LOCUS       NM_011810               1032 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Fas apoptotic inhibitory molecule (Faim), transcript
            variant 2, mRNA.
ACCESSION   NM_011810 XM_976720 XM_990152 XM_992352
VERSION     NM_011810.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1032)
  AUTHORS   Sires,A., Pazo-Gonzalez,M., Lopez-Soriano,J., Mendez,A., de la
            Rosa,E.J., de la Villa,P., Comella,J.X., Hernandez-Sanchez,C. and
            Sole,M.
  TITLE     The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers
            Arrestin-1 Translocation upon Light Reception in the Retina
  JOURNAL   Cells 12 (3), 487 (2023)
   PUBMED   36766830
  REMARK    GeneRIF: The Absence of FAIM Leads to a Delay in Dark Adaptation
            and Hampers Arrestin-1 Translocation upon Light Reception in the
            Retina.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1032)
  AUTHORS   Luo,W., Dai,J., Liu,J., Huang,Y., Zheng,Z., Xu,P. and Ma,Y.
  TITLE     PACAP attenuates hepatic lipid accumulation through the
            FAIM/AMPK/IRbeta axis during overnutrition
  JOURNAL   Mol Metab 65, 101584 (2022)
   PUBMED   36055580
  REMARK    GeneRIF: PACAP attenuates hepatic lipid accumulation through the
            FAIM/AMPK/IRbeta axis during overnutrition.
REFERENCE   3  (bases 1 to 1032)
  AUTHORS   Sires,A., Turch-Anguera,M., Bogdanov,P., Sampedro,J., Ramos,H.,
            Ruiz Lasa,A., Huo,J., Xu,S., Lam,K.P., Lopez-Soriano,J.,
            Perez-Garcia,M.J., Hernandez,C., Simo,R., Sole,M. and Comella,J.X.
  TITLE     Faim knockout leads to gliosis and late-onset neurodegeneration of
            photoreceptors in the mouse retina
  JOURNAL   J Neurosci Res 99 (12), 3103-3120 (2021)
   PUBMED   34713467
  REMARK    GeneRIF: Faim knockout leads to gliosis and late-onset
            neurodegeneration of photoreceptors in the mouse retina.
REFERENCE   4  (bases 1 to 1032)
  AUTHORS   Sansa,A., de la Fuente,S., Comella,J.X., Garcera,A. and Soler,R.M.
  TITLE     Intracellular pathways involved in cell survival are deregulated in
            mouse and human spinal muscular atrophy motoneurons
  JOURNAL   Neurobiol Dis 155, 105366 (2021)
   PUBMED   33845129
REFERENCE   5  (bases 1 to 1032)
  AUTHORS   Coccia,E., Planells-Ferrer,L., Badillos-Rodriguez,R., Pascual,M.,
            Segura,M.F., Fernandez-Hernandez,R., Lopez-Soriano,J., Gari,E.,
            Soriano,E., Barneda-Zahonero,B., Moubarak,R.S., Perez-Garcia,M.J.
            and Comella,J.X.
  TITLE     SIVA-1 regulates apoptosis and synaptic function by modulating XIAP
            interaction with the death receptor antagonist FAIM-L
  JOURNAL   Cell Death Dis 11 (2), 82 (2020)
   PUBMED   32015347
  REMARK    GeneRIF: SIVA-1 regulates apoptosis and synaptic function by
            modulating XIAP interaction with the death receptor antagonist
            FAIM-L.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1032)
  AUTHORS   Qiu,H., Golas,A., Grzmil,P. and Wojnowski,L.
  TITLE     Lineage-specific duplications of Muroidea Faim and Spag6 genes and
            atypical accelerated evolution of the parental Spag6 gene
  JOURNAL   J Mol Evol 77 (3), 119-129 (2013)
   PUBMED   24071998
REFERENCE   7  (bases 1 to 1032)
  AUTHORS   Segura,M.F., Sole,C., Pascual,M., Moubarak,R.S., Perez-Garcia,M.J.,
            Gozzelino,R., Iglesias,V., Badiola,N., Bayascas,J.R., Llecha,N.,
            Rodriguez-Alvarez,J., Soriano,E., Yuste,V.J. and Comella,J.X.
  TITLE     The long form of Fas apoptotic inhibitory molecule is expressed
            specifically in neurons and protects them against death
            receptor-triggered apoptosis
  JOURNAL   J Neurosci 27 (42), 11228-11241 (2007)
   PUBMED   17942717
REFERENCE   8  (bases 1 to 1032)
  AUTHORS   Zhong,X., Schneider,T.J., Cabral,D.S., Donohoe,T.J. and
            Rothstein,T.L.
  TITLE     An alternatively spliced long form of Fas apoptosis inhibitory
            molecule (FAIM) with tissue-specific expression in the brain
  JOURNAL   Mol Immunol 38 (1), 65-72 (2001)
   PUBMED   11483211
REFERENCE   9  (bases 1 to 1032)
  AUTHORS   Rothstein,T.L., Zhong,X., Schram,B.R., Negm,R.S., Donohoe,T.J.,
            Cabral,D.S., Foote,L.C. and Schneider,T.J.
  TITLE     Receptor-specific regulation of B-cell susceptibility to
            Fas-mediated apoptosis and a novel Fas apoptosis inhibitory
            molecule
  JOURNAL   Immunol Rev 176, 116-133 (2000)
   PUBMED   11043772
  REMARK    Review article
REFERENCE   10 (bases 1 to 1032)
  AUTHORS   Schneider,T.J., Fischer,G.M., Donohoe,T.J., Colarusso,T.P. and
            Rothstein,T.L.
  TITLE     A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM)
            isolated from inducibly Fas-resistant B lymphocytes
  JOURNAL   J Exp Med 189 (6), 949-956 (1999)
   PUBMED   10075978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU962258.1, BY055691.1 and BC079662.1.
            
            On Mar 28, 2008 this sequence version replaced NM_011810.2.
            
            Transcript Variant: This variant (2) lacks the exon containing the
            translation start codon compared to variant 1. The resulting
            isoform (Faim-S) has a shorter N-terminus compared to isoform
            Faim-L.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF615847.1, BF019986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BU962258.1         4-34
            32-155              BY055691.1         2-125
            156-1032            BC079662.1         1-877
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 51.41 cM"
     gene            1..1032
                     /gene="Faim"
                     /note="Fas apoptotic inhibitory molecule"
                     /db_xref="GeneID:23873"
                     /db_xref="MGI:MGI:1344387"
     exon            1..140
                     /gene="Faim"
                     /inference="alignment:Splign:2.1.0"
     exon            141..273
                     /gene="Faim"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..702
                     /gene="Faim"
                     /note="isoform Faim-S is encoded by transcript variant 2;
                     fas apoptotic inhibitory molecule 1"
                     /codon_start=1
                     /product="fas apoptotic inhibitory molecule 1 isoform
                     Faim-S"
                     /protein_id="NP_035940.3"
                     /db_xref="CCDS:CCDS23431.1"
                     /db_xref="GeneID:23873"
                     /db_xref="MGI:MGI:1344387"
                     /translation="MTDLVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRREW
                     MFKLVGKETFFVGAAKTKATINIDAISGFAYEYTLEIDGKSLKKYMENRSKTTSTWVL
                     RLDGEDLRVVLEKDTMDVWCNGQKMETAGEFVDDGTETHFSVGNHGCYIKAVSSGKRK
                     EGIIHTLIVDNREIPELTQ"
     exon            274..502
                     /gene="Faim"
                     /inference="alignment:Splign:2.1.0"
     exon            503..552
                     /gene="Faim"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1017
                     /gene="Faim"
                     /inference="alignment:Splign:2.1.0"
     regulatory      992..997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Faim"
                     /note="hexamer: AATAAA"
     polyA_site      1017
                     /gene="Faim"
                     /note="major polyA site"
ORIGIN      
        1 agtgggcggg gtctcgttga gcccggaagg cagtaggagg ctgggcgccc ggcatgcggg
       61 tgctggagcc cggtgggcgc ggccgcgaga gctgctgact acgtcgtggg atcgggagcc
      121 ggtggcggcg cgcggagcag ccctctctat agcctggaaa aaatgacgga tctcgtagct
      181 gtttgggacg tagcattaag tgacggagtc cacaagattg aatttgaaca tgggaccaca
      241 tcaggcaagc gggttgtgta cgtggatggg aaggaagaga taagaagaga gtggatgttc
      301 aagttggtgg gcaaagaaac gttctttgtc ggagctgcaa aaaccaaagc caccatcaat
      361 atagatgcca taagtggctt cgcatacgag tacacgctgg aaattgatgg gaagagcctc
      421 aagaagtaca tggagaacag gtcaaagacc accagcacct gggtgctgcg cctggatggc
      481 gaggacctga gagttgtttt ggaaaaagac actatggacg tatggtgcaa tggtcagaaa
      541 atggagacag cgggcgagtt tgtagatgat gggactgaga cgcacttcag cgttgggaac
      601 cacggctgtt acataaaagc tgtgagcagc ggaaagagga aagaagggat tatccatacc
      661 ctcattgtgg ataacaggga aatcccagag ctcactcagt gacaccttct tactgagttc
      721 tgagccgagg aggtgacctc gggactcgcc gatggctgtg gtaattaaat gggttcaata
      781 tgtacatatt gttagattta gtctgcaatg tttttatttt tatcttttgt tacttgaaac
      841 tgtaatattc caatggtcaa gaaaaaacaa ggactcataa aaatgtattt tttaactaat
      901 ataaagtgtt tctaattcaa atggaaaata aaatgtggac caaaccacta acatcccaca
      961 acagtaacct tgactgtagt taacactgta aaataaaatg gtgctgctgg ccctgcaaaa
     1021 aaaaaaaaaa aa
//
