LOCUS       NM_001004180            2717 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus family with sequence similarity 222, member A
            (Fam222a), mRNA.
ACCESSION   NM_001004180 XM_485671
VERSION     NM_001004180.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2717)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2717)
  AUTHORS   Tzani,A., Haemmig,S., Cheng,H.S., Perez-Cremades,D.,
            Heuschkel,M.A., Jamaiyar,A., Singh,S.A., Aikawa,M., Yu,P.B.,
            Wang,T., Sun,Y., Feinberg,M.W. and Plutzky,J.
  TITLE     FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome,
            Is a Novel Determinant of Endothelial Biology and
            Angiogenesis-Brief Report
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (1), 143-155 (2024)
   PUBMED   37942611
  REMARK    GeneRIF: FAM222A, Part of the BET-Regulated Basal Endothelial
            Transcriptome, Is a Novel Determinant of Endothelial Biology and
            Angiogenesis-Brief Report.
REFERENCE   3  (bases 1 to 2717)
  AUTHORS   Choquet,H., Melles,R.B., Anand,D., Yin,J., Cuellar-Partida,G.,
            Wang,W., Hoffmann,T.J., Nair,K.S., Hysi,P.G., Lachke,S.A. and
            Jorgenson,E.
  CONSRTM   23andMe Research Team
  TITLE     A large multiethnic GWAS meta-analysis of cataract identifies new
            risk loci and sex-specific effects
  JOURNAL   Nat Commun 12 (1), 3595 (2021)
   PUBMED   34127677
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2717)
  AUTHORS   Yan,T., Liang,J., Gao,J., Wang,L., Fujioka,H., Zhu,X. and Wang,X.
  CONSRTM   Alzheimer Disease Neuroimaging Initiative
  TITLE     FAM222A encodes a protein which accumulates in plaques in
            Alzheimer's disease
  JOURNAL   Nat Commun 11 (1), 411 (2020)
   PUBMED   31964863
  REMARK    GeneRIF: Study reports FAM222A as a putative brain atrophy
            susceptibility gene. The protein encoded by FAM222A is
            predominantly expressed in the CNS and is increased in brains of
            patients with Alzheimer's disease (AD) and in an AD mouse model. It
            accumulates within amyloid deposits, physically interacts with
            amyloid-beta (Abeta) via its N-terminal Abeta binding domain and
            facilitates Abeta aggregation.
            Erratum:[Nat Commun. 2022 Jul 11;13(1):4006. doi:
            10.1038/s41467-022-31711-8. PMID: 35817794]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2717)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC057022.1.
            
            On Sep 9, 2004 this sequence version replaced XM_485671.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057022.1, BX529316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2717
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     gene            1..2717
                     /gene="Fam222a"
                     /note="family with sequence similarity 222, member A"
                     /db_xref="GeneID:433940"
                     /db_xref="MGI:MGI:3605543"
     exon            1..174
                     /gene="Fam222a"
                     /inference="alignment:Splign:2.1.0"
     exon            175..301
                     /gene="Fam222a"
                     /inference="alignment:Splign:2.1.0"
     exon            302..2693
                     /gene="Fam222a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2674..2679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam222a"
                     /note="hexamer: AAGAAA"
     polyA_site      2686
                     /gene="Fam222a"
     polyA_site      2693
                     /gene="Fam222a"
                     /note="major polyA site"
ORIGIN      
        1 ccggacgcag ggatcgccct caccgacggc tcccctttcc atacgaagaa agacatcggc
       61 cccctaaggg ggcctttctc cagcaatctt tatcacccct gcatggccgc aacccgcaga
      121 tcggagcgtc gtggcctctg agatttggtg cccttcgtcc gactgcctga tacggattcc
      181 tgctgcggaa cgcgcccgcc cagggctccc agctcagcca tgctggcctg tctgcagagg
      241 actcagaacc caccaggcca acacctggcc tgtccaagca agagcctgga tctgcgcaag
      301 tgtgagtcag tggccagctc tatgcattcc tcgcgctacc ctagcccagc ggagctggat
      361 gcctacgcgg agaaggtagc caacagtccc ctgtccatca agatcttccc caccaacatc
      421 cgagtgccgc agcacaagca cctgagccgc acggtcaatg gctacgacac cagcggccag
      481 cgttacagcc cctaccctca gcacaccgcc ggctaccagg gccttctggc catcgtcaag
      541 gccgccgtct cctcgagtgc tcatgcgccc gccggccacc ccaaaagcgt gctcaagagt
      601 gtggagggca agcggactaa actgtcgccg gccaccgtgc aggtgggcat tgcgccttac
      661 ccagtgccca gcaccctggg gcccttggcc tacccgaagc cacccgaggc acctgcacca
      721 ccgcccagcc tgcctgcagc agccactgcc acctctgtga tccctctgcc cggccggggc
      781 cttcccctcc ccccctccaa cctaccctct atccatagca tcctgtacca gctcaaccag
      841 caatgccagg ccccgggtgc tgcaccaagc gcctgtcagg gcgtggctgt gccccacccc
      901 agtccagcta agcatggccc agtccccagc tttcccaacc tggcttactc ggccacagcc
      961 ggtctgccag actgccggaa gggcacagaa ctgagccagg gagccacccc agccctgaca
     1021 ctggctgggg ccaccaaacc tgcagggtat gcagaaggtg gcctggatta cctgctgtgg
     1081 ccacagaagc cacccccacc cccaccccag ccgctgcggg cctacagtag cagcaccgta
     1141 gccggcaagt cccagtcccc agagatttgt ggcgggaggg ccttcgaaag ggccaacggg
     1201 tcgccccaca actgcggaat ggggctgccc ggcagcttca ccgtgggcca gtacttcgct
     1261 gccccttgga acagtgttct ggtgacacct accagtgact gctacaatcc agcagctgct
     1321 gccgtagtga cagagctggc accaggagcc gcccgggagc tagccgggcc tcctggagac
     1381 gtactctcgg gcctgaccag caagagtgtg tgtaacacag cggtgctgag cagcagcctc
     1441 cagtcgctgg agtatctcat caacgacatc cggccaccct gcatcaaaga acagatgctg
     1501 ggtaagggtt acgagacggt ggccgtgccc cggctgctgg accaccagca cgcccacatc
     1561 cgcctacctg tctacagata aggtctgccc tgcggacaca cggacagggt gatgggggtt
     1621 gccaggccat agcacagggc gggaagctag cagggcgccc cgcccgccct gtgtccacgg
     1681 ggaagccagg ctggttacct cctcacttca gtgggcaggc gggttgacct cacacaccag
     1741 ggcttctttc ctctcccgct tgctgcccca ggcagcaggg agggtcccag gctggccacg
     1801 aggctccttc atctttcatc caggcaggga aagaggacct tctgccaaca agaagttcct
     1861 tctgggtctc cagcagaggg cgctccagtc atcccgtgtc atacacgggg tctctatcca
     1921 caatctccca gtccctgggt ccaaagtgcc ccaccccacc aactaatcca ggtgaagacc
     1981 gccctgactc cacaccccca gaggtctcag gactaccccc cccccgttcc tgctgactct
     2041 ccccctaccc acccaccctc cctactagga atcacgccca acctacccgg tacgccccag
     2101 accaacctct tctccatccc tacactacat ctcacagggc tgctgggaac agttggtgcg
     2161 ttgcacaagg gcaccttgcc caaggagact ccacacacat cctagatttg tgtatttatt
     2221 acagttgtct gcatttcaag gaagggacac tatcttccta ttcgcacaaa gatgtcacgg
     2281 ggggctaaca agggacctgt aaattcaggc tccattcaca aggacggtct tgccttcttc
     2341 gcatctctgg gtctcctggg gaccagtggg agggtgacct ggctgtaact ggaataccca
     2401 atccagctcc cgttctcatt ccccccaccc ccaccgcact gctgcggggc gtggggaaga
     2461 gagaagccca ggaagtcctc aaggcctgca gtccccgggc cctgccggcc ccaggcgctc
     2521 cggaaagcgg tactgtatct cgccaaggcc tgtctgagca ctaagtgcat ttacaaagct
     2581 ctgagaatgt tttttttata ctaaaattga ccattatatt ctactgtgag aagtgcagtc
     2641 tgtctgcact atattgtttt aaaaacgaag agaaagaaaa aaaacggaaa acaaaaaaaa
     2701 aaaaaaaaaa aaaaaaa
//
