LOCUS       NP_001004061             333 aa            linear   ROD 06-MAY-2025
DEFINITION  protein FAM170A isoform 1 [Mus musculus].
ACCESSION   NP_001004061 XP_128916
VERSION     NP_001004061.1
DBSOURCE    REFSEQ: accession NM_001004061.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 333)
  AUTHORS   Cheng,J., Gu,Y., Wang,Y., Xun,J., Wang,G., Wang,Y., Wang,J., Li,Y.
            and Sun,F.
  TITLE     Fam170a deficiency causes male infertility by impairing
            histone-to-protamine exchange during mouse spermiogenesis
  JOURNAL   Nucleic Acids Res 53 (3) (2025)
   PUBMED   39868537
  REMARK    Erratum:[Nucleic Acids Res. 2025 Mar 20;53(6):gkaf237. doi:
            10.1093/nar/gkaf237. PMID: 40138720]
REFERENCE   2  (residues 1 to 333)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 333)
  AUTHORS   Devlin,D.J., Nozawa,K., Ikawa,M. and Matzuk,M.M.
  TITLE     Knockout of family with sequence similarity 170 member A (Fam170a)
            causes male subfertility, while Fam170b is dispensable in
            micedagger
  JOURNAL   Biol Reprod 103 (2), 205-222 (2020)
   PUBMED   32588889
  REMARK    GeneRIF: Knockout of family with sequence similarity 170 member A
            (Fam170a) causes male subfertility, while Fam170b is dispensable in
            micedagger.
REFERENCE   4  (residues 1 to 333)
  AUTHORS   Xu,F., Wang,W., Lei,C., Liu,Q., Qiu,H., Muraleedharan,V., Zhou,B.,
            Cheng,H., Huang,Z., Xu,W., Li,B. and Wang,M.
  TITLE     Activation of transcriptional activity of HSE by a novel mouse zinc
            finger protein ZNFD specifically expressed in testis
  JOURNAL   Mol Cell Biochem 363 (1-2), 409-417 (2012)
   PUBMED   22231842
  REMARK    GeneRIF: Suggest that ZNFD may probably participate in the
            development of mouse testis and function as a transcription
            activator in HSE-mediated gene expression and signaling pathways.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY692449.1 and AV259944.1.
            
            On Sep 3, 2004 this sequence version replaced XP_128916.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY692449.1, BC147592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 27.3 cM"
     Protein         1..333
                     /product="protein FAM170A isoform 1"
                     /note="family with sequence similarity 170, member B; zinc
                     finger protein ZNFD; zinc finger domain-containing
                     protein; protein FAM170A"
                     /calculated_mol_wt=37261
     Region          1..45
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66LM6.1)"
     Region          73..107
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66LM6.1)"
     Region          143..214
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66LM6.1)"
     Region          <148..265
                     /region_name="Spt46"
                     /note="Spermatogenesis-associated protein 46; pfam17734"
                     /db_xref="CDD:375300"
     Site            213
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q66LM6.1)"
     Region          267..333
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66LM6.1)"
     Site            308
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q66LM6.1)"
     CDS             1..333
                     /gene="Fam170a"
                     /gene_synonym="Gm93; Znfd"
                     /coded_by="NM_001004061.2:256..1257"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS29243.1"
                     /db_xref="GeneID:225497"
                     /db_xref="MGI:MGI:2684939"
ORIGIN      
        1 mkrrqkrkhl eieeskeagi sksqedishp estgvpkaqs pgvgevssas eyfscvsspq
       61 klihrskgtw kllqdsskpr spldqvpege attapsqqas sscpsyktcv sslcmnkeer
      121 gmkiyymqvq mkkgvaiswd tketseslek qprmeeatlp egvwvgtpps dvstrnllsd
      181 sepigeekeh eekpesdspp gspaveerpr aktpdwlvtm engfrcmacc rvfatmeslq
      241 ehvqygireg fschvfhltm aqligsmese stqeeeedht eetekpkeek aeeqqpteed
      301 vgmkkpwsqc pgcvfdspkd rrrrkdhcdn sgs
//
