LOCUS       NM_029629               1242 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus fumarylacetoacetate hydrolase domain containing 2A
            (Fahd2a), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_029629 XM_985846
VERSION     NM_029629.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1242)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1242)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1242)
  AUTHORS   Choi,H., Baik,M. and Myung,K.
  TITLE     Differential expression of murine CGI-105 gene in 3T3-L1 cells by
            adrenocorticotropic hormones
  JOURNAL   Cell Biol Int 29 (2), 177-179 (2005)
   PUBMED   15774318
  REMARK    GeneRIF: CGI-105 mRNA is induced in differentiating 3T3-L1 cells by
            adrenocorticotropic hormones.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY269533.1, AK080868.1 and AI841210.1.
            
            On Aug 15, 2009 this sequence version replaced NM_029629.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030182.1, AK080868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BY269533.1         2-16
            16-1225             AK080868.1         2-1211
            1226-1242           AI841210.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.01 cM"
     gene            1..1242
                     /gene="Fahd2a"
                     /gene_synonym="1500003K14Rik; B430104H02Rik; Cgi-105;
                     Fahd2"
                     /note="fumarylacetoacetate hydrolase domain containing 2A"
                     /db_xref="GeneID:68126"
                     /db_xref="MGI:MGI:1915376"
     exon            1..149
                     /gene="Fahd2a"
                     /gene_synonym="1500003K14Rik; B430104H02Rik; Cgi-105;
                     Fahd2"
                     /inference="alignment:Splign:2.1.0"
     exon            150..400
                     /gene="Fahd2a"
                     /gene_synonym="1500003K14Rik; B430104H02Rik; Cgi-105;
                     Fahd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1097
                     /gene="Fahd2a"
                     /gene_synonym="1500003K14Rik; B430104H02Rik; Cgi-105;
                     Fahd2"
                     /EC_number="5.3.2.2"
                     /note="fumarylacetoacetate hydrolase domain-containing
                     protein 2A"
                     /codon_start=1
                     /product="oxaloacetate tautomerase Fahd2a, mitochondrial"
                     /protein_id="NP_083905.1"
                     /db_xref="CCDS:CCDS16702.1"
                     /db_xref="GeneID:68126"
                     /db_xref="MGI:MGI:1915376"
                     /translation="MLGFGRRRLFSALLQVQKRPCQPSRNMRLVQFQAPHLEEPHLGL
                     ESGVGGGVVDLNAFDSTLPKTMVQFLEQGETTLSVARRALATQLPVIPRSQVTFLAPV
                     TRPDKVICVGLNYADHCQEQNVRVPKSPIIFSKFSSSIVGPYDEIILPPESKEVDWEV
                     EMAVVIGKKGKHIKATDVMAHVAGFTVAHDVSARDWQMRNGKQWLLGKTFDTFCPLGP
                     ALVTKDTIADPHNLKICCRVNGEVVQSSNTNQMVFKTEYLIAWVSQFVTLYPGDLLLT
                     GTPPGVGMFRKPPVFLKKGDEVQCEIEELGVIINKVV"
     exon            401..617
                     /gene="Fahd2a"
                     /gene_synonym="1500003K14Rik; B430104H02Rik; Cgi-105;
                     Fahd2"
                     /inference="alignment:Splign:2.1.0"
     exon            618..677
                     /gene="Fahd2a"
                     /gene_synonym="1500003K14Rik; B430104H02Rik; Cgi-105;
                     Fahd2"
                     /inference="alignment:Splign:2.1.0"
     exon            678..837
                     /gene="Fahd2a"
                     /gene_synonym="1500003K14Rik; B430104H02Rik; Cgi-105;
                     Fahd2"
                     /inference="alignment:Splign:2.1.0"
     exon            838..946
                     /gene="Fahd2a"
                     /gene_synonym="1500003K14Rik; B430104H02Rik; Cgi-105;
                     Fahd2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1034
                     /gene="Fahd2a"
                     /gene_synonym="1500003K14Rik; B430104H02Rik; Cgi-105;
                     Fahd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1226
                     /gene="Fahd2a"
                     /gene_synonym="1500003K14Rik; B430104H02Rik; Cgi-105;
                     Fahd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1203..1208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fahd2a"
                     /gene_synonym="1500003K14Rik; B430104H02Rik; Cgi-105;
                     Fahd2"
                     /note="hexamer: AATAAA"
     polyA_site      1226
                     /gene="Fahd2a"
                     /gene_synonym="1500003K14Rik; B430104H02Rik; Cgi-105;
                     Fahd2"
                     /note="major polyA site"
ORIGIN      
        1 gaaggggcgg tccctatatt ccttggagaa gagttaagtg cttgcagcgg tactggctgt
       61 ggcttctccg ccctcccctc ttgtcctgcg gctccgcagg cgtccgctga cagcgcagga
      121 agccggacaa gtccggctgc aacgaccagg ctttgatgct gggctttggg aggaggaggc
      181 tgttctcagc tctgctgcag gttcagaaga ggccctgtca accctccaga aacatgagac
      241 tggtacagtt ccaggcacct cacctggaag agcctcacct gggtctggag tcaggggttg
      301 gtgggggagt tgtagactta aatgcttttg actcaacact ccctaagaca atggtgcagt
      361 tcctggagca aggagagacc accctttcag tggcaagaag agccctggct acccagctgc
      421 ctgtcatccc tcggtcacag gtgaccttct tggcccctgt cacccggcca gacaaggtga
      481 tatgtgtggg cttgaattat gcagaccact gccaagaaca gaatgtgcgg gtgcccaaga
      541 gccccatcat cttcagcaag ttctccagct ctatcgtggg gccctacgat gagatcatcc
      601 tcccaccaga gagcaaggaa gttgactggg aggtcgagat ggccgtggtc attgggaaga
      661 aaggcaaaca catcaaggcc acagatgtca tggctcacgt ggctggcttc actgtggctc
      721 atgatgtgag tgctcgggac tggcaaatga gaaatggaaa gcagtggtta ctgggaaaaa
      781 cttttgatac tttctgcccc ctgggccctg ccttggttac caaggatacc atagcagatc
      841 cacacaattt aaagatctgc tgtcgagtga atggagaggt agtccagagc agcaacacca
      901 accagatggt gttcaagact gaatatctga tagcctgggt ctcccagttt gtcactcttt
      961 acccagggga cctcctcctg actgggacgc ctccaggtgt tggcatgttt aggaagcctc
     1021 ctgtcttcct caagaagggc gatgaagtcc agtgtgagat tgaagaactt ggtgtcatca
     1081 tcaacaaggt ggtgtgatgg tgtccctgtt agcactggac ttgacacaag gcgggacttc
     1141 tgctcccacc cagctaactg ctggccctgt ccacttgagg ctgctcttag gtaggccttg
     1201 gaaataaatt ttctctcaga gttgcaaaaa aaaaaaaaaa aa
//
