LOCUS       NM_021427               1853 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus family with sequence similarity 181, member B
            (Fam181b), mRNA.
ACCESSION   NM_021427
VERSION     NM_021427.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1853)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1853)
  AUTHORS   Timmermans,S. and Libert,C.
  TITLE     Overview of inactivating mutations in the protein-coding genome of
            the mouse reference strain C57BL/6J
  JOURNAL   JCI Insight 3 (13), 121758 (2018)
   PUBMED   29997285
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1853)
  AUTHORS   Marks,M., Pennimpede,T., Lange,L., Grote,P., Herrmann,B.G. and
            Wittler,L.
  TITLE     Analysis of the Fam181 gene family during mouse development reveals
            distinct strain-specific expression patterns, suggesting a role in
            nervous system development and function
  JOURNAL   Gene 575 (2 Pt 2), 438-451 (2016)
   PUBMED   26407640
  REMARK    GeneRIF: Data show that Fam181b encodes a protein containing
            highly-conserved motifs with mainly nuclear localization. Its
            expression is affected by genetic background and its oscillation is
            confirmed in the presomitic mesoderm under Notch signaling.
            regulation
REFERENCE   4  (bases 1 to 1853)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043957.1, AK140685.1 and AI845962.1.
            
            On Jan 4, 2007 this sequence version replaced NM_021427.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1574              AK043957.1         16-1589
            1575-1836           AK140685.1         1528-1789
            1837-1853           AI845962.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 51.66 cM"
     gene            1..1853
                     /gene="Fam181b"
                     /gene_synonym="A830059I20Rik"
                     /note="family with sequence similarity 181, member B"
                     /db_xref="GeneID:58238"
                     /db_xref="MGI:MGI:1930951"
     exon            1..1843
                     /gene="Fam181b"
                     /gene_synonym="A830059I20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1396
                     /gene="Fam181b"
                     /gene_synonym="A830059I20Rik"
                     /codon_start=1
                     /product="protein FAM181B"
                     /protein_id="NP_067402.2"
                     /db_xref="GeneID:58238"
                     /db_xref="MGI:MGI:1930951"
                     /translation="MAVQAALLSSHPFIPFGFGGSADGLVSAFGSLDKGCCFEDDESG
                     ATAGALLSGSEGGDVREATRDLLSFIDSASSNIKLALDKPGKSKRKVNHRKYLQKQIK
                     RCSGLMGTAPPRPASPSAADAPAKRPPGAPTVATPAHCKAAPRREATQAAAAASLQSR
                     SLAALFDSLRHIPGGAETAGGAEAVSVPGLGAASAVGDGAGTAVSSVAPGTRKVPLRA
                     RNLPPSFFTEPSRVGCGGASGVPSGQGVSLGDLEKGAEAVEFFELLAPDFGSGNDSGV
                     LMAADPLDPFPAGATVLRGPLELESGPFEQPAMVGNLLYPEPWNTPSCPQTKKPPVAG
                     VRGGVTLNEPVRLLYPTALDSPGGEDAPALSSFTPFFPDCALPPPHQVSYDYSAGYSR
                     AVYPSLWRPDGVWEGASGEEGGHPD"
     regulatory      1821..1826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam181b"
                     /gene_synonym="A830059I20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1843
                     /gene="Fam181b"
                     /gene_synonym="A830059I20Rik"
                     /note="major polyA site"
ORIGIN      
        1 cctctggctt acaagatcta atgagctccc ccgggaggct gagccgtgag cctgggtcgg
       61 agcgagcaga cagcgcctcg cctgggctgg agcgggccgg gtgcgcacgg gccgcgctgc
      121 ggacggccgg ggagccgcag cgatggcggt gcaggctgcg ctgctcagct cgcacccctt
      181 catacccttc ggtttcggag gctccgcgga cgggctggtg agcgccttcg gaagtctgga
      241 caaaggctgc tgtttcgaag acgatgagag cggggcgacc gcgggagcgc tgctatcggg
      301 gtccgagggc ggggacgtgc gcgaggccac ccgcgacctg ctcagcttca tagactcggc
      361 gtccagcaac atcaagctgg cgctggacaa gccaggcaag tctaagcgga aagtgaacca
      421 ccgcaagtac ttgcagaagc agattaagcg ctgcagtggc ctcatgggga ctgcacctcc
      481 gagacccgcg tccccgagcg ctgcagatgc tccagccaaa cggcctccgg gagccccgac
      541 cgtcgcgacc ccagcgcact gtaaggccgc cccgcggagg gaggcgaccc aggctgcagc
      601 tgccgccagc ctgcagagcc ggagcctggc tgctcttttc gactctctgc gccacatccc
      661 cgggggtgca gagacggctg gcggtgcgga ggcggtgtca gtcccgggcc tcggagcagc
      721 aagcgctgtg ggagacgggg cgggcaccgc ggtgagctca gtggctcccg gcaccaggaa
      781 ggtcccgctg cgtgcccgaa acctgccccc gtccttcttc actgaaccat cccgggtggg
      841 ctgcggcggc gccagcggcg tcccatcggg ccagggcgtg agtctgggtg acctggagaa
      901 aggggcggag gccgttgagt tctttgagtt gctggcgcca gacttcggca gtggcaacga
      961 ttcgggtgtc ttgatggccg cggaccctct cgatccgttc cccgccggag ccacggtcct
     1021 acggggaccc ctggagctgg agtcaggccc ctttgagcag ccggcgatgg tggggaacct
     1081 actatacccc gagccctgga acaccccgag ctgtcctcag accaagaagc ctcctgtggc
     1141 tggcgttcgc ggcggcgtga ccttgaacga gcctgtgcgc ctcctgtacc ccacagcctt
     1201 ggactctcca ggtggggagg acgcgccagc cttgtcttct ttcaccccct tcttcccaga
     1261 ttgtgcgttg ccgccgcccc atcaggtgtc ctatgattac agcgcgggct acagccgcgc
     1321 ggtttacccc agcctctgga gaccagatgg ggtctgggaa ggggcttctg gggaggaagg
     1381 agggcatcca gactgactgc gaggaactcg ttcctttcat tatgactact gtgggctgcg
     1441 tgccactttg ggtttcttct gagaggagag aacgatggga gaacgcaagt aaagacgaaa
     1501 tgggattaaa acaaacaaac aaacaaacaa acaaacaaac aaaccctcaa tccatttaat
     1561 aaaggatctt caggaaaaca gacgaagtga ggattgtttt aatcacagcc tcagattttc
     1621 ttttcttttc taagtgagtc atagattcct acttggacag accaattaaa aaacccagag
     1681 acaggatttg ggtgggatga tcaagggtca agagtaagac agcttttact gtctcatctc
     1741 agttcagcca aggtcagtgt gtttaatgtc attatcccct tcaaacagct ccctggtgtc
     1801 ctcccctgac tacattatga attaaagcct atattgaaag aaaaaaaaaa aaa
//
