catcgtcatt tcctactata
     1681 tcagaagact tcaacaatgt ggaagagggc taagggaagc cagcagtggc cgccattcaa
     1741 gagcaacaca cagttcagtt gtatcagttt aattggagca gtgttcaatt aaaagtacat
     1801 tttgctgttc atcttttaaa tcttcatatc aataaatctt aatcatacct caaaggtc
//
