LOCUS       NM_146261               8308 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus family with sequence similarity 199, X-linked
            (Fam199x), mRNA.
ACCESSION   NM_146261
VERSION     NM_146261.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8308)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY198610.1, AK039695.1, AL954296.9 and AI181994.1.
            
            On Dec 12, 2009 this sequence version replaced NM_146261.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154624.1, BC031748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               BY198610.1         4-235
            233-3280            AK039695.1         161-3208
            3281-7847           AL954296.9         83570-88136
            7848-8308           AI181994.1         1-461               c
FEATURES             Location/Qualifiers
     source          1..8308
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 59.1 cM"
     gene            1..8308
                     /gene="Fam199x"
                     /note="family with sequence similarity 199, X-linked"
                     /db_xref="GeneID:245622"
                     /db_xref="MGI:MGI:2384304"
     exon            1..476
                     /gene="Fam199x"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1446
                     /gene="Fam199x"
                     /codon_start=1
                     /product="protein FAM199X"
                     /protein_id="NP_666373.1"
                     /db_xref="CCDS:CCDS30428.1"
                     /db_xref="GeneID:245622"
                     /db_xref="MGI:MGI:2384304"
                     /translation="MSDEASATTSYEKFLTPEEPFPFLGAPRGVGTCPSEEPGCLDIS
                     DFGCQLSSCHRTDPLHRFHTNRWNLTSCGTSVASSECSEELFSSVSVGDQDDCYSLLD
                     DQDFTSFDLFPEGSVCSDVSSSISTYWDWSDSEFEWQLPGSDIASGSDVLSDVIPSIP
                     SSPCLVSKKKNKHRNLDELAWSAMTNDEQVEYIEYLSRKVSTEMGLREQLDIIKIIDP
                     SAQISPTDSEFIIELNCLTDEKLKQVRNYIKEHSLRQRPTREAWKRSNFSCASTSGVS
                     GASASASSSSASMVSSASSSGSSVGNSASNSSANMSRAHSDSNLSASAAERIRDSKKR
                     SKQRKLQQKAFRKRQLKEQRQARKERLSGLFLNEEVLSLKVTEEDHEADVDVLM"
     exon            477..696
                     /gene="Fam199x"
                     /inference="alignment:Splign:2.1.0"
     exon            697..846
                     /gene="Fam199x"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1008
                     /gene="Fam199x"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1275
                     /gene="Fam199x"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..8299
                     /gene="Fam199x"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5529..5534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam199x"
                     /note="hexamer: AATAAA"
     polyA_site      5551
                     /gene="Fam199x"
                     /note="major polyA site"
     regulatory      6670..6675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam199x"
                     /note="hexamer: ATTACA"
     polyA_site      6693
                     /gene="Fam199x"
                     /note="major polyA site"
ORIGIN      
        1 agtgggcggg gcggccgggc cgggcggcgg cgccgcagtg actcgtcggg cttggcggcg
       61 gtggcggcgg cttctgaggt ttcagaggag cggactgtgt ggccggtggg ctgctgcggc
      121 ctcgcagcaa cctttgtgca gagccctccc ctcctcgggc ggctgcggtg ggcacactcg
      181 ggggcggagg ccaccgcggc caggttagcg tgggggaagg ggcgagtgcc agagtagccc
      241 atctgcagcc agtgagacca agccggccca tctcccacca tgtccgacga ggcgtcggcc
      301 accacttcct atgagaagtt tttaacccca gaggagccct tccctttcct aggagctcct
      361 cgcggggtgg gcacctgccc cagcgaggaa cctggctgcc tggacatcag cgacttcggc
      421 tgccagctct cctcctgcca tcgcacggat ccgctccacc ggtttcacac caacaggtgg
      481 aacctcactt cgtgtggtac aagtgtcgca agctctgaat gtagtgagga gctgttctca
      541 tccgtttctg ttggagatca agatgactgc tactccctgt tagatgatca agacttcact
      601 tcttttgact tgttccccga ggggagtgtc tgcagtgatg tctcctcatc tatcagcacg
      661 tactgggatt ggtcagatag tgaatttgag tggcagttac caggcagtga cattgccagt
      721 ggaagcgatg tgctttctga cgtcataccc agtattccaa gttcaccttg cctggtttct
      781 aaaaagaaaa acaaacaccg gaatctagat gagcttgctt ggagtgcgat gacaaatgat
      841 gagcaggtgg aatatattga gtatctgagc cgtaaagtca gtactgagat gggcctccgg
      901 gagcaacttg acattattaa aatcattgat ccttctgctc agatctcccc tacagacagt
      961 gagttcatta ttgaacttaa ctgtctcaca gatgaaaaac tgaagcaggt cagaaactat
     1021 atcaaggagc atagccttcg tcagcggcct acaagggagg cctggaagag aagcaacttc
     1081 agctgtgcaa gcaccagtgg agtgagcggt gccagcgcca gtgccagcag cagcagtgcc
     1141 agcatggtca gctctgcaag cagcagtggc tccagtgttg gaaactctgc ttcaaactcc
     1201 agtgccaaca tgagccgagc acacagtgac agcaacctgt ctgcaagtgc ggcagagcgg
     1261 attcgggatt caaaaaagcg atccaagcag cgaaagctcc agcagaaggc cttccgcaag
     1321 aggcagctga aggagcagag gcaggcgcgg aaggagaggc tcagtgggct cttcctcaac
     1381 gaagaggtgc tctccttgaa agtgactgag gaagaccatg aagcagatgt tgatgttttg
     1441 atgtaatagg gtgaatccgt cagtgtccct ttgaagcgtt attctctctt cattagttta
     1501 cattcatctt gaccaaactt ttggttaggg ttgtgctgat gtaattaata atttaggccg
     1561 gtggttttca gagagtagcc ccagcaccct cagctttcag catcccgaaa agaccttaga
     1621 attgtgtttg ggccccattc cagagccaca ggcagtgtgg gtttggagca gcactgtgtt
     1681 ttaactaacg ccagactatt ctcgtgcaca ttctcattta aggaccactg ggaagtgtct
     1741 taactacttt aactttatgg tgattaagta ggcttttcaa agactactgt atttacagtt
     1801 tgggaaactt caaagtactg atatcaagga gttaattttg tcagtataca tttagggtcc
     1861 gtaattcagt tctcttctta atggtaagat tttttttaag tttacttttt caaaagggcc
     1921 atagtataat tcttagttcc taggggcaaa tcttttttga ggtgagggtg cacataagga
     1981 atgcattgct gtttacaata gtgccttcat taggtttagt tctgttttca ctaattatta
     2041 atgcaaaggt ataaaaaagg gccctagtct tttccaatta gatgtgagtt tctttgtttt
     2101 tctctacttt atgtcaagtg agaatcattt ccgcaagtga taactactga gaagtaatgc
     2161 tacattagtg aaattttaga cttaacgttg tgtttcaagt ggggattaag tttcaagtgg
     2221 agattccagt taggcaatga taccaatcaa attttcctgt tgtagcctta aagttaaggc
     2281 tgtcaaagaa tctctaaact agaacgttta tctgtttctc tctatcaaaa aattttaatg
     2341 tagtatatct caattttata tgtttgacgt gtggacaggt tgatgtttca aattaactga
     2401 cagaccactt ggagttcaac aaactttaga gactgctgtg ggtatataaa gcagtatgca
     2461 gtagaaaaca cctttgttgg tgcctagtag gactcttata tctaaatgtg aaatcatgga
     2521 gtttttgaaa tcatgttttc aaagaattca ttatcatgac cttagaaata gcctggctcc
     2581 ttttcttgta tgtgtctttg agcattggca tgggctagag aagatacaaa ctgagactac
     2641 tgacaatcaa tttgttttct gactttcagg attttcactt ttactcttgc atctatctag
     2701 aaagcaacct ataatctttt gaaaaggcca cggagttcag aggttaatag agtttcaaca
     2761 tctttaactt tagttcttca aagagattaa caacttaaaa ttcttaattt ttacttgcta
     2821 taaaggctta gattttactg aattaaaaac tgaagttttt gtcctggtct gttgacagac
     2881 acctttaatc ctagcgttca ggaggctgag gtgaggattt gtaagttcaa aacaagccta
     2941 ggctacatag tgctacgaaa attttctata cctttaaaat tttttatttt ttttttggtt
     3001 tctttgaagg ctatagaatt gaaactgagg gtaaaaatta gtaccttgca gcattgctga
     3061 ggcctgtggt tgggctttaa ctttcgaatg cctactaaga tcagaattta aaatgctacg
     3121 aagataaaag tgtgaatatg tgtgctttca gttacagtag tatttctgac tttcctccta
     3181 cctcctttgg tactccatct tagtttaaag gaaccaaaga gatcttgggg tcagatccta
     3241 gaatacttaa taaagaatgt acgcagtttt ccctgtaagt acagaaatag aaaaagaaga
     3301 gaagcaaatg catctaaact gtctgccttc ccttagtcat agcaaaatcc cacagaggag
     3361 ataatctgca tgctcttcct attctctaag gaaggtgggg ccacattgag atacagggca
     3421 acatttatcc atcacccact tgcaaactat ttgtttgttg atgctcagta aaagaaaatc
     3481 caaaactggt tcaggatata acttaagact agtgtctcta ttctcccaaa aatcaccaag
     3541 tcttcttaac ttagatttaa cttaagtcac cattgagtaa gtttaccaaa gtgccatggg
     3601 cagattttaa atgtctataa aggtttgagt atttatagaa ggtatgtcat gaaattttct
     3661 gtaagtccag cttcactctc tatggtagaa ctggaatgta aagtgtcgat ttggtggaga
     3721 ttgaaaatac tgctttcatt ttaaaaacag aaacaaaaac tgtggaactc ctagagttgt
     3781 ttatgatctg agagagagga agggagagag agagagaggg agagattaaa atctttctcc
     3841 ttccctctaa aacaaactat cgcaaaaggg caaaagtctc tttgagtctt tgttatcagt
     3901 gctccgttat ctgttaggat gtttcatgta gataatccag agagaattgt tgaaataggt
     3961 agtaatttat taaatctggt atctccacga ggtatattta aaacaacttc aagtcagcat
     4021 ctttttttcc ttttcagtgg aaaacctact taatcagtta attaaaagga aaaatcaggg
     4081 aaatgctcat caaaagtgtt gagtctgttc tactccagtc acaatggcta tctgtcatca
     4141 agaaaggcaa aaaaacttac tggtgagaag agaggataga aggaatctgt atgtactgct
     4201 agcgatagaa actgtctgta gcagtggata cctgtatggg agttcttttt tttttttaaa
     4261 aattacaatt atgatggagc tatatcatcc tttggtatat gctgaaagta aacgaactca
     4321 gcatatgaca gggatttgta tgtgtgcttc catgtctatt acagtactgc tcccaatagc
     4381 caataaatga atacccatca gcaggtggat agataaataa aatgtaacat agatacatag
     4441 cagagctgta ttcagccata atgaagactg gaattttgtc actagcaaga aaagagatgg
     4501 aactagacgg agatcatgtt aagcaaagca ggccagattc agaaacacaa acattgcatt
     4561 tttttttaca agtggactct agatttaata aaatgaaaca catgaaacta gaataggata
     4621 ctatctggga agaggaaagg ctctggtgaa aaggggagca aaaatggtgg gtgtatatga
     4681 tggaagtata aatatgtatg gataaataaa tggaagaata gaagtccaga ttttgttcca
     4741 gtgttggtta tcttctgtcc acaactgaca gtggagtgaa taagtctcct tttcatagat
     4801 ttatccagag acattttatt agagatcttg taagagtgtg tcagtcctta ttgcagcttt
     4861 taaaagtgtg aacaatgaat taagcaaaat ggcatgtatt tttatacagt tttgcaaatg
     4921 tttaaaggaa ggtgttgttt tagaatgtag taagttgtaa agggctagtt cattctatct
     4981 ttccaagtac ttaaagtcaa atgacacttt ttcttcattc tttggtagat agtgacagtt
     5041 tagttgactt ctgttgtttg ggtaagttag acatttctga attaagtccc agaagctgat
     5101 ttataaaaaa aaaaaaaaaa aaaaaatgac ctatagagtg ggtagatgtc tcattttttc
     5161 cctaggtttt aaaaagtggt aaattccctc aaaaaggaaa aattatatga aactattgta
     5221 taaaggtatc ctgattctga tgagctttaa acattgtaaa atctattata tatctttata
     5281 tttaagccaa aaatgttaca acataaactc tatagcagtc tttttgtttt aggttctctt
     5341 agcaggcttt tttgttcatg gcttctctgt agcctcatgt gccttaacgg tggtgaacgt
     5401 tgccatttgc atctatataa ggctttctca aaatcaaata atcagaatgt tatcatttgg
     5461 ttcatataat gctcatggtg tttggatatt agtaaaactt atcaatcagt agtaatagta
     5521 taaaacaaaa taaaaacctt cagatcttgg actcatttgc ttaaaactag ttttgatcca
     5581 ccacattaat gaagggcctt gcatttacat aaaatttgct taatatattt tttcccactg
     5641 aaaaaatacc tgagtcaagg atactctttt acttcgtttt tctttttgaa acaaggtctc
     5701 cctatacatt ctaggctagc cttgaacttg ttttgttgcc caggctgatc tggaacttgt
     5761 aatctttctc cttagcttcc tgggttttgg ggacccagac gtgcctgggg aatatatctt
     5821 tttaaactag gtgagtttta tcaggaaaga aaatttttag ggtctgtaca gaaacacttg
     5881 aagagccaag attatataga aaggtgtttc ttctgttaac tttaaggatt cttcggattc
     5941 gttttgtaat cgttggggca ccctattctg cttggtttaa caaattacct cttagcactg
     6001 tcttcaagaa ttcttctcgg gaattgatgg agggtaaagt tagtttgggt tgctgatagt
     6061 atagttcgtt tgtgttcaat agtagtattg atgttgaatg cactggcatt tgacttattt
     6121 aagttagaga taaattccat ctttaaagag actattagga aataaatcat tgagcaaaaa
     6181 tctaatatga tagctttgca gtagatttaa gcttcgtaaa gtgagatgaa tttatctcag
     6241 atttgaatgt tattaagtag gaagcctttg aggcattttg agctagacgt ttctgtcagt
     6301 atataatttg gaagatagtc cttgaaatat ttgaatttgg tccctgaaaa ataatttata
     6361 ttctctatga gacttagaag gaactctggc aattcctgta actggctgtt aagaatgagg
     6421 aagctgtaca gcatagctca aaatccaagc tggctcacta caattaaatt tccatttctt
     6481 aaatactaaa atttgcttgc ggctcactgc ccaaatattg tttgaattga gcttattgat
     6541 attttagctt aaaccagaca atggcaaatt gcattttaat ttgacattca ttgccaaact
     6601 cagaaaaacc agtgtgatct tttctgatgt caatatgtag taatttttct ctattgtcag
     6661 ctttcttcaa ttacatcttg gtggtgaatg gaacttgtgg aaatctgtgt tcttttttgt
     6721 ggggatggat gggatggaaa ggggaagaat tgcttaatta atgaatatcc gttttgacta
     6781 tgtcaatgta aatgtggaat taccgtgtgc caatgacagg tacacactta agttggctga
     6841 attgttcaga aggacagcca tggcttgttc tgtgcagttg cttgttctta aattgaagct
     6901 gatctcttgt gttcgtttac gttgagattt caaggctttt ggaaaatggg gctgatagtg
     6961 tctcttcctg tagtaggtga atttaatttc ctgttttcct gtttagattt taaaaaatac
     7021 ataaatcttt gtgttggcaa tttaatagta ctgttaccaa aagaagttac taataatcac
     7081 aaacacacat gaaacacctc atagatggtt aagagttgca aattgtggga ctttctgctc
     7141 cccttctttt caaaaagtag ttctgtagaa tcaatataac caaagcaagt aggaagttga
     7201 ctggtttgga ggatctacaa gtagtcttag atactgtaaa gtatcagatt gtcaaccagg
     7261 acttttttcc tgtattcctg cgaaatgtat tctgaattac tgcacttttg tatatacgac
     7321 agtcccctgt acattctcta tttcctacag tgtatataaa acctggctgg tttttctgga
     7381 agctgtgtga ggggataaca atagttataa tacaattggt ttctattttt gagttccttt
     7441 ttgcacatga aaatatttta gcaggtatat ctaaatgagt ttgggtggtt gtaacggaag
     7501 ctggctatgt gatggagctg ctttttgaac ctagtgtcag aattaagagt cactttagtt
     7561 attaaggatt ttggtactca tactatccta agtatatctc tttccctgct ccttataact
     7621 ttatactcta aatcagcttc tttcaaagtt tcatcccaga ataattacta ctaacagaga
     7681 attgccattt tctttggttc acagtttgat tagactctat aaacttgttt tgtgagggtc
     7741 tcagtttccc agaagtcatg aacaaaacta actttctgaa gagatcagat ttctagagag
     7801 attatcattc acacagtaag tgaaaattag gtcaaagttt tgttgacaga aatgatctat
     7861 tttccttaaa agattctgct gtagaatctt ttaaagttaa gtttctagaa atgaaatgtc
     7921 tatgattggt tgtatgtata gattcaggtg ctgttttggg ttttgtgtgt agggttgttt
     7981 ttttgttttg gtattttttc tttcttttgt tttttgtttt tcttgggttt tggggttttt
     8041 tgatcaccaa tgttgttttt gccgctagag ggacattagt gattcttctt ggaaaaatct
     8101 tagccgtttt ttgttttttg tttttgtttt ttagtttcat agattggcag gacttattct
     8161 caaaatgttt tgtgtgagta aatatgttca tttattagtc aacggtagat taattaagct
     8221 tgtttaatga agaaggcagt cattcttgct gtctgtaacc ttttgttttt aataaatgtg
     8281 agttaaatac taagtaaaaa aaaaaaaa
//
