LOCUS       NM_001418245            3140 bp    mRNA    linear   ROD 05-FEB-2025
DEFINITION  Mus musculus family with sequence similarity 107, member B
            (Fam107b), transcript variant 3, mRNA.
ACCESSION   NM_001418245 XM_006497518
VERSION     NM_001418245.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3140)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3140)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3140)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3140)
  AUTHORS   Masana,M., Jukic,M.M., Kretzschmar,A., Wagner,K.V., Westerholz,S.,
            Schmidt,M.V., Rein,T., Brodski,C. and Muller,M.B.
  TITLE     Deciphering the spatio-temporal expression and stress regulation of
            Fam107B, the paralog of the resilience-promoting protein DRR1 in
            the mouse brain
  JOURNAL   Neuroscience 290, 147-158 (2015)
   PUBMED   25637808
  REMARK    GeneRIF: Fam107B and DRR1 show different spatio-temporal expression
            patterns in the central nervous system, suggesting at least
            partially different functional roles in the brain; glucocorticoid
            receptor-induced regulation appears to be a unique property of DRR1
REFERENCE   5  (bases 1 to 3140)
  AUTHORS   White,J.K., Gerdin,A.K., Karp,N.A., Ryder,E., Buljan,M.,
            Bussell,J.N., Salisbury,J., Clare,S., Ingham,N.J., Podrini,C.,
            Houghton,R., Estabel,J., Bottomley,J.R., Melvin,D.G., Sunter,D.,
            Adams,N.C., Tannahill,D., Logan,D.W., Macarthur,D.G., Flint,J.,
            Mahajan,V.B., Tsang,S.H., Smyth,I., Watt,F.M., Skarnes,W.C.,
            Dougan,G., Adams,D.J., Ramirez-Solis,R., Bradley,A. and Steel,K.P.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     Genome-wide generation and systematic phenotyping of knockout mice
            reveals new roles for many genes
  JOURNAL   Cell 154 (2), 452-464 (2013)
   PUBMED   23870131
REFERENCE   6  (bases 1 to 3140)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3140)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732328.12 and AL844530.7.
            
            On Mar 17, 2023 this sequence version replaced XM_006497518.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD554163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AL732328.12        133621-133783
            164-347             AL844530.7         25975-26158
            348-498             AL844530.7         31597-31747
            499-3140            AL844530.7         32680-35321
FEATURES             Location/Qualifiers
     source          1..3140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 2.05 cM"
     gene            1..3140
                     /gene="Fam107b"
                     /gene_synonym="3110001A13Rik; Gm50615"
                     /note="family with sequence similarity 107, member B"
                     /db_xref="GeneID:66540"
                     /db_xref="MGI:MGI:1913790"
     exon            1..163
                     /gene="Fam107b"
                     /gene_synonym="3110001A13Rik; Gm50615"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..615
                     /gene="Fam107b"
                     /gene_synonym="3110001A13Rik; Gm50615"
                     /note="isoform 2 is encoded by transcript variant 3; novel
                     DUF1151 domain containing protein; protein FAM107B"
                     /codon_start=1
                     /product="protein FAM107B isoform 2"
                     /protein_id="NP_001405174.1"
                     /db_xref="GeneID:66540"
                     /db_xref="MGI:MGI:1913790"
                     /translation="MKSHLLGPEANEGHSELSASHLVAELKPEKTNLYGPLENIDPKD
                     SCLIPRNIMAEPDYIEDDNPELIRPQKLINPVKSSRNHQDLHRELLMNQKRGLAPQNK
                     PELQKVMEKRRRDQVIKQKEEEAQKKKSDLEIELLKRQQKLEQLELEKQKLQEEQENA
                     PEFVKVKGNLRRTGQEVAQAQES"
     exon            164..347
                     /gene="Fam107b"
                     /gene_synonym="3110001A13Rik; Gm50615"
                     /inference="alignment:Splign:2.1.0"
     exon            348..498
                     /gene="Fam107b"
                     /gene_synonym="3110001A13Rik; Gm50615"
                     /inference="alignment:Splign:2.1.0"
     exon            499..3140
                     /gene="Fam107b"
                     /gene_synonym="3110001A13Rik; Gm50615"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3111..3116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam107b"
                     /gene_synonym="3110001A13Rik; Gm50615"
                     /note="hexamer: AATAAA"
     polyA_site      3140
                     /gene="Fam107b"
                     /gene_synonym="3110001A13Rik; Gm50615"
                     /note="major polyA site"
ORIGIN      
        1 aaacagtttt gctccccaac caagtctgtt ggcaaaacta ctactgtgga acgttttgtt
       61 catatgaaga gtcacttatt gggtccagag gcgaatgaag gacacagtga gttaagtgcc
      121 agtcacctgg tggcagagct gaaaccagaa aaaacaaatc tctacggccc ccttgagaat
      181 attgacccca aagactcctg tctcattcca agaaacatca tggctgagcc agactacata
      241 gaagatgaca atcctgagct aattaggccc cagaagctta tcaaccctgt caaaagctcc
      301 cgaaatcacc aagacctcca cagagagctt cttatgaatc agaaaagagg tcttgcccct
      361 cagaataaac cagaactgca gaaggtgatg gagaagagaa gacgagacca agtgataaag
      421 cagaaggagg aagaagctca gaagaagaaa tccgacctgg aaatagaact attaaagcga
      481 cagcagaagc tggagcagct tgaacttgag aagcagaaat tgcaagaaga gcaagaaaat
      541 gccccagagt ttgtgaaggt gaaaggcaat ctcaggagaa caggccaaga ggtggctcag
      601 gcccaggagt cctaggccca ggctgtgtgt gacctgatgt gtccccacca tctctgtagg
      661 agccccgtct agacacctct acagtactgt tcttgggcca aagtcctgag gaagagaatc
      721 cagacagctg agaattttga ctatcaaaaa aggattgcgt ttgatttacc attgtggtag
      781 atgagttgtc tctgatggtt gcaattccca ttcgccaaat gaaagacatc gaccagcaca
      841 caagatacca tggacctgtg tttagaccaa gaaagccaca aaaggagtga aaagaggcag
      901 gaagcgggca ctggaacacg caagagggtt gtactactcg gcctttcttc cattccaagt
      961 ttagtgggac acagagcctt ccttgttaag agaattgttt ggaatccctc cttgggttat
     1021 ctgttagatt gttttgattg catcaaaatg tatttcatct gttacatcca gtatttgtat
     1081 ttcattctga gaacccagat ttccccccac caccaccaca ttataaatta agaaaggagg
     1141 ctattactgt ttatgtttaa ttatacctat tactttggtt gacattgaag ttcagaaaca
     1201 ggataagaca tttgaacatg tcagcaccca tcatgaacta actgtaattc ccttaggttc
     1261 ttggcatgac agtatgccag atattgcctt ttcacttcta agaaggtata tacagcttgt
     1321 cgattccttt ctcgccttga taaccatagc ctttctgttc cattttagtt tgtcatttct
     1381 tgctcaacta ttcctttcag ttgaagcaat ttctcagttc tttttcggat gaaaccagag
     1441 tgtgtaactc aacttctgtg tcccatatag agagaccagc tcttttgagt tctcctgaga
     1501 gcagtgtaga ggagtgtata ttaggactgg tgatgaggcc tttagagatt gtatggaatg
     1561 caaatagaga tctgtttcta agagacttta ggggaaggct tgatactttt tacattttga
     1621 atattttaga cttgagcttt gaacatctcc ggcggatggt cacaagtttc tttccctttt
     1681 gtttcctgtg aagatgacca tcttggcgct cttggcatga tgctgttggt aggatgatcc
     1741 tgactactgt gttgcatctc tcaggaaaag ctgaggtgct gggcaaggct gctcagttcc
     1801 ctcttgctag ctagcatgct gttcaaagag acatctaagt tacaaataat atgaaagttc
     1861 tcatgcaaaa tatattttgt actacaggca tgagattttt tttggctttt tttttctttt
     1921 ttgtatttag tacttctcca tagagatgat ttaaccagta atttctacac tgaagacttc
     1981 tgtttccttt catgatgcat agaatagcag atgtagcgct ttggaatcct tgcttagcac
     2041 actagatgct agttttctct gggaccactt cagtctggta gtttacaggc ccacattccc
     2101 ttccagtctg cataagaagt aagtgggtga taattcactg ctagataaga agcctgagag
     2161 ctgagtacag cagagcggat tcttggtcct atcagcaagt gctatctaaa taaaatatga
     2221 gacgctgaag ataaggtggt ttgcccttga agattggctc agtgaccact ttgtcatctt
     2281 cctttccttt gagaaagaaa agttcattca ctgattgttg aaataagcct ctccatgcac
     2341 actgcttagt ctttctctat gcatacagaa taatgacatc aggtggtagg gtgacgagtc
     2401 ggggcaatta gaccttttta tctacctgga agctagctct ggagatgtcc tgccacttgg
     2461 caggatcttc aagggccatc gctagctccc atagaaggcc tgatgctgtt ctactctaca
     2521 acactggggg aaaagttagc tacaaacatg tttgcttcct ggttgcactc agaccggcca
     2581 tcatccttgg tggttagtgc tgcagggtct atcaaaagac gacttgtaca tacaagaagt
     2641 gatggcttct gctaggtctc agagcatccg gggagcagag cggggccttt aggaatctgc
     2701 tgggaactca ctgagaatgc tgtcagtcac tcatttcttg cacttaacac tgcacaaagc
     2761 ctcagtccaa agcctgagga caggtcacca actgagcagt gtcgtgcttt gagccactaa
     2821 taggggggaa aaggctccat ttttccactc tgtagttttc ttaaaatagt tctgtgtttt
     2881 gtagtctcct gctagtaaag tagtattgct ttctaagcta taccagttga ctttattctt
     2941 ctactccaag aatctaaacc catttgagtg tacataatat atataaaggg agccttaatg
     3001 gatttgtttt cataatttaa tattttttgt atttgctctt gtataattgt ttttttaatg
     3061 gaaagtatta cagaatcgag ggtgaaattc ttagaaccaa agttattctt aataaaaatc
     3121 accaatgctt ggaccacgca
//
