LOCUS       NM_028224               4668 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus Fas apoptotic inhibitory molecule 2 (Faim2),
            transcript variant 1, mRNA.
ACCESSION   NM_028224
VERSION     NM_028224.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4668)
  AUTHORS   Griffin,E.N., Jucius,T., Sim,S.E., Harris,B.S., Heinz,S. and
            Ackerman,S.L.
  TITLE     RREB1 regulates neuronal proteostasis and the microtubule network
  JOURNAL   Sci Adv 10 (2), eadh3929 (2024)
   PUBMED   38198538
REFERENCE   2  (bases 1 to 4668)
  AUTHORS   Hwang,I., Kim,B.S., Ko,H.R., Cho,S., Lee,H.Y., Cho,S.W., Ryu,D.,
            Shim,S. and Ahn,J.Y.
  TITLE     Cerebellar dysfunction and schizophrenia-like behavior in
            Ebp1-deficient mice
  JOURNAL   Mol Psychiatry 27 (4), 2030-2041 (2022)
   PUBMED   35165395
REFERENCE   3  (bases 1 to 4668)
  AUTHORS   Habib,P., Stamm,A.S., Zeyen,T., Noristani,R., Slowik,A., Beyer,C.,
            Wilhelm,T., Huber,M., Komnig,D., Schulz,J.B. and Reich,A.
  TITLE     EPO regulates neuroprotective Transmembrane BAX Inhibitor-1
            Motif-containing (TMBIM) family members GRINA and FAIM2 after
            cerebral ischemia-reperfusion injury
  JOURNAL   Exp Neurol 320, 112978 (2019)
   PUBMED   31211943
REFERENCE   4  (bases 1 to 4668)
  AUTHORS   Komnig,D., Gertz,K., Habib,P., Nolte,K.W., Meyer,T.,
            Brockmann,M.A., Endres,M., Rathkolb,B., Hrabe de Angelis,M.,
            Schulz,J.B., Falkenburger,B.H. and Reich,A.
  CONSRTM   German Mouse Clinic Consortium
  TITLE     Faim2 contributes to neuroprotection by erythropoietin in transient
            brain ischemia
  JOURNAL   J Neurochem 145 (3), 258-270 (2018)
   PUBMED   29315561
  REMARK    GeneRIF: Faim2 up-regulation may contribute to the neuroprotective
            effects of low-dose erythropoietin in transient brain ischemia
REFERENCE   5  (bases 1 to 4668)
  AUTHORS   Pawar,M., Busov,B., Chandrasekhar,A., Yao,J., Zacks,D.N. and
            Besirli,C.G.
  TITLE     FAS apoptotic inhibitory molecule 2 is a stress-induced intrinsic
            neuroprotective factor in the retina
  JOURNAL   Cell Death Differ 24 (10), 1799-1810 (2017)
   PUBMED   28708137
  REMARK    GeneRIF: that FAIM2 is an intrinsic neuroprotective factor
            activated by stress in photoreceptors and delays FAS-mediated
            photoreceptor apoptosis
REFERENCE   6  (bases 1 to 4668)
  AUTHORS   Wang,S.Z., Ou,J., Zhu,L.J. and Green,M.R.
  TITLE     Transcription factor ATF5 is required for terminal differentiation
            and survival of olfactory sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 109 (45), 18589-18594 (2012)
   PUBMED   23090999
REFERENCE   7  (bases 1 to 4668)
  AUTHORS   Besirli,C.G., Zheng,Q.D., Reed,D.M. and Zacks,D.N.
  TITLE     ERK-mediated activation of Fas apoptotic inhibitory molecule 2
            (Faim2) prevents apoptosis of 661W cells in a model of
            detachment-induced photoreceptor cell death
  JOURNAL   PLoS One 7 (9), e46664 (2012)
   PUBMED   23029562
  REMARK    GeneRIF: Expression of Faim2 is triggered, at least in part, by
            Fas-receptor activation and subsequent ERK signaling.
REFERENCE   8  (bases 1 to 4668)
  AUTHORS   Hurtado de Mendoza,T., Perez-Garcia,C.G., Kroll,T.T., Hoong,N.H.,
            O'Leary,D.D. and Verma,I.M.
  TITLE     Antiapoptotic protein Lifeguard is required for survival and
            maintenance of Purkinje and granular cells
  JOURNAL   Proc Natl Acad Sci U S A 108 (41), 17189-17194 (2011)
   PUBMED   21957071
  REMARK    GeneRIF: mechanism of action of LFG as an inhibitor of the Fas
            pathway and evidence of the neuroprotective role of LFG in
            cerebellar granule neurons and Purkinje cells in an organotypic
            cerebellar culture system
            Erratum:[Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11906]
REFERENCE   9  (bases 1 to 4668)
  AUTHORS   Reich,A., Spering,C., Gertz,K., Harms,C., Gerhardt,E.,
            Kronenberg,G., Nave,K.A., Schwab,M., Tauber,S.C., Drinkut,A.,
            Harms,K., Beier,C.P., Voigt,A., Gobbels,S., Endres,M. and
            Schulz,J.B.
  TITLE     Fas/CD95 regulatory protein Faim2 is neuroprotective after
            transient brain ischemia
  JOURNAL   J Neurosci 31 (1), 225-233 (2011)
   PUBMED   21209208
  REMARK    GeneRIF: This study demonistrated that lack of Faim2 caused an
            increase in susceptibility to combined oxygen-glucose deprivation
            in primary neurons as well as in caspase-associated cell death,
            stroke volume, and neurological impairment after cerebral ischemia.
REFERENCE   10 (bases 1 to 4668)
  AUTHORS   Fernandez,M., Segura,M.F., Sole,C., Colino,A., Comella,J.X. and
            Cena,V.
  TITLE     Lifeguard/neuronal membrane protein 35 regulates Fas
            ligand-mediated apoptosis in neurons via microdomain recruitment
  JOURNAL   J Neurochem 103 (1), 190-203 (2007)
   PUBMED   17635665
  REMARK    GeneRIF: LFG is an endogenous inhibitor of FasL-mediated neuronal
            death detected in lipid rafts microdomains, and it mediates the
            FasL resistance of CNS differentiated neurons
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072560.1, AK158960.1, AK030513.1 and CJ283203.1.
            
            On Oct 10, 2012 this sequence version replaced NM_028224.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072560.1, AK158960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2296              BC072560.1         1-2296
            2297-3061           AK158960.1         2090-2854
            3062-3210           AK030513.1         2551-2699
            3211-4657           AK158960.1         3004-4450
            4658-4668           CJ283203.1         390-400
FEATURES             Location/Qualifiers
     source          1..4668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..4668
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /note="Fas apoptotic inhibitory molecule 2"
                     /db_xref="GeneID:72393"
                     /db_xref="MGI:MGI:1919643"
     exon            1..586
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /inference="alignment:Splign:2.1.0"
     CDS             572..1525
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neural membrane protein 35; protein lifeguard 2"
                     /codon_start=1
                     /product="protein lifeguard 2 isoform 1"
                     /protein_id="NP_082500.2"
                     /db_xref="CCDS:CCDS37203.1"
                     /db_xref="GeneID:72393"
                     /db_xref="MGI:MGI:1919643"
                     /translation="MTQGKLSVANKAPGTEGQQHQANGEKKDAPAVPSAPPSYEEATS
                     GEGLKAGTFPQGPTAVPLHPSWAYVDPSGSSGYEGGFPAGHHEHFTTFSWDDQKVRRL
                     FIRKVYTILLVQLLVTLAVVALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCS
                     GPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLVITALVCLSVTIFSFQTK
                     FDFTSCQGVLFVLLMTLFFSGLLLAVLLPFQYVPWLHAVYAVLGAGVFTLFLAFDTQL
                     LMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE"
     exon            587..785
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..889
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /inference="alignment:Splign:2.1.0"
     exon            890..954
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1008
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1059
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1099
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1137
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1225
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1321
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1375
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..4668
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4642..4647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /note="hexamer: AATAAA"
     polyA_site      4661
                     /gene="Faim2"
                     /gene_synonym="2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35;
                     Tmbim2"
                     /note="major polyA site"
ORIGIN      
        1 tggaccggga gccctggtgg gaggcagagt aggcaagcca tccagaactt tctcagtcta
       61 tgtgaacgct gaaatagacg atgagagggc tgtggagatg gagacaaatt gaggccattc
      121 gaacagggag gggggaacaa ggccgaagct ggtggctgct tgcgctgaga tgaggccttt
      181 atacaagctc tgtacactgg cagacagaat cagctggtcg ggtgtcaggg agtcctggtg
      241 cctcctccca cccctgtgga cccatccacc tgctgctcca cggcgcaaag ctccccggtc
      301 ccctgggatg gctgaagtgt gtgggagaag cagaggaggc caaagcgcat gtcttgccct
      361 gctctcaggt ccgcagcatc ctgcgtccgc agcagcatct tcccaggccc tccccctccc
      421 cccgtgtgcg gatggtacgc tccggtaagc ctggccgggt tgcagtggat gttgctagaa
      481 tccacgcgga ggaaagaaga gacgcaggca ggctgcggtg acccaagcgg ccacccccgc
      541 ttcagggacc ccttcctcga gagaagacat catgacccag ggaaagctct ctgtggctaa
      601 caaggccccc gggactgagg ggcagcagca ccaggcaaat ggagagaaga aggatgctcc
      661 ggcagtgccc tcggcgccac cctcctatga ggaggccacc tctggagagg ggctgaaggc
      721 agggaccttc ccccagggcc caacagctgt gccactccat ccaagctggg cctacgtgga
      781 ccccagcggc agctccggct atgaaggtgg tttccccgca ggacatcacg agcatttcac
      841 caccttcagc tgggatgacc agaaagttcg tcggctcttc atcagaaagg tctataccat
      901 cctattggtc cagctgctgg tgaccttggc tgtggtggct ctctttacct tctgtgatgt
      961 cgttaaggac tatgtccagg ctaaccccgg ctggtactgg gcgtcctatg ccgtgttctt
     1021 tgcaacttac ctgactctgg cttgctgttc tggacccagg agacatttcc cttggaacct
     1081 gattctgctg accatcttta ccctgtccat ggcctacctc actgggatgc tgtccagtta
     1141 ctacaacacc acatctgtgc tgctgtgcct ggtcatcacg gctctcgtct gcctctcggt
     1201 caccatcttc agtttccaga ccaagtttga cttcacctcc tgtcagggtg tgctgtttgt
     1261 gctgctcatg accctcttct tcagtggact cctcctcgct gtcctcctgc ccttccaata
     1321 cgtcccctgg ctccacgcgg tctatgctgt actgggagcg ggtgtgttca cgttgttcct
     1381 ggcctttgat acccagttgc tgatgggtaa ccgtcgacac tcgctgagcc ccgaggagta
     1441 tatttttgga gccctcaaca tctacttaga cattatctat atcttcacct tcttcctgca
     1501 gctttttggc accaaccggg aatgaggagc catccccgcc cccacccctc ctccagagaa
     1561 tgtcccttcc ctgtcctgtg accctctccg tgctcctgtg agaccagaca taaactcgct
     1621 gcagccagct tgtgagcagc cgcttgctcc ctcctgcagc cagccctcac ggtgtccttc
     1681 tgcagcttgt acatatgcca tgcttggggc cctgcagatc tgaggccata ccatcccctg
     1741 cggtgcccct ggcacccaac tgcatcttcc aaatggcaca gtcaaggctg agggcacctc
     1801 tgggtttgca gacccaagga atgagcagga ggagcccggc aggatctcag aggtggggag
     1861 gagaccccag gaaacctggc tgtgactgtg acccccacca agtcttctag ggctccattt
     1921 tctctttcag atcaaacaac catgcttcgt aagaaaaaaa tagccaaggg ggcatggcta
     1981 gagcatgaag tcagggctct gtggcgtagg gtgaagctgt ccccagctgt cactcgctta
     2041 gctgaaggcc agttgcttgt tctagggacc tgggaataga atgagaatag gaagccactg
     2101 gtttcgttac ttgcctcagt ttcccctcct gggtcatcca ggtcatagaa caggggggtg
     2161 ggggcaagat gtgctaagca tagcctgagc tcccagggga agctgggagg gctgaactgg
     2221 gggctgtcaa tcaaattgca tccactggaa aggcacatat gaccataggg ctagaacccc
     2281 atctctctct ctctctttct ctctctctct ctctctctct ctctctctct ctctctctct
     2341 ctcttccact cagtgccatt cccacaggcc tgaaggggag gtggggtaga gggcctggtg
     2401 tggaagtggt tctgtctgct ggactagccc ttaccagggg ctgtccttca ggcgcttcta
     2461 catgcatttc ctgggtcttc ccctgtattc tgctgcactc tgtcttacct gcagcctgaa
     2521 gagtagaggc atccatttcc ctccccccag cttccctggc cactcagccc agagtccctg
     2581 ggcccttgcc cccttatctc cacatctctg taatttggaa gctgtccagc taatggtcac
     2641 agccagggcc agtcccttga gcctatccct tgcgatgagg ccagagctcc ttatcaacct
     2701 ccaggctgct gggatctcag gcagagtgtg cgtcagccac cctgccctgg ctgactgcct
     2761 gttggagagg ggaccagggg cccacacctg gggcagcatg tgggcgacac atgcacccgg
     2821 ccagctctag tccagtggaa agttactggg tgaaggctac aaggccctga gtggatgcag
     2881 gggaccctgt ctgccccagg aaaggggact aggtagccca tccattccca cccctaccct
     2941 ttcccaccct gcctactcca gcctttgaga aatattacag aagcatttga aattttgttc
     3001 catcttggat atttgaggag ggagggtggt atggagggac agttggggtg ggtgctggtt
     3061 caaatgagcc tacttgcagc agtccagact ggtcctgcag ggttatcggc atatccccat
     3121 ttcagaagca aagccaagta gctccggaag gcttggataa acccactgtc gtctaataaa
     3181 cctgagggac agcccacagc tacttcctcc agtctgagtc tgggctggat tgagacttgt
     3241 gtagcccata ggtgtgtggg tagacaagca ctgacatctc cggggagttg tgacaccccc
     3301 acctgccact gtcacccagc ctgcggatgc caaactctta gcttttccct ccctggaggt
     3361 cagctgggaa gcagggttct tggcttctgg ttctgacccc actgccaaca gacttattac
     3421 tctctgtgac tctgttttcc tatctgcaag atggaagtcc ccaaccggtg ccagtggggc
     3481 agggagagag gcaccaagac acttggctga cttcctcctc tgcttgttcc cctttgagtg
     3541 cctttcctaa tctccagctt cagttctaga aaggtttaga gtccctcccc cacccccact
     3601 gacatgtcac cctcacactg gccagtttcc cagaatccac ttgtccaagt cctcttctga
     3661 gacaatttat gcagagagcg aggattgaga aaaattttcc aaggctaagt tccaaaaacc
     3721 attgggggag gggcaagccc tcagccataa ataatgtgac cagggcacaa gtcacagtga
     3781 tctcaaagat ggctggtgac ggtggggagg cacggcggct gaactggctc cagggccaga
     3841 gaaagccttg atgttgaccc ctggtggggc agtgaggagt cccagggaca cctgggtggg
     3901 tcttggcagg aggaagggcg gagaaacaag aatgcaggat tatgaggaat gcgggattat
     3961 gagaaaccta aactgggcag gtgcggcaag ctgtgtagga ggaaggactg acgcctcctg
     4021 gccccccgca tttttagctt gggtgtagcc agacctatga cggggtagat tagatttcat
     4081 aaggcttgag ggagccagga atatctgatg tgaggctcaa agctctctga gaaaccgtga
     4141 cagaccagga tgtcccctcc gaggctcaag atgggaccaa gtaggggcat taagtccctc
     4201 actccccaca ccaattcctg ggtccatgca cagctttttc agtatagccc aaggaagcca
     4261 caagacatcc ttgggtgtgg tatggttctt ccattccata ccctttcttc tgtgttagcc
     4321 tgcaggatcc cttaagtacc cttattccaa taggccaggg tggggggtgg gggcgtgtca
     4381 agttgggaat tttacacaag gactttgctg cccccttctg gctgttagag gaaaagcaga
     4441 gtctggcttt gcacaaaccc atctctattc agtcccctgc tctgagtgtc agagaatgga
     4501 gatatagcac caggcacaag gacttgcctg ctacacaccc agacgggcct gcccttttgg
     4561 catcagctct tcaagttccc tatctcttcc gtgtgcctgt ctccggcctc acctgcccaa
     4621 gatctgtgac tgattggaaa taataaaagc aattacgaag acacctgg
//
