LOCUS       NM_001408350            3406 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus family with sequence similarity 161, member A
            (Fam161a), transcript variant 12, mRNA.
ACCESSION   NM_001408350 XM_006514834
VERSION     NM_001408350.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3406)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3406)
  AUTHORS   Mercey,O., Kostic,C., Bertiaux,E., Giroud,A., Sadian,Y.,
            Gaboriau,D.C.A., Morrison,C.G., Chang,N., Arsenijevic,Y.,
            Guichard,P. and Hamel,V.
  TITLE     The connecting cilium inner scaffold provides a structural
            foundation that protects against retinal degeneration
  JOURNAL   PLoS Biol 20 (6), e3001649 (2022)
   PUBMED   35709082
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3406)
  AUTHORS   Beryozkin,A., Matsevich,C., Obolensky,A., Kostic,C.,
            Arsenijevic,Y., Wolfrum,U., Banin,E. and Sharon,D.
  TITLE     A new mouse model for retinal degeneration due to Fam161a
            deficiency
  JOURNAL   Sci Rep 11 (1), 2030 (2021)
   PUBMED   33479377
  REMARK    GeneRIF: A new mouse model for retinal degeneration due to Fam161a
            deficiency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3406)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3406)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3406)
  AUTHORS   Di Gioia,S.A., Letteboer,S.J., Kostic,C., Bandah-Rozenfeld,D.,
            Hetterschijt,L., Sharon,D., Arsenijevic,Y., Roepman,R. and
            Rivolta,C.
  TITLE     FAM161A, associated with retinitis pigmentosa, is a component of
            the cilia-basal body complex and interacts with proteins involved
            in ciliopathies
  JOURNAL   Hum Mol Genet 21 (23), 5174-5184 (2012)
   PUBMED   22940612
  REMARK    GeneRIF: FAM161A-associated RP can be considered as a novel retinal
            ciliopathy and that its molecular pathogenesis may be related to
            other ciliopathies.
REFERENCE   7  (bases 1 to 3406)
  AUTHORS   Zach,F., Grassmann,F., Langmann,T., Sorusch,N., Wolfrum,U. and
            Stohr,H.
  TITLE     The retinitis pigmentosa 28 protein FAM161A is a novel ciliary
            protein involved in intermolecular protein interaction and
            microtubule association
  JOURNAL   Hum Mol Genet 21 (21), 4573-4586 (2012)
   PUBMED   22791751
REFERENCE   8  (bases 1 to 3406)
  AUTHORS   Bandah-Rozenfeld,D., Mizrahi-Meissonnier,L., Farhy,C.,
            Obolensky,A., Chowers,I., Pe'er,J., Merin,S., Ben-Yosef,T.,
            Ashery-Padan,R., Banin,E. and Sharon,D.
  TITLE     Homozygosity mapping reveals null mutations in FAM161A as a cause
            of autosomal-recessive retinitis pigmentosa
  JOURNAL   Am J Hum Genet 87 (3), 382-391 (2010)
   PUBMED   20705279
  REMARK    GeneRIF: These data suggest a pivotal role for FAM161A in
            photoreceptors and reveal that FAM161A loss-of-function mutations
            are a major cause of autosomal-recessive Retinitis pigmentosa.
REFERENCE   9  (bases 1 to 3406)
  AUTHORS   Langmann,T., Di Gioia,S.A., Rau,I., Stohr,H., Maksimovic,N.S.,
            Corbo,J.C., Renner,A.B., Zrenner,E., Kumaramanickavel,G.,
            Karlstetter,M., Arsenijevic,Y., Weber,B.H., Gal,A. and Rivolta,C.
  TITLE     Nonsense mutations in FAM161A cause RP28-associated recessive
            retinitis pigmentosa
  JOURNAL   Am J Hum Genet 87 (3), 376-381 (2010)
   PUBMED   20705278
  REMARK    GeneRIF: Null mutations in FAM161A are responsible for the
            RP28-associated autosomal-recessive retinitis pigmentosa.
REFERENCE   10 (bases 1 to 3406)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX001008.3 and AL691470.17.
            
            On Jun 16, 2022 this sequence version replaced XM_006514834.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.1255145.1,
                                           SRR17784646.588641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               BX001008.3         33617-33813
            198-423             BX001008.3         40846-41071
            424-1557            BX001008.3         45187-46320
            1558-1725           AL691470.17        2340-2507
            1726-1825           AL691470.17        4276-4375
            1826-1980           AL691470.17        9702-9856
            1981-3406           AL691470.17        10212-11637
FEATURES             Location/Qualifiers
     source          1..3406
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 14.25 cM"
     gene            1..3406
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="family with sequence similarity 161, member A"
                     /db_xref="GeneID:73873"
                     /db_xref="MGI:MGI:1921123"
     exon            1..197
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            198..423
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..2110
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="isoform 5 is encoded by transcript variant 12;
                     protein FAM161A"
                     /codon_start=1
                     /product="protein FAM161A isoform 5"
                     /protein_id="NP_001395279.1"
                     /db_xref="GeneID:73873"
                     /db_xref="MGI:MGI:1921123"
                     /translation="MNFSDIYHSDEEYFRKLKDLKAVHEETMSKLEKMYQDKLNIKDI
                     QAGFIRDGISDSSSSSASEKSCSHPALSVTSLSEPDLDGSSSLSTTTDEGLPDLEEKT
                     PGESSAMVHAQELINNMWNDFSVEDYIQYDSDSRTAKKKRKKAKSLTPKITVPVPFEM
                     TVREQNRREKALSARSDLETKLLKRDEDDAECKKKFRANPVPSCVLLPLYEDLVKQSE
                     ERRKKARERNRAALLASLKPFKFIAREEQKQAVREKKLRDLFRAKRKTNQFKAKPVPR
                     FIYRPAASDKPKEEELYGDSRMLPKVRDLLQNSPWPSRSACRRFRDPRSPAKPRGKHR
                     RRCLRRDGDLEKWKEPFSEYSFLKCPMLCEECCLHESPCDSDKRQKLLADIRADEEIL
                     RETRRPGRSPRRKSPGRSSNPKPRPHECSPPMPTASSRGREQAIRKSLEEKKMLEEER
                     NRILTKQKQRMKDLQKLLATRVKAYGSHQSLSQIVKARVKELRRSEKARMREYWQELE
                     EQEEKLQKRPMLFERVTQRNARMAAERCYSNTLKALGLLEEFVSEKGQSGKVSEDFTR
                     QELRSCTLEKESSYGEERENEEESYLTDISSQDSCKGNKEDIKDIKSGEENSGE"
     exon            424..1557
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1725
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1825
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1980
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..3406
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2739..2744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2763
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
     regulatory      3377..3382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3406
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaggcggggc gatggcttcg ccgcaccagg aggccagact ggcggcagcc agccttctcc
       61 tgtctgcaaa tcccatcacc ggagcaaggg tcgcccagta cgaaagcgaa gactccttag
      121 agtccttggt agcagcgggg ttggcggcgg ccatggagga ggaggaacag aagaaagtgt
      181 ggcagatgcg ggcgtcggtt gtcacaactt ttctgggaag gatgaagagg tggcattcga
      241 gagcactatg aacttctctg atatttacca ctctgatgaa gagtatttca ggaaactcaa
      301 agacctgaag gctgtccatg aagaaaccat gtcaaaatta gagaaaatgt accaggacaa
      361 gctaaatata aaagacatcc aggcggggtt catcagggat gggatcagcg attcgtcttc
      421 gagttctgca tcggaaaaga gctgctcaca tcctgccttg tcagtgacct cactttcaga
      481 gcctgaccta gacgggtcgt cctccttgtc cacaactact gatgaggggt tgcccgacct
      541 agaggaaaag actcccgggg aaagcagcgc aatggtccat gcccaggagc tcataaacaa
      601 catgtggaac gacttttctg ttgaagatta tattcagtat gactcagact cccgaacagc
      661 taagaaaaaa aggaagaaag ctaaatcctt gacacccaag attacagtgc ctgtaccctt
      721 tgaaatgacg gtaagagagc agaatcggag agagaaggcc ttgagtgctc ggtcagatct
      781 ggaaacaaag ctgctcaaga gggacgagga cgatgcagag tgtaagaaga aattccgagc
      841 caatcccgtt ccttcctgcg tgctccttcc cctttatgag gatctagtca agcagagtga
      901 ggagcgccgg aagaaggccc gggagaggaa cagagctgcg ctcctggcct ccctgaagcc
      961 ctttaagttc attgcgaggg aggaacagaa gcaagcagtc cgcgagaaga agctgagaga
     1021 cctttttagg gctaaaagga aaacgaatca gtttaaagcc aaacctgtgc ctcgttttat
     1081 ttacaggcca gctgcgagtg acaagccaaa ggaagaagag ctctatgggg acagcaggat
     1141 gctgccaaag gtcagagatc tgttacagaa ttcgccttgg cccagtcggt cagcttgcag
     1201 acgtttcagg gaccccagaa gtcctgcaaa gcccaggggt aaacacaggc gtaggtgcct
     1261 gaggcgtgat ggagacttag aaaaatggaa ggagcccttc tctgaataca gctttctgaa
     1321 atgcccaatg ctttgtgaag agtgttgtct tcacgaatcc ccttgtgact ctgataaaag
     1381 acagaaactc ttggcagaca tcagagcaga tgaagaaatt ttgagagaaa cacgcaggcc
     1441 gggtcggtct cctaggcgca agtcaccggg aagaagctcg aacccaaagc ccaggcctca
     1501 tgaatgcagc ccaccgatgc ccaccgcgtc ttcccgaggg cgggagcaag ccatcaggaa
     1561 atcccttgag gaaaagaaaa tgttggaaga agagagaaat cggatcctaa ctaaacagaa
     1621 gcaaagaatg aaagacttgc agaaactgct ggcaacccgg gttaaggctt atggctccca
     1681 ccagagcttg tctcagatag ttaaagccag ggtgaaggag ctcagaagga gtgaaaaggc
     1741 caggatgaga gaatattggc aagaactgga ggaacaagag gaaaaactgc agaagaggcc
     1801 gatgttgttt gaaagagtca cccagagaaa tgcaaggatg gccgcagaga ggtgttactc
     1861 taacactcta aaagcactag gactccttga ggagtttgtt tcagagaaag gccaaagtgg
     1921 aaaagtgtct gaagacttca ccaggcaaga gctgagaagc tgcacactgg agaaagaaag
     1981 ctcttatgga gaagaaagag agaatgagga agaaagctat ttaactgata tcagcagcca
     2041 ggattcttgc aagggaaaca aggaagatat taaagatatt aaaagtggag aagaaaattc
     2101 tggagaatga atccgaatca caaggtttct tgtctcgctg accctcccca tgtgcagcct
     2161 caggactcag agcctgcgct tgggttactg tgagcatccg cggggacagc tctcacacac
     2221 gcaggcctgc tgaaccagga caccatgcct ggaaaggctg agtccacagg acaagtgatt
     2281 tggttgctac cttacagctt tgcatgctga agtttagaaa ttgctatgct ctttatgatt
     2341 atgattatat ttgtattttc aaagtgtttg agggttggag aaccacagct gacacaaatg
     2401 gattagttat ggaaatgtat atttgcattt gatagggaaa aattggtatt gatagaacta
     2461 ttagcttttg aagatctatt tttaaatgca ctattttcat tttttttctc agaaccagtt
     2521 ttaaataagt aatatactac agaaaaagta gatatttgga aatttacagt aattttgata
     2581 ctgaaaagat ttactgctaa atccacacca tggctacttt ttcctttttt tgcccttttt
     2641 ctggtgaaga ttaaacctag agctcacaca tacttaactc aatgaattct accatttgct
     2701 atatcctcaa tcctcccgtt atttttgata gataaagtat taaaattact tatgctactt
     2761 ttagaatcct gtgtattctt gtatatagac taattatggc ccttgtgagt ggtaatctta
     2821 agagataagg gttactgttc tatatatgct gacattgtga tcctaacttg ccaaaggaaa
     2881 atcctaaacg taattcagat ttatttattt atccttggct tttttttatt ttttagtgtt
     2941 tcatttttgt ttgtttcttt ttcctttttt tttctttctt ttccttgatt tttttttttt
     3001 tttttttttg agacaaagtt tctctgtgta gccctggctg tcctgaactt aatttgtaga
     3061 tcaggctgac ctggaactca gagatccacc tgcctctgcc tttctagtgc tgaacaatta
     3121 aagaagtgtg gcaccactgc tggacagttt tatccatgac tttgtgtctg tctgtgtgta
     3181 ggaatgtgga tgtgagtttg ggtgcctatg gaggccagaa gagagtgtca gtatccctgg
     3241 ggctgaggct cccagtgctg tgaactgggt gctggaaatt acacttgtgt cctttgtaag
     3301 agcagtgtgt gtgtttaacc actgagccag ctctccaatc gaaccagctt ggtattatac
     3361 ttcaaaaata atcaataata aaatataatc agtaatattg accata
//
