LOCUS       NM_025591               1643 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus family with sequence similarity 136, member A
            (Fam136a), transcript variant 1, mRNA.
ACCESSION   NM_025591
VERSION     NM_025591.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1643)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1643)
  AUTHORS   Babu,V., Bahari,R., Laban,N., Kulaga,J., Abdul,Z., Zakkar,B.,
            Al-Najjar,A., Lesus,J., Al-Rifai,A.A., Sattar,H., Irukulla,S.,
            Gunniya,P., Requena,T. and Lysakowski,A.
  TITLE     RotaRod and acoustic startle reflex performance of two potential
            mouse models for Meniere's disease
  JOURNAL   Eur J Neurosci 58 (3), 2708-2723 (2023)
   PUBMED   37461313
REFERENCE   3  (bases 1 to 1643)
  AUTHORS   Fancy,S.P., Baranzini,S.E., Zhao,C., Yuk,D.I., Irvine,K.A.,
            Kaing,S., Sanai,N., Franklin,R.J. and Rowitch,D.H.
  TITLE     Dysregulation of the Wnt pathway inhibits timely myelination and
            remyelination in the mammalian CNS
  JOURNAL   Genes Dev 23 (13), 1571-1585 (2009)
   PUBMED   19515974
REFERENCE   4  (bases 1 to 1643)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155947.8.
            
            On Feb 8, 2019 this sequence version replaced NM_025591.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103775.1, AK141279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC155947.8         26848-27021         c
            175-315             AC155947.8         25917-26057         c
            316-1643            AC155947.8         22609-23936         c
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.69 cM"
     gene            1..1643
                     /gene="Fam136a"
                     /gene_synonym="2010309E21Rik; Hyccin"
                     /note="family with sequence similarity 136, member A"
                     /db_xref="GeneID:66488"
                     /db_xref="MGI:MGI:1913738"
     exon            1..174
                     /gene="Fam136a"
                     /gene_synonym="2010309E21Rik; Hyccin"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..504
                     /gene="Fam136a"
                     /gene_synonym="2010309E21Rik; Hyccin"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM136A"
                     /codon_start=1
                     /product="protein FAM136A isoform 1"
                     /protein_id="NP_079867.1"
                     /db_xref="CCDS:CCDS20309.1"
                     /db_xref="GeneID:66488"
                     /db_xref="MGI:MGI:1913738"
                     /translation="MAEVQQLRVQEAVDAMVKSVERENIRKMQGLMFRCSANCCEDTQ
                     ASMQQVHQCIERCHAPLAQAQALVTSELERFQDRLARCTMHCNDKAKDSMDAGTKELQ
                     VKRQLDSCVTKCVDDHMHLIPTMTKKMKESLSSIGK"
     exon            175..315
                     /gene="Fam136a"
                     /gene_synonym="2010309E21Rik; Hyccin"
                     /inference="alignment:Splign:2.1.0"
     exon            316..1643
                     /gene="Fam136a"
                     /gene_synonym="2010309E21Rik; Hyccin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1623..1628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam136a"
                     /gene_synonym="2010309E21Rik; Hyccin"
                     /note="hexamer: AATAAA"
     polyA_site      1643
                     /gene="Fam136a"
                     /gene_synonym="2010309E21Rik; Hyccin"
                     /note="major polyA site"
ORIGIN      
        1 agtggcttga gaagcccgca cgggcgcagg gggcggggcg cagcgggtgc acacgcgggc
       61 gccggcgcgg ctgagctcag ggtcgccatg gcggaggtgc agcaactccg agtgcaggag
      121 gctgtggacg ccatggtgaa aagtgtggag agagagaaca tccggaagat gcagggcctc
      181 atgttccggt gcagcgccaa ctgctgtgaa gacacccaag catctatgca gcaggtgcac
      241 caatgcatcg agcgctgcca tgcgcctctg gctcaagccc aggctctggt caccagcgag
      301 ctggaaaggt tccaggaccg cctggcccgc tgcaccatgc attgcaatga caaagccaaa
      361 gactcaatgg atgcaggaac taaggagctt caggtgaagc gacagctaga cagctgtgtg
      421 accaagtgtg tggatgacca catgcacctc atcccaacaa tgaccaagaa gatgaaggag
      481 tctctgtcat ccatagggaa ataaaattgt ttgccagtga ccatcgggac tgcgggcagg
      541 ctatttaaaa ggaagaatgg aagtttaata tgttaagcaa cgtttacgaa tgaggaaaac
      601 ttagacacag caagttccag gcaaatgctg ctcactgctg gacactagtc cctttacatt
      661 cggatcttag aaggtgaagt aggaagaagc tggtgctaag atttggatca cagatagctc
      721 agaggagaag tctagatcct aaatattcat atgcaagtgt ctgtactgta gtagagatca
      781 accttgtacc aagagctgag cttcttacta caaacatcca ggctggcagc tctcttcaac
      841 ctgctggtaa aatctgagga tcggtgcatc tcctcagaga agcttgacaa atcctgttga
      901 ccagaagtat catcacacca ccttgcatat gctgggaaac aaaacccagt aggctaggaa
      961 ttcagaggaa aggatttcct tttcaaatct atattttgct tagttttgtc ttatatgcag
     1021 ggcacactgg atttatgata caggagggaa agtggtttga gtcacttcta aaggttccta
     1081 gtattatgta ccgtcaagat gggaatgtcc atttcttcaa attctgttac tctagaagcc
     1141 cctgaagaat ccggacagtg tcacacagtg aacatgggaa acagccttct ttactgactt
     1201 gtgcagcaaa gtgacacatc cttatgaaaa gcaagggggt aggctgtcac tcacatgcca
     1261 gtcgctaaga ataagcagta actaggaatt attgagaagt gcaaacccag tattaatcag
     1321 ctctgaatct acagagcctt atagcaacaa gaaagccaga aactgagcaa cttgggccac
     1381 agatgggtag gaccactgta gaacaagaga ggcacacact ttcttgccaa atgccatttt
     1441 tgcctgggtg gtttttattt tttattttct ttgcagtgca gtgttgctgg cccaacatag
     1501 caccttatct tttggataag tactatgttg tatttatacc aattaattac ttgaaacagt
     1561 gatacatctg tctttttgct gtgtcaagcc tgcaatatat tttccaagtg gtttggtttt
     1621 taaataaagt ttcattgtct cca
//
