LOCUS       NM_001408349            3519 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus family with sequence similarity 161, member A
            (Fam161a), transcript variant 11, mRNA.
ACCESSION   NM_001408349 XM_006514832
VERSION     NM_001408349.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3519)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3519)
  AUTHORS   Mercey,O., Kostic,C., Bertiaux,E., Giroud,A., Sadian,Y.,
            Gaboriau,D.C.A., Morrison,C.G., Chang,N., Arsenijevic,Y.,
            Guichard,P. and Hamel,V.
  TITLE     The connecting cilium inner scaffold provides a structural
            foundation that protects against retinal degeneration
  JOURNAL   PLoS Biol 20 (6), e3001649 (2022)
   PUBMED   35709082
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3519)
  AUTHORS   Beryozkin,A., Matsevich,C., Obolensky,A., Kostic,C.,
            Arsenijevic,Y., Wolfrum,U., Banin,E. and Sharon,D.
  TITLE     A new mouse model for retinal degeneration due to Fam161a
            deficiency
  JOURNAL   Sci Rep 11 (1), 2030 (2021)
   PUBMED   33479377
  REMARK    GeneRIF: A new mouse model for retinal degeneration due to Fam161a
            deficiency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3519)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3519)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3519)
  AUTHORS   Di Gioia,S.A., Letteboer,S.J., Kostic,C., Bandah-Rozenfeld,D.,
            Hetterschijt,L., Sharon,D., Arsenijevic,Y., Roepman,R. and
            Rivolta,C.
  TITLE     FAM161A, associated with retinitis pigmentosa, is a component of
            the cilia-basal body complex and interacts with proteins involved
            in ciliopathies
  JOURNAL   Hum Mol Genet 21 (23), 5174-5184 (2012)
   PUBMED   22940612
  REMARK    GeneRIF: FAM161A-associated RP can be considered as a novel retinal
            ciliopathy and that its molecular pathogenesis may be related to
            other ciliopathies.
REFERENCE   7  (bases 1 to 3519)
  AUTHORS   Zach,F., Grassmann,F., Langmann,T., Sorusch,N., Wolfrum,U. and
            Stohr,H.
  TITLE     The retinitis pigmentosa 28 protein FAM161A is a novel ciliary
            protein involved in intermolecular protein interaction and
            microtubule association
  JOURNAL   Hum Mol Genet 21 (21), 4573-4586 (2012)
   PUBMED   22791751
REFERENCE   8  (bases 1 to 3519)
  AUTHORS   Bandah-Rozenfeld,D., Mizrahi-Meissonnier,L., Farhy,C.,
            Obolensky,A., Chowers,I., Pe'er,J., Merin,S., Ben-Yosef,T.,
            Ashery-Padan,R., Banin,E. and Sharon,D.
  TITLE     Homozygosity mapping reveals null mutations in FAM161A as a cause
            of autosomal-recessive retinitis pigmentosa
  JOURNAL   Am J Hum Genet 87 (3), 382-391 (2010)
   PUBMED   20705279
  REMARK    GeneRIF: These data suggest a pivotal role for FAM161A in
            photoreceptors and reveal that FAM161A loss-of-function mutations
            are a major cause of autosomal-recessive Retinitis pigmentosa.
REFERENCE   9  (bases 1 to 3519)
  AUTHORS   Langmann,T., Di Gioia,S.A., Rau,I., Stohr,H., Maksimovic,N.S.,
            Corbo,J.C., Renner,A.B., Zrenner,E., Kumaramanickavel,G.,
            Karlstetter,M., Arsenijevic,Y., Weber,B.H., Gal,A. and Rivolta,C.
  TITLE     Nonsense mutations in FAM161A cause RP28-associated recessive
            retinitis pigmentosa
  JOURNAL   Am J Hum Genet 87 (3), 376-381 (2010)
   PUBMED   20705278
  REMARK    GeneRIF: Null mutations in FAM161A are responsible for the
            RP28-associated autosomal-recessive retinitis pigmentosa.
REFERENCE   10 (bases 1 to 3519)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX001008.3 and AL691470.17.
            
            On Jun 16, 2022 this sequence version replaced XM_006514832.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.155088.1,
                                           SRR17784645.581362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               BX001008.3         33617-33813
            198-306             BX001008.3         38726-38834
            307-536             BX001008.3         40842-41071
            537-1670            BX001008.3         45187-46320
            1671-1838           AL691470.17        2340-2507
            1839-1938           AL691470.17        4276-4375
            1939-2093           AL691470.17        9702-9856
            2094-3519           AL691470.17        10212-11637
FEATURES             Location/Qualifiers
     source          1..3519
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 14.25 cM"
     gene            1..3519
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="family with sequence similarity 161, member A"
                     /db_xref="GeneID:73873"
                     /db_xref="MGI:MGI:1921123"
     exon            1..197
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            198..306
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            307..536
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..2223
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="isoform 5 is encoded by transcript variant 11;
                     protein FAM161A"
                     /codon_start=1
                     /product="protein FAM161A isoform 5"
                     /protein_id="NP_001395278.1"
                     /db_xref="GeneID:73873"
                     /db_xref="MGI:MGI:1921123"
                     /translation="MNFSDIYHSDEEYFRKLKDLKAVHEETMSKLEKMYQDKLNIKDI
                     QAGFIRDGISDSSSSSASEKSCSHPALSVTSLSEPDLDGSSSLSTTTDEGLPDLEEKT
                     PGESSAMVHAQELINNMWNDFSVEDYIQYDSDSRTAKKKRKKAKSLTPKITVPVPFEM
                     TVREQNRREKALSARSDLETKLLKRDEDDAECKKKFRANPVPSCVLLPLYEDLVKQSE
                     ERRKKARERNRAALLASLKPFKFIAREEQKQAVREKKLRDLFRAKRKTNQFKAKPVPR
                     FIYRPAASDKPKEEELYGDSRMLPKVRDLLQNSPWPSRSACRRFRDPRSPAKPRGKHR
                     RRCLRRDGDLEKWKEPFSEYSFLKCPMLCEECCLHESPCDSDKRQKLLADIRADEEIL
                     RETRRPGRSPRRKSPGRSSNPKPRPHECSPPMPTASSRGREQAIRKSLEEKKMLEEER
                     NRILTKQKQRMKDLQKLLATRVKAYGSHQSLSQIVKARVKELRRSEKARMREYWQELE
                     EQEEKLQKRPMLFERVTQRNARMAAERCYSNTLKALGLLEEFVSEKGQSGKVSEDFTR
                     QELRSCTLEKESSYGEERENEEESYLTDISSQDSCKGNKEDIKDIKSGEENSGE"
     exon            537..1670
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1838
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1938
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2093
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..3519
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2852..2857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2876
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
     regulatory      3490..3495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3519
                     /gene="Fam161a"
                     /gene_synonym="4930430E16Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaggcggggc gatggcttcg ccgcaccagg aggccagact ggcggcagcc agccttctcc
       61 tgtctgcaaa tcccatcacc ggagcaaggg tcgcccagta cgaaagcgaa gactccttag
      121 agtccttggt agcagcgggg ttggcggcgg ccatggagga ggaggaacag aagaaagtgt
      181 ggcagatgcg ggcgtcggtt gggtttctct gtgtaacctc ggctgtccag gaactcattc
      241 cataaaccag gctggcctgg aactcagtga tctgccagct tctgcctccc aagtgtgggg
      301 attaaggcag gttgtcacaa cttttctggg aaggatgaag aggtggcatt cgagagcact
      361 atgaacttct ctgatattta ccactctgat gaagagtatt tcaggaaact caaagacctg
      421 aaggctgtcc atgaagaaac catgtcaaaa ttagagaaaa tgtaccagga caagctaaat
      481 ataaaagaca tccaggcggg gttcatcagg gatgggatca gcgattcgtc ttcgagttct
      541 gcatcggaaa agagctgctc acatcctgcc ttgtcagtga cctcactttc agagcctgac
      601 ctagacgggt cgtcctcctt gtccacaact actgatgagg ggttgcccga cctagaggaa
      661 aagactcccg gggaaagcag cgcaatggtc catgcccagg agctcataaa caacatgtgg
      721 aacgactttt ctgttgaaga ttatattcag tatgactcag actcccgaac agctaagaaa
      781 aaaaggaaga aagctaaatc cttgacaccc aagattacag tgcctgtacc ctttgaaatg
      841 acggtaagag agcagaatcg gagagagaag gccttgagtg ctcggtcaga tctggaaaca
      901 aagctgctca agagggacga ggacgatgca gagtgtaaga agaaattccg agccaatccc
      961 gttccttcct gcgtgctcct tcccctttat gaggatctag tcaagcagag tgaggagcgc
     1021 cggaagaagg cccgggagag gaacagagct gcgctcctgg cctccctgaa gccctttaag
     1081 ttcattgcga gggaggaaca gaagcaagca gtccgcgaga agaagctgag agaccttttt
     1141 agggctaaaa ggaaaacgaa tcagtttaaa gccaaacctg tgcctcgttt tatttacagg
     1201 ccagctgcga gtgacaagcc aaaggaagaa gagctctatg gggacagcag gatgctgcca
     1261 aaggtcagag atctgttaca gaattcgcct tggcccagtc ggtcagcttg cagacgtttc
     1321 agggacccca gaagtcctgc aaagcccagg ggtaaacaca ggcgtaggtg cctgaggcgt
     1381 gatggagact tagaaaaatg gaaggagccc ttctctgaat acagctttct gaaatgccca
     1441 atgctttgtg aagagtgttg tcttcacgaa tccccttgtg actctgataa aagacagaaa
     1501 ctcttggcag acatcagagc agatgaagaa attttgagag aaacacgcag gccgggtcgg
     1561 tctcctaggc gcaagtcacc gggaagaagc tcgaacccaa agcccaggcc tcatgaatgc
     1621 agcccaccga tgcccaccgc gtcttcccga gggcgggagc aagccatcag gaaatccctt
     1681 gaggaaaaga aaatgttgga agaagagaga aatcggatcc taactaaaca gaagcaaaga
     1741 atgaaagact tgcagaaact gctggcaacc cgggttaagg cttatggctc ccaccagagc
     1801 ttgtctcaga tagttaaagc cagggtgaag gagctcagaa ggagtgaaaa ggccaggatg
     1861 agagaatatt ggcaagaact ggaggaacaa gaggaaaaac tgcagaagag gccgatgttg
     1921 tttgaaagag tcacccagag aaatgcaagg atggccgcag agaggtgtta ctctaacact
     1981 ctaaaagcac taggactcct tgaggagttt gtttcagaga aaggccaaag tggaaaagtg
     2041 tctgaagact tcaccaggca agagctgaga agctgcacac tggagaaaga aagctcttat
     2101 ggagaagaaa gagagaatga ggaagaaagc tatttaactg atatcagcag ccaggattct
     2161 tgcaagggaa acaaggaaga tattaaagat attaaaagtg gagaagaaaa ttctggagaa
     2221 tgaatccgaa tcacaaggtt tcttgtctcg ctgaccctcc ccatgtgcag cctcaggact
     2281 cagagcctgc gcttgggtta ctgtgagcat ccgcggggac agctctcaca cacgcaggcc
     2341 tgctgaacca ggacaccatg cctggaaagg ctgagtccac aggacaagtg atttggttgc
     2401 taccttacag ctttgcatgc tgaagtttag aaattgctat gctctttatg attatgatta
     2461 tatttgtatt ttcaaagtgt ttgagggttg gagaaccaca gctgacacaa atggattagt
     2521 tatggaaatg tatatttgca tttgataggg aaaaattggt attgatagaa ctattagctt
     2581 ttgaagatct atttttaaat gcactatttt catttttttt ctcagaacca gttttaaata
     2641 agtaatatac tacagaaaaa gtagatattt ggaaatttac agtaattttg atactgaaaa
     2701 gatttactgc taaatccaca ccatggctac tttttccttt ttttgccctt tttctggtga
     2761 agattaaacc tagagctcac acatacttaa ctcaatgaat tctaccattt gctatatcct
     2821 caatcctccc gttatttttg atagataaag tattaaaatt acttatgcta cttttagaat
     2881 cctgtgtatt cttgtatata gactaattat ggcccttgtg agtggtaatc ttaagagata
     2941 agggttactg ttctatatat gctgacattg tgatcctaac ttgccaaagg aaaatcctaa
     3001 acgtaattca gatttattta tttatccttg gctttttttt attttttagt gtttcatttt
     3061 tgtttgtttc tttttccttt ttttttcttt cttttccttg attttttttt tttttttttt
     3121 ttgagacaaa gtttctctgt gtagccctgg ctgtcctgaa cttaatttgt agatcaggct
     3181 gacctggaac tcagagatcc acctgcctct gcctttctag tgctgaacaa ttaaagaagt
     3241 gtggcaccac tgctggacag ttttatccat gactttgtgt ctgtctgtgt gtaggaatgt
     3301 ggatgtgagt ttgggtgcct atggaggcca gaagagagtg tcagtatccc tggggctgag
     3361 gctcccagtg ctgtgaactg ggtgctggaa attacacttg tgtcctttgt aagagcagtg
     3421 tgtgtgttta accactgagc cagctctcca atcgaaccag cttggtatta tacttcaaaa
     3481 ataatcaata ataaaatata atcagtaata ttgaccata
//
