LOCUS       NM_029608                649 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus family with sequence similarity 209 (Fam209), mRNA.
ACCESSION   NM_029608 XM_130728 XM_913316
VERSION     NM_029608.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 649)
  AUTHORS   Jin,H.J., Fan,Y., Yang,X., Dong,Y., Zhang,X.Z., Geng,X.Y., Yan,Z.,
            Wu,L., Ma,M., Li,B., Lyu,Q., Pan,Y., Liu,M., Kuang,Y. and Chen,S.R.
  TITLE     Disruption in CYLC1 leads to acrosome detachment, sperm head
            deformity, and male in/subfertility in humans and mice
  JOURNAL   Elife 13, 95054 (2024)
   PUBMED   38573307
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 649)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 649)
  AUTHORS   Castaneda,J.M., Shimada,K., Satouh,Y., Yu,Z., Devlin,D.J., Ikawa,M.
            and Matzuk,M.M.
  TITLE     FAM209 associates with DPY19L2, and is required for sperm acrosome
            biogenesis and fertility in mice
  JOURNAL   J Cell Sci 134 (21) (2021)
   PUBMED   34471926
REFERENCE   4  (bases 1 to 649)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 649)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            BC137933.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_913316.2, XM_130728.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137933.1, BC137932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 94.87 cM"
     gene            1..649
                     /gene="Fam209"
                     /gene_synonym="1700029J11Rik"
                     /note="family with sequence similarity 209"
                     /db_xref="GeneID:76426"
                     /db_xref="MGI:MGI:1923676"
     exon            1..288
                     /gene="Fam209"
                     /gene_synonym="1700029J11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..552
                     /gene="Fam209"
                     /gene_synonym="1700029J11Rik"
                     /note="likely orthologue of H. sapiens chromosome 20 open
                     reading frame 106 (C20orf106); protein FAM209"
                     /codon_start=1
                     /product="protein FAM209 precursor"
                     /protein_id="NP_083884.1"
                     /db_xref="CCDS:CCDS50809.1"
                     /db_xref="GeneID:76426"
                     /db_xref="MGI:MGI:1923676"
                     /translation="MRTLLRWCLFLSLCVSCACAFMFSSMREKTKESPGKVPCGGHFR
                     IRQNLPENAQGWLGNKWLWLFVAIMIYVMLKFRGDGENKEQHPPGLRGCQLRSPPKKA
                     QNISPSKDFTFNTLTQLEMELVKFVSKVRNLKVSMATNSNSRQQVPESPTNLYNNVTI
                     YEIWGEEDSE"
     exon            289..649
                     /gene="Fam209"
                     /gene_synonym="1700029J11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      609..614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam209"
                     /gene_synonym="1700029J11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      633
                     /gene="Fam209"
                     /gene_synonym="1700029J11Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccccaccatg tgtagctccc tgggccagct ctgctcacca tgcggacgct gctgagatgg
       61 tgcctgttct tgtctctgtg cgtctcttgt gcctgtgcct tcatgttttc ttcgatgagg
      121 gagaaaacca aggaaagccc agggaaggtg ccttgcggcg gacacttccg gattagacag
      181 aatcttccag agaatgccca aggctggctt gggaacaaat ggctctggct ttttgttgcc
      241 attatgatat atgtgatgct gaagtttcga ggagatggcg agaataagga gcagcatcct
      301 cctggcctcc gaggctgcca gctccgctct ccaccaaaga aagctcaaaa tatttccccc
      361 agcaaagact tcactttcaa tactttaacc cagctcgaga tggaattggt gaaatttgtg
      421 tccaaggtgc ggaaccttaa ggtctccatg gcaactaaca gtaactccag gcagcaggtt
      481 ccagagagcc ccacgaacct gtacaataat gtcacaatat atgagatatg gggggaggag
      541 gactctgagt gaagaggttt atagtaaagt ataagaaaag acaagtattg acagacagta
      601 tccgaactaa taaagactat tctgaagaag aaagagtccc ccacgtgag
//
