LOCUS       NM_001004061            1343 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus family with sequence similarity 170, member A
            (Fam170a), transcript variant 1, mRNA.
ACCESSION   NM_001004061 XM_128916
VERSION     NM_001004061.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1343)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1343)
  AUTHORS   Devlin,D.J., Nozawa,K., Ikawa,M. and Matzuk,M.M.
  TITLE     Knockout of family with sequence similarity 170 member A (Fam170a)
            causes male subfertility, while Fam170b is dispensable in
            micedagger
  JOURNAL   Biol Reprod 103 (2), 205-222 (2020)
   PUBMED   32588889
  REMARK    GeneRIF: Knockout of family with sequence similarity 170 member A
            (Fam170a) causes male subfertility, while Fam170b is dispensable in
            micedagger.
REFERENCE   3  (bases 1 to 1343)
  AUTHORS   Xu,F., Wang,W., Lei,C., Liu,Q., Qiu,H., Muraleedharan,V., Zhou,B.,
            Cheng,H., Huang,Z., Xu,W., Li,B. and Wang,M.
  TITLE     Activation of transcriptional activity of HSE by a novel mouse zinc
            finger protein ZNFD specifically expressed in testis
  JOURNAL   Mol Cell Biochem 363 (1-2), 409-417 (2012)
   PUBMED   22231842
  REMARK    GeneRIF: Suggest that ZNFD may probably participate in the
            development of mouse testis and function as a transcription
            activator in HSE-mediated gene expression and signaling pathways.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY692449.1 and AV259944.1.
            
            On Nov 4, 2017 this sequence version replaced NM_001004061.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY692449.1, BC147592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1342              AY692449.1         1-1342
            1343-1343           AV259944.1         262-262
FEATURES             Location/Qualifiers
     source          1..1343
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 27.3 cM"
     gene            1..1343
                     /gene="Fam170a"
                     /gene_synonym="Gm93; Znfd"
                     /note="family with sequence similarity 170, member A"
                     /db_xref="GeneID:225497"
                     /db_xref="MGI:MGI:2684939"
     exon            1..310
                     /gene="Fam170a"
                     /gene_synonym="Gm93; Znfd"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1257
                     /gene="Fam170a"
                     /gene_synonym="Gm93; Znfd"
                     /note="isoform 1 is encoded by transcript variant 1;
                     family with sequence similarity 170, member B; zinc finger
                     protein ZNFD; zinc finger domain-containing protein;
                     protein FAM170A"
                     /codon_start=1
                     /product="protein FAM170A isoform 1"
                     /protein_id="NP_001004061.1"
                     /db_xref="CCDS:CCDS29243.1"
                     /db_xref="GeneID:225497"
                     /db_xref="MGI:MGI:2684939"
                     /translation="MKRRQKRKHLEIEESKEAGISKSQEDISHPESTGVPKAQSPGVG
                     EVSSASEYFSCVSSPQKLIHRSKGTWKLLQDSSKPRSPLDQVPEGEATTAPSQQASSS
                     CPSYKTCVSSLCMNKEERGMKIYYMQVQMKKGVAISWDTKETSESLEKQPRMEEATLP
                     EGVWVGTPPSDVSTRNLLSDSEPIGEEKEHEEKPESDSPPGSPAVEERPRAKTPDWLV
                     TMENGFRCMACCRVFATMESLQEHVQYGIREGFSCHVFHLTMAQLIGSMESESTQEEE
                     EDHTEETEKPKEEKAEEQQPTEEDVGMKKPWSQCPGCVFDSPKDRRRRKDHCDNSGS"
     exon            311..457
                     /gene="Fam170a"
                     /gene_synonym="Gm93; Znfd"
                     /inference="alignment:Splign:2.1.0"
     exon            458..1219
                     /gene="Fam170a"
                     /gene_synonym="Gm93; Znfd"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1343
                     /gene="Fam170a"
                     /gene_synonym="Gm93; Znfd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1321..1326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam170a"
                     /gene_synonym="Gm93; Znfd"
                     /note="hexamer: AATAAA"
     polyA_site      1340
                     /gene="Fam170a"
                     /gene_synonym="Gm93; Znfd"
                     /note="major polyA site"
ORIGIN      
        1 aggcctggtg acctttgacc cttaacagcc atgcagcatg gtgaacactg ggcagggctg
       61 ctgtttgatt aaataatcaa agagctcttc agccagttaa gagatttaat tacttttaat
      121 ttgtgtcgaa ttatctcaac ggatttcctg aaggcctaaa agggtcagcc agcctgtagg
      181 gaaaaggtga ctttggactt taagtatcct caaaggactt taagtatcct cgaagggatt
      241 attctggctg acaccatgaa acggcgacaa aagaggaaac atctggaaat tgaagagtca
      301 aaggaagctg gaatttcaaa gtcacaagag gatatctctc atcctgaatc cactggagtg
      361 cccaaagccc agagcccagg ggtaggggag gtctcctctg cctccgaata cttctcctgt
      421 gtttcttctc cacaaaagct catccatcgt agtaagggaa cctggaaatt gctacaggac
      481 agttccaagc ctagatcacc actagatcag gttccggaag gagaggcgac tactgccccc
      541 tcacaacagg cctcttcatc ctgtccatcg tataagactt gtgtgtcctc tctgtgtatg
      601 aacaaagagg agagggggat gaaaatatac tacatgcagg tgcaaatgaa aaaaggtgtg
      661 gccatctcct gggacacaaa ggaaacctca gagtccctag aaaagcagcc aaggatggaa
      721 gaagccaccc ttcctgaggg tgtgtgggta ggtactccac cctctgatgt gtccaccaga
      781 aacctcctgt cggacagtga acccattggg gaagagaaag aacatgagga aaaaccagag
      841 tcagacagcc caccagggtc tcccgcggtt gaagagagac caagggcaaa gacacctgac
      901 tggctcgtga ccatggagaa tggctttagg tgtatggcct gctgcagggt cttcgccacc
      961 atggaaagcc tccaagagca tgtgcagtat gggatcaggg aaggcttcag ctgccacgtc
     1021 ttccatctca ccatggctca gctgattggc agcatggaat cagagagcac ccaggaggag
     1081 gaagaggacc acaccgagga aaccgagaaa cccaaggaag agaaggctga ggagcagcag
     1141 cccacagagg aagatgtcgg catgaagaaa ccctggagcc aatgtccagg ctgtgtgttt
     1201 gattctccaa aggacagaag aagaagaaag gaccattgcg acaacagcgg cagctgacaa
     1261 tgccagtagt acaaaggaag acgagaacaa cactccgtcg gacacataaa catcctacgc
     1321 aataaagctt gttttccaaa ctg
//
