LOCUS       NM_153782               2523 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus FAM20A, golgi associated secretory pathway
            pseudokinase (Fam20a), mRNA.
ACCESSION   NM_153782
VERSION     NM_153782.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2523)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2523)
  AUTHORS   Liu,L., Yao,L., Lu,Z., Jiang,L., Zhang,X., Liu,X., Zhang,W.,
            Luan,X., Zhang,S., Xu,W., Wang,T., Zhang,F., Wei,X., Da,J.,
            Wang,J., Zhang,J., Li,Y., Jin,H. and Zhang,B.
  TITLE     Epithelial-specific deletion of FAM20A leads to short root defects
  JOURNAL   Gene 884, 147731 (2023)
   PUBMED   37625561
  REMARK    GeneRIF: Epithelial-specific deletion of FAM20A leads to short root
            defects.
REFERENCE   3  (bases 1 to 2523)
  AUTHORS   Yin,M., Liu,X., Da,J., Yuan,H., Jin,H., Miao,N., Liu,L., Wang,A.,
            Zhang,B. and Li,Y.
  TITLE     The effect and mechanism of gene Fam20a on the development and
            function of salivary glands in mice
  JOURNAL   Arch Oral Biol 137, 105367 (2022)
   PUBMED   35278791
  REMARK    GeneRIF: The effect and mechanism of gene Fam20a on the development
            and function of salivary glands in mice.
REFERENCE   4  (bases 1 to 2523)
  AUTHORS   Li,L., Saiyin,W., Zhang,H., Wang,S., Xu,Q., Qin,C. and Lu,Y.
  TITLE     FAM20A is essential for amelogenesis, but is dispensable for
            dentinogenesis
  JOURNAL   J Mol Histol 50 (6), 581-591 (2019)
   PUBMED   31667691
  REMARK    GeneRIF: Resulta indicate that family with sequence similarity 20
            member A (FAM20A) is essential for amelogenesis, but is dispensable
            for dentinogenesis.
REFERENCE   5  (bases 1 to 2523)
  AUTHORS   Li,L.L., Liu,P.H., Xie,X.H., Ma,S., Liu,C., Chen,L. and Qin,C.L.
  TITLE     Loss of epithelial FAM20A in mice causes amelogenesis imperfecta,
            tooth eruption delay and gingival overgrowth
  JOURNAL   Int J Oral Sci 8 (2), 98-109 (2016)
   PUBMED   27281036
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2523)
  AUTHORS   Vogel,P., Hansen,G.M., Read,R.W., Vance,R.B., Thiel,M., Liu,J.,
            Wronski,T.J., Smith,D.D., Jeter-Jones,S. and Brommage,R.
  TITLE     Amelogenesis imperfecta and other biomineralization defects in
            Fam20a and Fam20c null mice
  JOURNAL   Vet Pathol 49 (6), 998-1017 (2012)
   PUBMED   22732358
  REMARK    GeneRIF: Fam20a null mice develop amelogenesis imperfecta and
            ectopic mineralization of muscular arteries and the gene is highly
            expressed in ameloblasts and the parathyroid gland
REFERENCE   7  (bases 1 to 2523)
  AUTHORS   Ishikawa,H.O., Xu,A., Ogura,E., Manning,G. and Irvine,K.D.
  TITLE     The Raine syndrome protein FAM20C is a Golgi kinase that
            phosphorylates bio-mineralization proteins
  JOURNAL   PLoS One 7 (8), e42988 (2012)
   PUBMED   22900076
REFERENCE   8  (bases 1 to 2523)
  AUTHORS   O'Sullivan,J., Bitu,C.C., Daly,S.B., Urquhart,J.E., Barron,M.J.,
            Bhaskar,S.S., Martelli-Junior,H., dos Santos Neto,P.E.,
            Mansilla,M.A., Murray,J.C., Coletta,R.D., Black,G.C. and Dixon,M.J.
  TITLE     Whole-Exome sequencing identifies FAM20A mutations as a cause of
            amelogenesis imperfecta and gingival hyperplasia syndrome
  JOURNAL   Am J Hum Genet 88 (5), 616-620 (2011)
   PUBMED   21549343
REFERENCE   9  (bases 1 to 2523)
  AUTHORS   An,C., Ide,Y., Nagano-Fujii,M., Kitazawa,S., Shoji,I. and Hotta,H.
  TITLE     A transgenic mouse line with a 58-kb fragment deletion in
            chromosome 11E1 that encompasses part of the Fam20a gene and its
            upstream region shows growth disorder
  JOURNAL   Kobe J Med Sci 55 (4), E82-E92 (2010)
   PUBMED   20847595
  REMARK    GeneRIF: possible link between Fam20a mutation and growth disorder
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2523)
  AUTHORS   Nalbant,D., Youn,H., Nalbant,S.I., Sharma,S., Cobos,E., Beale,E.G.,
            Du,Y. and Williams,S.C.
  TITLE     FAM20: an evolutionarily conserved family of secreted proteins
            expressed in hematopoietic cells
  JOURNAL   BMC Genomics 6, 11 (2005)
   PUBMED   15676076
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL691448.24 and AL732387.10.
            
            On Jul 4, 2018 this sequence version replaced NM_153782.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029169.1, SRR14777535.1577799.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-927               AL691448.24        44914-45840         c
            928-1112            AL691448.24        8945-9129           c
            1113-1163           AL691448.24        8240-8290           c
            1164-1242           AL691448.24        6439-6517           c
            1243-1292           AL691448.24        2001-2050           c
            1293-1335           AL732387.10        1-43
            1336-1451           AL732387.10        513-628
            1452-1632           AL732387.10        1065-1245
            1633-1742           AL732387.10        2447-2556
            1743-1824           AL732387.10        3212-3293
            1825-1884           AL732387.10        3717-3776
            1885-2523           AL732387.10        4835-5473
FEATURES             Location/Qualifiers
     source          1..2523
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 72.37 cM"
     gene            1..2523
                     /gene="Fam20a"
                     /note="FAM20A, golgi associated secretory pathway
                     pseudokinase"
                     /db_xref="GeneID:208659"
                     /db_xref="MGI:MGI:2388266"
     exon            1..927
                     /gene="Fam20a"
                     /inference="alignment:Splign:2.1.0"
     CDS             524..2149
                     /gene="Fam20a"
                     /note="ortholog of human family with sequence similarity
                     20, member A FAM20A; protein FAM20A; pseudokinase FAM20A"
                     /codon_start=1
                     /product="pseudokinase FAM20A precursor"
                     /protein_id="NP_722477.1"
                     /db_xref="CCDS:CCDS25584.1"
                     /db_xref="GeneID:208659"
                     /db_xref="MGI:MGI:2388266"
                     /translation="MPGLRRDRLLALLLLGALFSADLYFHLWPQVQRQLRPGERPAAC
                     PCSGRAPSASLHSAAASRDLGTASHNFSGALPRVEHPSRGHPAPRSKLQALFAHSLYQ
                     VLEDPPLLGPEDWLLASQEALRYYRRKVARWNRRHKIYKEQFNLTSLDPPLQFRPEAS
                     WVQFHLGINSHGLYSRSSLAISKLLHDMRHFPTISADYSQDEKALLGACDCSQIVKPS
                     GVHLKLVLRFSDFGKAMFKPMRQQREEETPEDFFYFIDFQRHNAEIAAFHLDRILDFR
                     RVPPTVGRLVNVTKEILEVTKNEILQSVFFVSPANNVCFFAKCPYMCKTEYAVCGNPH
                     LLEGSLSAFLPSLNLAPRLSVPNPWIRSYSLSGKEEWELNPLYCDTVKQIYPYNSSNR
                     LLGIIDMAVFDFLIGNMDRHHYEMFTKFGDDGYLIHLDNARGFGRHSQDEISILAPLA
                     QCCMIKRKTLLHLQLLAQADYRLSDVMRESLLEDQLSPVLTEPHLLALDRRLQIILKT
                     VEDCIEAHGERRVIAEGSAQRSAPDSGQANLTS"
     exon            928..1112
                     /gene="Fam20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1163
                     /gene="Fam20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1242
                     /gene="Fam20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1335
                     /gene="Fam20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1451
                     /gene="Fam20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1632
                     /gene="Fam20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1742
                     /gene="Fam20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1824
                     /gene="Fam20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1884
                     /gene="Fam20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2523
                     /gene="Fam20a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2503..2508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam20a"
                     /note="hexamer: AATAAA"
     polyA_site      2523
                     /gene="Fam20a"
                     /note="major polyA site"
ORIGIN      
        1 ctgagtcgcc cctgctttgt caactctgcg ttccctccgc tcctgccagc ccggggcaca
       61 ggagtccctg ccgcctgcag gaggagccgc tggatctgtc tcagcagctg cggagagaca
      121 gcatccttgg aagagacgcc ccgggctacg cagtctctcc agcctcctcc tagggggcga
      181 gagctccttt gcgctccctc cagtgatcgc cctctacacg gccaccagag ccagcactcc
      241 tccacgggac ctccccacct gagcggtccc tggcagaggg ggtcacaggg caaagagact
      301 caaataacaa ccgggtagcc agggaacccc aaccctgcct ctctactggg caagaaaaga
      361 cgacgctgtc aacactgtga gcttcctgca cgcggtcccc aagttcaggg aagacaccct
      421 tccaggaaga gctaatcccc tgtgtgagca ttccagcctc ctccggactc caggagcttc
      481 ttccgtctgc accccaagtg tttcccgggt gtccgcttgg gccatgcccg ggctgcgcag
      541 ggaccgcctg ctggccctgc tgctcctggg cgcgctcttc tccgccgacc tctacttcca
      601 cctctggccg caagtgcagc gccagctccg gccgggcgag cgccccgccg cctgcccgtg
      661 ctctggccgc gccccctccg cgtctctaca ctcagccgca gcctcccgag accttggcac
      721 agcctcgcac aacttttcag gagctttgcc ccgggttgag catcccagcc gcggccaccc
      781 tgccccgcgc tctaagctgc aggccctctt cgcccactcg ctctaccaag tcctggagga
      841 tccgcctctc ctgggacccg aagactggct cctggccagc caggaggcgc tgcggtatta
      901 ccggaggaag gtggcccgct ggaacagacg gcacaagata tacaaagaac aattcaacct
      961 tacctccttg gatcccccgc tccagtttcg accagaggcc agctgggtcc agttccactt
     1021 ggggatcaac agccacgggc tgtactccag gtccagcctt gccatcagca agctcctcca
     1081 tgacatgaga cacttcccca ccatcagtgc tgattacagc caggatgaaa aagccttgct
     1141 aggggcctgt gactgctcac agattgtgaa acccagtggg gtccacctga aattggttct
     1201 gaggttctcg gacttcggga aagccatgtt caaacccatg agacagcagc gagaggagga
     1261 gacgcctgag gacttcttct atttcataga ctttcagaga cacaatgctg agatcgcagc
     1321 tttccacctg gacaggattc tggacttccg acgggtaccg ccaacagtag ggaggctagt
     1381 gaatgtcacc aaggaaatcc tagaggtcac caagaacgag atcctacaga gtgtgttctt
     1441 tgtgtctcca gctaacaacg tgtgcttctt cgccaagtgt ccgtacatgt gcaagaccga
     1501 gtacgctgtc tgtggcaacc cacacctgct ggaaggctcc ctctccgcct tcctgccatc
     1561 cctcaaccta gcccccagac tgtctgtgcc caacccctgg atccgttcct actcgctgtc
     1621 aggaaaagag gagtgggagc tcaaccccct ttactgtgac acagtcaagc agatctaccc
     1681 gtacaacagc agcaacagac tcctcggcat cattgacatg gccgtctttg acttcctgat
     1741 tggaaatatg gaccgacacc attatgagat gttcaccaaa tttggggatg atggatacct
     1801 tattcatctt gacaatgcca gagggttcgg acgacattcc caggatgaaa tctctatcct
     1861 cgcccctcta gcgcagtgtt gcatgatcaa aaggaaaaca ctcttgcacc ttcagctgct
     1921 ggctcaggct gactacaggc tcagcgacgt gatgcgggag tcacttctag aagaccagct
     1981 cagccctgtc ctcacagaac cccacctcct ggccctggac cgcagactcc agatcatcct
     2041 gaagaccgtg gaggactgca tagaggccca cggcgagcga agagtcatag ccgaagggtc
     2101 agcacaacgt tcggctccag actccggcca ggctaatctg acgagctaat ggcaacaaac
     2161 gtgggacctc agaacacaca actggagtca gcacctcatg ctggtttgta ggcccctgtt
     2221 gccccattcc atcctggggc actggaggcc aaggcacaag ctcagggagg aggcaggaac
     2281 gctttgaaaa aggcaaacgg gatccactga acctcatctt tatccttggg tggaggtcac
     2341 tgcttttacg gtgcactggc tggggctctc tcttcccaac gagctctggc tccatcagga
     2401 ctgcagatta tcttctgagc acactgtgaa acctggatct ggaccaggct tggaaggttt
     2461 ggaagctctg ttcccaggag cggtttttat tctaccatat caaataaagg gacatcaagc
     2521 gga
//
