LOCUS       NM_153574               4300 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus family with sequence similarity 13, member A (Fam13a),
            mRNA.
ACCESSION   NM_153574
VERSION     NM_153574.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4300)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4300)
  AUTHORS   Lin,X., Li,Y., Gong,L., Yun,J.H., Xu,S., Tesfaigzi,Y., Qiao,D. and
            Zhou,X.
  TITLE     Tempo-spatial regulation of the Wnt pathway by FAM13A modulates the
            stemness of alveolar epithelial progenitors
  JOURNAL   EBioMedicine 69, 103463 (2021)
   PUBMED   34224973
  REMARK    GeneRIF: Tempo-spatial regulation of the Wnt pathway by FAM13A
            modulates the stemness of alveolar epithelial progenitors.
REFERENCE   3  (bases 1 to 4300)
  AUTHORS   Lin,X., Liou,Y.H., Li,Y., Gong,L., Li,Y., Hao,Y., Pham,B., Xu,S.,
            Jiang,Z., Li,L., Peng,Y., Qiao,D., Lin,H., Liu,P., Wei,W.,
            Zhang,G., Lee,C.H. and Zhou,X.
  TITLE     FAM13A Represses AMPK Activity and Regulates Hepatic Glucose and
            Lipid Metabolism
  JOURNAL   iScience 23 (3), 100928 (2020)
   PUBMED   32151973
REFERENCE   4  (bases 1 to 4300)
  AUTHORS   Fathzadeh,M., Li,J., Rao,A., Cook,N., Chennamsetty,I., Seldin,M.,
            Zhou,X., Sangwung,P., Gloudemans,M.J., Keller,M., Attie,A.,
            Yang,J., Wabitsch,M., Carcamo-Orive,I., Tada,Y., Lusis,A.J.,
            Shin,M.K., Molony,C.M., McLaughlin,T., Reaven,G., Montgomery,S.B.,
            Reilly,D., Quertermous,T., Ingelsson,E. and Knowles,J.W.
  TITLE     FAM13A affects body fat distribution and adipocyte function
  JOURNAL   Nat Commun 11 (1), 1465 (2020)
   PUBMED   32193374
  REMARK    GeneRIF: GWAS-associated variants within the FAM13A locus alter
            adipose FAM13A expression, which in turn, regulates adipocyte
            differentiation and contribute to changes in body fat distribution.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4300)
  AUTHORS   Rinastiti,P., Ikeda,K., Rahardini,E.P., Miyagawa,K., Tamada,N.,
            Kuribayashi,Y., Hirata,K.I. and Emoto,N.
  TITLE     Loss of family with sequence similarity 13, member A exacerbates
            pulmonary hypertension through accelerating
            endothelial-to-mesenchymal transition
  JOURNAL   PLoS One 15 (2), e0226049 (2020)
   PUBMED   32053709
  REMARK    GeneRIF: Fam13a expression was reduced in the lungs of mice with
            hypoxia-induced pulmonary hypertension. Genetic loss of Fam13a
            exacerbated pulmonary hypertension in mice exposed to chronic
            hypoxia in association with deteriorated pulmonary artery
            remodeling. Study data revealed a protective role of Fam13a in the
            development of pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4300)
  AUTHORS   Yun,J.H., Morrow,J., Owen,C.A., Qiu,W., Glass,K., Lao,T., Jiang,Z.,
            Perrella,M.A., Silverman,E.K., Zhou,X. and Hersh,C.P.
  TITLE     Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced
            Emphysema Murine Models and Human Chronic Obstructive Pulmonary
            Disease Show Shared and Distinct Pathways
  JOURNAL   Am J Respir Cell Mol Biol 57 (1), 47-58 (2017)
   PUBMED   28248572
REFERENCE   7  (bases 1 to 4300)
  AUTHORS   Jiang,Z., Knudsen,N.H., Wang,G., Qiu,W., Naing,Z.Z.C., Bai,Y.,
            Ai,X., Lee,C.H. and Zhou,X.
  TITLE     Genetic Control of Fatty Acid beta-Oxidation in Chronic Obstructive
            Pulmonary Disease
  JOURNAL   Am J Respir Cell Mol Biol 56 (6), 738-748 (2017)
   PUBMED   28199134
REFERENCE   8  (bases 1 to 4300)
  AUTHORS   Jiang,Z., Lao,T., Qiu,W., Polverino,F., Gupta,K., Guo,F.,
            Mancini,J.D., Naing,Z.Z., Cho,M.H., Castaldi,P.J., Sun,Y., Yu,J.,
            Laucho-Contreras,M.E., Kobzik,L., Raby,B.A., Choi,A.M.,
            Perrella,M.A., Owen,C.A., Silverman,E.K. and Zhou,X.
  TITLE     A Chronic Obstructive Pulmonary Disease Susceptibility Gene,
            FAM13A, Regulates Protein Stability of beta-Catenin
  JOURNAL   Am J Respir Crit Care Med 194 (2), 185-197 (2016)
   PUBMED   26862784
  REMARK    GeneRIF: A genetic locus within the FAM13A gene has been
            consistently associated with chronic obstructive pulmonary disease
            (COPD) in genome-wide association studies.
            Erratum:[Am J Respir Crit Care Med. 2020 Dec 15;202(12):1746. doi:
            10.1164/rccm.v202erratum8.. PMID: 33320073]
REFERENCE   9  (bases 1 to 4300)
  AUTHORS   Jin,Z., Chung,J.W., Mei,W., Strack,S., He,C., Lau,G.W. and Yang,J.
  TITLE     Regulation of nuclear-cytoplasmic shuttling and function of Family
            with sequence similarity 13, member A (Fam13a), by B56-containing
            PP2As and Akt
  JOURNAL   Mol Biol Cell 26 (6), 1160-1173 (2015)
   PUBMED   25609086
REFERENCE   10 (bases 1 to 4300)
  AUTHORS   Cohen,M., Reichenstein,M., Everts-van der Wind,A., Heon-Lee,J.,
            Shani,M., Lewin,H.A., Weller,J.I., Ron,M. and Seroussi,E.
  TITLE     Cloning and characterization of FAM13A1--a gene near a milk protein
            QTL on BTA6: evidence for population-wide linkage disequilibrium in
            Israeli Holsteins
  JOURNAL   Genomics 84 (2), 374-383 (2004)
   PUBMED   15234000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC080861.1 and BE135986.1.
            
            On Jul 15, 2005 this sequence version replaced NM_153574.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080861.1, AJ510136.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4279              BC080861.1         1-4279
            4280-4300           BE135986.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..4300
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.93 cM"
     gene            1..4300
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /note="family with sequence similarity 13, member A"
                     /db_xref="GeneID:58909"
                     /db_xref="MGI:MGI:1889842"
     exon            1..191
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2244
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /codon_start=1
                     /product="protein FAM13A"
                     /protein_id="NP_705802.1"
                     /db_xref="CCDS:CCDS39499.1"
                     /db_xref="GeneID:58909"
                     /db_xref="MGI:MGI:1889842"
                     /translation="MACEIMPLRSSQEDERPLSPFYLSAHVSQVSNVSTTGELLERTI
                     RSAVEEHLFDVSNAGDQSSEDSEPGPSSASSIPTRQRGHQFKKQDDVWHGCDKELINK
                     ENIPSGFSGCAECILNSQEAERFQDDICDYVGERSKPKRQKSSSRLAKLSDNHDGALS
                     MESLSSMQSQETLEPEAAEPLSSESKEIERGGRDTQHCENPTMKIQEHPSLSDTKQQR
                     NQDGEDQQESFVPDMPQLDLTALCDEKTWEEPIPSWQPENADSDEARLSPQAGRLIHQ
                     FLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDEQEDLT
                     PVQLTRRIQTLKKKIRKFEDRFEEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKES
                     KLKISEEDLTPRTRQRSNTLPKSFGSQLEKEDEKKQELLDKAIRPSVEATLEGILRKL
                     QEKRVESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKTERQIMKPLYDRY
                     RLVKQILSRASTVPIIGSPSSKRRSPSLQPIIEGETASFFKEIKEQEEGSEDDSSTKP
                     DFAVTLKTDCSAHCFLDQLEDDADGFISPMDDKMPSKCSQDSGLSNLHSASIPELLEY
                     LQEMREEKKMIRKKLHDFEDNFFRQNGRNVQKEDRTPMAEEYNEYKHIKAKLRLLEVL
                     ISKRDSDSKSM"
     exon            192..233
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..275
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..452
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..639
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..716
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..759
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..907
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1112
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1251
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1333
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1554
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1638
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1734
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1818
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..2015
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2117
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..4293
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3911..3916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /note="hexamer: AATAAA"
     polyA_site      3929
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /note="major polyA site"
     regulatory      4251..4256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /note="hexamer: AATAAA"
     regulatory      4274..4279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /note="hexamer: AATAAA"
     polyA_site      4279
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
     polyA_site      4293
                     /gene="Fam13a"
                     /gene_synonym="D430015B01Rik; FAM13A1; Precm1"
                     /note="major polyA site"
ORIGIN      
        1 gtggactgca gtgtaaatgt ggaggcagcc gataaatatc cttgcctgca gctggaggtg
       61 gagaggcagt gtcagctgca gcaggttgtg tgttccgcgg gtcctgcaca cagggcttga
      121 ctggaaggca ctcggggatc ccgtgcagat tcgcacacga ggatggcttg tgaaatcatg
      181 ccgctgcgaa gctcacagga agatgaaaga cctttatcac ctttctatct gagtgctcat
      241 gtatcccaag tcagcaatgt ttcaacaact ggagaactct tagaaagaac catcaggtca
      301 gcagtagaag agcatctttt tgatgtcagc aacgctggag accaaagttc agaggactca
      361 gaacccggac catcttcagc atcttctata cccaccaggc agcgagggca tcaatttaag
      421 aagcaggatg atgtctggca tggttgcgac aaggagctta tcaacaagga gaatatcccc
      481 tctggcttca gcggctgtgc tgagtgcatc ttgaacagcc aggaagcaga aagattccag
      541 gacgatattt gtgactacgt tggggaaaga agcaaaccca agcgtcagaa atccagttcc
      601 aggcttgcca agctcagtga caaccacgat ggggccctga gcatggaaag tctcagttcc
      661 atgcaatctc aagaaacact ggaacctgaa gctgctgaac cgttatcttc tgagagcaaa
      721 gaaattgaaa gaggcggtag agacactcag cattgtgaga accccacgat gaagattcag
      781 gagcatccca gtctatctga caccaaacag cagaggaatc aagatggtga agatcagcag
      841 gagagctttg tcccagatat gccccagttg gacctgacag cattgtgcga tgagaagacc
      901 tgggaagaac ccattccttc ctggcagcca gagaatgcag actctgatga agcccgcctc
      961 tccccacagg ccgggcgcct gattcaccag tttctggatg aagacagcga ccccatgctg
     1021 tcccccaggt tctatgccta tgggcagagc aggcagtatc tggatgatac agaagtgcct
     1081 ccttctcccc ccaattccca ttctttcatg aggcggcgaa gctcctccct ggggtcctac
     1141 gatgacgagc aagaggacct gacaccagtg cagctcacca gaaggatcca gacccttaaa
     1201 aagaagatcc ggaagttcga ggacaggttt gaagaagaga ggaagtacag accctcccac
     1261 agtgataagg cagctaatcc agaagttctg aaatggacaa atgacttggc caaattccgg
     1321 aaacagctga aagaatcaaa actgaagatc tctgaagagg acctcacccc caggacacgg
     1381 caacgaagta acacactccc caagagtttt ggttcccagc tagaaaaaga agatgagaag
     1441 aagcaagaac tgctggataa agccatcagg cccagtgttg aagctacact ggaagggata
     1501 ctaagaaaac tccaagagaa gcgagtggag tccagccgtc ctgaggacat taaggatatg
     1561 accaaggacc agattgctaa tgagaaagtg gctctgcaga aagccctgct atactacgaa
     1621 agtatccatg ggcggccggt gacaaagact gagcgtcaga taatgaagcc actgtatgat
     1681 cggtaccgac tagtcaaaca gatcctgtcc cgggccagca ctgtccccat cattggttcc
     1741 ccctccagca aaaggagaag cccttcgctg cagccgatta tcgagggtga aactgcttcc
     1801 ttcttcaagg agataaagga acaagaggag ggttcagaag atgacagctc cacaaagcca
     1861 gactttgctg tcactttgaa aacagactgc agtgcacatt gctttctgga ccaacttgaa
     1921 gatgatgctg atggatttat ttcaccaatg gatgacaaaa tgccatcgaa atgcagccag
     1981 gactcaggcc tttcaaacct ccactctgct tcaatacctg aactcttgga ataccttcag
     2041 gaaatgagag aagaaaaaaa aatgattcga aagaaacttc atgattttga agacaatttt
     2101 ttcagacaaa atgggagaaa tgtccagaag gaagaccgta ctccaatggc tgaagagtac
     2161 aatgaataca agcacataaa ggcaaagcta cgtttgctgg aggtgctcat cagcaaaaga
     2221 gattctgatt cgaaatccat gtgaaggact ggtggtgtgg atgaatgaca gttctccctg
     2281 gaaagaacag ctctggaagg cagccttgga gctgtactca caaagcaggc aatcccctgc
     2341 ctctgaccca tcagattgac tcctgcttcc attgcctgcc ttagaaactg cctgcatgga
     2401 agataccagt gtgacctgac taaggaattt tatagtggga gagtcaagac tcctacacat
     2461 gtcaatacac actgcagtag gaacttcact gacatgagca gcgattagac acaccatcag
     2521 actcggcaga taacctgttc ttccctgaca actgagaaac atgaggccat tctaaaactg
     2581 tgacaggcac aagctcagga cttcccttgc aaagcctgct tgttgtggag gtccgtgccc
     2641 accctggacc ccaccacatg gttgaccatg tgttggcaca ttatttgctg ccttggccat
     2701 ttcccgagct gcgcttatcc actctgacaa atccatttcc ctgttagctc tcaggtagaa
     2761 ggaggctgca tccatccagt ggcggggcag tcatttcatt gactagatct ctcaactgac
     2821 agactttaag tccctgcctc atacctgtgt acactgagga cagagtgact aaacaagtag
     2881 ctatgcagat gttattttaa aatcaggtga cagctgaaga gcctgaaaac tcttcaagac
     2941 actgactgca ctttccagtc tcagacattg atgccgaaca caaaatgcgg ccggtgttcc
     3001 tatgataacc tgtttggggc tcaattttgt tgttgcacta gccaaacaaa ggagtcttgc
     3061 ttcattatta gatgagatat aaaatattat gggagagagg gagtctgtat cagtctccta
     3121 aacttaccag agcataattt ttctacgaaa gtaaatctgc actaaaatcc ctaaatggat
     3181 ggggaagatg tagccctaag tgctcagctc attctcaagg cagaatctag atcacaccgt
     3241 tttcaagatc atacataaac aaaatggtgt gtggcccatt ttgatgctgt ggtttttgtt
     3301 tttcccaaag actatgtcac aaagctgtct atattagaca ttttggaggg accagggaac
     3361 ttaagacacc cccctcccca ttattcatct cttctgtgtg cctgctgtca ttcctgtgat
     3421 gtgttctttc ttttcatcta ccacgcccgc cggaagagtg caggcttggt tttgcagctg
     3481 tgcaacagcc ctgtgtctga gagactgaac tgtaggctgg gcagacagca gagagaccct
     3541 gttctgtttg gagagtcacc ttcgagaggg cacaatgtta atgagaagaa tggaaaactg
     3601 taccaccaat tacaatgata aaataggttt gggggtctcc agtcagatga ttttcagcac
     3661 tgattccccc actgtagctc tgtcaccagg aggctctttc agtaacgggt ggggtgggtg
     3721 gaggattcct tcagttttgc ttttacaaac aatcccctag aagcatgagc tatgtgttgg
     3781 aaatactgtt tttatccaca cacttaaaga cgatacataa tcctacaaat ttcaatgtac
     3841 atgaaaatgt agtttgatat tctttgctct gctgtttaca tttgctatga tttccaggag
     3901 ttatactatg aataaaattc tgtaatgtag gacgttttct attttttgag gcctgaacat
     3961 gaatcatgca catgaccaaa aaaattgtat ttttaaaagg aaatccatat ctagtctgta
     4021 atttttaagt acttaatctc ctaaggaaac tggaatgact caaatcagca ccagttaact
     4081 tttaaagcac atctgcttaa gagcactgtt ttgaaaagaa tacactagag atttcttctt
     4141 taaagctgca tacaaatgag aagctattag atgttttgaa atccatcctt tgcaccaaag
     4201 gtaaatgaac taagatttat tcacgactcc ccattcagtt ttatgtgatc aataaattac
     4261 cacgttattg gaaaataaat catgtatgga ataaaaaaaa
//
