LOCUS       NM_001408354            3408 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus family with sequence similarity 161, member A
            (Fam161a), transcript variant 16, mRNA.
ACCESSION   NM_001408354
VERSION     NM_001408354.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3408)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3408)
  AUTHORS   Mercey,O., Kostic,C., Bertiaux,E., Giroud,A., Sadian,Y.,
            Gaboriau,D.C.A., Morrison,C.G., Chang,N., Arsenijevic,Y.,
            Guichard,P. and Hamel,V.
  TITLE     The connecting cilium inner scaffold provides a structural
            foundation that protects against retinal degeneration
  JOURNAL   PLoS Biol 20 (6), e3001649 (2022)
   PUBMED   35709082
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3408)
  AUTHORS   Beryozkin,A., Matsevich,C., Obolensky,A., Kostic,C.,
            Arsenijevic,Y., Wolfrum,U., Banin,E. and Sharon,D.
  TITLE     A new mouse model for retinal degeneration due to Fam161a
            deficiency
  JOURNAL   Sci Rep 11 (1), 2030 (2021)
   PUBMED   33479377
  REMARK    GeneRIF: A new mouse model for retinal degeneration due to Fam161a
            deficiency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3408)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3408)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3408)
  AUTHORS   Di Gioia,S.A., Letteboer,S.J., Kostic,C., Bandah-Rozenfeld,D.,
            Hetterschijt,L., Sharon,D., Arsenijevic,Y., Roepman,R. and
            Rivolta,C.
  TITLE     FAM161A, associated with retinitis pigmentosa, is a component of
            the cilia-basal body complex and interacts with proteins involved
            in ciliopathies
  JOURNAL   Hum Mol Genet 21 (23), 5174-5184 (2012)
   PUBMED   22940612
  REMARK    GeneRIF: FAM161A-associated RP can be considered as a novel retinal
            ciliopathy and that its molecular pathogenesis may be related to
            other ciliopathies.
REFERENCE   7  (bases 1 to 3408)
  AUTHORS   Zach,F., Grassmann,F., Langmann,T., Sorusch,N., Wolfrum,U. and
            Stohr,H.
  TITLE     The retinitis pigmentosa 28 protein FAM161A is a novel ciliary
            protein involved in intermolecular protein interaction and
            microtubule association
  JOURNAL   Hum Mol Genet 21 (21), 4573-4586 (2012)
   PUBMED   22791751
REFERENCE   8  (bases 1 to 3408)
  AUTHORS   Bandah-Rozenfeld,D., Mizrahi-Meissonnier,L., Farhy,C.,
            Obolensky,A., Chowers,I., Pe'er,J., Merin,S., Ben-Yosef,T.,
            Ashery-Padan,R., Banin,E. and Sharon,D.
  TITLE     Homozygosity mapping reveals null mutations in FAM161A as a cause
            of autosomal-recessive retinitis pigmentosa
  JOURNAL   Am J Hum Genet 87 (3), 382-391 (2010)
   PUBMED   20705279
  REMARK    GeneRIF: These data suggest a pivotal role for FAM161A in
            photoreceptors and reveal that FAM161A loss-of-function mutations
            are a major cause of autosomal-recessive Retinitis pigmentosa.
REFERENCE   9  (bases 1 to 3408)
  AUTHORS   Langmann,T., Di Gioia,S.A., Rau,I., Stohr,H., Maksimovic,N.S.,
            Corbo,J.C., Renner,A.B., Zrenner,E., Kumaramanickavel,G.,
            Karlstetter,M., Arsenijevic,Y., Weber,B.H., Gal,A. and Rivolta,C.
  TITLE     Nonsense mutations in FAM161A cause RP28-associated recessive
            retinitis pigmentosa
  JOURNAL   Am J Hum Genet 87 (3), 376-381 (2010)
   PUBMED   20705278
  REMARK    GeneRIF: Null mutations in FAM161A are responsible for the
            RP28-associated autosomal-recessive retinitis pigmentosa.
REFERENCE   10 (bases 1 to 3408)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX001008.3 and AL691470.17.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.180676.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               BX001008.3         33617-33818
            203-428             BX001008.3         40846-41071
            429-1562            BX001008.3         45187-46320
            1563-1730           AL691470.17        2340-2507
            1731-1827           AL691470.17        4279-4375
            1828-1982           AL691470.17        9702-9856
            1983-3408           AL691470.17        10212-11637
FEATURES             Location/Qualifiers
     source          1..3408
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 14.25 cM"
     gene            1..3408
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="family with sequence similarity 161, member A"
                     /db_xref="GeneID:73873"
                     /db_xref="MGI:MGI:1921123"
     exon            1..202
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            203..428
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..2112
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="isoform 6 is encoded by transcript variant 16;
                     protein FAM161A"
                     /codon_start=1
                     /product="protein FAM161A isoform 6"
                     /protein_id="NP_001395283.1"
                     /db_xref="GeneID:73873"
                     /db_xref="MGI:MGI:1921123"
                     /translation="MNFSDIYHSDEEYFRKLKDLKAVHEETMSKLEKMYQDKLNIKDI
                     QAGFIRDGISDSSSSSASEKSCSHPALSVTSLSEPDLDGSSSLSTTTDEGLPDLEEKT
                     PGESSAMVHAQELINNMWNDFSVEDYIQYDSDSRTAKKKRKKAKSLTPKITVPVPFEM
                     TVREQNRREKALSARSDLETKLLKRDEDDAECKKKFRANPVPSCVLLPLYEDLVKQSE
                     ERRKKARERNRAALLASLKPFKFIAREEQKQAVREKKLRDLFRAKRKTNQFKAKPVPR
                     FIYRPAASDKPKEEELYGDSRMLPKVRDLLQNSPWPSRSACRRFRDPRSPAKPRGKHR
                     RRCLRRDGDLEKWKEPFSEYSFLKCPMLCEECCLHESPCDSDKRQKLLADIRADEEIL
                     RETRRPGRSPRRKSPGRSSNPKPRPHECSPPMPTASSRGREQAIRKSLEEKKMLEEER
                     NRILTKQKQRMKDLQKLLATRVKAYGSHQSLSQIVKARVKELRSEKARMREYWQELEE
                     QEEKLQKRPMLFERVTQRNARMAAERCYSNTLKALGLLEEFVSEKGQSGKVSEDFTRQ
                     ELRSCTLEKESSYGEERENEEESYLTDISSQDSCKGNKEDIKDIKSGEENSGE"
     exon            429..1562
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1730
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1827
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1982
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..3408
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2741..2746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2765
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
     regulatory      3379..3384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3408
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaggcggggc gatggcttcg ccgcaccagg aggccagact ggcggcagcc agccttctcc
       61 tgtctgcaaa tcccatcacc ggagcaaggg tcgcccagta cgaaagcgaa gactccttag
      121 agtccttggt agcagcgggg ttggcggcgg ccatggagga ggaggaacag aagaaagtgt
      181 ggcagatgcg ggcgtcggta atgttgtcac aacttttctg ggaaggatga agaggtggca
      241 ttcgagagca ctatgaactt ctctgatatt taccactctg atgaagagta tttcaggaaa
      301 ctcaaagacc tgaaggctgt ccatgaagaa accatgtcaa aattagagaa aatgtaccag
      361 gacaagctaa atataaaaga catccaggcg gggttcatca gggatgggat cagcgattcg
      421 tcttcgagtt ctgcatcgga aaagagctgc tcacatcctg ccttgtcagt gacctcactt
      481 tcagagcctg acctagacgg gtcgtcctcc ttgtccacaa ctactgatga ggggttgccc
      541 gacctagagg aaaagactcc cggggaaagc agcgcaatgg tccatgccca ggagctcata
      601 aacaacatgt ggaacgactt ttctgttgaa gattatattc agtatgactc agactcccga
      661 acagctaaga aaaaaaggaa gaaagctaaa tccttgacac ccaagattac agtgcctgta
      721 ccctttgaaa tgacggtaag agagcagaat cggagagaga aggccttgag tgctcggtca
      781 gatctggaaa caaagctgct caagagggac gaggacgatg cagagtgtaa gaagaaattc
      841 cgagccaatc ccgttccttc ctgcgtgctc cttccccttt atgaggatct agtcaagcag
      901 agtgaggagc gccggaagaa ggcccgggag aggaacagag ctgcgctcct ggcctccctg
      961 aagcccttta agttcattgc gagggaggaa cagaagcaag cagtccgcga gaagaagctg
     1021 agagaccttt ttagggctaa aaggaaaacg aatcagttta aagccaaacc tgtgcctcgt
     1081 tttatttaca ggccagctgc gagtgacaag ccaaaggaag aagagctcta tggggacagc
     1141 aggatgctgc caaaggtcag agatctgtta cagaattcgc cttggcccag tcggtcagct
     1201 tgcagacgtt tcagggaccc cagaagtcct gcaaagccca ggggtaaaca caggcgtagg
     1261 tgcctgaggc gtgatggaga cttagaaaaa tggaaggagc ccttctctga atacagcttt
     1321 ctgaaatgcc caatgctttg tgaagagtgt tgtcttcacg aatccccttg tgactctgat
     1381 aaaagacaga aactcttggc agacatcaga gcagatgaag aaattttgag agaaacacgc
     1441 aggccgggtc ggtctcctag gcgcaagtca ccgggaagaa gctcgaaccc aaagcccagg
     1501 cctcatgaat gcagcccacc gatgcccacc gcgtcttccc gagggcggga gcaagccatc
     1561 aggaaatccc ttgaggaaaa gaaaatgttg gaagaagaga gaaatcggat cctaactaaa
     1621 cagaagcaaa gaatgaaaga cttgcagaaa ctgctggcaa cccgggttaa ggcttatggc
     1681 tcccaccaga gcttgtctca gatagttaaa gccagggtga aggagctcag gagtgaaaag
     1741 gccaggatga gagaatattg gcaagaactg gaggaacaag aggaaaaact gcagaagagg
     1801 ccgatgttgt ttgaaagagt cacccagaga aatgcaagga tggccgcaga gaggtgttac
     1861 tctaacactc taaaagcact aggactcctt gaggagtttg tttcagagaa aggccaaagt
     1921 ggaaaagtgt ctgaagactt caccaggcaa gagctgagaa gctgcacact ggagaaagaa
     1981 agctcttatg gagaagaaag agagaatgag gaagaaagct atttaactga tatcagcagc
     2041 caggattctt gcaagggaaa caaggaagat attaaagata ttaaaagtgg agaagaaaat
     2101 tctggagaat gaatccgaat cacaaggttt cttgtctcgc tgaccctccc catgtgcagc
     2161 ctcaggactc agagcctgcg cttgggttac tgtgagcatc cgcggggaca gctctcacac
     2221 acgcaggcct gctgaaccag gacaccatgc ctggaaaggc tgagtccaca ggacaagtga
     2281 tttggttgct accttacagc tttgcatgct gaagtttaga aattgctatg ctctttatga
     2341 ttatgattat atttgtattt tcaaagtgtt tgagggttgg agaaccacag ctgacacaaa
     2401 tggattagtt atggaaatgt atatttgcat ttgataggga aaaattggta ttgatagaac
     2461 tattagcttt tgaagatcta tttttaaatg cactattttc attttttttc tcagaaccag
     2521 ttttaaataa gtaatatact acagaaaaag tagatatttg gaaatttaca gtaattttga
     2581 tactgaaaag atttactgct aaatccacac catggctact ttttcctttt tttgcccttt
     2641 ttctggtgaa gattaaacct agagctcaca catacttaac tcaatgaatt ctaccatttg
     2701 ctatatcctc aatcctcccg ttatttttga tagataaagt attaaaatta cttatgctac
     2761 ttttagaatc ctgtgtattc ttgtatatag actaattatg gcccttgtga gtggtaatct
     2821 taagagataa gggttactgt tctatatatg ctgacattgt gatcctaact tgccaaagga
     2881 aaatcctaaa cgtaattcag atttatttat ttatccttgg ctttttttta ttttttagtg
     2941 tttcattttt gtttgtttct ttttcctttt tttttctttc ttttccttga tttttttttt
     3001 tttttttttt tgagacaaag tttctctgtg tagccctggc tgtcctgaac ttaatttgta
     3061 gatcaggctg acctggaact cagagatcca cctgcctctg cctttctagt gctgaacaat
     3121 taaagaagtg tggcaccact gctggacagt tttatccatg actttgtgtc tgtctgtgtg
     3181 taggaatgtg gatgtgagtt tgggtgccta tggaggccag aagagagtgt cagtatccct
     3241 ggggctgagg ctcccagtgc tgtgaactgg gtgctggaaa ttacacttgt gtcctttgta
     3301 agagcagtgt gtgtgtttaa ccactgagcc agctctccaa tcgaaccagc ttggtattat
     3361 acttcaaaaa taatcaataa taaaatataa tcagtaatat tgaccata
//
