LOCUS       NM_024203               4540 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus family with sequence similarity 120, member B
            (Fam120b), transcript variant 1, mRNA.
ACCESSION   NM_024203 XM_484593
VERSION     NM_024203.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4540)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4540)
  AUTHORS   Liu,Z., Gao,X., Zhou,Z., Kang,S.W., Yang,Y., Liu,H., Zhang,C.,
            Wen,Z., Rao,X., Wang,D., White,D. 3rd, Yang,Q. and Long,Q.
  TITLE     San1 deficiency leads to cardiomyopathy due to excessive
            R-loop-associated DNA damage and cardiomyocyte hypoplasia
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1867 (11), 166237 (2021)
   PUBMED   34339838
  REMARK    GeneRIF: San1 deficiency leads to cardiomyopathy due to excessive
            R-loop-associated DNA damage and cardiomyocyte hypoplasia.
REFERENCE   3  (bases 1 to 4540)
  AUTHORS   Andrews,A.M., McCartney,H.J., Errington,T.M., D'Andrea,A.D. and
            Macara,I.G.
  TITLE     A senataxin-associated exonuclease SAN1 is required for resistance
            to DNA interstrand cross-links
  JOURNAL   Nat Commun 9 (1), 2592 (2018)
   PUBMED   29968717
  REMARK    GeneRIF: Study report a previously uncharacterized protein, SAN1,
            the Fam120b gene product, as a 5' exonuclease that acts
            independently of the Fanconi anemia pathway in response to
            inter-strand DNA cross-links (ICLs). Deletion of SAN1 in HeLa cells
            and mouse embryonic fibroblasts causes sensitivity to ICLs. SAN1
            binds to senataxin (SETX). SAN1-SETX binding is increased by ICLs
            and is required to prevent cross-link sensitivity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4540)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 4540)
  AUTHORS   Keil,S., Matter,H., Schonafinger,K., Glien,M., Mathieu,M.,
            Marquette,J.P., Michot,N., Haag-Diergarten,S., Urmann,M. and
            Wendler,W.
  TITLE     Sulfonylthiadiazoles with an unusual binding mode as partial dual
            peroxisome proliferator-activated receptor (PPAR) gamma/delta
            agonists with high potency and in vivo efficacy
  JOURNAL   ChemMedChem 6 (4), 633-653 (2011)
   PUBMED   21400663
  REMARK    GeneRIF: Sulfonylthiadiazoles with an unusual binding mode were
            shown as partial dual peroxisome proliferator-activated receptor
            (PPAR) gamma/delta agonists with high potency and in vivo efficacy.
REFERENCE   6  (bases 1 to 4540)
  AUTHORS   Mihola,O., Trachtulec,Z., Vlcek,C., Schimenti,J.C. and Forejt,J.
  TITLE     A mouse speciation gene encodes a meiotic histone H3
            methyltransferase
  JOURNAL   Science 323 (5912), 373-375 (2009)
   PUBMED   19074312
REFERENCE   7  (bases 1 to 4540)
  AUTHORS   Trachtulec,Z., Vlcek,C., Mihola,O., Gregorova,S., Fotopulosova,V.
            and Forejt,J.
  TITLE     Fine haplotype structure of a chromosome 17 region in the
            laboratory and wild mouse
  JOURNAL   Genetics 178 (3), 1777-1784 (2008)
   PUBMED   18245833
REFERENCE   8  (bases 1 to 4540)
  AUTHORS   Li,D., Kang,Q. and Wang,D.M.
  TITLE     Constitutive coactivator of peroxisome proliferator-activated
            receptor (PPARgamma), a novel coactivator of PPARgamma that
            promotes adipogenesis
  JOURNAL   Mol Endocrinol 21 (10), 2320-2333 (2007)
   PUBMED   17595322
  REMARK    GeneRIF: CCPG is a bona fide coactivator and promotes adipogenesis
            in a PPARgamma-dependent manner.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY073650.1, AK132211.1 and BC085163.1.
            
            On Sep 20, 2005 this sequence version replaced NM_024203.2.
            
            Transcript Variant: This variant (1) encodes a 786aa protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066088.1, AK132211.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BY073650.1         2-25
            25-3476             AK132211.1         3-3454
            3477-4540           BC085163.1         4742-5805
FEATURES             Location/Qualifiers
     source          1..4540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.95 cM"
     gene            1..4540
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /note="family with sequence similarity 120, member B"
                     /db_xref="GeneID:67544"
                     /db_xref="MGI:MGI:1914794"
     exon            1..315
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            316..1700
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1881
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1983
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2156
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2249
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2456
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2565
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2652
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2704
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..4519
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2953..2958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /note="hexamer: ATTAAA"
     polyA_site      2978
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /note="major polyA site"
     regulatory      4348..4353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /note="hexamer: AATAAA"
     polyA_site      4383
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
     regulatory      4496..4501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
                     /note="hexamer: AATAAA"
     polyA_site      4519
                     /gene="Fam120b"
                     /gene_synonym="4932442K08Rik; CCPG; mKIAA1838; Pgcc1"
ORIGIN      
        1 aacggaagcg gaagtgagca cgccgtagac tgtgggtctg aaatctggtt gacgcagtct
       61 gcggccactg ctgagctttg ggtaggccag gctggggaat cggccctgga tctctgctgt
      121 cgcatctccc taccccagac tccttccagc atcaagtcca ctatcctcgc cgtggccacg
      181 cccctccgca tcctggcttc tctgcgtcct ggctgttcct ccctgggtgg aggggagagg
      241 cagccatcca cttgcaggtg gagcggggtg gagactcttc ctgagcccag ctgcaggaca
      301 ctgaggacca gcgagattca taggacccaa ttatgggtgt aagaggtttg caggggtttg
      361 tggggagtac gtgcccacac atatgtacca tagtcaatat ccacgagctg gcagagcgtc
      421 accgaaacaa gtaccctgga tgtacgccta ccatcgtggt ggacgccatg tgctgtctcc
      481 gatactggta cacagcagag tcgtgggtct gcggcggcca gtggagagaa tactactgtg
      541 ctttgagaaa ttttgttgca gccttcacct ctgccggcat caagttgata ttcttctttg
      601 atggcatggt ggagccgggg aagcgagatg agtgggtaaa gcgtagactc aaaaacaacc
      661 gggagatatc caagattttt cactacatca agtcaaaaag agaccagcca ggcagaaaca
      721 tgttcttcat tccctctggg ctggccatat tcacacggtt cgccctgaag acactgggcc
      781 aggagacttt ctgttcatta caggaggcag actacgaggt ggcttcttat ggcctccagc
      841 acaactgtct ggggatcctt ggggaagaca ctgactactt aatttatgac acttgcccct
      901 acttttcaat tggcgatctc tgcctagaga gtctccaaac catcatgctc tgtcgagaga
      961 agctctgtga gagcctgggc ctccgtgtgg cagaccttcc tcttctggcc tgtctgcttg
     1021 gcaatgacat cactccagag agcatgtttg aaagctttcg gtacaagtgc ttgtcatcct
     1081 atgcttctgt gaaagagaat gctggcaaaa aaggaaatat tatcctagct gtctcagact
     1141 atatctccaa agttcttcat ttgtatcaag gtgagaagaa gatagaagag atgctaccct
     1201 tggggccaaa caaagctctc ttttataaag gagtaacctc atatcttttg ccagggcaga
     1261 aatctccatg gttagttcaa aaacccaaag gcatgataac agacaaacag caaatggtga
     1321 gtttaaatcc cgaatccaag caagaagtcc ctatgtgtat tgatcctgaa ttcaagcaag
     1381 aagttcctgt gtgcactaat cccgagtcca tgcaagaagt tcccatgtgt atggatcctg
     1441 agcccaacca ggaagcttcc atgtgcacag atcccgaatc caaacaagaa gttcccatgt
     1501 gcacagactc cgaatccaag ccagaagttt cccaatatac aaacccagag agcaagcaaa
     1561 aattaccttc aggaatagac actgaattta acctagaagc actcatgtgt acacaccctg
     1621 aatttaaaca agaagatgtc atggatatgg aacctgaaat aaagcaagta accatggttt
     1681 ccgagtctga gatcttaaag gttgccagga tgcatcacgt ccactcagaa agctacctag
     1741 tgtacaacat tctgagcagt ggggagatag aatgcagtaa caccctggag gatgagctgg
     1801 accaagccct cccgagccaa gcctttatct accgcccagt ccggcagcgc gtctacgcac
     1861 tcctactcgg ggactggaaa gatggagcca gcactggccc agtggtcaag gagtggtttg
     1921 tgtaccccgg taactccctg aagcacccag acctagttag gcctctgcag atgaccgttc
     1981 aagggggaac acctagcttg gaagttctgt ggctgagcca agagccagca gtgcaggccc
     2041 agcgcctgga caccttgcta gcctgcttca acctttcctc ctcaagagaa gagctgcaag
     2101 cagttgagag cccgttgaga gcgctgtgct gcctcctgat ctacctcttt gtccaggtgg
     2161 acactctttc cctggaagat ctgcatgcat ttatcgctca ggccttgtgc ctccaaggaa
     2221 aatcaacctc ccagctcatg cacttacagc tggattacat taactccaga gctgtgcagc
     2281 tgggatccct cctcgtccgt ggcctcacca cattggtact agtcaatagc gcatgtggct
     2341 tcccctggac aacaagtgag tttatgccct ggaatgtgtt tgatggcaag cttttccatc
     2401 agaagtacct gcagtctgaa aagggatatg ccgtggaagt tcttttggaa caaaatagat
     2461 cgtggctcac caagttccac aacctgaagg cagtggtctg caaggcctgc tccaaggaga
     2521 accggcgcat cgtaggcaga acgcattggg actctcctta cacagggagg caagggagac
     2581 agggctacag ctcctacagg acagactcca cacatggcca ttctgggcag tcatggagaa
     2641 accagggttc agggggcaga cagcatgagc gtaaccactg gagaagatac tagatgctgt
     2701 acagaagagt gtggaaacag gatcaatgtc cagactctgc cctccggtct cagcaacaag
     2761 gacagcaact ggggcaaccc tttaaaggaa ggaaaattgc ttttcagagg tttctcctac
     2821 acaaactata aaaatatccc attggtttgt ttcagaggtt gctcctgact ccatgatcca
     2881 gaacacttga cactatcatt gagaatgctc tcctgacctt agcaggagtc taactccaaa
     2941 cattttctta ctattaaatt gtgaaaatgt ttcctcaagt cattagtctt tgaactcatg
     3001 atgtcttctt attttcctgt tactgtgaaa aggcactgtg aacaaagcaa cttacagaag
     3061 agagcatttg atttgggtct tagagttcca tagggtggta gagcctcgga ccatcatgtt
     3121 ggggtatgtg acaggagcca ggcgaggacg agccaactgg gaatggctca gggttttgaa
     3181 acttcaaagc ccacccccca agtgacacac ctccatcagc aaagccacac ctcctccagt
     3241 aaggccactc ctcctagtcc ttcccaccaa ctggagacca agctttcaaa catactagct
     3301 tatggggcca ttctcattca gaccaccaac catgatatct aatagctatg caatctgtca
     3361 gaaattactt tttcattaga aaatctaaca aaagtaagta ttcatctatt tttttttctt
     3421 gatccacaaa gtatttggat agaaaaaaaa aagcaactaa ataaattctt gctctcttgt
     3481 gggcgagttg gttctgcttg gaggaaacct ggctcagcgg ttaagaacag ggtctgctct
     3541 tccagattcc cctcacccac acggtggctc acaactaact gtctgaaact ccagttccag
     3601 gggatcgaaa gcctcttctg gcctctgtga gaggcagaca cacagtgatg cccagacatg
     3661 cacacaggca aaacacccat aaagatgaaa taaataagtt taaaaaaaaa aagaattttt
     3721 ttttttaaaa gaagcatagt gggttaagct taaaaagtaa gatcctcttt gaggttctta
     3781 tccatctcca ctggggatcc aagagtatct gtgcctgtcc agggccctta tggccctgcc
     3841 gtatctctgg ggacactgag ttccgtcagg agatgcaagc actttggtca ctggaagatg
     3901 tatcctttca gtgctcctgt ctaagatttt aataacgctt ctaaaaatgt accttgtcac
     3961 ctttacgctg acagttttcc agaccactgg ctcaaccatg ctgtgcagag agaggccttg
     4021 cgtttctcct tgagattctt gtgtttacca gaaaggtatc tcgcctgcat ttgaacatgg
     4081 ttgtatttgt tcagcttcct tctgctcctg caggacttaa gcatagtgtg tctgcagagc
     4141 ttgtagctgc catgactttg ctgcctagtt tggctcttct ggtccttccc tcgaataccg
     4201 tcctcttcaa acactgctgc cgttagaaat cctgtttcct tgctgtctac ttgtgtaact
     4261 tttaattcag attctgatct cttaagttga aagtctattt ctatgaaagt tgttttccgt
     4321 catggaaact gcatcctgac acttgtcaat aaaatgcatg agtacgtcag tcacaagttt
     4381 aaataggcca ctgtgttgat ggaatattta tcacctttag agctttccca gtgacagcat
     4441 tgcttacgct gtttcccagt caagtcttgg gatagaattt ccacatatac aataaaataa
     4501 aaatacattt ttaaactcaa aaaaaaaaaa aaaaaaaaaa
//
