LOCUS       NM_001408363            1855 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus family with sequence similarity 161, member A
            (Fam161a), transcript variant 25, mRNA.
ACCESSION   NM_001408363
VERSION     NM_001408363.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1855)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1855)
  AUTHORS   Mercey,O., Kostic,C., Bertiaux,E., Giroud,A., Sadian,Y.,
            Gaboriau,D.C.A., Morrison,C.G., Chang,N., Arsenijevic,Y.,
            Guichard,P. and Hamel,V.
  TITLE     The connecting cilium inner scaffold provides a structural
            foundation that protects against retinal degeneration
  JOURNAL   PLoS Biol 20 (6), e3001649 (2022)
   PUBMED   35709082
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1855)
  AUTHORS   Beryozkin,A., Matsevich,C., Obolensky,A., Kostic,C.,
            Arsenijevic,Y., Wolfrum,U., Banin,E. and Sharon,D.
  TITLE     A new mouse model for retinal degeneration due to Fam161a
            deficiency
  JOURNAL   Sci Rep 11 (1), 2030 (2021)
   PUBMED   33479377
  REMARK    GeneRIF: A new mouse model for retinal degeneration due to Fam161a
            deficiency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1855)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1855)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1855)
  AUTHORS   Di Gioia,S.A., Letteboer,S.J., Kostic,C., Bandah-Rozenfeld,D.,
            Hetterschijt,L., Sharon,D., Arsenijevic,Y., Roepman,R. and
            Rivolta,C.
  TITLE     FAM161A, associated with retinitis pigmentosa, is a component of
            the cilia-basal body complex and interacts with proteins involved
            in ciliopathies
  JOURNAL   Hum Mol Genet 21 (23), 5174-5184 (2012)
   PUBMED   22940612
  REMARK    GeneRIF: FAM161A-associated RP can be considered as a novel retinal
            ciliopathy and that its molecular pathogenesis may be related to
            other ciliopathies.
REFERENCE   7  (bases 1 to 1855)
  AUTHORS   Zach,F., Grassmann,F., Langmann,T., Sorusch,N., Wolfrum,U. and
            Stohr,H.
  TITLE     The retinitis pigmentosa 28 protein FAM161A is a novel ciliary
            protein involved in intermolecular protein interaction and
            microtubule association
  JOURNAL   Hum Mol Genet 21 (21), 4573-4586 (2012)
   PUBMED   22791751
REFERENCE   8  (bases 1 to 1855)
  AUTHORS   Bandah-Rozenfeld,D., Mizrahi-Meissonnier,L., Farhy,C.,
            Obolensky,A., Chowers,I., Pe'er,J., Merin,S., Ben-Yosef,T.,
            Ashery-Padan,R., Banin,E. and Sharon,D.
  TITLE     Homozygosity mapping reveals null mutations in FAM161A as a cause
            of autosomal-recessive retinitis pigmentosa
  JOURNAL   Am J Hum Genet 87 (3), 382-391 (2010)
   PUBMED   20705279
  REMARK    GeneRIF: These data suggest a pivotal role for FAM161A in
            photoreceptors and reveal that FAM161A loss-of-function mutations
            are a major cause of autosomal-recessive Retinitis pigmentosa.
REFERENCE   9  (bases 1 to 1855)
  AUTHORS   Langmann,T., Di Gioia,S.A., Rau,I., Stohr,H., Maksimovic,N.S.,
            Corbo,J.C., Renner,A.B., Zrenner,E., Kumaramanickavel,G.,
            Karlstetter,M., Arsenijevic,Y., Weber,B.H., Gal,A. and Rivolta,C.
  TITLE     Nonsense mutations in FAM161A cause RP28-associated recessive
            retinitis pigmentosa
  JOURNAL   Am J Hum Genet 87 (3), 376-381 (2010)
   PUBMED   20705278
  REMARK    GeneRIF: Null mutations in FAM161A are responsible for the
            RP28-associated autosomal-recessive retinitis pigmentosa.
REFERENCE   10 (bases 1 to 1855)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX001008.3 and AL691470.17.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.168620.1,
                                           SRR17784648.1046029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               BX001008.3         33617-33813
            198-427             BX001008.3         40842-41071
            428-1561            BX001008.3         45187-46320
            1562-1855           AL691470.17        4279-4572
FEATURES             Location/Qualifiers
     source          1..1855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 14.25 cM"
     gene            1..1855
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="family with sequence similarity 161, member A"
                     /db_xref="GeneID:73873"
                     /db_xref="MGI:MGI:1921123"
     exon            1..197
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1676
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="isoform 9 is encoded by transcript variant 25;
                     protein FAM161A"
                     /codon_start=1
                     /product="protein FAM161A isoform 9"
                     /protein_id="NP_001395292.1"
                     /db_xref="GeneID:73873"
                     /db_xref="MGI:MGI:1921123"
                     /translation="MASPHQEARLAAASLLLSANPITGARVAQYESEDSLESLVAAGL
                     AAAMEEEEQKKVWQMRASAGCHNFSGKDEEVAFESTMNFSDIYHSDEEYFRKLKDLKA
                     VHEETMSKLEKMYQDKLNIKDIQAGFIRDGISDSSSSSASEKSCSHPALSVTSLSEPD
                     LDGSSSLSTTTDEGLPDLEEKTPGESSAMVHAQELINNMWNDFSVEDYIQYDSDSRTA
                     KKKRKKAKSLTPKITVPVPFEMTVREQNRREKALSARSDLETKLLKRDEDDAECKKKF
                     RANPVPSCVLLPLYEDLVKQSEERRKKARERNRAALLASLKPFKFIAREEQKQAVREK
                     KLRDLFRAKRKTNQFKAKPVPRFIYRPAASDKPKEEELYGDSRMLPKVRDLLQNSPWP
                     SRSACRRFRDPRSPAKPRGKHRRRCLRRDGDLEKWKEPFSEYSFLKCPMLCEECCLHE
                     SPCDSDKRQKLLADIRADEEILRETRRPGRSPRRKSPGRSSNPKPRPHECSPPMPTAS
                     SRGREQAIRSEKARMREYWQELEEQEEKLQKRPMLFERVTQVVFIG"
     exon            198..427
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            428..1561
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1855
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1855
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaggcggggc gatggcttcg ccgcaccagg aggccagact ggcggcagcc agccttctcc
       61 tgtctgcaaa tcccatcacc ggagcaaggg tcgcccagta cgaaagcgaa gactccttag
      121 agtccttggt agcagcgggg ttggcggcgg ccatggagga ggaggaacag aagaaagtgt
      181 ggcagatgcg ggcgtcggca ggttgtcaca acttttctgg gaaggatgaa gaggtggcat
      241 tcgagagcac tatgaacttc tctgatattt accactctga tgaagagtat ttcaggaaac
      301 tcaaagacct gaaggctgtc catgaagaaa ccatgtcaaa attagagaaa atgtaccagg
      361 acaagctaaa tataaaagac atccaggcgg ggttcatcag ggatgggatc agcgattcgt
      421 cttcgagttc tgcatcggaa aagagctgct cacatcctgc cttgtcagtg acctcacttt
      481 cagagcctga cctagacggg tcgtcctcct tgtccacaac tactgatgag gggttgcccg
      541 acctagagga aaagactccc ggggaaagca gcgcaatggt ccatgcccag gagctcataa
      601 acaacatgtg gaacgacttt tctgttgaag attatattca gtatgactca gactcccgaa
      661 cagctaagaa aaaaaggaag aaagctaaat ccttgacacc caagattaca gtgcctgtac
      721 cctttgaaat gacggtaaga gagcagaatc ggagagagaa ggccttgagt gctcggtcag
      781 atctggaaac aaagctgctc aagagggacg aggacgatgc agagtgtaag aagaaattcc
      841 gagccaatcc cgttccttcc tgcgtgctcc ttccccttta tgaggatcta gtcaagcaga
      901 gtgaggagcg ccggaagaag gcccgggaga ggaacagagc tgcgctcctg gcctccctga
      961 agccctttaa gttcattgcg agggaggaac agaagcaagc agtccgcgag aagaagctga
     1021 gagacctttt tagggctaaa aggaaaacga atcagtttaa agccaaacct gtgcctcgtt
     1081 ttatttacag gccagctgcg agtgacaagc caaaggaaga agagctctat ggggacagca
     1141 ggatgctgcc aaaggtcaga gatctgttac agaattcgcc ttggcccagt cggtcagctt
     1201 gcagacgttt cagggacccc agaagtcctg caaagcccag gggtaaacac aggcgtaggt
     1261 gcctgaggcg tgatggagac ttagaaaaat ggaaggagcc cttctctgaa tacagctttc
     1321 tgaaatgccc aatgctttgt gaagagtgtt gtcttcacga atccccttgt gactctgata
     1381 aaagacagaa actcttggca gacatcagag cagatgaaga aattttgaga gaaacacgca
     1441 ggccgggtcg gtctcctagg cgcaagtcac cgggaagaag ctcgaaccca aagcccaggc
     1501 ctcatgaatg cagcccaccg atgcccaccg cgtcttcccg agggcgggag caagccatca
     1561 ggagtgaaaa ggccaggatg agagaatatt ggcaagaact ggaggaacaa gaggaaaaac
     1621 tgcagaagag gccgatgttg tttgaaagag tcacccaggt tgtgtttatt ggttagggcc
     1681 atcaccagct ttctgtttct cagtacttct ggcctccacc tttgtgctcc gtcttacggt
     1741 gtcctacagt tgccaagaca tgatgtttct ggggcggctt catccagtcc accaagaaag
     1801 taatttcact taagatgtga caacgcttgt agctcaataa agaacatgtc actaa
//
