LOCUS       NM_172727               2096 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus family with sequence similarity 221, member A
            (Fam221a), transcript variant 1, mRNA.
ACCESSION   NM_172727
VERSION     NM_172727.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY145860.1, AK052323.1 and BC039996.1.
            
            On Feb 18, 2010 this sequence version replaced NM_172727.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140239.1, AK052323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                BY145860.1         1-87
            88-1426             AK052323.1         2-1340
            1427-2096           BC039996.1         754-1423
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.87 cM"
     gene            1..2096
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
                     /note="family with sequence similarity 221, member A"
                     /db_xref="GeneID:231946"
                     /db_xref="MGI:MGI:2442161"
     exon            1..235
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1076
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C7orf46 homolog; protein FAM221A"
                     /codon_start=1
                     /product="protein FAM221A isoform 1"
                     /protein_id="NP_766315.1"
                     /db_xref="CCDS:CCDS20126.1"
                     /db_xref="GeneID:231946"
                     /db_xref="MGI:MGI:2442161"
                     /translation="MERLTLPPGGAEAVDEYLEYRRIVGEDDGGKLFTPEEYEEYKKK
                     VLPMRLQNRLFVSWRSPTGMDCKLVGPETLCFCTHRYKQHKTDFETIPQQRPIALPCR
                     VSGCRCKAYHYVPLNGTQPIRCRCKHFADQHSAALGFTCNACSKCSGFHSCYTCACGQ
                     PAYAHDTVVETRQERLAQGKPVGRDVPYAAMGGLTGFSSLAEGYMRLDDSGIGAPSVE
                     VLDSAVSAMDHPFLRAMHAPSTSSPQPLAGGNEVGPSTQLSSLRKPEEDDMAYFERQY
                     QERIKLEKAAKQKGKVPPLPSTKPS"
     exon            236..409
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            410..600
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            601..807
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            808..924
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1007
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..2096
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1453..1458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1471
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
                     /note="major polyA site"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
                     /note="hexamer: AATACA"
     polyA_site      2096
                     /gene="Fam221a"
                     /gene_synonym="D330028D13Rik"
ORIGIN      
        1 ggtgaaacag aggggcgggg cccaggacgg ggcggggcta agggggcggg accgggcagt
       61 ttctggcggc aaggctgttt gttactcgcg caggtctggt ggatcctgcc tggcagctgc
      121 agggcggact caagagctcg aggcaagggc tcctttcgct tcccgcggcc atggagcggc
      181 tgacgttgcc tcctggtggt gcggaggcag tggacgagta cttggagtac cggagaattg
      241 ttggtgagga tgatggaggg aaacttttta ctcctgaaga atatgaagaa tacaagaaaa
      301 aagttttacc catgcgttta cagaacagat tatttgtgag ttggcggtca ccaacaggaa
      361 tggattgcaa acttgttggc ccggagacat tgtgtttttg tacccatagg tataaacagc
      421 acaaaactga ctttgaaacg atcccacagc agcgtcccat tgccctgccg tgccgagtga
      481 gtggttgccg gtgcaaggct taccactatg tccctctgaa tggtacccag cctattcgct
      541 gcaggtgcaa gcactttgct gatcagcaca gtgccgctct tggcttcaca tgcaatgcct
      601 gctccaagtg ctcgggcttc cacagctgct acacttgtgc ctgtggccag ccggcatatg
      661 cccacgacac agtggtggaa acacggcaag aaaggctggc tcagggaaaa ccggtaggac
      721 gggatgttcc ttatgcggca atgggaggtt taactggttt cagctccctg gcagaaggct
      781 acatgcgctt agatgacagt ggcatcggtg caccctcggt tgaagttttg gactctgcgg
      841 tttcggccat ggaccatccg ttcctaagag ccatgcacgc accatctact tcttctccac
      901 agccactagc aggcggtaat gaagtaggtc caagcactca gctttcttcc ttaaggaaac
      961 ctgaagagga tgatatggca tactttgaaa gacagtacca ggagaggata aagctggaaa
     1021 aggctgctaa gcagaaagga aaagtgccac cgctgccgag cacaaagcca tcgtgaagtc
     1081 tggtgaacag atcgagccgt catccagatg catcttctat ttatttattt tctcccaata
     1141 tatatacttt ctaattgtgt aaatatgtcc ttttgaattg gcttagctta ttgaaacaag
     1201 tgaagtgaat ttttgttttt tgtcagaact catgacttaa agcactttct atgcctttta
     1261 aagatgtcta ttgggtagca cagcctggcg ttgggatcac ggtattcttg ccttaccgtg
     1321 tgtatgctcg ctctctctct cttagcaagt tttatgttat ttttatgtga ttcaaacccc
     1381 aaaaatacag taaatatttt tagtttatca taatttaatt ttttttagtc tacctaaaaa
     1441 attaaggata ttattaaagg ttttaaacaa atacataggg tcagattttt cattcaatgt
     1501 agcaagactt ggcttggata tcctgttgtt gcccagagtc agggtgacca tgtggctggg
     1561 cagtgctgca ctcttctgtg cccttagtga cagttgtcct gctggctcac ccgatgtgac
     1621 cattgtgctt tcaggcctgg gcagcgccta ggttccaggt cctcctccct tcaataggac
     1681 aaccagcgag ggctctagca atggctccat gcttctactg aactgctggg cctcacctcc
     1741 cagttggcta aggactggcc ctacctgttc tttgttcgct gcccagtgct gcttctccag
     1801 tttttaacag tctcctaccc ctgagtttct gagcccttaa tcaagtatta tggccccagc
     1861 cataccaccc acccacagag tcaccctgcc tttgggtagg agtcttagca gtaacccagt
     1921 atttatggtg cttcggaaac cagaaacatt gaatcagacc aattactagt tgcaatatgg
     1981 atttgcatgt aaagctgttt gtgcaacacc ccccacccca aaaccccaaa actgtatgac
     2041 atattgttgt ttgcagtgcc acctcaatga ataaaaatac aaggagagat gggaaa
//
