LOCUS       NM_001360339            2979 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus family with sequence similarity 107, member A
            (Fam107a), transcript variant 4, mRNA.
ACCESSION   NM_001360339 XM_006518019
VERSION     NM_001360339.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2979)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2979)
  AUTHORS   Lu,F., Zhu,L., Jia,X., Wang,J. and Mu,P.
  TITLE     Downregulated in renal carcinoma 1 (DRR1) mediates the
            differentiation of neural stem cells through transcriptional
            regulation
  JOURNAL   Neurosci Lett 756, 135943 (2021)
   PUBMED   33965500
  REMARK    GeneRIF: Downregulated in renal carcinoma 1 (DRR1) mediates the
            differentiation of neural stem cells through transcriptional
            regulation.
REFERENCE   3  (bases 1 to 2979)
  AUTHORS   Manigandan,S., Mukherjee,S. and Yun,J.W.
  TITLE     Loss of family with sequence similarity 107, member A (FAM107A)
            induces browning in 3T3-L1 adipocytes
  JOURNAL   Arch Biochem Biophys 704, 108885 (2021)
   PUBMED   33878327
  REMARK    GeneRIF: Loss of family with sequence similarity 107, member A
            (FAM107A) induces browning in 3T3-L1 adipocytes.
REFERENCE   4  (bases 1 to 2979)
  AUTHORS   Muthu,V., Rohacek,A.M., Yao,Y., Rakowiecki,S.M., Brown,A.S.,
            Zhao,Y.T., Meyers,J., Won,K.J., Ramdas,S., Brown,C.D.,
            Peterson,K.A. and Epstein,D.J.
  TITLE     Genomic architecture of Shh-dependent cochlear morphogenesis
  JOURNAL   Development 146 (18) (2019)
   PUBMED   31488567
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2979)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2979)
  AUTHORS   Schmidt,M.V., Schulke,J.P., Liebl,C., Stiess,M., Avrabos,C.,
            Bock,J., Wochnik,G.M., Davies,H.A., Zimmermann,N., Scharf,S.H.,
            Trumbach,D., Wurst,W., Zieglgansberger,W., Turck,C., Holsboer,F.,
            Stewart,M.G., Bradke,F., Eder,M., Muller,M.B. and Rein,T.
  TITLE     Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is
            a stress-induced actin bundling factor that modulates synaptic
            efficacy and cognition
  JOURNAL   Proc Natl Acad Sci U S A 108 (41), 17213-17218 (2011)
   PUBMED   21969592
  REMARK    GeneRIF: Endogenous DRR1 localizes to some, but not all, synapses,
            with preference for the presynaptic region. Enhancement of DRR1
            expression reduced spine density, diminished the probability of
            synaptic glutamate release, and altered cognitive performance.
REFERENCE   7  (bases 1 to 2979)
  AUTHORS   Shimogori,T., Lee,D.A., Miranda-Angulo,A., Yang,Y., Wang,H.,
            Jiang,L., Yoshida,A.C., Kataoka,A., Mashiko,H., Avetisyan,M.,
            Qi,L., Qian,J. and Blackshaw,S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   8  (bases 1 to 2979)
  AUTHORS   Asano,Y., Kishida,S., Mu,P., Sakamoto,K., Murohara,T. and
            Kadomatsu,K.
  TITLE     DRR1 is expressed in the developing nervous system and
            downregulated during neuroblastoma carcinogenesis
  JOURNAL   Biochem Biophys Res Commun 394 (3), 829-835 (2010)
   PUBMED   20298674
REFERENCE   9  (bases 1 to 2979)
  AUTHORS   Feng,W., Leach,S.M., Tipney,H., Phang,T., Geraci,M., Spritz,R.A.,
            Hunter,L.E. and Williams,T.
  TITLE     Spatial and temporal analysis of gene expression during growth and
            fusion of the mouse facial prominences
  JOURNAL   PLoS One 4 (12), e8066 (2009)
   PUBMED   20016822
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2979)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF172036.1, BY244357.1, CT025547.17 and AW047303.1.
            
            On Feb 1, 2018 this sequence version replaced XM_006518019.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044219.1, CJ166395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               CF172036.1         417-682
            267-281             BY244357.1         457-471
            282-435             CT025547.17        86009-86162         c
            436-2379            CT025547.17        83353-85296         c
            2380-2979           AW047303.1         1-600               c
FEATURES             Location/Qualifiers
     source          1..2979
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 4.8 cM"
     gene            1..2979
                     /gene="Fam107a"
                     /gene_synonym="DRR1"
                     /note="family with sequence similarity 107, member A"
                     /db_xref="GeneID:268709"
                     /db_xref="MGI:MGI:3041256"
     exon            1..103
                     /gene="Fam107a"
                     /gene_synonym="DRR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..543
                     /gene="Fam107a"
                     /gene_synonym="DRR1"
                     /note="isoform 2 is encoded by transcript variant 4;
                     protein FAM107A; actin-associated protein FAM107A"
                     /codon_start=1
                     /product="actin-associated protein FAM107A isoform 2"
                     /protein_id="NP_001347268.1"
                     /db_xref="CCDS:CCDS88566.1"
                     /db_xref="GeneID:268709"
                     /db_xref="MGI:MGI:3041256"
                     /translation="MAQKLGEWASAPAEATGLYRAVLLRSASMYSEIQRERADIEGLM
                     ARPEYREWNSELIKPKKLLNPVKASRSHQELHRELLMNHKRGLGMDSKPELQRVLEHR
                     RRNQLIKKKEEELEAKRMQCPFKQELLRRQQRLNQLENPPQRDEDHAPEFIKVRENLR
                     RITTLTSEERAL"
     exon            104..278
                     /gene="Fam107a"
                     /gene_synonym="DRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..435
                     /gene="Fam107a"
                     /gene_synonym="DRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..2963
                     /gene="Fam107a"
                     /gene_synonym="DRR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2933..2938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam107a"
                     /gene_synonym="DRR1"
                     /note="hexamer: AATAAA"
     regulatory      2939..2944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fam107a"
                     /gene_synonym="DRR1"
                     /note="hexamer: AATAAA"
     polyA_site      2944
                     /gene="Fam107a"
                     /gene_synonym="DRR1"
     polyA_site      2959
                     /gene="Fam107a"
                     /gene_synonym="DRR1"
                     /note="major polyA site"
ORIGIN      
        1 cggtggggat acacagcgca gggcatggcg cagaagctgg gcgagtgggc cagtgcgccc
       61 gccgaggcca ccgggctgta ccgagccgtg ctgctcaggt cagcctccat gtactcagag
      121 atccagaggg agcgggctga catcgaggga ctcatggcca gaccagagta cagagagtgg
      181 aactcagagc tcatcaaacc caagaagctg ctgaaccctg tgaaggcttc tcggagccat
      241 caggagctgc accgtgagct gcttatgaac cacaaaaggg gcttgggtat ggacagcaag
      301 cctgagctgc agcgagttct agagcaccgt cgcaggaatc agctgatcaa aaagaaggag
      361 gaggagctag aggccaagcg gatgcagtgc cccttcaagc aggagctgct gaggcggcag
      421 cagagactga accagctgga aaacccacca cagagagacg aggaccacgc ccctgagttc
      481 atcaaagtcc gggaaaacct acgcagaatc accacactga ccagcgagga aagagcactg
      541 tagagctccc tccatccagc tcctgccact tactctggcc cagccctcct ccagccagtc
      601 tgaacctgag gaccctagcc cacaatgctg ccagcaaggc acacctgaaa ggccagctat
      661 tcctgggaag ctggagacac acacacacac acacacacac acacacacac acacacacac
      721 acacagagga aggtctctgg acttttcttt ctgagcacct agccttcttg caccagagag
      781 gaagccactg ccaggaaaga cctccagagg tgccatcccc gatcagactc actgatattt
      841 ccctagcaga agtgaggaag agggccaagt gtccctccat tctgcctcag ttgcccaata
      901 aggcctattt cttggagcag ctcagctcct agtgttggga acagctcaac tctggcttag
      961 cctgaggcca aggacacctg ttttagaaat cacagggcaa gcaaagaagg caccagatgt
     1021 ttgtagcaag gaagggcatg ggaggcgaca gcaggctgtg gtcaggtggg aagggtccca
     1081 agcaaagcag ctttcggtct tgccagcttg cctcagagtt tggcttttat tgctcctccc
     1141 cactgccctc cctaaattac taaccacacc tcacctcaga gctctggctt ccagcctaga
     1201 tcagcacatt gccaagttta ctgtatacac aaatcagaga atcttgtgaa cagtccctgg
     1261 aagctacatg tctaacacac tcccggaggt ggtcctggac gtgggttgga acatatagtt
     1321 aggctgacgc acccaagagt ggtatattaa aaatagccaa ctctcttggc tccctggcct
     1381 gaaggttccc agtgcctcct ctgaagcccc caaattcttc attcactatc catagtgttc
     1441 ccaccacaca cacacacaca cagaattcct tggcctggtc aggggattgt aactgccaat
     1501 ctttatttct tactggtata aaaacactat catacaattc tagccaaaaa gaagggggaa
     1561 agaaccttag ctttctacag ctttttggaa agcaactata caatgatttc ctatggaaca
     1621 atatatatgc tattttgaag accccactgc catggtgatg gaataaactc ttaggtcaat
     1681 attgccagca ctgttacctg agaccctgcc cctccttccc cccagtctgg gtcttcccca
     1741 cccattcttc ttcctcagaa gccccttcct ccctctgtta cacccgaatt acttgaatct
     1801 tttgctccta tgccattttt gaagatctac agagtacgcc aggccgaaat tctttcacct
     1861 gaagaatgaa atccataatt caccttcgca ggtgggaaga gcacttccag acaagcagaa
     1921 gttctcactc cccagagcac agatttccct gctggggcac caggggctct gcctcctgga
     1981 aatgatggtg ggatggccag cagggtctga cagtgaatgg agattctatc tcttccttat
     2041 ggatgttacc tgcatagatg tgtaacacac acacacatcg tgtgtgtgtg tgtatgtgtg
     2101 tgtgtgtgtg tgtgtgtgtg tgtgtgttct aactctaaag ttctaaggca gtgcttctca
     2161 actttcctaa tgcaaccctt taacatagtt tctcatgttg tggtgacccc ctcaaccata
     2221 aattattttc attgcttttt catgactaat tttactacta ttaaacacca taatgtaaat
     2281 atctgatatg caggatatct gatgtgtggc ctcccacccc catgaagggg tcacaaccca
     2341 caggttgaga aacactggta aatacagtga acctgtctta agtatctgct ggtgaggttt
     2401 tatgctgaag atgtgtttcc taaataaaga aagggttggg ggttgtcacc ttacaggtac
     2461 atgtgttgtt ctgacatgta atgaggagta ggacaggacg tctgggatag agtaggacca
     2521 cccaagggac ttagcagtcc ccagggaaat ggcaaatcat ggagagacct caaggcaggt
     2581 catccagagg aaccatagta gctaccttga tactctgtga ctctgttagt cccaattccg
     2641 tctctctcgc tgcttcccac cagagattgt aggcctagcc tcctctgcac atttgggtga
     2701 gcatgtgacc aggtatggcc aatgaaattg aagtggaagt ctataggagc tactagaaaa
     2761 gcccatgcct tttctgagag ccttgctttg tttcttcctt cttgattgag gatgcaatgc
     2821 ctggaccatt agcaaccatg ttttacctaa agaaaaggcc aaaagatcca taaaccctat
     2881 gatcatctga ccaagcaagt gccaacagct ctccatctcc agaacccttg taaataaaaa
     2941 taaattcctg tttggtaaag ccaaaaaaaa aaaaaaaaa
//
